78,434 research outputs found

    Localization of Mediator proteins to chromatin requires function of <i>aly</i> but not the tTAFs.

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    (A-B) Western blots of wild type and indicated testes extracts probed with (A) anti-HA to detect MED22-3HA and (B) anti-MED26. Anti-actin: loading control. Crude extract of 30 pairs of testes loaded per lane. (C-N) Indirect immunofluorescence of (C-F) wild type (G-J) sa-/- and (K-N) aly-/- spermatocytes stained for (C, G and K) anti-V5 to detect V5-MED22, (D, H and L) Fibrillarin, (E, I and M) DAPI and (F, J and N) merge, red: V5-MED22, green: Fibrillarin, blue: DAPI. (O-Z) Indirect immunofluorescence of (O-R) wild type (S-V) sa-/- and (W-Z) aly-/- spermatocytes stained for (O, S and W) anti-MED26, (P, T and X) Fibrillarin, (Q, U and Y) DAPI and (R, V and Z) merge, red: anti-MED26, green: Fibrillarin, blue: DAPI. Insets in (F, J, N, R V and Z): close view of nucleoli marked by arrowheads. Bar: 10 μm.</p

    The Benefits of Being Economics Professor A (and not Z)

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    Alphabetic name ordering on multi-authored academic papers, which is the convention in the economics discipline and various other disciplines, is to the advantage of people whose last name initials are placed early in the alphabet. As it turns out, Professor A, who has been a first author more often than Professor Z, will have published more articles and experienced afaster growth rate over the course of her career as a result of reputation and visibility. Moreover, authors know that name ordering matters and indeed take ordering seriously: Several characteristics of an author group composition determine the decision to deviate from the default alphabetic name order to a significant extent.performance measurement, incentives, economists, name ordering

    Final word on Jersey Dutch

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    In this article, William Z. Shetter compares and contrasts the dialects that developed between different Dutch colonies in the New World. He explores in-depth the nuances of Jersey Dutch, and provides theories to explain how Dutch and colonial languages blended. The article is reprinted from American Speech, December 1958, Volum XXXIII, No. 4

