277 research outputs found
‘A Scandal to the Whole Clergy’: Priests and their Partners
No full textRuth Mazo Karras, Professor of History at the University of Minnesota, is the author of Sexuality in Medieval Europe: Doing Unto Others (2005) and From Boys to Men: Formations of Masculinity in Late Medieval Europe (2003)
Northern Rover: The Life Story of Olaf Hanson
No full textFrom 1919 to 1970, Olaf Hanson was a trapper, fur trader, prospector, game guardian, fisherman, and road blasting expert in northeastern Saskatchewan. He told his life story to popular Saskatchewan author A. L. Karras, who wrote this historical memoir in the 1980s. In an uncompromising, straightforward style, Karras and Hanson reveal the geography, wildlife, natural history of the region as well as the business and social interactions between people. Their book offers a look at the vanished subsistence and commercial economy of the boreal forest, wound around a fascinating personal story of courage and physical stamina
Northern Rover: The Life Story of Olaf Hanson
No full textFrom 1919 to 1970, Olaf Hanson was a trapper, fur trader, prospector, game guardian, fisherman, and road blasting expert in northeastern Saskatchewan. He told his life story to popular Saskatchewan author A. L. Karras, who wrote this historical memoir in the 1980s. In an uncompromising, straightforward style, Karras and Hanson reveal the geography, wildlife, natural history of the region as well as the business and social interactions between people. Their book offers a look at the vanished subsistence and commercial economy of the boreal forest, wound around a fascinating personal story of courage and physical stamina
A Helper of Providence: "Justified Providential War" in Vladimir Solov'ev '
No full textThis is the author accepted manuscript. The final version is available from University of Notre Dame Press via the link in this recor
Assessment of Marine Pipelines Subjected to Impact from Dropped Objects
No full textWhen damage assessment is needed for an operating pipeline due to impact with an accidentally dropped object, DNV standards treat this case with conservatism and thus fail to give a realistic estimation. Usually, damage is measured as the dent deformation that the pipeline will experience. Depending on the size of the dent, leakage, rupture or cease of production might occur. Thus, it is important to quantify how a pipeline behaves and interacts with its environment during an impact with a dropped object.Initially, a simple finite element model has been developed in order to verify some laboratory experiments from Karamanos and Gresnigt that have been conducted under quasi-static conditions, where no inertia or velocity need to be taken into account. The falling object’s geometry, external or internal pressure and different material models have been investigated in order to derive preliminary conclusions regarding the stiffness of the system and the shape of the dent.Next, velocity and mass of the indenter and of pipeline are taken into account in order to simulate the previous experiments dynamically. It has been observed that there are significant differences when inertia is taken into account in the denting behavior of a pipeline for low-velocity impact scenarios. Moreover, the effect of strain-rate sensitivities of steel have been incorporated by using the Cowper-Symonds law and their importance is stressed out in the results especially for mild steel pipelines.In an effort to model closer the reality, simplified fluid models have been created using both the Lagrangian approach and the acoustic element formulation. This way, the partial incompressibility of the fluids, their inertia and their pressure can be modeled more accurately in order to reach valuable conclusions as to how they contribute in the system behavior.All the aforementioned analyses have been conducted under the assumption that the bed upon the pipeline is resting is completely rigid. However, in reality the pipeline rests on a soil bed which is flexible and deformable. This is the most significant aspect of this thesis. Specifically, the energy dissipation due to the soil deformation and the pipe penetration into the soil is investigated. A soil – structure finite element model has been developed, considering a simplified Mohr-Coulomb elastoplastic model of failure which is adequate to obtain a good estimate regarding the soil contribution. It has been shown that for a range of different soil profiles of clay and sand, the energy dissipation is significant resulting in decrease of the dent deformation compared to a rigid bed case. Sensitivity analyses have been carried out regarding the impact velocity, mass and the initial embedment of the pipeline into the soil where it is shown that for the same kinetic energy input different results are being derived.A final model is considered, where pressure, soil and strain-rate of steel are combined. The system behavior can be explained based on fundamental physics which give additional confidence in the interpretation of the results. Useful conclusions are derived in the end, showing that in many cases current practice is over conservative when assessing damage from dropped objects and thus a more detailed analysis and approach should be used in the future when conducting a risk or integrity assessment.Offshore and Dredging Engineerin
Battery – Supercapacitor Hybrid Energy Storage System: A Practical Approach to Improve Lifecycle Performance of Seagoing Vessels
