139 research outputs found
Bill Harney and Jane Goodale, American anthropologist, with a Tiwi Island ceremonial pole, Melville Island, 1954 [picture].
No full textTitle based on information from acquisition documentation and from caption on verso.; Part of collection: Collection of photographs of author and bushman, Bill Harney, ca. 1940-1962.; Condition: Fold and creases on lower right corner.; Jane Goodale, from the university of Pennsylvania and a member of the National Geographic Scientific Expedition to Melville Island, had interest in customs and social position of islander women. Bill Harney was a guide to the expedition.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3705444; Purchased from Michael Treloar Antiquarian Booksellers, List 90, Lot 64, 2006
Elaine Goodale Eastman, Modernist Author? Re-visiting a Border-crossing Woman Writer's Place in Literary History
No full textElaine Goodale Eastman is not a name generally associated with transnational literary modernism. Yet, a review of her extensive oeuvre demonstrates that her writings interacted in diverse complex ways with that cultural movement. She wrote in a range of genres, including lyric poetry, journalism, didactic children's books and what she herself termed "potboilers" aimed primarily at supporting her family's finances. As an editor and co-author with her husband Charles, she contributed to the development of Native American literatures in an intense period of U.S. suppression of indigenous culture--a process in which she played conflicting roles. Through autobiographical texts published late in her life, we see that Eastman continued to have aspirations consistent with a number of modernism's familiar tenets, even as she also struggled to reconcile the intersectional elements in her gendered personal history with both the successes and the limitations of her multi-faceted publishing career. On associe rarement le nom d’Elaine Goodale Eastman au modernisme littéraire transnational. Prise dans son ensemble, toutefois, son oeuvre prolifique peut se lire comme une réponse complexe et variée au mouvement moderniste. Eastman a expérimenté avec divers genres, comme la poésie lyrique, le journalisme ou la littérature enfantine ¿ visée didactique, en sus de produire ce qu’elle considérait comme des « oeuvres alimentaires » destinées ¿ subvenir aux besoins de sa famille. Son travail de rédactrice et sa collaboration avec son époux Charles Eastman ont contribué ¿ l’essor de la littérature amérindienne ¿ une période marquée par la volonté des États-Unis de supprimer la culture indigène, processus auquel l’écrivaine s’est opposée de manière parfois ambivalente. Les écrits autobiographiques publiés tard dans sa carrière montrent que les aspirations d’Eastman ne sont pas sans lien avec celles du modernisme, alors même que l’écrivaine s’efforce de concilier les éléments intersectionnels de son parcours personnel avec les succès et les revers d’une carrière littéraire protéiforme
Group photograph taken at Government House
No full textStanding L-R: Colonel R H Weddell, Government Resident; Miss M Preece, Secretary; Captain Bird, representative of Lord Wakefield. Seated L-R: Amy Johnson and possibly Mrs Weddell. Probably taken at Government House.Goodale, M.Date:192
Abstract B43: Towards a Cancer Dependency Map
No full textAbstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR02) of the Conference Proceedings.
Citation Format: Aviad Tsherniak, Francisca Vazquez, Barbara Weir, Philip Montgomery, Glenn Cowley, Stanley Gill, Gregory Kryukov, Sasha Pantel, Will Harrington, Mike Burger, Robin Meyers, Levi Ali, Amy Goodale, Yenarae Lee, Levi Garraway, Jesse Boehm, David Root, Todd Golub, William Hahn. Towards a Cancer Dependency Map. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr B43.</jats:p
Age of smile: a cross-cultural replication report of Ganel and Goodale (2018).
