210 research outputs found
Analise do mecanismo de ação das respostas contrateis e relaxantes induzidas pelas cininas no fundo de estomago de rato e na vesicula biliar de cobaia "in vitro"
No full textStudy of Atrato river plume in a tropical estuary: Effects of the wind and tidal regime on the Gulf of Uraba, Colombia [Estudio de la pluma del río Atrato en un estuario en el trópico: Efectos del viento y del régimen de mareas en el Golfo de Urabá, Colombia]
No full textThis study focuses on the relative importance of the forcing agents of Atrato River plume as it propagates in a tropical estuary located in the Gulf of Uraba in the Colombian Caribbean Sea. Six campaigns of intensive field data collection were carried out from 2004 to 2007 to identify the main features of the plume and to calibrate and validate a numerical model. Field data and numerical models revealed high spatial and temporal plume variability according to the magnitudes of river discharges, tidal cycles, and wind stress. Atrato River discharge spreads over a considerable portion of the gulf, but only occupies the top 2 m of the surface layer. The tide modifies the position of the plume by inducing a horizontal migration of the salinity front during the day. Two principal modes of circulation in the gulf were identified under different wind conditions. © The author; licensee Universidad Nacional de Colombia
Postintubation Injuries And Open Surgical Tracheostomy: Should We Always Perform Isthmectomy? [sequelas Pós-intubação E Traqueostomia Cirúrgica Aberta: Devemos Sempre Fazer A Istmectomia?]
No full textObjective: To evaluate the influence of the surgical team (general surgery or thoracic surgery) and the surgical technique (with or without isthmectomy) on the incidence of postintubation injuries in the airways of tracheostomized patients. Methods: Between January 1st and August 31st, 2007, 164 patients admitted to the adult intensive care unit and tracheally intubated for more than 24 h were studied prospectively at the Sumaré State Hospital, located in the city of Sumaré, Brazil. When tracheostomy was necessary, these patients were randomly assigned to thoracic or general surgery teams. All of the patients were submitted to fiberoptic tracheoscopy for decannulation or late evaluation of the airway. Results: Of the 164 patients in the study, 90 (54.88%) died (due to causes unrelated to the procedure), 67 (40.85%) completed follow-up, and 7 (4.27%) were lost to follow-up. Of the 67 patients who completed follow-up, 32 had undergone tracheostomy (21 by the general surgery team and 11 by the thoracic surgery team), and 22 had been submitted to isthmectomy (11 by the general surgery team and 11 by the thoracic surgery team). There was no difference between the surgical teams in terms of the incidence of stoma complications. However, there was a significant difference when the surgical techniques (with or without isthmectomy) were compared. Conclusions: Not performing isthmectomy in parallel with tracheostomy leads the surgeon to open the tracheal stoma more distally than expected. In such cases, there were more stoma complications.353227233Maddaus, M.A., Pearson, F.G., Postintubation injury (2002) Pearson's Thoracic and Esophageal Surgery, pp. 300-314. , In: Pearson FG, Patterson GA, editors, Philadelphia: Churchill Livingstone/ElsevierStreitz Jr, J.M., Shapshay, S.M., Airway injury after tracheotomy and endotracheal intubation (1991) Surg Clin North Am, 71 (6), pp. 1211-30Park, M., Brauer, L., Sanga, R.R., Kajdacsy-Balla, A.C., Ladeira, J.P., Azevedo, L.C., Percutaneous Tracheostomy in Critically-ill Patients: The Experience of a Medical Intensive Care Unit (2004) J Bras Pneumol., 30 (3), pp. 237-242Ciaglia, P., Firsching, R., Syniec, C., Elective percutaneous dilatational tracheostomy. A new simple bedside procedurepreliminary report (1985) Chest, 87 (6), pp. 715-9Epstein, S.K., Late complications of tracheostomy (2005) Respir Care, 50 (4), pp. 542-9Pearson, F.G., Goldberg, M., da Silva, A.J., A prospective study of tracheal injury complicating tracheostomy with a cuffed tube (1968) Ann Otol Rhinol Laryngol, 77 (5), pp. 867-82Braz, J.R., Navarro, L.H., Takata, I.H., Nascimento Júnior, P., Endotracheal tube cuff pressure: Need for precise measurement (1999) Sao Paulo Med J, 117 (6), pp. 243-7Goldstraw, P., Morgam, C., Tracheostomy (2002) Pearson's Thoracic and Esophageal Surgery, pp. 375-383. , In: Pearson FG, Patterson GA, editors, Philadelphia: Churchill Livingstone/ ElsevierPutnam Jr., J.B., Traquéia (2005) Sabiston Tratado De Cirurgia, pp. 1792-1793. , In: Townsend MC, editor, Rio de Janeiro: ElsevierVianna, A., Tracheostomy in patients on mechanical ventilation: When is it indicated? (2007) J Bras Pneumol., 33 (6), pp. xxxvii-xxxviiiPerfeiro, J.A., Mata, C.A., Forte, V., Carnaghi, M., Tamura, N., Leão, L.E., Tracheostomy in the ICU: Is it worthwhile? (2007) J Bras Pneumol., 33 (6), pp. 687-90Leite, A.G., Kussler, D., Management of recurrent distal tracheal stenosis using an endoprosthesis: A case report (2008) J Bras Pneumol., 34 (2), pp. 121-5Arabi, Y., Haddad, S., Shirawi, N., Al Shimemeri, A., Early tracheostomy in intensive care trauma patients improves resource utilization: A cohort study and literature review (2004) Crit Care, 8 (5), pp. R347-52Croshaw, R., McIntyre, B., Fann, S., Nottingham, J., Bynoe, R., Tracheostomy: Timing revisited (2004) Curr Surg, 61 (1), pp. 42-8Walts, P.A., Murthy, S.C., Arroliga, A.C., Yared, J.P., Rajeswaran, J., Rice, T.W., Tracheostomy after cardiovascular surgery: An assessment of long-term outcome (2006) J Thorac Cardiovasc Surg, 131 (4), pp. 830-7Plummer, A.L., Gracey, D.R., Consensus conference on artificial airways in patients receiving mechanical ventilation (1989) Chest, 96 (1), pp. 178-80Leung, R., Macgregor, L., Campbell, D., Berkowitz, R.G., Decannulation and survival following tracheostomy in an intensive care unit (2003) Ann Otol Rhinol Laryngol., 112 (10), pp. 853-8Pinet, C., Quenee, V., Sainty, J.M., Significance of systematic endoscopic decannulation. Retrospective study on intensive care patients [Article in French] (1998) Rev Pneumol Clin., 54 (2), pp. 81-4Nouraei, S.A., Singh, A., Patel, A., Ferguson, C., Howard, D.J., Sandhu, G.S., Early endoscopic treatment of acute inflammatory airway lesions improves the outcome of postintubation airway stenosis (2006) Laryngoscope., 116 (8), pp. 1417-21Coelho, M.S., Zampier, J.A., Zanin, S.A., Silva, E.M., Guimarães, P.S., Fístula traqueoesofágica como complicação tardia de traqueostomia (2001) J Pneumol., 27 (2), pp. 119-22Grillo, H.C., Mathisen, D.J., Wain, J.C., Laryngotracheal resection and reconstruction for subglottic stenosis (1992) Ann Thorac Surg., 53 (1), pp. 54-63Saueressig, M.G., Macedo-Neto, A.V., Moreschi, A.H., Xavier, R.G., Sanches, P.R., A correção das estenoses traqueobrônquicas mediante o emprego de órteses (2002) J Pneumol., 28 (2), pp. 84-93Terra, R.M., Minamoto, H., Tedde, M.L., Almeida, J.L., Jatene, F.B., Self-expanding stent made of polyester mesh with silicon coating (Polyflex®) in the treatment of inoperable tracheal stenoses (2007) J Bras Pneumol., 33 (3), pp. 241-7Gravvanis, A.I., Tsoutsos, D.A., Iconomou, T.G., Papadopoulos, S.G., Percutaneous versus Conventional Tracheostomy in Burned Patients with Inhalation Injury (2005) World J Surg., 29 (12), pp. 1571-5Karagiannidis, C., Velehorschi, V., Obertrifter, B., Macha, H.N., Linder, A., Freitag, L., High-level expression of matrix-associated transforming growth factor-beta1 in benign airway stenosis (2006) Chest., 129 (5), pp. 1298-30
Perturbation of elliptic operators in 1-sided NTA domains satisfying the capacity density condition
No full textLet ω ⊂ Rn+1, n ≥ 2, be a 1-sided non-tangentially accessible domain (aka uniform domain), that is, ω satisfies the interior Corkscrew and Harnack chain conditions, which are respectively scale-invariant/quantitative versions of openness and path-connectedness. Let us assume also that ω satisfies the so-called capacity density condition, a quantitative version of the fact that all boundary points are Wiener regular. Consider L0 u = - div (A0 ∇ u), Lu = - div (A ∇ u), two real (non-necessarily symmetric) uniformly elliptic operators in ω, and write ω L0, ωL for the respective associated elliptic measures. The goal of this program is to find sufficient conditions guaranteeing that ωL satisfies an A ∞-condition or a RHq-condition with respect to ω L0. In this paper we establish that if the discrepancy of the two matrices satisfies a natural Carleson measure condition with respect to ω L 0, then ω L A ∞ (ω L 0). Additionally, we can prove that ωL RH q (ω L0) for some specific q (1, ∞), by assuming that such Carleson condition holds with a sufficiently small constant. This "small constant"case extends previous work of Fefferman-Kenig-Pipher and Milakis-Pipher together with the last author of the present paper who considered symmetric operators in Lipschitz and bounded chord-arc domains, respectively. Here we go beyond those settings, our domains satisfy a capacity density condition which is much weaker than the existence of exterior Corkscrew balls. Moreover, their boundaries need not be Ahlfors regular and the restriction of the n-dimensional Hausdorff measure to the boundary could be even locally infinite. The "large constant"case, that is, the one on which we just assume that the discrepancy of the two matrices satisfies a Carleson measure condition, is new even in the case of nice domains (such as the unit ball, the upper-half space, or non-tangentially accessible domains) and in the case of symmetric operators. We emphasize that our results hold in the absence of a nice surface measure: all the analysis is done with the underlying measure ω L0, which behaves well in the scenarios we are considering. When particularized to the setting of Lipschitz, chord-arc, or 1-sided chord-arc domains, our methods allow us to immediately recover a number of existing perturbation results as well as extend some of them
Predicting adherence to antiretroviral therapy and retention to HIV care : effects of baseline biopsychosocial status and neuropsychological functioning
No full textThese drugs have demonstrated efficacy in improving immune function and reducing HIV-related morbidity and mortality, and while a cure is not available, patients on treatment may live longer, healthier lives. However, early optimism has been tempered by the growing recognition that meticulous adherence is a prerequisite for optimal clinical response and prevention of drug resistance