    Superconducting quantum point contacts and Maxwell potential

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    The quantization of the current in a superconducting quantum point contact is reviewed and the critical current is discussed at different temperatures depending on the carrier concentration as well by suggesting a constant potential in the semiconductor and then a Maxwell potential. When the Fermi wavelength is comparable with the constriction width we showed that the critical current has a step-like variation as a function of the constriction width and the carrier concentration. © World Scientific Publishing Company.Abdalla E, 1998, PHYS REV LETT, V80, P238, DOI 10.1103-PhysRevLett.80.238; AKAZAKI T, 1991, APPL PHYS LETT, V59, P2037, DOI 10.1063-1.106124; ALY AH, 1998, EGYPTIAN J PHYS, V70, P35; ANDREEV AF, 1964, SOV PHYS JETP-USSR, V19, P1228; Andreev A.F., 1964, Zhurnal Eksperimental'noi i Teoreticheskoi Fiziki, V46; BARDEEN J, 1972, PHYS REV B, V5, P72, DOI 10.1103-PhysRevB.5.72; Bauch T, 2005, PHYS REV B, V71, DOI 10.1103-PhysRevB.71.174502; BECKER T, 1995, PHYSICA B, V204, P183, DOI 10.1016-0921-4526(94)00261-S; Chang VCY, 1997, PHYS REV B, V55, P6004, DOI 10.1103-PhysRevB.55.6004; CHRESTIN A, 1994, PHYS REV B, V49, P498, DOI 10.1103-PhysRevB.49.498; Chtchelkatchev NM, 2000, PHYS REV B, V62, P3559, DOI 10.1103-PhysRevB.62.3559; Colatto LP, 2003, PHYS LETT A, V314, P184, DOI 10.1016-S0375-9601(03)00903-4; Dai Z, 2006, APPL PHYS LETT, V88, DOI 10.1063-1.2206697; De Franceschi S, 1998, APPL PHYS LETT, V73, P3890, DOI 10.1063-1.122926; DEGENNES PG, 1995, SUPERCONDUCTIVITY ME, pCH5; DESER S, 1982, ANN PHYS-NEW YORK, V140, P372, DOI 10.1016-0003-4916(82)90164-6; DUNNE GV, HEPTH9902115; FROLOV SM, 2004, MAT04042434; FURUSAKI A, 1991, PHYS REV LETT, V67, P132, DOI 10.1103-PhysRevLett.67.132; FURUSAKI A, 1998, CONDMAT9811026; FURUSAKI A, 1992, PHYS REV B, V45, P10563, DOI 10.1103-PhysRevB.45.10563; Giazotto F, 2001, APPL PHYS LETT, V78, P1772, DOI 10.1063-1.1357211; Imamura H, 2002, J APPL PHYS, V91, P7032, DOI 10.1063-1.1447188; ISHII C, 1970, PROG THEOR PHYS, V44, P1525, DOI 10.1143-PTP.44.1525; ISHII C, 1972, PROG THEOR PHYS, V47, P1464, DOI 10.1143-PTP.47.1464; KASTALSKY A, 1991, PHYS REV LETT, V67, P3026, DOI 10.1103-PhysRevLett.67.3026; Khare A, 1998, FRACTIONAL STAT QUAN; Kikuchi K., 2002, Physical Review B (Condensed Matter and Materials Physics), V65, DOI 10.1103-PhysRevB.65.020508; KLAPWIJK TM, 1994, PHYSICA B, V197, P481, DOI 10.1016-0921-4526(94)90248-8; KULIK IO, 1970, SOV PHYS JETP-USSR, V30, P944; Lachenmann SG, 1998, J APPL PHYS, V83, P8077, DOI 10.1063-1.367905; MAGNEE PHC, 1994, PHYS REV B, V50, P4594, DOI 10.1103-PhysRevB.50.4594; NGUYEN C, 1994, APPL PHYS LETT, V65, P103, DOI 10.1063-1.113047; NITTA J, 1992, PHYS REV B, V46, P14286, DOI 10.1103-PhysRevB.46.14286; Poirier W, 1997, PHYS REV LETT, V79, P2105, DOI 10.1103-PhysRevLett.79.2105; Regul J, 2002, APPL PHYS LETT, V81, P2023, DOI 10.1063-1.1506417; STERN J, 1991, PHYS LETT B, V265, P119, DOI 10.1016-0370-2693(91)90024-K; SVIDZINS.AV, 1973, J LOW TEMP PHYS, V10, P131, DOI 10.1007-BF00655245; Sze S. M., 1981, PHYS SEMICONDUCTOR D; Taboryski R, 1996, APPL PHYS LETT, V69, P656, DOI 10.1063-1.117796; TAKAYANAGI H, 1995, PHYS REV LETT, V75, P3533, DOI 10.1103-PhysRevLett.75.3533; TAKAYANAGI H, 1995, PHYS REV B, V51, P1374, DOI 10.1103-PhysRevB.51.1374; VANHOUTEN H, 1991, PHYSICA B, V175, P187, DOI 10.1016-0921-4526(91)90712-N; VANHUFFELEN WM, 1993, PHYS REV B, V47, P5170, DOI 10.1103-PhysRevB.47.5170; VANWEES BJ, 1988, PHYS REV LETT, V60, P848, DOI 10.1103-PhysRevLett.60.848; WHARAM DA, 1988, J PHYS C SOLID STATE, V21, pL887, DOI 10.1088-0022-3719-21-24-00223

    Seminar Pendidikan Karakter Generasi Z pada Era Digital bagi Peserta Didik di SMP Amanatulloh Banyuwangi

