31 research outputs found
Synthesis of N-(6-Arylbenzo[d]thiazole-2-acetamide derivatives and their biological activities: An experimental and computational approach
No full textA new series of N-(6-arylbenzo[d]thiazol-2-yl)acetamides were synthesized by C-C coupling methodology in the presence of Pd(0) using various aryl boronic pinacol ester/acids. The newly synthesized compounds were evaluated for various biological activities like antioxidant, haemolytic, antibacterial and urease inhibition. In bioassays these compounds were found to have moderate to good activities. Among the tested biological activities screened these compounds displayed the most significant activity for urease inhibition. In urease inhibition, all compounds were found more active than the standard used. The compound N-(6-(p-tolyl)benzo[d]thiazol-2-yl)acetamide was found to be the most active. To understand this urease inhibition, molecular docking studies were performed. The in silico studies showed that these acetamide derivatives bind to the non-metallic active site of the urease enzyme. Structure-activity studies revealed that H-bonding of compounds with the enzyme is important for its inhibition
Advanced polymeric/inorganic nanohybrids: An integrated platform for gas sensing applications
No full textRapid industrial development, vehicles, domestic activities and mishandling of garbage are the main sources of pollutants, which are destroying the atmosphere. There is a need to continuously monitor these pollutants for the safety of the environment and human beings. Conventional instruments for monitoring of toxic gases are expensive, bigger in size and time-consuming. Hybrid materials containing organic and inorganic components are considered potential candidates for diverse applications, including gas sensing. Gas sensors convert the information regarding the analyte into signals. Various polymeric/inorganic nanohybrids have been used for the sensing of toxic gases. Composites of different polymeric materials like polyaniline (PANI), poly (4-styrene sulfonate) (PSS), poly (3,4-ethylene dioxythiophene) (PEDOT), etc. with various metal/metal oxide nanoparticles have been reported as sensing materials for gas sensors because of their unique redox features, conductivity and facile operation at room temperature. Polymeric nanohybrids showed better performance because of the larger surface area of nanohybrids and the synergistic effect between polymeric and inorganic materials. This review article focuses on the recent developments of emerging polymeric/inorganic nanohybrids for sensing various toxic gases including ammonia, hydrogen, nitrogen dioxide, carbon oxides and liquefied petroleum gas. Advantages, disadvantages, operating conditions and prospects of hybrid composites have also been discussed.Rivers, Ports, Waterways and Dredging EngineeringHydraulic EngineeringAerospace Manufacturing Technologie
Synthesis and Characterization of Azo-Guanidine Based Alcoholic Media Naked Eye DNA Sensor
No full textDNA sensing always has an open meadow of curiosity for biotechnologists and other researchers. Recently, in this field, we have introduced an emerging class of molecules containing azo and guanidine functionalities. In this study, we have synthesized three new compounds (UA1, UA6 and UA7) for potential application in DNA sensing in alcoholic medium. The synthesized materials were characterized by elemental analysis, FTIR, UV-visible, 1H NMR and 13C NMR spectroscopies. Their DNA sensing potential were investigated by UV-visible spectroscopy. The insight of interaction with DNA was further investigated by electrochemical (cyclic voltammetry) and hydrodynamic (viscosity) studies. The results showed that compounds have moderate DNA binding properties, with the binding constants range being 7.2 x 103, 2.4 x 103 and 0.2 x 103 M-1, for UA1, UA6 and UA7, respectively. Upon binding with DNA, there was a change in colour (a blue shift in the lambda(max) value) which was observable with a naked eye. These results indicated the potential of synthesized compounds as DNA sensors with detection limit 1.8, 5.8 and 4.0 ng μl-1 for UA1, UA6 and UA7, respectively
Ataf Ali - Excell Data from Synthesis and characterization of azo-guanidine based alcoholic media naked eye DNA sensor
No full textDNA sensing always has an open meadow of curiosity for biotechnologists and other researchers. Recently, in this field, we have introduced an emerging class of molecules containing azo and guanidine functionalities. In this study, we have synthesized three new compounds (UA1, UA6 and UA7) for potential application in DNA sensing in alcoholic medium. The synthesized materials were characterized by elemental analysis, FTIR, UV-visible, 1H NMR and 13C NMR spectroscopies. Their DNA sensing potential were investigated by UV-visible spectroscopy. The insight of interaction with DNA was further investigated by electrochemical (cyclic voltammetry) and hydrodynamic (viscosity) studies. The results showed that compounds have moderate DNA binding properties, with the binding constants range being 7.2 x 103, 2.4 x 103 and 0.2 x 103M-1, for UA1, UA6 and UA7, respectively. Upon binding with DNA, there was a change in colour (a blue shift in the λmax value) which was observable with a naked eye. These results indicated the potential of synthesized compounds as DNA sensors with detection limit 1.8, 5.8 and 4.0ng µl-1 for UA1, UA6 and UA7, respectively
Supramolecular dithiocarbamatogold(III) complex a potential DNA binder and antioxidant agent
No full textLithium Pyrene Squarate Covalent Organic Frameworks for Efficient Lithium and Magnesium Separation from Salt Water
No full textThe increasing pressure for lithium resources from the
electric
vehicle and nuclear energy industries means that new technologies
to separate Mg2+ from Li+ from salt water are
in demand. To address this need, we fabricated lithium pyrene squarate
covalent organic frameworks (Li-SQCOFs) to separate Mg2+/Li+ mixtures from salt water. We optimized the effect
of the electrolyte and the amount of the adsorbent and then carried
out a kinetics study on the adsorbent recovery at various pH levels
using both batch and continuous flow adsorption methods. Li-SQCOF
was found to have excellent selectivity for solutions containing a
mixture of Mg2+/Li+ ions. This work represents
a unique path for the separation of Mg2+/Li+ through direct adsorption using a covalent organic framework (COF).
