22 research outputs found
AN ANALYTICAL, STATISTICAL STUDY OF THYROID CANCER INCIDENCE IN SUDAN DURING 2005-2015
No full textIntroduction: Sudan, the most diverse country in the African continent, is experiencing growing cancers problems. However, little is known about thyroid cancer epidemiology and patterns. the study aimed to analyse and describe the epidemiological characteristics and trends of thyroid cancer in, in the period1st January 2005 and 31st December 2015. Methods: This is retrospective population and hospital-based study. We analysed epidemiological data for digital medical records at both Radiation and Isotope Centre Khartoum (RICK), and Soba University Hospital, Khartoum, Sudan were reviewed. Results: In total, 1,062 cases were reported during 1st January 2005 and 31st December 2015. Of these, (360; 33.9%) were male and (702; 66.1%) were female. The highest number of cases was in the 25-54-year-old age group (451; 42.5%), and more than 65-year-old age (331; 31.2%). The most predominant type of thyroid cancer among the Sudanese population was Papillary carcinoma (734; 69.1%) followed by Follicular carcinoma 178(16.8%) and Medullary carcinoma (150; 14.1%). There were significant differences in gender, age groups and types of thyroid cancer (P=0.001). Based on geographical distribution thyroid cancer showed high prevalence in Khartoum, North Kurdufan, River Nile, Kassala, North Darfur, Northern, and south Kurdufan. Whereas, low distribution is seen in Red sea, West Darfur, West Kurdufan, East Darfur, Al Gadarif, and the Blue Nile. Conclusion: our results suggest that thyroid cancer continuous presenting alarming challenge with an increasing the prevalence in females. Papillary carcinoma is the most common type among Sudanese populations. Further epidemiological studies are required in policy strategies for control and prevention strategies of thyroid cancer in Sudan
an e-Delphi consensus study
No full textUPDATE NOTICE: Correction: Moving towards a core measures set for patient safety in perioperative care: an e-Delphi consensus study (PLoS One. 2024;19(10):e0311896). PLoS One. 2025;20(1):e0317063. Doi: 10.1371/journal.pone.0317063. Funding Information: The work underlying this manuscript is encompassed in the European project SAFEST (Improving quality and patient SAFEty in surgical care through STandardisation and harmonisation of perioperative care in Europe). This project receives funding from the European Union\u2019s Horizon Europe research and innovation programme under grant agreement No 101057825. Link: https://cordis.europa.eu/project/ id/101057825 The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors would like to commend the SAFEST consortium members for their contribution: Daniel Arnal-Velasco, Joaquim Baneres, Ashish Bartakke, Hiske Calsbeek, Genis Carrasco, Pedro Casaca-Carvalho, Edoardo De Robertis, Yvette Emond, Neus Fabregas, Javier Garc\u00EDa-Silva, Pascal Garel, Oliver Groene, Anita Heideveld-Chevalking, Mari Kangasniemi, Janne Kommusaar, Kaja Kristensen, Andreia Leite, Irene Leon, Ismael Mart\u00EDnez-Nicol\u00E1s, David Marx, Marie Nabbe, Ana Beatriz Nunes, Carola Orrego, Kaja Polluste, Janne P\u00FChvel, Eva Romero-Garcia, Yolanda Sanduende-Otero, Willemijn Sch\u00E4fer, Caroline Schlinkert, Ayshe Seyfulayeva, Victor Soria-Aledo, Paulo Sousa, Joel Starkopf, Rosa Sunol, Helena Vall, Claudia Valli, Nina van der Schoot, Lilian Van Tuyl, Frantisek Vlcek, Marieke Voshaar, Cordula Wagner, Sophie Wang, Adam \u017Daludek, and Sandro Zamarian. The authors would also like to acknowledge the SAFEST Scientific Advisory Group members for contributing to