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    Abstract Character education is currently very important for the younger generation, as they will become the benchmark for the success of national development. Whether acknowledged or not, the character of today’s youth has recently experienced significant moral degradation. This community service activity was conducted in collaboration with users through a triangular model, in which the functions of research, counseling, and users are interconnected, forming a reciprocal triangular relationship. The model implemented in the field consists of four stages: action/experience, reflection, integration, and planning. As an operational process, the activity emphasizes pragmatism, beginning with identifying, understanding, and solving real problems, followed by reflection. The results of this community service activity indicate an increase in students’ understanding and awareness at SMP Amanatulloh Banyuwangi regarding the importance of character education for Generation Z in the digital era, as well as encouraging its application in daily life. Keywords: Character Education, Digital Era, Generation Z Abstrak Pendidikan karakter saat ini sangat penting untuk generasi muda, karena generasi muda akan menjadi tolak ukur keberhasilan pembangunan bangsa.  Diakui ataupun tidak bahwa karakter generasi muda akhir-akhir ini banyak mengalami kelunturan yang sangat dahsyat. Kegiatan pengabdi ini bekerjasama dengan pengguna dengan model triangular yaitu antara fungsi penelitian, penyuluhan, dan pengguna terjadi saling hubungan, sehingga membentuk segitiga hubungan timbal balik (triangular). Model yang diterapkan dilapangan, meliputi empat langkah, yaitu: aksi/mengalami, refleksi, integrasi, dan perencanaan. Sebagai proses kegiatan operasionalnya menekankan pragmatisme yang dimulai dari mengidentifikasi, memahami, dan memecahkan masalah riil, lalu merefleksikannya lagi. Hasil kegiatan pengabdian ini menunjukkan adanya peningkatan pemahaman dan kesadaran peserta didik SMP Amanatulloh Banyuwangi tentang pentingnya pendidikan karakter bagi Generasi Z di era digital, serta mendorong penerapannya dalam kehidupan sehari-hari. Kata kunci: Pendidikan Karakter, Era Digital, Generasi Z

    Chemical characterization, antioxidant and inhibitory effects of some marine sponges against carbohydrate metabolizing enzymes

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    UNLABELLED: BACKGROUND: More than 15,000 marine products have been described up to now; Sponges are champion producers, concerning the diversity of products that have been found. Most bioactive compounds from sponges were classified into anti-inflammatory, antitumor, immuno- or neurosurpressive, antiviral, antimalarial, antibiotic, or antifouling. Evaluation of in vitro inhibitory effects of different extracts from four marine sponges versus some antioxidants indices and carbohydrate hydrolyzing enzymes concerned with diabetes mellitus was studied. The chemical characterizations for the extracts of the predominating sponges; SP1 and SP3 were discussed. METHODS: All chemicals served in the biological study were of analytical grade and purchased from Sigma, Merck and Aldrich. All kits were the products of Biosystems (Spain), Sigma Chemical Company (USA), Biodiagnostic (Egypt). Carbohydrate metabolizing enzymes; α-amylase, α-glucosidase, and β-galactosidase (EC3.2.1.1, EC3.2.1.20, and EC3.2.1.23, respectively) were obtained from Sigma Chemical Company (USA). RESULTS: Four marine sponges; Smenospongia (SP1), Callyspongia (SP2), Niphates (SP3), and Stylissa (SP4), were collected from the Red Sea at Egyptian coasts, and taxonomically characterized. The sponges' extracts exhibited diverse inhibitory effects on oxidative stress indices and carbohydrate hydrolyzing enzymes in linear relationships to some extent with concentration of inhibitors (dose dependant). The extracts of sponges (3, 1, and 2) showed, respectively, potent-reducing power. Purification and Chemical characterization of sponge 1 using NMR and mass spectroscopy, recognized the existence of di-isobutyl phthalate (1), di-n-butyl phthalate (2), linoleic acid (3), β-sitosterol (4), and cholesterol (5). Sponge 3 produced bis-[2-ethyl]-hexyl-phthylester (6) and triglyceride fatty acid ester (7). CONCLUSION: Marine sponges are promising sources for delivering of bioactive compounds. Four marine sponges, collected from Red Sea at Egyptian coasts, were identified as Smenospongia (SP1), Callyspongia (SP2), Niphates (SP3), and Stylissa (SP4). The results demonstrated that different sponges extracts exhibited inhibitory effects on oxidative stress indices and carbohydrate hydrolyzing enzymes in linear relationships to some extent with concentration of inhibitors (dose dependant). The extracts of sponges (3, 1, and 2) showed, respectively, potent-reducing power. Chemical characterizations of sponges SP1 and SP3 were discussed. Based on this study, marine sponges are considered as talented sources for production of diverse and multiple biologically active compounds

    Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection

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    We report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either

    Statistics of the subgrid scales after the shock-turbulence interaction

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    The interaction of a normal shock with isotropic turbulence (IT) represents a basic problem for studying some of the phenomena associated with high speed flows, such as hypersonic flight, supersonic combustion and Inertial Confinement Fusion (ICF). In general, in practical applications, the shock width is much smaller than the turbulence scales and the upstream turbulent Mach number is modest. In this case, recent high resolution shock-resolved Direct Numerical Simulations (DNS) (Ryu and Livescu, J. Fluid Mech., 756, R1, 2014) show that the interaction can be described by the Linear Interaction Approximation (LIA). By using LIA to alleviate the need to solve the shock, DNS post-shock data can be generated at much higher Reynolds numbers than previously possible. Here, such results with Taylor Reynolds number around 180180 are used to investigate the properties of the subgrid scales (SGS). In particular, it is shown that the shock interaction decreases the asymmetry of the SGS dissipation PDF as the shock Mach number increases, with a significant enhancement in size of the regions and magnitude of backscatter

    Hybrid learning model in Ma’had ‘Aly UIN Maulana Malik Ibrahim Malang

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    This research identifies and implements a multimedia-based Hybrid Learning Model at Ma'had Aly UIN Malang, integrated with the university system. Utilizing a qualitative case study approach with thematic analysis, it explores factors influencing the model. Supporting factors encompass leadership policies, component synergy, adequate facilities, and tech-savvy Generation Z students. Inhibiting factors include the Covid-19 pandemic, limited media, suboptimal communication, and underutilized human resources. Despite challenges, the Hybrid Learning Model accelerates the transformation of Ma'hadi education, serving as a transformative role model. Implementation of the Hybrid Learning Model at Ma'had Aly UIN Malang involves various strategies such as Project-Based Learning, Problem-Based Learning, and Blended Learning, along with strict adherence to health protocols. Supporting factors such as leadership policies and students' tech proficiency, along with inhibiting factors such as the Covid-19 pandemic and media limitations, play crucial roles in this process. The effects of implementing this Hybrid Learning Model include the development of new learning strategies, enhanced facility provision, mastery of digital technology, preparation for integrated self-learning, and support for the transformation of Ma'hadi education as a model for change

    Transition to turbulence in a qblique shock-wave/boundary-layer interaction at M=15

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    Direct numerical simulations are carried out for different forcing techniques to trigger transition during the interaction between an oblique shock-wave and a laminar boundary-layer at M = 1.5. Three forcing methods are used: a) forcing of oblique unstable modes, whose shape and behaviour are determined by the local linear stability theory, b) broadband free-stream acoustic disturbances, and c) a cold plasma flow control device. While the oblique-mode breakdown is dominant for low-amplitude forcing, long streaky structures drive the transition process in a high-amplitude disturbance environment. LES are also performed on the experimental setup by the Institute of Theoretical and Applied Mechanics (ITAM) from Novosibirsk State University with cold plasma actuation. As well as the disturbance type, the effect of Reynolds number and forcing amplitude will be investigated
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