33,318 research outputs found
Genetic Algorithm Assisted Minimum Bit Error Rate Multiuser Detection in Multiple Antenna Aided OFDM
No full textThe family of minimum bit error rate (MBER) multiuser detectors (MUD) is capable of outperforming the classic minimum mean-squared-error (MMSE)MUDin term of the achievable bit-error rate (BER) owing to directly minimising the BER cost function. In this paper, we will invoke genetic algorithms (GA) for finding the optimum weight vectors of the MBERMUDin the context of multipleantenna aided multi-user OFDM
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings
No full textCharacterization of segmental flexibility is needed to understand the biological mechanisms of the very large category of functionally diverse proteins, exemplified by the regulators of complement activation, that consist of numerous compact modules or domains linked by short, potentially flexible, sequences of amino acid residues. The use of NMR-derived residual dipolar couplings (RDCs), in magnetically aligned media, to evaluate interdomain motion is established but only for two-domain proteins. We focused on the three N-terminal domains (called CCPs or SCRs) of the important complement regulator, human factor H (i.e., FH1-3). These domains cooperate to facilitate cleavage of the key complement activation-specific protein fragment, C3b, forming iC3b that no longer participates in the complement cascade. We refined a three-dimensional solution structure of recombinant FH1-3 based on nuclear Overhauser effects and RDCs. We then employed a rudimentary series of RDC data sets, collected in media containing magnetically aligned bicelles (disklike particles formed from phospholipids) under three different conditions, to estimate interdomain motions. This circumvents a requirement of previous approaches for technically difficult collection of five independent RDC data sets. More than 80% of conformers of this predominantly extended three-domain molecule exhibit flexions of <40°. Such segmental flexibility (together with the local dynamics of the hypervariable loop within domain 3) could facilitate recognition of C3b via initial anchoring and eventual reorganization of modules to the conformation captured in the previously solved crystal structure of a C3b:FH1-4 complex.</p
Differential mechanisms of Thought-Action Fusion among older adolescents: Refining measures for greater conceptual clarity
No full textFully Turbulent Mean Velocity Profile for Purely Viscous non-Newtonian Fluids
No full textThe characteristic near wall behavior of turbulent flow of purely-viscous non-Newtonian fluids is discussed for both power-law (P.-L.) and Herschel-Bulkley (H.-B.) rheological models. A proper scaling is presented for H.-B. fluids to establish an analogy with power-law fluids with same flow index. To provide reference data for turbulent flow of non-Newtonian fluids, DNS simulations of power-law fluids are conducted in a rectangular channel for a large range of power-law indices ( = 0.5, 0.69, 0.75, 0.9, 1, 1.2). The DNS data show that the mean velocity profile in the viscous and logarithmic layers follow expressions of the form and respectively, where shows a logarithmic dependency on the flow index.Comparison with some experimental data shows the above formulation to be valid for Reynolds numbers (based on shear velocity) as high as 1000
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Sub-nyquist sampling techniques
No full textA number of novel theoretical methods have been developed in an attempt to analyse data produced by sampling a signal at below the Nyquist rate and the limitations of the approaches have been investigated. A technique is developed that allows, under specified conditions, the frequency and amplitude of a band-limited sinusoidal signal (with no harmonics) to be determined when the signal is sampled simultaneously with three uniform samplers at below the Nyquist rate. The three samplers operate at slightly different rates. Each has its output ideally low-pass filtered with a cut-off frequency at half the sampling rate. The frequencies of the signals output from the ideal filters are analysed to determine the input sinusoid parameters. The frequency of the sinusoid can also be found within a calculated tolerance when approximate filter output frequencies are known. Two approaches extending this technique for a band-limited periodic signal consisting of more than just the fundamental, enable the frequencies of the harmonics to be found for the signal, but there is the possibility that other erroneous harmonics may be identified as part of the signal. The probability of this occurring can be reduced by uniformly sampling simultaneously with a greater number of samplers. This probability cannot reach zero. Furthermore, as the number of samplers increases or the number of signal harmonics increases, the computational workload imposed in determining the harmonic frequencies rises dramatically. The approaches are rendered impractical and sampling at irregular intervals is suggested as an alternative to using a very large number of uniform samplers. A modified discrete Fourier transform and its inverse are developed to allow an estimated spectral analysis of a continuous periodic signal sampled at irregular intervals. Additive pseudo-random sampling and periodic sampling with dither are rigorously defined as two proposed irregular sampling schemes. The periodicity and symmetrical properties of the modified transform are derived for the two schemes. Consistently alias-free spectral analysis of a band-limited periodic signal is demonstrated using additive pseudo-random sampling with a maximum sampling rate below the Nyquist rate. This does not apply when using periodic sampling with dither
Contribution of Information and Communication Technology (ICT) in Country’S H-Index
No full textThe aim of this study is to examine the effect of Information and Communication Technology (ICT) development on country’s scientific ranking as measured by H-index. Moreover, this study applies ICT development sub-indices including ICT Use, ICT Access and ICT skill to find the distinct effect of these sub-indices on country’s H-index. To this purpose, required data for the panel of 14 Middle East countries over the period 1995 to 2009 is collected. Findings of the current study show that ICT development increases the H-index of the sample countries. The results also indicate that ICT Use and ICT Skill sub-indices positively contribute to higher H-index but the effect of ICT access on country’s H-index is not clear
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Abnormal Addition of NHC to a Conjugate Acid of CAAC: Formation of N-Alkyl-Substituted CAAC
No full textThe addition reactions of N-heterocyclic carbenes (NHCs) are mostly known to occur through the carbenic centre (C2), which leads to a "normal" adduct. Herein, we report the abnormal addition of NHCDip 1 (1,3-(2,6-iPr(2)C(6)H(3))-imidazole-2-ylidene) to a conjugate acid of cyclic (alkyl)(amino)carbene 2 (CAAC(iPr)=1-iPr-3,3,5,5-Me-4-pyrrolinium triflate). Mechanistic study revealed that this reaction proceeded through the in situ formation of 1,3-(2,6-iPr(2)C(6)H(3))-imidazolium cation 4 and N-iPr-substituted CAAC 5 followed by the oxidative addition of compound 5 across the C4-H bond (alias backbone C-H) of compound 4. The in situ formation of compound 5 was also proven by the oxidative addition of it to the N-H group of iPrNH(2). DFT calculations also supported the mechanistic findings. A different methodology for the in situ generation of compound 5 by using TMPLi is also described
TIL-derived MRI-restricted TCRs recognize breast cancer-specific antigen
No full textArticle富山大学・富医薬博甲第430号・UBEDULLAH ABDUL HAYEE ALIAS・2023/09/28
公表論文
Hayee A, Kobayashi E, Motozono C, Hamana H, My HTV, Okada T, Toyooka N, Yamaguchi S, Ozawa T, Kishi H. Characterization of Tumor-Infiltrating Lymphocyte-Derived Atypical TCRs Recognizing Breast Cancer in an MR1-Dependent Manner. Cells. 2024 Oct 16;13(20):1711. doi: 10.3390/cells13201711. PMID: 39451228; PMCID: PMC11506377
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