Por el alma y por el bolsillo. Literatura de viajes y viajes en la literatura en la Edad Media catalana
No full textDynamic feedback generation in virtual patients using semantic web technologies
No full textVirtual patients are interactive tools commonly used by medical schools for teaching and learning, and as training tools for the development of clinical reasoning. The feedback delivered to students is a crucial feature in virtual patients. Personalised feedback, in particular, helps students to reflect on their mistakes and to organise their knowledge in order to use it appropriately in a clinical context. However, authoring personalised feedback in virtual patient systems can become a difficult task, due to the large number of choices available to students and the complex implications of each choice. Additionally, the current technologies used for the design and exchange of virtual patients have limitations in terms of interoperability and data reusability.Semantic web technologies are designed to model complex knowledge in a flexible manner, allowing easy data sharing from multiple sources and automatic data processing. This thesis demonstrates the benefits of Semantic Web technologies for the design of virtual patients, in particular for the automatic generation of personalised feedback.Seven important types of personalised feedback were identified from the literature, and a preliminary survey showed that students in year 3 to 5 consider two of these types of feedback to be particularly useful: feedback indicating actions that each student should have chosen but neglected, and feedback indicating the diagnoses that each student should have tested and rule out or confirmed, given the initial presentation of the patient. SemVP, a Semantic Web-based virtual patient system, was created and evaluated by medical students, using a quantitative survey and qualitative interviews. This study showed that SemVP can generate useful personalised feedback, without the need for a virtual case author to write feedback manually, using a semantic model representing both the virtual patient and each student's actions, and leveraging existing data sources available online
Multi-site genetic analysis of diffusion images and voxelwise heritability analysis : a pilot project of the ENIGMA–DTI working group
No full textThe ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic variants that influence the brain. Diffusion tensor imaging (DTI) yields quantitative measures sensitive to brain development and degeneration, and some common genetic variants may be associated with white matter integrity or connectivity. DTI measures, such as the fractional anisotropy (FA) of water diffusion, may be useful for identifying genetic variants that influence brain microstructure. However, genome-wide association studies (GWAS) require large populations to obtain sufficient power to detect and replicate significant effects, motivating a multi-site consortium effort. As part of an ENIGMA–DTI working group, we analyzed high-resolution FA images from multiple imaging sites across North America, Australia, and Europe, to address the challenge of harmonizing imaging data collected at multiple sites. Four hundred images of healthy adults aged 18–85 from four sites were used to create a template and corresponding skeletonized FA image as a common reference space. Using twin and pedigree samples of different ethnicities, we used our common template to evaluate the heritability of tract-derived FA measures. We show that our template is reliable for integrating multiple datasets by combining results through meta-analysis and unifying the data through exploratory mega-analyses. Our results may help prioritize regions of the FA map that are consistently influenced by additive genetic factors for future genetic discovery studies. Protocols and templates are publicly available at (http://enigma.loni.ucla.edu/ongoing/dti-working-group/)
Acid Volatile Sulfides And Simultaneously Extracted Metals In The Assessment Of Freshwater Sediments [sulfetos Volatilizáveis Por Acidificação E Metais Extraídos Simultaneamente Na Avaliação De Sedimentos De água Doce]
No full textThis paper discusses the historical and methodological fundaments of the dynamics and quantification of acid volatile sulfides (AVS) and simultaneously extracted metals (SEM) in aquatic sediments. It also discusses the SEM/AVS relationship, which involves several controversial aspects such as sulfide stability, sulfide-organic matter interaction, and the inability to predict the toxicity of organic compounds in the environment. This relationship is an important tool for the inference of metal bioavailability. The use of ecotoxicological tests with target organisms regulated by international standards is also a relevant aspect.34916181628Manahan, S.E., (1999) Industrial Ecology: Environmental Chemistry and Hazardous Waste, , 1st ed., CRC: LewisAllen, H.E., Hall, R.H., Brisbin, T.D., (1980) Environ. Sci. Technol., 14, p. 411Berry, W.J., Hansen, D.J., Mahony, J.D., Robson, D.L., Di Toro, D.M., Shipley, B.P., Rogers, B., Boothman, W.S., (1996) Environ. Toxicol. 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Author Correction: A detailed map of Higgs boson interactions by the ATLAS experiment ten years after the discovery
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