this study: Aamer Ahmed, Fragkiskos Angelis, Catarina Baptista, Metaxia Bareka, Kateryna Bielka, Mercedes Bilbao, Federico Bilotta, Elvira Bisbe, Dialina Brilhante, Pedro Carrascal, Pedro Delgado, Zsuzsanna Farkas-Pall, Loredana Gigli, Helen Haskell, Arvid Steinar Haugen, Jan Hofland, Beverley Hunt, Ib Jammer, Janek Kapper, Natasa Kovac, Susana Lorenzo, Rui Malheiro, Xose Manuel Meijome, Jannicke Mellin-Olsen, Margaret Murphy, Maria Ntalouka, Marta Dora Ornelas, Margarita Ovsepyan, Maria Papadakaki, Danica Rotar Pavlic, Julien Picard, Marek Pietruszka, Benedikt Preckel, Finn Radktke, Jos\u00E9 Manuel Rodr\u00EDguez, Narimantas Evaldas Samalavicius, Pedro Vieira dos Santos, Ed Schoemaker, Kawaldip Sehmi, Henri\u00EBtte Smid-Nanninga, Joel Starkopf, John Tansley, Francesco Venneri, Matthias Weigl, and Argyro Zoumprouli. Publisher Copyright: Copyright: © 2024 Dinis-Teixeira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.A Core Measures Set (CMS) is an agreed standardized group of measures that should be assessed and reported in research for a specific condition or clinical area. This study undertook the development of a CMS for Patient Safety through a two-round, web-based Delphi consensus approach, in the context of the “Improving quality and patient SAFEty in surgical care through STandardisation and harmonization of perioperative care in Europe” (SAFEST) project—a collaborative, patient-centered and evidence-based European Union-funded project that aims to generate action-oriented evidence in perioperative care. We developed an Initial List of Measures via an umbrella review following the deployment of an e-Delphi method with an inclusive panel of experts to prioritize measures towards a consensualized Final List of Measures. All measures were rigorously assessed for both importance and feasibility. After the two rounds of the e-Delphi consensus method we observed 13 preoperative measures (40.6% of the initial number), 24 intraoperative measures (66.7%), 25 postoperative measures (20.3%) and 23 mixed period measures (41.1%) met consensus criteria for both importance and feasibility. Higher scores were detected in importance ratings compared to feasibility across all groups of measures. Importantly, numeric averages regarding pain-related measures differed in the assessment of patients when compared to that of Healthcare Professionals (HCPs). This work not only informs future SAFEST iterations but also sets a precedent for research into valid, patient-centered, and action-oriented perioperative safety measures.publishersversionpublishersversionpublishe
Author Correction: Federated learning enables big data for rare cancer boundary detection.
No full text10.1038/s41467-023-36188-7NATURE COMMUNICATIONS14
Citizenship and political participation in the State of Kuwait : the case of National Assembly (1963-1996)
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
A Possible Alignment Between the Orbits of Planetary Systems and their Visual Binary Companions
No full textFull list of authors: Christian, Sam; Vanderburg, Andrew; Becker, Juliette; Yahalomi, Daniel A.; Pearce, Logan; Zhou, George ; Collins, Karen A.; Kraus, Adam L.; Stassun, Keivan G.; de Beurs, Zoe; Ricker, George R.; Vanderspek, Roland K.; Latham, David W.; Winn, Joshua N.; Seager, S.; Jenkins, Jon M.; Abe, Lyu; Agabi, Karim; Amado, Pedro J.; Baker, David; Barkaoui, Khalid; Benkhaldoun, Zouhair; Benni, Paul; Berberian, John; Berlind, Perry; Bieryla, Allyson; Esparza-Borges, Emma; Bowen, Michael; Brown, Peyton; Buchhave, Lars A.; Burke, Christopher J.; Buttu, Marco; Cadieux, Charles; Caldwell, Douglas