384,896 research outputs found
Entrevista a Josep Gustems por Ana M. Vernia
No full textInterview with Josep Gustems by Ana M. VerniaEntrevista a Josep Gustems por Ana M. Verni
Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
No full text14 pags., 7 figs., 3 tabs.Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities. We now present a thorough study combining NMR and other biophysical methods together with state-of-the-art theoretical calculations on a fully modified 10-mer hybrid duplex. Comparison between the solution structure of 2′F-ANA•RNA and ANA•RNA hybrids indicates that the increased binding affinity of 2′F-ANA is related to several subtle differences, most importantly a favorable pseudohydrogen bond (2′F-purine H8) which contrasts with unfavorable 2′-OH-nucleobase steric interactions in the case of ANA. While both 2′F-ANA and ANA strands maintained conformations in the southern/eastern sugar pucker range, the 2′F-ANA strand's structure was more compatible with the A-like structure of a hybrid duplex. No dramatic differences are found in terms of relative hydration for the two hybrids, but the ANA•RNA duplex showed lower uptake of counterions than its 2′F-ANA•RNA counterpart. Finally, while the two hybrid duplexes are of similar rigidities, 2′F-ANA single strands may be more suitably preorganized for duplex formation. Thus the dramatically increased stability of 2′F-ANA•RNA and ANA•RNA duplexes is caused by differencesin at least four areas, of which structure and pseudohydrogen bonding are the most important. © The Author(s) 2010. Published by Oxford University Press.Spanish Ministerio de Ciencia e Innovacion (grants
CTQ2007-68014-C02-02 to CG and BIO2009-10964 to
MO); Fundacion Marcelino Botin (grant to MO);
Canadian Institutes for Health Research (grant to
M.J.D.); Natural Sciences and Engineering Research
Council of Canada (postgraduate scholarship to
J.K.W.). Funding for open access charge: Canadian
Institutes for Health Research
Ana M. López
No full textAna M. López, in memoriam_________________ ARK CAICYT:http://id.caicyt.gov.ar/ark:/s24690767/6ejuojp96Ana M. López, in memoriam_________________ ARK CAICYT:http://id.caicyt.gov.ar/ark:/s24690767/6ejuojp96
Matute, Ana M.: La felicidad
No full textMatute, Ana M.: La felicidad / [Übers.: Thomas M. Scheerer]. - In: Die Orange ist eine Frucht des Winters / hrsg. von Mercedes Figueras. - München u.a. : Piper, 1991. - S. 157-16
Matute, Ana M.: Señorita Bibiana
No full textMatute, Ana M.: Señorita Bibiana / [Übers.: Thomas M. Scheerer]. - In: Die Orange ist eine Frucht des Winters / hrsg. von Mercedes Figueras. - München u.a. : Piper, 1991. - S. 163-17
Matute, Ana M.: La felicidad
No full textMatute, Ana M.: La felicidad / [Übers.: Thomas M. Scheerer]. - In: Die Orange ist eine Frucht des Winters / hrsg. von Mercedes Figueras. - München u.a. : Piper, 1991. - S. 157-16
Ana Alcoy and Hilariona (Leona) Puyot Sevilla, 1993
No full text"A portrait of Ana Alcoy and Hilariona (Leona) Puyot Sevilla taken by Rita M. Cacas in Washington, D.C. in 1993. Ana was born July 23, 1911 in the Philippines. She arrived in Washington, D.C. in 1947. Leona was born February 16, 1917, and she died in June of 2001. She arrived in Washington, D.C. in 1941." This photograph may be a part of Cacas's photograph documentary, "A Visit with My Elders: portraits and stories of the early 20th century Filipino pioneers.
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Rosa Ana Gutierrez poses for camera in Dr. Hector P. Garcia's office (photograph)
No full textRosa Ana Gutierrez poses for camera in Dr. Hector P. Garcia's office
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Portrait of Rosa Ana Gutierrez, Assistant to Dr. Hector P. Garcia (photograph)
No full textPortrait of Rosa Ana Gutierrez, Assistant to Dr. Hector P. Garcia
Ana Cristina Cesar le Drummond
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e ExpressãoO objeto de estudo deste trabalho é a marginália de Ana Cristina Cesar contida num exemplar do livro Reunião de Carlos Drumond de Andrade. Além de trazer a público um material manuscrito inédito, através da transcrição da marginália, pretende-se fazer uma reflexão crítica, enfocando a leitura como elemento produtor e tentando depreender conceitos de poesia, poema e poeta oriundos dessas anotações. Portanto, a essência desta análise é saber como Ana Cristina Cesar, lê Carlos Drumond de Andrade, o poeta consagrado
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