4,651 research outputs found
Alsford lab bloodstream-form culture protocol v1
No full textThe protocol is provided by the Alsford Lab at the London School of Hygiene & Tropical Medicine (https://blogs.lshtm.ac.uk/alsfordlab/protocols/bloodstream-form-culture/) </p
Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis.
No full textMost African trypanosomes, including the veterinary species Trypanosoma brucei brucei and T. congolense are susceptible to lysis by human serum. A recent study by Alsford et al. [PLoS Pathogens (2014) 10, e1004130] has identified a T. b. brucei lysosomal cathepsin with an inhibitory effect on human serum's trypanolytic action
Bloodstream-form culture v1
No full textProtocol obtained from the Alsford Lab at the London School of Hygiene & Tropical Medicine (https://blogs.lshtm.ac.uk/alsfordlab/protocols/bloodstream-form-culture/) </p
Letter from Hayao (Sam) Chuman to the American Friends Service Committee
No full textA letter from Hayao (Sam) Chuman to the American Friends Service Committee, donating a portion of his redress check from the U.S. government to the Committee.The Chuman (Hayao "Sam" and Toshiko) Papers documents the World War II experiences of Hayao "Sam" and Toshiko Chuman, who were Kibei Nisei born in the United States but grew up and completed school in Japan, and then returned to the U.S. prior to the war. It chronicles the Chuman's incarceration from the Santa Anita Assembly Center, through Jerome, Rohwer, Tule Lake camps, and the Santa Fe and Crystal City internment camps as well as their struggle for restoring their U.S. citizenships in the 1960s. The digital collection consists of mostly textual material, including correspondence, affidavits, incarceration camp records, lease agreements, financial documents, receipts, pamphlets, and booklets
Letter from Hayao (Sam) Chuman to Earl Warren and "Attorney General Clark"
No full textA letter from Hayao (Sam) Chuman to Chief Justice of the Supreme Court Earl Warren and "Attorney General Clark". The letter is a request to regain his citizenship after renouncing his U.S. citizenship and requesting repatriation to Japan during his time incarcerated in World War II.The Chuman (Hayao "Sam" and Toshiko) Papers documents the World War II experiences of Hayao "Sam" and Toshiko Chuman, who were Kibei Nisei born in the United States but grew up and completed school in Japan, and then returned to the U.S. prior to the war. It chronicles the Chuman's incarceration from the Santa Anita Assembly Center, through Jerome, Rohwer, Tule Lake camps, and the Santa Fe and Crystal City internment camps as well as their struggle for restoring their U.S. citizenships in the 1960s. The digital collection consists of mostly textual material, including correspondence, affidavits, incarceration camp records, lease agreements, financial documents, receipts, pamphlets, and booklets
Sam "Kangaroo"
No full textabstract: Sam left Sudan when he was six years old. He also witnessed many people die when they tried to cross the Gilo river.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 23Region: Upper Nile (Bor)This picture and bio was donated to the "Lost Boys Found" oral history project from The Arizona Lost Boys Cente
the beat report piece detailing author Sam Pfeifle\u27s wishes for local music fo
No full textthe beat report piece detailing author Sam Pfeifle\u27s wishes for local music for 2004, mentioning radio stations WCYY and WCLZ, local band 6gig, and the Musicians Resource League
Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes.
No full textEukaryotic cells limit ribosomal DNA (rDNA) transcription by RNA polymerase I (RNAP-I) to maintain genome integrity. African trypanosomes present an excellent model for studies on RNAP-I regulation because they possess a bifunctional RNAP-I and because RNAP-II transcription appears unregulated. Since Elp3, the catalytic component of Elongator, controls RNAP-II transcription in yeast and human cells, we predicted a role for a trypanosome Elp3-related protein, ELP3a or ELP3b, in RNAP-I regulation. elp3b null and conditional strains specifically exhibited resistance to a transcription elongation inhibitor, suggesting that ELP3b negatively impacts elongation. Nascent RNA analysis and expression of integrated reporter cassettes supported this interpretation and revealed negative control of rDNA transcription. ELP3b specifically localized to the nucleolus, and ELP3b loss rendered cells hypersensitive to DNA damage and to translation inhibition, suggesting that anti-Elongator function was important to maintain genome integrity rather than to modulate ribosome production. Finally, ELP3b displayed discrimination between RNAP-I compartments in the same cell. Our results establish ELP3b as a major negative regulator of rDNA transcription and extend the roles of the Elp3-related proteins to RNAP-I transcription units. ELP3b is also the first trypanosome protein shown to distinguish between rDNA and variant surface glycoprotein transcription within different RNAP-I compartments
Izvori informacija u dostupnim EBSCO bazama podataka za istraživanja u visokom školstvu u Srbiji = Academic research in Serbia and available database resources
No full textUniversities in Serbia have access to large amounts of quality information through online full text databases. Specific details regarding the world’s two most comprehensive full text research data-bases, Academic Search Premier and Business Source Premier are provided. The paper examines which databases are strongest in each discipline, and covers issues such as the availability of journals most-cited, full text formats, peer-review status, embargo periods, backfills, and other important facets. Additional information depicts reasons for tremendous increase in the availability of information in the Serbia, and the value that these resources bring to researchers in universities
- …