A.; Charbonneau, David; Chazov, Nikita; Chimaladinne, Sudhish; Collins, Kevin I.; Combs, Deven; Conti, Dennis M.; Crouzet, Nicolas; de Leon, Jerome P.; Deljookorani, Shila; Diamond, Brendan; Doyon, René; Dragomir, Diana; Dransfield, Georgina; Essack, Zahra; Evans, Phil; Fukui, Akihiko; Gan, Tianjun; Esquerdo, Gilbert A.; Gillon, Michaël; Girardin, Eric; Guerra, Pere; Guillot, Tristan; K. Habich, Eleanor Kate; Henriksen, Andreea; Hoch, Nora; Isogai, Keisuke I.; Jehin, Emmanuël; Jensen, Eric L. N.; Johnson, Marshall C.; Livingston, John H.; Kielkopf, John F.; Kim, Kingsley; Kawauchi, Kiyoe; Krushinsky, Vadim; Kunzle, Veronica; Laloum, Didier; Leger, Dominic; Lewin, Pablo; Mallia, Franco; Massey, Bob; Mori, Mayuko; McLeod, Kim K.; Mékarnia, Djamel; Mireles, Ismael; Mishevskiy, Nikolay; Tamura, Motohide; Murgas, Felipe; Narita, Norio; Naves, Ramon; Nelson, Peter; Osborn, Hugh P.; Palle, Enric; Parviainen, Hannu; Plavchan, Peter; Pozuelos, Francisco J.; Rabus, Markus; Relles, Howard M.; Rodríguez López, Cristina; Quinn, Samuel N.; Schmider, Francois-Xavier; Schlieder, Joshua E.; Schwarz, Richard P.; Shporer, Avi; Sibbald, Laurie; Srdoc, Gregor; Stibbards, Caitlin; Stickler, Hannah; Suarez, Olga; Stockdale, Chris; Tan, Thiam-Guan; Terada, Yuka; Triaud, Amaury; Tronsgaard, Rene; Waalkes, William C.; Wang, Gavin; Watanabe, Noriharu; Wenceslas, Marie-Sainte; Wingham, Geof; Wittrock, Justin; Ziegler, Carl.--This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Astronomers do not have a complete picture of the effects of wide-binary companions (semimajor axes greater than 100 au) on the formation and evolution of exoplanets. We investigate these effects using new data from Gaia Early Data Release 3 and the Transiting Exoplanet Survey Satellite mission to characterize wide-binary systems with transiting exoplanets. We identify a sample of 67 systems of transiting exoplanet candidates (with well-determined, edge-on orbital inclinations) that reside in wide visual binary systems. We derive limits on orbital parameters for the wide-binary systems and measure the minimum difference in orbital inclination between the binary and planet orbits. We determine that there is statistically significant difference in the inclination distribution of wide-binary systems with transiting planets compared to a control sample, with the probability that the two distributions are the same being 0.0037. This implies that there is an overabundance of planets in binary systems whose orbits are aligned with those of the binary. The overabundance of aligned systems appears to primarily have semimajor axes less than 700 au. We investigate some effects that could cause the alignment and conclude that a torque caused by a misaligned binary companion on the protoplanetary disk is the most promising explanation. © 2022. The Author(s). Published by the American Astronomical Society.The IRSF project is a collaboration between Nagoya University and the South African Astronomical Observatory (SAAO) supported by the Grants-in-Aid for Scientific Research on Priority Areas (A) (grant Nos. 10147207 and 10147214) and Optical & Near-Infrared Astronomy Inter-University Cooperation Program, from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and the National Research Foundation (NRF) of South Africa. This work is partly supported by JSPS KAKENHI grant No. JP18H05439, and JST PRESTO grant No. JPMJPR1775, and a University Research Support Grant from the National Astronomical Observatory of Japan (NAOJ). This work is partly supported by Grant-in-Aid for JSPS Fellows, grant No. JP20J21872. This work is partly supported by JSPS KAKENHI grant No. JP17H04574.
