1,720,964 research outputs found
Impaired Renal Hemodynamic Response to L- Arginine in Essential Hypertensive Humans : Role of buffering anion and tubuloglomerular feedback
No full textAbstract
Objective To investigate whether changes in
tubuloglomerular feedback (TGF) dependent upon the
tubular effects of buffering anions affect the renal
haemodynamic response to L-arginine in healthy (control)
individuals and patients with essential hypertension.
Methods Mean arterial pressure (MAP), glomerular
filtration rate (GFR), renal blood flow (RBF) and fractional
excretion of sodium (FENa), chloride (FECl) and lithium
(FELi) were measured in 10 control individuals and 10
hypertensive patients during two 3-h infusions of
0.012 mmol/kg per min L-arginine buffered with either HCl
or citric acid.
Results FELi, FECl and FENa increased (P<0.001)
comparably in controls and hypertensive individuals with
arginine–HCl and decreased with arginine–citrate
(P<0.001). MAP was unchanged in controls with arginine–
HCl and decreased by 3% with arginine–citrate (P<0.001),
and decreased in hypertensive individuals with both
arginine–HCl and arginine–citrate (by 3 and 7%,
respectively; P<0.001). GFR increased with arginine–
citrate in controls and hypertensive individuals (by 6.1 and
5.4%, respectively; P<0.001), but did not change with
arginine–HCl in controls and declined by 4.6% in
hypertensive individuals (P<0.05). RBF increased equally
after arginine–citrate in controls and hypertensive
individuals (by 34 and 33%, respectively; P<0.001); it also
increased after arginine–HCl (22 and 13%, respectively;
P<0.001), but less than after arginine–citrate (P<0.001)
Endothelial Dysfunction and Cardiovascular Risk in Long-Term Withdrawing Alcoholics
No full textAbstract
Background Rates of cardiovascular morbidity and
mortality are greater in heavy alcoholics than in either
teetotallers or light-to-moderate drinkers.
Objective On the assumption that factors leading to
atherosclerotic damage remain operative even after
long-term alcohol withdrawal, we studied the possible
mechanisms of raised cardiovascular risk in former heavy
alcoholics.
Methods Forty-two apparently disease-free, normotensive
alcoholics detoxified for 37.1W31.9 (SD) months, median
24, participated in the study. They were compared with
39 lifetime alcohol-abstaining control subjects, carefully
matched for age, sex, body mass index, smoking and dietary
habits, physical activity, lipids and fasting glucose.
Endothelial function (flow-mediated dilation of brachial
artery, high-resolution ultrasound technique), blood
pressure, and some parameters of endothelial activation,
oxidative stress, vascular inflammation and insulin
sensitivity were measured.
Results The maximal percentage of flow-mediated
dilatation was reduced in detoxified alcoholics (10.1W4.6
versus 14.9W7.4, P < 0.001) who also showed significantly
higher blood pressure (systolic 127.5W12.9 versus
118.2W10.7mmHg, P < 0.001; diastolic 79.4W7.1 versus
74.6W6.4mmHg, P < 0.01; mean 95.4W8.2 versus
89.1W7.3mmHg, P < 0.001), uric acid (5.0W1.1 versus
4.4W0.8 mg/dl, P < 0.05), high-sensitivity C-reactive protei
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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