5 research outputs found
Environmental chemistry in high school textbooks
No full textTyön tarkoituksena oli selvittää, miten ympäristökemiaa käsitellään lukion kemian oppikirjasarjoissa, miten oppikirjasarjat palvelevat ylioppilaskirjoituksiin valmistautumista ja miten oppikirjasarjoja tulisi kehittää.
Työssä perehdyttiin Lukion opetussuunnitelman perusteisiin 2003 ja luonnokseen Lukion opetussuunnitelman perusteista 2016. Opetussuunnitelman perusteista keskityttiin etsimään ympäristökemiaan liittyviä määräyksiä. Lukion opetussuunnitelman perusteiden antamien suuntaviivojen perusteella määriteltiin kuusi ympäristökemian aihepiiriä (kestävä kehitys, alkuaineiden kierto, energiantuotanto, veden kemia, ilmakehän kemia sekä ympäristön pilaantuminen ja ympäristönsuojelu), joihin tutkimuksessa keskityttiin.
Tutkimus toteutettiin käymällä läpi neljä lukion kemian oppikirjasarjaa: Kemisti, Mooli, Neon ja Reaktio sekä lisäksi ylioppilastutkintokysymykset vuosilta 2008 – 2014. Valittujen ympäristökemian aihepiirien esiintymistä lukion kemian oppikirjasarjoissa tutkittiin selvittämällä oppikirjakohtaisesti kunkin ympäristökemian aihepiirin teoriaan käytetty rivimäärä, aihepiiriin liittyvien tehtävien lukumäärä, esimerkkien lukumäärä, demonstraatioiden ja laboratoriotöiden lukumäärä sekä aihepiiriin liittyvien kuvien ja taulukoiden lukumäärä. Ylioppilastutkintokysymysten osalta tutkittiin sitä, kuinka monta kysymystä vuosina 2008 - 2014 kuhunkin määriteltyyn ympäristökemian aihepiiriin liittyi.
Oppikirjasarjojen sisältöä ja ylioppilastutkintokysymyksiä tarkastelemalla arvioitiin ympäristökemian esiintymistä oppikirjoissa ja oppikirjojen kehittämistarpeita. Saatujen tulosten perusteella laadittiin kehittämisehdotuksia, joita voidaan käyttää lukion kemian oppikirjasarjojen päivittämisessä.
Jotta lukion kemian oppikirjat vastaisivat mahdollisimman hyvin opetussuunnitelman perusteiden ja ylioppilastutkinnon vaatimuksiin, oppikirjoja päivitettäessä tulisi kiinnittää huomiota seuraavien aihepiirien esiintymiseen oppikirjoissa: fossiilisten polttoaineiden synty, kasvihuoneilmiö, ilmastonmuutos, kestävä kehitys, energian säästäminen, ympäristövaikutusten arviointi, rehevöityminen, vedenkäsittely (talousvesi ja jätevesi), veden hydrologinen kierto ja alkuaineiden kierto
Homecare, emergency medical team and emergency department professionals' perspectives on patient safety in health information exchange: A descriptive qualitative study of socio-technical factors
No full textAbstract
Health information exchange plays a critical role in modern healthcare delivery, especially in complex inter-organizational care pathways. This study describes healthcare professionals’ perspectives on patient safety in health information exchange, with a focus on associated socio-technical factors. In 2023, semi-structured interviews were conducted with 21 healthcare professionals from home care, the emergency department, and an emergency medical team in one wellbeing services county in Finland, using a modified socio-technical model. Data were analyzed through content analysis, revealing 31 generic categories and 79 subcategories aligned with the model’s eight dimensions.
Findings emphasize the crucial role of organizational factors, including insufficient information infrastructure, lack of unified systems, and poor integration. Additionally, user-centered design and support during health information exchange development and health information technology procurement are lacking. Inter-organizational collaboration is inconsistent, and safety monitoring remains inadequate.Abstract
Health information exchange plays a critical role in modern healthcare delivery, especially in complex inter-organizational care pathways. This study describes healthcare professionals’ perspectives on patient safety in health information exchange, with a focus on associated socio-technical factors. In 2023, semi-structured interviews were conducted with 21 healthcare professionals from home care, the emergency department, and an emergency medical team in one wellbeing services county in Finland, using a modified socio-technical model. Data were analyzed through content analysis, revealing 31 generic categories and 79 subcategories aligned with the model’s eight dimensions.
Findings emphasize the crucial role of organizational factors, including insufficient information infrastructure, lack of unified systems, and poor integration. Additionally, user-centered design and support during health information exchange development and health information technology procurement are lacking. Inter-organizational collaboration is inconsistent, and safety monitoring remains inadequate
Infrared-A (IR-A) modulates the p53 pathway and diurnal clock in human skin and subcutaneous adipose tissue in vivo
No full textInfrared-A (IR-A) radiation is thought to protect the skin from damage due to ultraviolet radiation and alter its carcinogenic potential, possibly by preventing keratinocyte apoptosis via p53 pathway modulation. Solar radiation, including IR-A, is a major factor in contributing to the entrainment of circadian rhythms. We examined the impacts of IR-A on the intrinsic clock and transcriptomics in individuals with different diurnal preference to understand the mechanisms by which IR-A acts in the human skin and subcutaneous adipose tissue. IR-A caused multiple gene expressional changes, mainly as immediate stress responses in 15 min, that were reversed within 24 h. IR-A irradiation increased the skin surface temperature (mean peak temperature 42.9 degrees C). In skin, the zinc finger proteins ZNF490 and ZNHIT2 correlated negatively with the maximum skin surface temperature. In adipose tissue, CDKN1A, which codes p21 protein, had a negative correlation with the skin surface temperature change. In the skin immunohistochemical staining, the circadian regulators CRY1 and CRY2 increased significantly 24 h after the irradiation, CRY1 already in 15 min. According to the diurnal preferences, morning-type individuals develop mostly innate immune responses, whereas evening-type of individuals had more pronounced responses through p53 pathway modulation, apoptosis, and autophagy.Peer reviewe
Effects of partial replacement of red and processed meat with non-soya legumes on bone and mineral metabolism and amino acid intakes in BeanMan randomised clinical trial
No full textPublished online by Cambridge University Press: 10 July 202
Soft matrix promotes immunosuppression in tumor-resident immune cells via COX-FGF2 signaling
No full textAbstract Mechanical forces of the tumor microenvironment change dynamically during key events of tumorigenesis such as invasion and metastasis. These changes in compressive forces often affect the breast cancer cell phenotype. However, it is lesser known how these dynamic mechanical forces in the tumor microenvironment affect the phenotypes of tumor infiltrated leukocytes (TIL) and their subsequent anticancer activities. Here we find, in primary patient-derived explant cultures (PDEC) containing resident TILs, that low compression promotes a change in the original identity of breast cancer cells from luminal to a more mesenchymal and undifferentiated state. These altered tumor cells induce an upregulation of immunosuppressive cytokines such as interleukin-10 (IL-10) and Transforming Growth Factor Beta (TGF-β), as well as polarization of macrophages towards pro-tumor M2(Gc)-type and depletion of CD8+ effector memory T-cells. These immunosuppressive events are mediated by tumor cell derived fibroblast growth factor 2 (FGF2) and prostaglandin E2 (PGE2). We also find that FGF2 rich areas in primary tumors show enrichment in M2-like-macrophages and diminished numbers of CD8 + T and B-cells. Our results suggest that low compressive forces in the tumor microenvironment induce local immunosuppression via FGF2 secretion arising from phenotypic plasticity of tumor cells
