1,537 research outputs found
[Rezension zu:] Torsten Riotte, Der Monarch im Exil. Eine andere Geschichte von Staatswerdung und Legitimismus im 19. Jahrhundert, Göttingen (Wallstein) 2018, 427 S., 13 Abb. (Veröffentlichungen der Historischen Kommission für Niedersachsen und Bremen, 295), ISBN 978-3-8353-3058-0, EUR 39,90
No full textObwohl das Interesse an der Erforschung der Monarchie so alt ist wie die Geschichtswissenschaften selbst, bestand in der Untersuchung der Begebenheiten nach dem Sturz eines Monarchen bisher eine weitgehende Forschungslücke. Nachdem er das Thema in einem mit Philip Mansel 2011 herausgegebenen Sammelband bereits angeschnitten hatte, legt Torsten Riotte mit seiner Habilitationsschrift nun eine erste komparative und umfassende Studie des modernen monarchischen Exils vor. Riotte widmet sich dabei mit großer Sorgfalt zwei Fallstudien: dem Comte de Chambord, Prinz Henri d’Artois (1820–1883), der Frankreich nach der Revolution von 1830 noch als Kind verlassen musste, und dem Herzog von Cumberland, Prinz Ernst August von Hannover (1845–1923), der seinem Vater dem König 1866, nach der Annexion Hannovers durch preußische Truppen, ins Exil folgte. Beide fanden Zuflucht in Österreich und ließen sich dauerhaft in der Nähe Wiens nieder. ..
Mit Panzer lebt sich’s länger
No full textÜBERLEBENSKÜNSTLER ⋅ Grosse Schildkröten werden nicht nur sehr alt, sondern haben auch schon 250 Millionen Jahre und damit alle Massensterben überlebt. Der Paläontologe Torsten Scheyer erforscht sie bis auf die Knochen
Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood
No full textPurpose: Elongation of telomeres is necessary for tumor cell immortalization and senescence escape; neoplastic cells use to
alternative pathways to elongate telomeres: telomerase reactivation or a telomerase-independent mechanism termed alternative
lengthening of telomeres (ALT). Telomerase and ALT pathway has been explored in adult and pediatric gliomas and
medulloblastomas (MDBs); however, these mechanisms were not previously investigated in MDBs metastatic at the onset.
Therefore, we analyzed the activation of telomerase and ALT pathway in a homogenous cohort of 43 pediatric metastatic
medulloblastomas, to investigate whether telomere elongation could play a role in the biology of metastatic MDB.
Methods: We evaluated telomeres length via telomere-specific fluorescence in situ hybridization (Telo-FISH); we assessed
nuclear expression of ATRX by immunohistochemistry (IHC). H3F3A and TERT promoter mutations were analyzed by
pyrosequencing, while UTSS methylation status was analyzed via methylation-specific-PCR (MS-PCR).
Results: H3F3A mutations were absent in all MDBs, 30% of samples showed ATRX nuclear loss, 18.2% of cases were
characterized by TERT promoter mutations, while 60.9% harboured TERT promoter hyper-methylation in the UTSS region.
Elongation of telomeres was found in 42.8% of cases. Metastatic MDBs control telomere elongation via telomerase activation
(10.7%), induced by TERT promoter mutations in association with UTSS hyper-methylation, and ALT mechanism
(32.1%), triggered by ATRX inactivation. Among non-metastatic MDBs, only 5.9% (1/17) showed ATRX nuclear loss with
activation of ALT.
Conclusions: Our metastatic cases frequently activate ALT pathway, suggesting that it is a common process for senescence
escape in primary metastatic medulloblastomas. Furthermore, the activation of mechanisms for telomere elongation is not
restricted to certain molecular subgroups in this high-risk group of MDBs
MEDB-68. Analysis of telomeres length and Alternative Lengthening of Telomeres (ALT) in molecular subgroups of infant medulloblastoma
No full textWe investigated the association between the molecular profile and telomere length in a infant medulloblastoma (iMB) cohort, retrospectively studied. Activation of telomeres maintenance mechanisms was analyzed to determine whether the senescence escape triggered by telomere-elongation mechanisms could explain the aggressivity of some iMB belonging to the same molecular subgroup. Interestingly, several telomerase- and ALT-targeted therapies have recently been tested on pediatric cancers and might represent a promising strategy for the future treatment of aggressive telomerase- or ALT-positive iMB. We analyzed a cohort of 50 FFPE tissues from young MB patients (age ≤ 3); IHC, FISH, and an Illumina 850K methylation profile were used to identify molecular subgroups. Telomere length was measured using Telo-quantitative FISH, and image analysis was performed using TFL-Telo software. Three distinct telomere intensity categories (low (L), medium (M), and high (H)) were identified by comparing neoplastic- to endothelial-cell signals in each sample. ATRX loss and TERTp mutation/methylation were investigated using IHC and Sanger sequencing/methylation-specific PCR. SHH-MBs accounted for 59% of our cohort, while Group3/4-MBs accounted for 41%; no WNT-MBs were detected. ALT was found to be activated in 10% of iMBs and was not exclusive to any molecular subgroup, implying that it could be a potential mechanism associated with aggressive behaviour in a subset of iMBs. Promising results have been found in the telomere length distribution among the iMB molecular subgroups: SHH iMBs had a higher frequency of High (H) telomeres length (85%) than NON-SHH/NON-WNT iMBs (p=0.046), which were more frequently associated with Medium (M) telomeres length. CONCLUSIONS: ALT activation in infant MBs (10%) could be a novel target for risk-stratification and personalized therapy. It may be useful to examine ALT as a potential predictor of aggressive behaviour and as a promising novel therapeutic approach for a subset of these tumors in the diagnostic workup
Entwicklung einer schnellen Pulsformanalyse für asymmetrische AGATA-Germanium-Detektoren
