1,720,981 research outputs found
The role of metal ions in amyloid formation: General principles from model peptides
No full textISI Document Delivery No.: 096NO Times Cited: 0 Cited Reference Count: 45 Alies, Bruno Hureau, Christelle Faller, Peter Royal soc chemistry CambridgeThe mechanistic understanding of peptide self-assembly mediated by metal ions into amyloids or other structures has gained a lot of interest, mainly due to their importance in several neurodegenerative diseases. The use of short, easy-to-handle peptides has contributed to a better knowledge of structures and mechanisms that are also relevant for the native and longer peptides involved in the neurodegenerative diseases. Here, we review the results obtained with such "model systems" with the aim to identify and discuss fundamental parameters determining the self-aggregation with a special focus on the role of metal ions in this process
Zn impacts Cu coordination to amyloid-beta, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity
No full textISI Document Delivery No.: 070SP Times Cited: 0 Cited Reference Count: 21 Alies, Bruno Sasaki, Isabelle Proux, Olivier Sayen, Stephanie Guillon, Emmanuel Faller, Peter Hureau, Christelle Royal soc chemistry CambridgeCombined coordination of Zn-II and Cu-I or Cu-II to the amyloid-beta peptide has been investigated using XANES, EPR and NMR spectroscopies. While ZnII does alter Cu-II binding to A beta, this has no effect on (A beta)Cu induced ROS production and associated cell toxicity
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Cu(II) affinity for the Alzheimer's peptide: Tyrosine fluorescence studies revisited
No full textISI Document Delivery No.: 086IA Times Cited: 0 Cited Reference Count: 49 Alies, Bruno Renaglia, Emelyne Rozga, Malgorzata Bal, Wojciech Faller, Peter Hureau, Christelle ANR (Agence Nationale de la Recherche) [NT09-488591]; National Centre for Science, Poland [2741/B/H03/2010/38]; Polish Ministry of Science and Higher Education [0463/IP1/2011/71] Authors thank the ANR (Agence Nationale de la Recherche) for financial support (ANR Grant Neurometals NT09-488591). The support of grant 2741/B/H03/2010/38 by National Centre for Science, Poland and the grant 0463/IP1/2011/71 by Polish Ministry of Science and Higher Education are also acknowledged. Amer chemical soc WashingtonCopper(II) binding to the amyloid-beta peptide has been proposed to be a key event in the cascade leading to Alzheimer's disease. As a direct consequence, the strength of the Cu(II) to A beta interaction, that is, the Cu(II) affinity of A beta, is a very important parameter to determine. Because A beta peptide contain one Tyr fluorophore in its sequence and because Cu(II) does quench Tyr fluorescence, fluorescence measurements appear to be a straightforward way to obtain this parameter. However, this proved to be wrong, mainly because of data misinterpretation in some previous studies that leads to a conflicting situation. In the present paper, we have investigated in details a large set of fluorescence data that were analyzed with a new method taking into account the presence of two Cu(II) sites and the inner-filter effect. This leads to reinterpretation of the published data and to the determination of a unified affinity value in the 10(10) M-1 range
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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