3,551 research outputs found
Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons.
No full textAmita Gupta and colleagues discuss priorities in clinical research aimed at improving tuberculosis prevention and treatment in pregnant women, children, and people with HIV
NMR‐based clinical metabolomics revealed distinctive serum metabolic profiles in patients with spondyloarthritis
No full textSpondyloarthritis (SpA) is an umbrella term for autoimmune rheumatic diseases that can affect the back, pelvis, neck and some larger joints, as well as internal organs, like the intestines and eyes. The most common of these diseases is ankylosing spondylitis (ASp) which predominantly affects the spine and sacroiliac joints causing characteristic inflammatory back pain (IBP) and severe spine stiffness. In addition, AsP may involve peripheral joints causing asymmetrical peripheral oligo-arthritis often associated with extra-articular symptoms such as acute anterior uveitis (iritis), psoriasis, enthesitis, dactylitis and chronic inflammatory bowel disease (IBD). These clinical features adversely affect the quality of life in ASp patients owing to restricted spinal/hip mobility, pain, fatigue, disease flares and depression. The clinical management of SpA is marred by delay in diagnosis, and paucity of biomarkers of disease activity. The present study aimed to explore the potential of serum metabolic profiling of patients with SpA to identify biomarker for the diagnosis and assessment of disease activity. The serum metabolic profiles of 81 patients with SpA were compared with that of 86 healthy controls (HC) using nuclear magnetic resonance (NMR) based metabolomics approach. Seventeen patients were followed-up after 3 months of standard treatment and paired sera were analyzed for effects of therapy. Comparisons were done using the multivariate partial least-squares discriminant analysis (PLS-DA) and the discriminatory metabolic entities were identified based on variable importance in projection (VIP) statistics and further evaluated for statistical significance (p-value<0.05). We found that the serum metabolic profiles differed significantly in SpA as compared with healthy controls. Compared to HC, the SpA patients were characterized by increased serum levels of amino-acids, acetate, choline, N-acetyl glycoproteins, N-alpha-acetyllysine, creatine/creatinine etc. and decreased levels of low/very-low density lipoproteins, and poly-unsaturated lipids. PLS-DA analysis also revealed metabolic differences between axial and peripheral SpA patients. Further metabolite profiles were found to differ with disease activity and treatment in responding patients. The results presented in this study demonstrate the potential of serum metabolic profiling of SpA as a useful tool for diagnosis, prediction of peripheral disease, assessment of disease activity, and treatment response.The decreased circulatory levels of glutamine were found to be associated with SpA disease activity
sj-pdf-1-lup-10.1177_0961203320918011 - Supplemental material for Nuclear magnetic resonance–based targeted profiling of urinary acetate and citrate following cyclophosphamide therapy in patients with lupus nephritis
No full textSupplemental material, sj-pdf-1-lup-10.1177_0961203320918011 for Nuclear magnetic resonance–based targeted profiling of urinary acetate and citrate following cyclophosphamide therapy in patients with lupus nephritis by Sujata Ganguly, Umesh Kumar, Nikhil Gupta, Anupam Guleria, Sanjukta Majumdar, Sanat Phatak, Smriti Chaurasia, Sandeep Kumar, Amita Aggarwal, Dinesh Kumar and Ramnath Misra in Lupus</p
Data for Gupta et al., "Estimating the Meridional Extent of Adiabatic Mixing in the Stratosphere using Age-of-Air", JGR:Atmospheres,
No full textModel data and post-processed data supporting the creation of the manuscript "Estimating the Meridional Extent of Adiabatic Mixing in the Stratosphere using Age-of-Air" submitted to JGR:Atmospheres in August 2022.
1) The netCDF files created through post-processing of full model data in FORTRAN are shared in the /data/ directory. These file contains the zonal mean circulation statistics based on Gupta et al. (2020), age-of-air transport diagnostics based on Linz et al. (2021), and the novel \Gamma-\Theta circulation streamfunction introduced in this study. The /data/ directory also contains MATLAB .mat data files for the transport diagnostics obtained from WACCM. 150 days of actual GFDL-FV3 model data in the northern hemisphere, between 0.1 hPa-500 hPa pressure levels is also provided to support external computations and validation.
2) The Jupyter notebook used for final computation and figures production is provided in .ipynb, .html and .pdf formats in /code/. All the files referred to in the notebook are stored in the /data/ directory.
Corresponding author : Aman Gupta, [email protected], [email protected], [email protected]
Corrigendum: Capital Inflows and House Prices: Aggregate and Regional Evidence from China
No full textIn the paper ‘Capital Inflows and House Prices: Aggregate and Regional Evidence from China’ by H. An, et al., printed in the December 2016 issue, there was a missing acknowledgement section for funding resources.
On page 451, the acknowledgement section should appear after the corresponding information as:
“Correspondence: Rakesh Gupta, Department of Accounting, Finance and Economics, Griffith Business School, Griffith University, Nathan Campus QLD 4111. [email protected]
*This work was financially supported by the Humanities and Social Science Foundation of Ministry of Education of China (16YJA790001).”
The author apologises for this error and any confusion it may have caused.No Full Tex
First person – Akash Gupta
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Akash Gupta is first author on ‘A novel and cost-effective ex vivo orthotopic model for the study of human breast cancer in mouse mammary gland organ culture’, published in BiO. Akash conducted the research described in this article while a PhD Scholar in Rajendra Mehta's lab at IIT Research Institute, Chicago, USA. He is now an assistant research scientist in the lab of Syreeta L. Tilghman at the University of Arizona, Department of Medicine, Tucson, USA, investigating drug efficacy modeling using human organoids culture for the treatment of cancers
MORPHOLOGICAL VARIATION IN SHAPE AND SIZE OF SACCUS VASCULOSUS OF ANABAS TES TUDINELIS
No full textIn fish saccus vasculosus is a highly vascularised infundibular protrusion located posterior to pituitary gland, secretory in (unction. h exhibits vide variations in regards to its shape and size in different fishc. Author has taken an attempt to slud the variation in shape and size in about 900 specimens in Ioçally available fish Anabu.s iesgudine,,’ round the year and noted variations in shape and Size but could no establish the actual fact behind these variations. These variations might be due to accumulation o(blood or secrelorv material in this organ
Engineering materials : research, applications and advances / author, K.M. Gupta.
No full text"A CRC title."Includes bibliographical references and index.596 p.
Leishmaniasis presenting as myelodysplasia: A diagnostic dilemma
No full textKala azar is a chronic parasitic infection which usually presents with fever, splenomegaly, and pancytopenia. Here is a case of a 9-month-old girl who presented with history of repeated blood transfusions for 3 months and later with fever and splenomegaly. Complete blood count showed bicytopenia with significant dysplasia seen in marrow aspiration smears. Secondary causes of dysplasia such as vitamin deficiency, drugs and toxins, and viral infections were ruled out and the patient was advised cytogenetic study to rule out refractory cytopenia of childhood. Subsequently, RK39 antigen result came out to be positive, and on reexamination, the slides showed few amastigote forms of Leishmania donovani. Hence, a diagnosis of Leishmaniasis with secondary dysplasia was made. Some cases may have the classic clinical features of LD infection although it has been emphasized here that myelodysplasia is a relatively uncommon presentation of LD infection. Hence, serological tests for Leishmania should be carried out along with a careful search for the parasite in all smears to avoid a grave diagnosis of myelodysplastic syndrome
- …
