9 research outputs found
Suddenly developed hemorrhagic olecranon bursitis releated to traumatic asymptomatic heterotopic ossification
No full textSuddenly developed haemorrhagic olecranon bursitis is related to traumatic asymptomatic heterotopic ossification
No full textMonetary thought of the sixteenth century muslim scholars
Get PDFMuslim scholars of the sixteenth century continued the tradition of writing on economic issues. Their work, however is characterized by the period's overall feature of imitation and repetition and thus reflects hardly any advancement of monetary thought since the works of earlier Muslim scholars. This is clearly reflected in the two representative treatises on money: those of al-Suyuti (d. 1506) written at the beginning of the century, and al-Tumurtashi (d. 1598), written at its the end. History of Islamic economic thought is a well-researched area of Islamic Economics. To the best of our knowledge, however, all such research stopped at the end of the fifteenth century – the age of Ibn Khaldun and al-Maqrizi. The present paper seeks to advance this research and intends to investigate monetary thought of Muslim scholars during the sixteenth century (corresponding to tenth century Hijrah, exactly from 906 AH to 1009 AH). Beginning with an overview of earlier monetary thought in Islam to provide background information, then it goes on to note that particular century's monetary problems in order to provide a perspective for the discussion of monetary thought among Muslim scholars. For the purpose of comparison, European monetary thought of the same period is also analyzed.Monetary thought; Quantity theory of money;Sixteenth century Monetary Thought; al-Suyuti; al-Tumurtashi.
Structural and Dynamics Aspects of ASC Speck Assembly
No full textSummaryActivation of the inflammasome is accompanied by rapid formation of a micrometer-sized perinuclear structure called the ASC speck, a platform for caspase-1 activity. The ASC speck is often referred to as an aggregate and shares certain features with aggresomes. It is thus an open question whether the ASC speck formation takes place via nonspecific aggregation of hydrophobic patches or specific interactions of its domains; PYD and CARD, which belong to the death fold superfamily. Bringing together structure and dynamics studies using the Gaussian network model of PYD and CARD, and molecular dynamics simulations of the wild-type and in silico mutated PYD, with the mutational analysis on the ASC structure and its separate domains in human cells, we show that the ASC speck is an organized structure with at least two levels of distinct compaction mechanisms based on the specific interactions of PYD and CARD
Suddenly developed haemorrhagic olecranon bursitis is related to traumatic asymptomatic heterotopic ossification
No full textUse of Shear Wave Elastography for Quantitative Assessment of Muscle Stiffness After Botulinum Toxin Injection in Children With Cerebral Palsy
No full textFigure S1-S8 from CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function
No full textSupplementary Figure S1-S8</p
Supplementary Table from CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function
No full textSupplementary Table 1: CRASH-IT switches, variant constructs lacking one or more functional domains and codon optimized DNA sequences</p
Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behets syndrome patients
No full textThe role of mutations in NLRP3 in inflammatory features of Behets syndrome.Behets syndrome (BS) is a systemic inflammatory disorder with unknown etiology. Features of both innate and adaptive immunity have been claimed in the pathogenesis of BS. To test the possible dysregulation of the NLRP3/cryopyrin (Nod-like receptor with a pyrin domain 3) inflammasome, as a result of mutation(s), we performed single-strand conformation polymorphism analyses and/or sequencing of all the coding regions and intronexon boundaries of NLRP3/cryopyrin and ASC (apoptosis-associated speck-like protein containing CARD) genes from Turkish BS patients and healthy controls. At the same time, we determined pro-inflammatory cytokine secretion profiles of peripheral blood cells in response to LPS treatment using ELISA. BS patients with vascular involvement showed significantly increased levels of TNF- release at 2-, 4- and 8-h post-treatment and significantly increased IL-1 levels were detected at 2h (P 0.005) and 4h (P 0.025) (n 10). We identified four mutations in the NLRP3/cryopyrin gene, V200M (n 3/104) and T195M (n 1/104), in BS patients but none in control samples. No mutations were detected in the ASC gene. The effect of these NLRP3/cryopyrin mutants on ASC speck assembly and IL-1 secretion was tested and the V200M mutant was shown to induce IL-1 secretion. Thus, it is likely that certain mutations in NLRP3/cryopyrin in combination with yet unknown other factors may contribute to the pro-inflammatory cytokine profiles in BS patients
