100,391 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING DISERTAI TEKNIK MIND MAPPING TERHADAP HASIL BELAJAR BIOLOGI SISWA KELAS X DI SMA MUHAMMADIYAH GISTING
No full textABSTRAK
PENGARUH MODEL PEMBELAJARAN INKUIRI TERBIMBING
DISERTAI TEKNIK MIND MAPPING TERHADAP
HASIL BELAJAR BIOLOGI SISWA KELAS X
DI SMA MUHAMMADIYAH GISTING
Oleh
Lilik Alfiani
Proses belajar mengajar di SMA Muhammadiyah Gisting masih bersifat
teacher centered, siswa hanya diberikan bahan ajar yang bersumber dari LKS
(Lembar Kerja Siswa) sehingga mengakibatkan rendahnya hasil belajar siswa
yang hanya 34% mencapai KKM. Tujuan dari penelitin ini adalah untuk
mengetahui pengaruh model inkuiri terbimbing disertai teknik mind mapping
dalam pembelajaran biologi materi plantae terhadap hasil belajar kognitif, afektif
dan psikomotorik.
Metode penelitian yang digunakan adalah Quasi Eksperimen dengan
desain postest only control group. Populasi penelitian ini adalah siswa kelas X
SMA Muhammadiyah Gisting dengan sampel penelitian terdiri dari 2 kelas yang
diperoleh menggunakan teknik cluster random sampling yakni kelas eksperimen (
X 2) yang diterapkan model inkuiri terbimbing dan kelas kontrol (X 5)
menggunakan pembelajaran direct intruction. Teknik pengumpulan data dengan
tes dan non tes. Secara tes yaitu dengan soal pilihan ganda untuk melihat hasil
belajar ranah kognitif, Secara nontes yaitu dengan angket untuk melihat hasil
belajar afektif dan lembar observasi untuk melihat hasil belajar ranah psikomotor.
Setelah data penelitian dikumpulkan kemudian akan dianalisis menggunakan
analisis statistik dengan menggunakan uji prasyarat uji normalitas, uji
homogenitas dan uji t dengan menggunakan aplikasi SPSS.
Berdasarkan hasil penelitian didapati nilai hasil belajar siswa pada kelas
eksperimen lebih unggul dibandingkan dengan kelas kontrol. Maka dapat
disimpulkan bahwa Terdapat Pengaruh Model Pembelajaran Inkuiri Terbimbing
Disertai Teknik Mind Mapping Terhadap Hasil Belajar Biologi Siswa kelas X
SMA Muhammadiyah Gisting.
Kata kunci : Inkuiri Terbimbing, Teknik Mind Mapping, Hasil Belajar Siswa
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
FORCE MAJEURE OLEH LESSEE TERHADAP LESSOR DALAM PERJANJIAN LEASING AKIBAT PANDEMI COVID-19 PADA PT. MANDALA FINANCE DI KABUPATEN ACEH BARAT
No full textABSTRAKGhina Alfiani Fardja2021Force Majeure oleh Lessee Terhadap Lessordalam Perjanjian Leasing Akibat PandemiCovid-19 pada PT. Mandala Finance diKabupaten Aceh BaratFakultas Hukum Universitas Syiah Kuala(vii, 56, pp., bibl., app)T. Haflisyah,SH.,M.HumSewa Guna Usaha adalah kegiatan pembiayaan berupa penyediaanbarang modal secara guna usaha dengan hak opsi atau tanpa hak opsi yangdigunakan oleh lessee selama jangka waktu tertentu dengan pembayaran secaraberkala. Diawal tahun 2020 Corona Virus Disease 2019 (Covid-19) melandaIndonesia menyebababkan lessee Force majeure. Force majeure adalah keadaandiluar kuasa para pihak yang mengikatkan dirinya tidak mampu melaksanakanprestasi. Dasar hukum force majeure adalah Pasal 1245 KUHPerdata.Pelaksanaan perjanjian leasing antara lessee dan lessor tahun 2019-Juni 2020 iniberjalan tidak sebagaimana mestinya karena Covid-19 mengakibatkanberkurangnya pemasukan lessee sehingga mempersulit pemenuhan prestasikepada lessor (PT. Mandala Finance).Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yangmenyebabkan lessee tidak memiliki kemampuan membayar kepada lessor dalamperjanjian pembiayaan leasing, perlindungan yang seharusnya terhadap lesseeyang tidak dapat melakukan kewajibannya dikarenakan force majeur danpenyelesaian hukum yang dilakukan oleh para pihak.Penelitian ini menggunakan metode penelitian yuridis empiris yangdiawali dengan penelaahan terhadap Peraturan Perundang-Undangan (normatif)yang dilanjutkan dengan observasi yang mendalam serta wawancara untukmendapatkan data empiris terkait penelitian yang sedang dilaksanakan.Hasil penelitian menunjukkan bahwa faktor-faktor lessee tidak memilikikemampuan membayar kepada lessor dalam perjanjian pembiayaan leasingadalah Covid-19 berdampak pada penurunan omset penjualan, faktor adanyakebijakan pemerintah dan faktor ekonomi sehingga lessee tidak dapat melakukanpembayaran kepada lessor. Perlindungan terhadap lessee ketika lessee tidak dapatmelakukan kewajibannya adalah apabila adanya Covid-19 berpengaruh padalessee seperti penurunan omset, namun jika perekonomian lessee stabil makatidak dapat dikatakan force majeure. Penyelesaian hukum yang dilakukan adalahpihak lessee meminta keringanan pada lessor melalui mediasi yang dibantu olehmediator. Hasil mediasi berupa pembuatan re-schedule ulang antara lessee danlessor berupa pembayaran angsuran leasing semampu lessee setiap bulannyaselama 6 bulan kedepan (dari bulan April 2020-September 2020).Disarankan kepada PT. Mandala Finance (lessor) mampu mencegahterjadinya kerugian akibat Covid-19 dengan memberikan solusi bagi kedua belahpihak melalui mediasi. Kepada lessee disarankan mengantisipasi diri apabilaterjadi force majeure dan mengukur kemampuan bayarnya sebelum melakukanleasing
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