No full textFor many maritime applications Li-Ion batteries are foreseen as energy storage units that can improve the performance of the on-board power system in terms of continuity of service, fuel consumption, emissions and running hours of main engines. However, one of main limitations of battery application in on-board power systems is the aging of batteries. Applications of instantaneous power input/output such as propulsion dynamic assistance and heavy seas operation of ships, have an adverse effect on battery lifetime meaning that degradation of energy capacity over time is accelerated. Additionally, limited by their maximum current rating, batteries cannot deliver effectively high C-rates and therefore are not able to fully absorb the engine fluctuations. A typical solution for this problem is to over-size the battery system. By paralleling more batteries, the max. C-rate is lowered, and battery lifetime can be extended. On the other hand, an over-sized battery system will result in additional capital cost and weight. Therefore, it is evident that in conventional approaches there is an undesirable trade-off between battery aging and battery size. As an alternative practical approach into this problem, this thesis proposes an on-board hybrid energy storage system (HESS) that comprises of a battery and a supercapacitor component. By placing the supercapacitor in parallel to the battery and by using it for high peak currents, it is possible to reduce the stress on the battery and thus extend battery lifetime while improving the availability and the reliability of the power system. In addition, by taking advantage of the high specific power of the supercapacitor and the high specific energy of the battery it is possible to optimize sizing of the energy storage system for high power applications. In this thesis, a parametric approach of combined sizing and energy management for hybrid energy storage system is developed and integrated into a typical DC shipboard power system . Based on a case load profile, the HESS operation is simulated and benchmarked to battery-only installations. The static outputs of the sizing process and the dynamic outputs of the simulation are extracted in the form of design exploration maps and arrays that are used to correlate them to the key design variables. Finally, through this work, it is demonstrated that for high power applications with significant fluctuations, the proposed battery-supercapacitor HESS, can lead into smaller and more cost-effective installations, without compromising battery lifetime and while maintaining same levels of reliability performance.Marine Technology | Marine Engineerin
Modifications des propriétés structurelles et fonctionnelles des gros troncs artériels dans l’insuffisance rénale : valeur pronostique et évolution après transplantation
No full textChronic Kidney Disease (CKD) is associated with frequent cardiovascular complications. Arterialstiffness is a marker of cardiovascular (CV) disease and is associated with mortality in patients with end-stagerenal disease (ESRD). Our group has previously suggested that a maladaptative arterial remodeling occurs earlyduring CKD, even in patients with mild kidney dysfunction. Our first prospective study was based on a large CKD cohort. Our data confirm that the large arteries modifications, which include increase of carotid stiffness, decrease of intima-media thickness, carotid arterydilatation with enhancement of circumferential wall stress (CWS), worsen during CKD progression. We also showthat initial CWS is associated with the rate of kidney function deterioration, even after adjustment for other CV andCKD risk factors. In addition, we found that aortic stiffness was associated with both the overall survival and therisk of cardiovascular events. The internal carotid diameter is predictive of the overall mortality, after multivariateanalysis. Kidney transplantation reduces the CV risk of ESRD patients. Our 2 prospective studies demonstratethat aortic stiffness can improve during the first year after transplantation. The maladaptative arterial remodelingcan also reverse after transplantation, with a significant reduction of the carotide diameter, an increase of theintima-media thickness and a partial correction of the CWS. The improvement of the aortic stiffness and thereversal of this maladaptative arterial remodeling is particularily important in patients receiving a kidney allograftform a young allograft donor, independently of the post-transplant renal function. The kidney recipients with aliving donor experience a major improvement of their arterial parameters when compared with recipients withdeceased donors, and this difference remains significant after adjustment for other confounding factors. Inconclusion, the quality of the kidney allograft (age and source) may play an important role in the cardiovascularoutcome of the recipient. This advantage could be mediated a beneficial effect of transplantation on centralarteries structure and function.La maladie rénale chronique (MRC) est caractérisée par une fréquence élevée de complications cardiovasculaires (CV). La rigidité artérielle est un marqueur de la maladie CV, corrélé avec la morbi-mortalité des patients en dialyse chronique. Notre équipe a déjà observé que des modifications structurelles et fonctionnelles des gros troncs artériels apparaissent néanmoins dès les stades précoces de la MRC.Le suivi prospectif d’une large cohorte de patients insuffisants rénaux non dialysés, nous a permis de démontrer que le remodelage artériel s’accentue avec la progression de la MRC, avec notamment une augmentation de la rigidité carotidienne, une diminution de l’épaisseur intima-média, une augmentation du diamètre interne de la carotide et du stress circomférentiel. Notre étude prospective a permis de montrer que le stress circonférentiel est prédictif de la vitesse de dégradation de la