No full textOnTEAM metadata: GDSID: DOC-2007-May-32; Attribute ID: LIBRARY-thesis_diss-2007-005; Title: [GSI Diss 2007-05] Entwicklung einer schnellen Pulsformanalyse für asymmetrische AGATA-Germanium-Detektoren; Author(s): Beck, Torsten; Corporate author(s): ; Publication date: 20070501; Creator: manton; Creation date: 15.05.2007 16:02:12; Change date: 29.10.2008 16:29:34; Access: nur berechtigte Gruppen; Attribute type: Text.Thesis.Diss; Directory path: ['GSI Publications', 'GSI as Publisher']; Attribute path: ['Infrastructure', 'Library and Documentation', 'thesis_diss', 'Added in 2007']; File name(s): ['DOC-2007-May-32-1.pdf']; File title(s): ['']; File access: ['nur berechtigte Gruppen'
Alt-right
No full textThis study examines the far right movement, Alt-right, who have transformed from an internet-niche to a movement with political influence in the last couple of years. The study analyses their use of symbols through semiotic theories by Charles Sanders Peirce, Søren Kjørup and Roland Barthes. It compares the methodology of the book The Authoritarian Personality from 1950 with the 2017 study A Psychological Profile of the Alt-right to determine which methods are needed to understand the movement. It concludes that the Alt-right movement are using a mix of already existing symbols and signs, in order to obscure their political agenda by changing the conventions behind the signs. The study finally concludes that the behaviour and attitude of the members of the Alt-right, can be mapped by using direct questions instead of ones that appeal to the unconscious mind
Manifolds, sheaves, and cohomology
No full textThis book explains techniques that are essential in almost all branches of modern geometry such as algebraic geometry, complex geometry, or non-archimedian geometry. It uses the most accessible case, real and complex manifolds, as a model. The author especially emphasizes the difference between local and global questions. Cohomology theory of sheaves is introduced and its usage is illustrated by many examples. Content Topological Preliminaries - Algebraic Topological Preliminaries - Sheaves - Manifolds - Local Theory of Manifolds - Lie Groups - Torsors and Non-abelian Cech Cohomology - Bundles - Soft Sheaves - Cohomology of Complexes of Sheaves - Cohomology of Sheaves of Locally Constant Functions - Appendix: Basic Topology, The Language of Categories, Basic Algebra, Homological Algebra, Local Analysis Readership Graduate Students in Mathematics / Master of Science in Mathematics About the Author Prof. Dr. Torsten Wedhorn, Department of Mathematics, Technische Universität Darmstadt, Germany
James Watson, Maclyn McCarty, and Torsten Wiesel
No full textTorsten Wiesel (right) with Professor Emeritus Maclyn McCarty (center), co-author of the paper with Oswald Avery and Colin MacLeod, and James D. Watson, director of Cold Spring Harbor Laboratory, 1994
Photo by Leif Carlsson
To commemorate the fiftieth anniversary of the discovery at The Rockefeller University that genes are made of DNA - considered by many to be the single most important biological discovery of the twentieth century - the university has kicked off a year-long series of events that were running through May 1994. The celebration was formally inaugurated in November 1993 with a lecture by Nobel laureate James D. Watson, best known for discovering the double-helical structure of DNA.
See also Search Winter 1994, vol. 4, no. 1https://digitalcommons.rockefeller.edu/group-portraits/1013/thumbnail.jp
Seltsame Schauspiele. Torsten Fogelqvists Deutschlandreise 1934
No full textIn 1934 Torsten Fogelqvist, a prominent member of the Swedish Academy and a well-known journalist and intellectual, visits Nazi Germany. He writes about his visit to the Third Reich in 17 articles published in the Stockholm daily newspaper Dagens Nyheter. The author, highly critical of the Hitler regime, scrutinizes several aspects of the nazified German society such as the attempts to re-educate the German citizen in accordance with the ideology of the new regime, the hero cult in the Nazi movement, and the relationship between the German state and the churches. In order to further an understanding of political and social developments in Germany Fogelqvist uses a specific strategy. He “translates” them into an imaginary Swedish context. This paper compares his views with those of other Swedish visitors
PISM glacial cycle sensitivity experiments of the Antarctic Ice Sheet
No full textThis dataset contains PISM simulation results (http://www.pism-docs.org) of the Antarctic Ice Sheet based on code release v1.0-paleo-ensemble (https://doi.org/10.5281/zenodo.3574033). PISM is the open-source Parallel Ice Sheet Model developed mainly at UAF, USA and PIK, Germany.
With the help of added python scripts, all figures can be reproduced as in the journal publication:
- Albrecht et al., 2020, doi:10.5194/tc-14-599-2020.
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Data:
Find PISM results as netCDF data. See 'README.md' for a list of all performed experiment.
All forcing input data for the experiments and plots can be downloaded and remapped via https://github.com/pism/pism-ais. Some of the original input data files are freely available, for others please contact the author or the corresponding data publisher.
Figure plotting scripts (jupyter notebook based on python, see https://jupyter.org) in 'plot_scripts' access the uploaded PISM results in 'model_data' and save the plots to 'final_figures'. Jupyter notebook can be run in the browser and shared, see https://nbviewer.jupyter.org/url/www.pik-potsdam.de/~albrecht/notebooks/paleo_paper/paleo_paper_final.ipynb.
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Contact:
Albrecht, Torsten ([email protected]) ; Potsdam-Institute for Climate Impact Research (PIK), Potsdam, German
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