2,231,930 research outputs found
XLV. Xosé Maria Alvarez Blazquez
No full textIntroduzione bio-bibliografica alla poesia di X. M. Alvarez Blazquez, con antologia di testi e traduzione
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Interview with Luis Alvarez
No full textMusician Luis Alvarez; rock band “El Haragán y Compañía” [English only] Música de “El Haragán y Compañía Musician Luis Alvarez; rock band “El Haragán y Compañía” Músico Luis Alvarez; grupo de rock “El Haragán y Compañía
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Interview with Luis Alvarez
No full textMusician Luis Alvarez; rock band “El Haragán y Compañía” Música de “El Haragán y Compañía Musician Luis Alvarez; rock band “El Haragán y Compañía” [Español exclusivamente] Músico Luis Alvarez; grupo de rock “El Haragán y Compañía
Elizabeth Hayes Alvarez: Valiant Woman [Audio interview]
No full textIn contemporary American culture the Virgin Mary is associated with Catholic devotion and worship. Because of this, it should come as a surprise to many readers that the mother of Jesus was a general cultural icon in the latter half of nineteenth century Christian America. Temple professor Elizabeth Hayes Alvarez details this history in her new book, The Valiant Woman: The Virgin Mary in Nineteenth Century American Culture (University of North Carolina Press, 2016). Images and references to Mary proliferated in popular magazines and on the walls of modest and fashionable homes, appealing to both Protestant and Catholic audiences. The Civil War, industrial revolution, and westward expansion transformed the United States. The rise of major urban centers like New York, Philadelphia, Chicago, and St. Louis drew in rural migrants and immigrants, unsettling religious, gender, and social norms. In these early years of mass society when the old agrarian ways were slipping away, the focus on the Virgin Mary offered a safe and familiar way of talking about and negotiating new female roles in this changing social landscape. Professor Alvarez traces the career of Mary from the declaration of the Immaculate Conception by Pope Pius IX in 1854 through its fiftieth anniversary in 1904. Fred Rowland spoke to Elizabeth Hayes Alvarez about her book on November 7, 2016.Temple University. College of Liberal ArtsTemple University. LibrariesLearning & Research ServicesReligionAudacityAudacit
Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist
Full text linkSince the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles. We have shown previously that a new analogue, cis-1S,2R-aminocyclohexanecarboxylic acid2-endomorphin-2 (ACHC-EM2), had elevated mu-receptor affinity, selectivity, and proteolytic stability over the parent compound. In the present work, we have studied its antinociceptive effects and receptor regulatory processes. ACHC-EM2 displayed a somewhat higher (60%) acute antinociceptive response than the parent peptide, EM2 (45%), which peaked at 10 min after intracerebroventricular (icv) administration in the rat tail-flick test. Analgesic tolerance developed to the antinociceptive effect of ACHC-EM2 upon its repeated icv injection that was complete by a 10-day treatment. This was accompanied by attenuated coupling of mu-sites to G-proteins in subcellular fractions of rat brain. Also, the density of mu-receptors was upregulated by about 40% in the light membrane fraction, with no detectable changes in surface binding. Distinct receptor regulatory processes were noted in subcellular fractions of rat brains made tolerant by the prototypic full mu-agonist peptide, DAMGO, and its chloromethyl ketone derivative, DAMCK. These results are discussed in light of the recently discovered phenomenon, that is, the “so-called biased agonism” or “functional selectivity
Alvarez-Amezquita, Jose -- 1966-68 -- Correspondence, Individual -- letter, 1966-08-23
No full textLetter from Alvarez-Amezquita, Jose to Sabin, Albert B. dated 1966-08-23.Sabin Collection Fair Use Policy</a
Ramos-Alvarez, Manuel -- ND-1992 -- Correspondence, Individual -- letter, 1979-05-15
No full textLetter from Ramos-Alvarez, Manuel to Sabin, Albert B. dated 1979-05-15.Sabin Collection Fair Use Policy</a
Ramos-Alvarez, Manuel -- ND-1992 -- Correspondence, Individual -- letter, 1991-03-31
No full textLetter from Ramos-Alvarez, Manuel to Sabin, Albert B. dated 1991-03-31.Sabin Collection Fair Use Policy</a
Alvarez-Amezquita, Jose -- 1966-68 -- Correspondence, Individual -- letter, 1967-03-10
No full textLetter from Alvarez-Amezquita, Jose to Sabin, Albert B. dated 1967-03-10.Sabin Collection Fair Use Policy</a
Ramos-Alvarez, Manuel -- ND-1992 -- Correspondence, Individual -- letter, 1978-08-14
No full textLetter from Ramos-Alvarez, Manuel to Sabin, Albert B. dated 1978-08-14.Sabin Collection Fair Use Policy</a
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