121,792 research outputs found
Letter from C. E. Allen to B. R. Colson
No full textLetter from C. E. Allen to B. R. Colson. The one-page typewritten correspondence is on C. E. Allen\u27s business letterhead and dated 19 June 1912
Letter to Sonora Dodd from C. R. Allen, November 7, 1910
No full textLetter to Sonora Dodd from C. R. Allen, with envelope. Also included are six postcards with poetic verses, referenced in the letter.https://digitalcommons.whitworth.edu/fathers-day-correspondence/1022/thumbnail.jp
Letter from B. R. Colson to C. E. Allen
No full textLetter dictated by B. R. Colson to C. E. Allen. The one-page typewritten note is dated 27 February 1912
Charles R. Allen
No full textR-C of C. Allen. 28 Mar. HR 410, 30-1, v2, 6p. [525] Seneca treaty negotiations, 1838
The Custom House
No full text'THE CUSTOM HOUSE. Drawn by J. M,, W. Turner, R. A,, Engraved by J C Allen [...] London Publised by J. C. Allen 132 Goswell Street and W. B. Cooke 9,, Soho Square,, Jun 1. 1827'
Mr R Allen
No full textResearch School of Pacific Studies - Research Scholars - Miss M. J. Steven, Dr. Ethel Drus, Dr. Paula Brown, Prof. J. A. Barnes, Dr. H. C. Brookfield, Dr. A. L. Epstein, Dr. F. J. West, Dr. G. J. R. Linge, Mr. H. E. Maude, Dr. E. S. Crawcour, Mr. T. W. Eckersley, Dr. S. A. Wurm, Mr. M. A. Jaspan, N. J. Hunter, R. L. Heathcote, Miss D. MacEachern, Mr. R. V. White, E. C. F. Bird, Mr. A. M. Healy, R. H. T. Smith, R. M. Frazer, A. Fraser, D. C. Laycock, M. R. Allen, R. D. Peranio, G. M. Appell, D. B. Howlett, J. Beckett, R. Crocombe, J. Mosley, Mrs. M. J. Retcher, P. G. Ganguly, A. Place, H. D. Chiang, M. Singarimbun, A. V. Mozley, J. J. Broomfield, B. Kent, D. Carrington, Mr. G. C. Bolton, Mr. E. P. Water
Hundreds of variants clustered in genomic loci and biological pathways affect human height
No full textMost common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits(1), but these typically explain small fractions of phenotypic variation, raising questions about the use of further studies. Here, using 183,727 individuals, we show that hundreds of genetic variants, in at least 180 loci, influence adult height, a highly heritable and classic polygenic trait(2,3). The large number of loci reveals patterns with important implications for genetic studies of common human diseases and traits. First, the 180 loci are not random, but instead are enriched for genes that are connected in biological pathways (P = 0.016) and that underlie skeletal growth defects (P<0.001). Second, the likely causal gene is often located near the most strongly associated variant: in 13 of 21 loci containing a known skeletal growth gene, that gene was closest to the associated variant. Third, at least 19 loci have multiple independently associated variants, suggesting that allelic heterogeneity is a frequent feature of polygenic traits, that comprehensive explorations of already-discovered loci should discover additional variants and that an appreciable fraction of associated loci may have been identified. Fourth, associated variants are enriched for likely functional effects on genes, being over-represented among variants that alter amino-acid structure of proteins and expression levels of nearby genes. Our data explain approximately 10% of the phenotypic variation in height, and we estimate that unidentified common variants of similar effect sizes would increase this figure to approximately 16% of phenotypic variation (approximately 20% of heritable variation). Although additional approaches are needed to dissect the genetic architecture of polygenic human traits fully, our findings indicate that GWA studies can identify large numbers of loci that implicate biologically relevant genes and pathways
Allen Collection; no.10799
No full textSepia image of downtown Mogollon, New Mexico. Traveling down street are two large wagon teams. Three mules are seen next to steps leading to a large wooden deck leading to the Hart -&- Belde__ Livery Feed & Tran___. Three unidentified men wearing early 20th century informal clothing stand on the pictured deck. Other business are as follows; Little Jim short - orders Open Day and Night, W. C. Field. M. D. Physician & Surgeon. Businesses lining the left side of the street; Drs. Hard___ ack. Physician & Surgeon, Office Hart and Belden Livery Fee and Transfer Line, Candy. Kitchen, Draft Beer. Image mounted on black matte paper.Master file: image/tiff; 108,079 KB: Computer Hardware: Intel Pentium (R) 4 3.20 GHz/ 1.99 GB RAM manufactured by Dell; Operating system: Windows XP 2002; Creation software: Adobe Photoshop CS2 version 9.0.2; Scanner: flatbed reflective scanner Microtek 1000XL; Scanner software: Microtek SilverFast Ai 6.4.2r2b; Scanned by Jason Dunlap on 2010-01-18
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