This work is partly supported by JSPS KAKENHI grant No. JP20K14518, and by Astrobiology Center SATELLITE Research project AB022006. M.T. is supported by MEXT/JSPS KAKENHI grant Nos. 18H05442, 15H02063, and 22000005. This work is partly supported by JSPS KAKENHI grant No. JP21K13955. This work is partly supported by JSPS KAKENHI grant No. 20K14521. C.R.-L. acknowledges financial support from the State Agency for Research of the Spanish MCIU through the Center of Excellence Severo Ochoa award for the Instituto de Astrofísica de Andalucía (SEV-2017-0709). M.R. acknowledges support from the Universidad Católica de lo Santísima Concepción grant DI-FIAI 03/2021. P.J.A. acknowledges support from grant AYA2016-79425-C3-3-P of the Spanish Ministry of Economy and Competitiveness (MINECO) and the Centre of Excellence "Severo Ochoa" award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). This paper is based on observations made with the T150 telescope at the Sierra Nevada Observatory (Granada, Spain), operated by the Instituto de Astrofísica de Andalucía (IAA—CSIC). The research leading to these results has received funding from the ARC grant for Concerted Research Actions, financed by the Wallonia-Brussels Federation. TRAPPIST is funded by the Belgian Fund for Scientific Research (Fond National de la Recherche Scientifique, FNRS) under the grant FRFC 2.5.594.09.F. TRAPPIST-North is a project funded by the University of Liège (Belgium), in collaboration with Cadi Ayyad University of Marrakech (Morocco). D.D. acknowledges support from the TESS Guest Investigator Program grant No. 80NSSC19K1727 and NASA Exoplanet Research Program grant No. 18-2XRP18_2-0136. M.G. and E.J. are F.R.S.-FNRS Senior Research Associates. K.K.M. acknowledges support from the New York Community Trust's Fund for Astrophysical Research. This work has been carried out within the framework of the NCCR PlanetS supported by the Swiss National Science Foundation.Peer reviewe
a European consensus study
No full textFunding Information: This study is part of the \u201CSAFEty in surgical care through the STandardisation and harmonisation of perioperative care in Europe\u201D (SAFEST) project, supported by the European Union - Horizon Europe Framework Programme (101057825). The funding source had no role in the collection, analysis, or interpretation of data, in the writing of the manuscript, nor in the decision to submit the manuscript for publication. Publisher Copyright: © 2025 The Author(s)Background: Surgery-related adverse events are among the most common adverse events in-hospital. However, no comprehensive, multidisciplinary perioperative guidelines exist at the European level. The aim of this study is to describe the process and results in achieving European multidisciplinary consensus on perioperative patient safety recommendations. Methods: This multimethod study included: (1) a systematic review of guidelines; (2) selection and synthesis of recommendations; and (3) a two-round modified Delphi technique including a 2-day face-to-face consensus conference. We recruited a panel of two expert groups balanced in terms of gender, geographical origin, and professional background, with meaningful participation from patient representatives. Consensus was defined as at least 70% of the panel rating a recommendation 7–9 on a 9-point Likert scale for importance to patient safety and feasibility of implementation. Results: The systematic review included 267 guidelines, from which 4666 patient safety recommendations were identified and extracted. After four synthesis rounds, 99 recommendations were presented for the Delphi survey, detailing their strength of recommendation, level of evidence, and methodological quality of the cited guidelines. An expert group, composed of 66 multidisciplinary experts from 19 European countries, participated with a response rate of 80.3%. After the two Delphi rounds and the consensus conference, the panel agreed on a final set of 101 recommended perioperative patient safety practices. Conclusions: A set of 101 comprehensive, evidence-based, patient-centred perioperative patient safety practices was developed through a European consensus process to improve the quality of care in healthcare facilities across Europe and beyond.publishersversioninpres
systematic review of clinical practice guidelines