The COF-supported ultrafiltration bed made in this study gave a Mg2+ separation flux of 60.5 h–1 m–2
Synthesis, antibacterial activity and docking studies of chloroacetamide derivatives
No full textStructural modification of lead compounds is a great challenge in organic synthesis. Introduction of different functional groups not only modify the structure of starting material but also improve their biological activeness. Small synthetic molecules are favored in spite of the reality that majority of drug molecules derived from natural sources, are in vogue. In the present work, acetamide derivatives were synthesized using chloroacetyl chloride. After synthesizing targeted series of acetamide derivatives these compounds were further modified using different amines including 2-aminobenzene thiol, benzyl amine, benzene 1,4-diamine, 4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one, 4-aminophenol, hydrazine and 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide. All of these synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR and X-ray crystallography. The compounds were assessed for their anti-bacterial activity using disc diffusion method against Staphylococcus aureus and Escherichia coli. The compounds were found to exhibit comparable activity to the standard drug used. This was further supported by molecular docking studies using bacterial DNA gyrase and Topoisomerase II targets causing bacterial death as they are major bacterial proteins known to be involved in transcription and replication process. Results proved that the compound 2b was the most efficacious antimicrobial compound among the synthesized set of compounds. To tackle the growing drug resistance acetamide based functionalities can be regarded as the active lead compounds to target different drug resistance microorganism
Synthesis, Crystal Structure, and DFT Calculations of 1,3-Diisobutyl Thiourea
No full text1,3-Diisobutyl thiourea was synthesized and characterized by single crystal X-ray diffraction. It gives a monoclinic (α = γ = 90 and β ≠ 90) structure with the space group P21/c. The unit cell dimensions are a = 11.5131 (4) Å, b = 9.2355 (3) Å, c = 11.3093 (5) Å, α = 90°, β = 99.569° (2), γ = 90°, V = 1185.78 (8) Å3, and Z = 4. The crystal packing is stabilized by intermolecular (N–H⋯S) hydrogen bonding in the molecules. The optimized geometry and Mullikan's charges of the said molecule calculated with the help of DFT using B3LYP-6-311G model support the crystal structure
Assessment and Removal of Heavy Metals and Other Ions from the Industrial Wastewater of Faisalabad, Pakistan
No full textThe contamination of surface and groundwater is of major concern around the globe due to the fast industrialization and urbanization. The groundwater and water quality of rivers, Ravi and Chenab in Faisalabad, Pakistan are contaminated due to the industrial wastewater. The aim of this study was the assessment of the physiochemical contaminants of Faisalabad’s industrial wastewater area and the adsorptive removal of ions present in high concentrations following the National Environmental Quality Standards (NEQS) for the municipal and industrial liquid effluents of Pakistan. One of the two samples was collected from a drain carrying wastewater from different industries and other from the outlet of a drain discharging wastewater into river Chenab. The analysis results obtained indicate that most of the contaminants were below the acceptable limit of industrial wastewater NEQS, Pakistan. However, contaminants like sulfate ions (714 mg/L), total dissolved solids (33,951–34,620 mg/L) and barium ions (11–15 mg/L) were found to be higher than the allowable level of NEQS for the municipal and industrial liquid effluents for Pakistan. A novel biosorbent synthesized indigenously from Monotheca buxifolia seeds was used for the removal of sulfate, barium and TDS from the wastewater effluent samples. This biosorbent successfully reduced the sulfate ion concentration in the wastewater sample from 714 to 420 mg/L at pH 6 in 1 h. Similarly, the concentration of TDS reduced to 33,951 from 6295 mg/L at pH 4, whereas barium ions were removed from 15 to 1 mg/L at pH 10 in 1 h. Treatment of wastewater through the synthesized biosorbent efficiently removed the high concentration ions and could potentially be applied to reduce the toxic effects of these contaminants on local public health
Role of Pyridine Nitrogen in Palladium-Catalyzed Imine Hydrolysis: A Case Study of (E)-1-(3-bromothiophen-2-yl)-N-(4-methylpyridin-2-yl)methanimine
No full textIn the present study, 4-methylpyridin-2-amine was reacted with 3-bromothiophene-2-carbaldehyde and the Schiff base (E)-1-(3-bromothiophen-2-yl)-N-(4-methylpyridin-2-yl)methanimine was obtained in a 79% yield. Coupling of the Schiff base with aryl/het-aryl boronic acids under Suzuki coupling reaction conditions, using Pd(PPh3)4 as catalyst, yielded products with the hydrolysis of the imine linkages (5a–5k, 6a–6h) in good to moderate yields. To gain mechanistic insight into the transition metal-catalyzed hydrolysis of the compounds, density functional theory (DFT) calculations were performed. The theoretical calculations strongly supported the experiment and provided an insight into the transition metal-catalyzed hydrolysis of imines