No full textYoshimura N, Morimoto K, Murai M, et al. Age of smile: a cross-cultural replication report of Ganel and Goodale (2018). Journal of cultural cognitive science. 2021.Smiling is believed to make people look younger. Ganel and Goodale (Psychon Bull Rev 25(6):612-616, 10.3758/s13423-017-1306-8, 2018) proposed that this belief is a misconception rooted in popular media, based on their findings that people actually perceive smiling faces as older. However, they did not clarify whether this misconception can be generalized across cultures. We tested the cross-cultural validity of Ganel and Goodale's findings by collecting data from Japanese and Swedish participants. Specifically, we aimed to replicate Ganel and Goodale's study using segregated sets of Japanese and Swedish facial stimuli, and including Japanese and Swedish participants in groups asked to estimate the age of either Japanese or Swedish faces (two groups of participants*two groups of stimuli; four groups total). Our multiverse analytical approach consistently showed that the participants evaluated smiling faces as older in direct evaluations, regardless of the facial stimuli culture or their nationality, although they believed that smiling makes people look younger. Further, we hypothesized that the effect of wrinkles around the eyes on the estimation of age would vary with the stimulus culture, based on previous studies. However, we found no differences in age estimates by stimulus culture in the present study. Our results showed that we successfully replicated Ganel and Goodale (2018) in a cross-cultural context. Our study thus clarified that the belief that smiling makes people look younger is a common cultural misconception. © The Author(s) 2021
Bill Harney with members of Second National Geographic Expedition to Melville Island, ca. 1954 [picture].
No full textTitle based on information from acquisition documentation and caption list on verso.; Part of collection: Collection of photographs of author and bushman, Bill Harney, ca. 1940-1962.; Back row left to right: George Joy (cook), Eric Jolliffe (cartoonist), Dr. Brian Daily (geologist), Bill Harney (guide). Front row left to right : Jane Goodale (anthropologist), Charles P. Mountford (expedition leader), David Parsons (ornithologist). The expedition was sponsored by the National Geographic Society and the Smithsonian Institution.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-vn3705155; Purchased from Michael Treloar Antiquarian Booksellers, List 90, Lot 64, 2006
Brief article on the two surviving eaglets hatched this year in Hancock County i
No full textBrief article on the two surviving eaglets hatched this year in Hancock County in view of BioDiversity Research\u27s eagle-cam. Wing Goodale of Gorham\u27s BioDiversity said there are 385 nesting pairs of bald eagles in Maine right now, and that the number is on the rise
Appalachian Festival Proposal
No full textA proposal to the city of Columbus to hold an Appalachian Festival in Goodale Park to increase awareness of Appalachian culture in the city
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An Interrogation of ORF Versus CRISPRa Pooled-Screening Technologies Used to Define Cancer Drug-Resistance Landscapes.
No full textResistance to cancer therapies is an ever-present problem, and preemptively understanding the underlying genetic causes will improve patient care, help predict clinical response rates, and elucidate new drug targets. Within the last several years, studying the drug-resistance landscape of a cancer type has been made easier with two gain-of-function pooled genetic-screening systems – open reading frames (ORFs) and CRISPR activation (CRISPRa). The ORF and CRISPRa screening systems produce the same overexpression phenotypes, but with ORF technology the gene of interest is exogenously expressed as a cDNA. Although directed overexpression of single genes provides valuable information, the genes are expressed at non-physiological levels, which can cause artifacts and non-meaningful biological insights. CRISPRa technology has the advantage of activating the endogenous gene transcript, and its splice isoforms, while expanding the capacity to conduct large-scale genetic screens. Despite these differences between the two technologies, both have proven successful in unfolding some of the unknown mechanisms of drug-resistance in cancer.
However, recent works have shown that the two gain-of-function mechanisms provide minimally concordant gene hit lists when screened in the same NRAS-mutant melanoma cell line. This study examines why the two technologies yield some discrepancies by generating follow-up, pooled ORF and CRISPRa libraries. These libraries contain the same set of genes hits from the primary screens, and secondary screens are performed in the same cell line. The data show that genes that were identified with only one of the methodologies in the primary screens, are confirmed more strongly with the same methodology in the secondary screens. Both ORF and CRISPRa validate the same percentage of gene hits, but unique sets of ‘ORF-only’ and ‘CRISPRa-only’ genes are defined. Follow-up assays show that certain genes do not emerge in an ORF screen because the ORF itself is lethal or is not expressed post-transduction. Other genes do not score with CRISPRa because the overall significance of the hit is decreased by averaging the magnitudes of all the sgRNAs for the gene. Altogether, the two activation systems produce distinctive results due to ineffective ORF and CRISPRa constructs, library design, and unaccountable biological factors specific to the cancer model of choice.Biotechnolog
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