No full textFunding Information: This work was funded by the European Union Horizon Europe Framework Programme under grant agreement No. 101057825. No other funding sources were received for this study. The authors wish to thank Eulalia Grifol Clar (Head of the Medical Library, Hospital Universitario Fundaci\u00F3n Alcorc\u00F3n) and Noelia \u00C1lvarez D\u00EDaz (Head of the Medical Library, Hospital Universitario Ram\u00F3n y Cajal) for conducting a literature search and Azahara Rodr\u00EDguez-Luna for the initial development of the protocol of this study. Funding Information: This work was funded by the European Union Horizon Europe Framework Programme under grant agreement No. 101057825. No other funding sources were received for this study. Acknowledgements Publisher Copyright: © The Author(s) 2024.Background: Surgical-related incidents are a common cause of in-hospital adverse events. Surgical patient safety would benefit from evidence-based practices, but a comprehensive collection of patient safety recommendations is still lacking. This study aimed to compile and assess the perioperative patient safety recommendations for adults. Method: A systematic review of clinical practice guidelines was conducted using Medline, Embase, Cochrane, Virtual Health Library Regional Portal, and Trip Database from 2012 to 2022. Eligibility criteria followed a PICAR strategy for patient safety recommendations in the perioperative care continuum. Guidelines were appraised for quality, particularly focusing on the ‘rigour of development’ domain of the AGREE-II tool for those containing strong recommendations. Descriptive analyses were conducted, emphasizing guideline quality, recommendation strength, and the supporting level of evidence. Results: From the 267 guidelines, 4666 perioperative patient safety recommendations were extracted, of which 44.9% (2095) were strongly recommended. Of these, 322 had the highest level of evidence, but only 18 guidelines met high standards in the AGREE-II ‘rigour of development’ domain. A subset of 78 recommendations ranked the highest in the strength of recommendation, level of evidence, and rigour of development of their guidelines. A gap was found within pre-admission and post-discharge care recommendations. Discussion: This review highlights the noteworthy variability in the methodological quality of the guidelines, and a discordance between strength of recommendation and evidence level of the available perioperative patient safety recommendations. These findings provide valuable information for advising policy decisions and promoting best practices to enhance global surgical safety.publishersversionpublishe
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
No full texta research protocol for a mixed methods study
No full textFunding Information: This work was supported by the European Union under the Horizon Europe Research and Innovation Programme under the grant agreement no 101057825. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2024 Valli et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Introduction Adverse events in health care affect 8% to 12% of patients admitted to hospitals in the European Union (EU), with surgical adverse events being the most common types reported. Aim SAFEST project aims to enhance perioperative care quality and patient safety by establishing and implementing widely supported evidence-based perioperative patient safety practices to reduce surgical adverse events. Methods We will conduct a mixed-methods hybrid type III implementation study supporting the development and adoption of evidence-based practices through a Quality Improvement Learning Collaborative (QILC) in co-creation with stakeholders. The project will be conducted in 10 hospitals and related healthcare facilities of 5 European countries. We will assess the level of adherence to the standardised practices, as well as surgical complications incidence, patient-reported outcomes, contextual factors influencing the implementation of the patient safety practices, and sustainability. The project will consist of six components: 1) Development of patient safety standardised practices in perioperative care; 2) Guided self-evaluation of the standardised practices; 3) Identification of priorities and actions plans; 4) Implementation of a QILC strategy; 5) Evaluation of the strategy effectiveness; 6) Patient empowerment for patient safety. Sustainability of the project will be ensured by systematic assessment of sustainability factors and business plans. Towards the end of the project, a call for participation will be launched to allow other hospitals to conduct the self-evaluation of the standardized practices. Discussion The SAFEST project will promote patient safety standardized practices in the continuum of care for adult patients undergoing surgery. This project will result in a broad implementation of evidence-based practices for perioperative care, spanning from the care provided before hospital admission to post-operative recovery at home or outpatient facilities. Different implementation challenges will be faced in the application of the evidence-based practices, which will be mitigated by developing context-specific implementation strategies. Results will be disseminated in peer-reviewed publications and will be available in an online platform.publishersversionpublishe
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 (Nature Medicine, (2020), 26, 5, (750-759), 10.1038/s41591-020-0807-6)
No full textAn amendment to this paper has been published and can be accessed via a link at the top of the paper