fonction rénale, même après ajustement sur les autres facteurs de risque CV et de progression de la MRC. Nous avons également étudié la morbi-mortalité globale et CV en fonction des paramètres artériels mesurés lors de l’inclusion. Après analyse multivariée, il apparaît que la rigidité aortique est corrélée au risque de décès ou de survenue d’un événement CV, alors que le diamètre interne de la carotide est associé à la mortalité globale, même après ajustement sur les facteurs CV classiques. La transplantation rénale permet une amélioration du pronostic CV des patients insuffisants rénaux. Nos études, réalisées sur 2 cohortes prospectives de patients transplantés rénaux ont permis d’objectiver une nette amélioration de la rigidité aortique dans les mois qui suivent la greffe. Nous démontrons par ailleurs que le remodelage artériel est également réversible, avec diminution du diamètre interne, augmentation de l’épaisseur intima-média et correction partielle du stress circonférentiel au niveau de la carotide interne. Cette réversibilité de la rigidité est particulièrement importante chez les receveurs bénéficiant d’une transplantation avec un donneur jeune, et ceci indépendamment du degré d’amélioration la fonction rénale observée dans la période post-greffe.Elle est aussi beaucoup plus marquée chez les patients recevant un greffon rénal provenant d’un donneur vivant.La qualité du greffon, déterminée par l’âge du donneur ou son origine (donneur vivant vs donneur décédé) est donc capitale pour prédire l’amélioration des paramètres artériels chez le receveur et indirectement son pronostic CV à moyen terme
Glomérulonéphrites associées aux vascularites à ANCA (clinique, pronostic rénal, quantification informatisée de la fibrose interstitielle)
No full textLes maladies associées aux ANCA (MAA) sont caractérisées par une atteinte nécrosante des petits vaisseaux. L atteinte rénale est fréquente. Sa présentation, classique, est une glomérulonéphrite rapidement progressive (GNRP). Une classification histologique basée sur les lésions glomérulaires a été proposée.par l EUVAS. Nous avons inclus 74 patients avec atteinte rénale, confirmée par biopsie, d une MAA. La GNRP est définie par l association d une hématurie, d une protéinurie et du doublement de la créatinine dans les 3 mois. Toutes les biopsies rénales ont été analysées selon la nouvelle classification. La FI a été quantifiée, chez 65 patients, en utilisant un logiciel spécifique, déjà décrit. Une section corticale est analysée par un programme d imagerie de segmentation couleur qui extrait les zones de couleur verte caractéristiques de la FI.La présentation est une GNRP chez 58% des patients. Les signes cliniques et biologiques sont plus marqués dans ce groupe avec un BVAS 20+-4 versus 16+-5; une créatinine de 436+-282 mol/l vs 132+-60 et une protéinurie de 0,296+-0,250g/mmolC vs 0,178+-0,161 ; (p=0,01). Il n y a pas de corrélation entre le score glomérulaire et la FI. Le DFG à 1 an n est pas significativement différent selon la classe glomérulaire. La créatinine initiale (p<0,001) et le FI (p<0,001) sont corrélés au DFG à 1 an.Dans notre cohorte, 42% des patients ne se présentent pas comme une GNRP. Ils ont des signes clinico-biologiques plus modérés, rendant le diagnostic moins aisé. La FI, et la créatinine initiale sont les deux meilleurs facteurs pronostiques de l évolution rénale. La classification glomérulaire est corrélée avec l atteinte initiale, mais pas avec le DFG à 1 an.PARIS6-Bibl.Pitié-Salpêtrie (751132101) / SudocSudocFranceF
Modifications of structural and functional properties of large arteries in chronic kidney disease : prognostic value and reversal of the maladaptative remodeling after kidney transplantation
No full textLa maladie rénale chronique (MRC) est caractérisée par une fréquence élevée de complications cardiovasculaires (CV). La rigidité artérielle est un marqueur de la maladie CV, corrélé avec la morbi-mortalité des patients en dialyse chronique. Notre équipe a déjà observé que des modifications structurelles et fonctionnelles des gros troncs artériels apparaissent néanmoins dès les stades précoces de la MRC.Le suivi prospectif d’une large cohorte de patients insuffisants rénaux non dialysés, nous a permis de démontrer que le remodelage artériel s’accentue avec la progression de la MRC, avec notamment une augmentation de la rigidité carotidienne, une diminution de l’épaisseur intima-média, une augmentation du diamètre interne de la carotide et du stress circomférentiel. Notre étude prospective a permis de montrer que le stress circonférentiel est prédictif de la vitesse de dégradation de la fonction rénale, même après ajustement sur les autres facteurs de risque CV et de progression de la MRC. Nous avons également étudié la morbi-mortalité globale et CV en fonction des paramètres artériels mesurés lors de l’inclusion. Après analyse multivariée, il apparaît que la rigidité aortique est corrélée au risque de décès ou de survenue d’un événement CV, alors que le diamètre interne de la carotide est associé à la mortalité globale, même après ajustement sur les facteurs CV classiques. La transplantation rénale permet une amélioration du pronostic CV des patients insuffisants rénaux. Nos études, réalisées sur 2 cohortes prospectives de patients transplantés rénaux ont permis d’objectiver une nette amélioration de la rigidité aortique dans les mois qui suivent la greffe. Nous démontrons par ailleurs que le remodelage artériel est également réversible, avec diminution du diamètre interne, augmentation de l’épaisseur intima-média et correction partielle du stress circonférentiel au niveau de la carotide interne. Cette réversibilité de la rigidité est particulièrement importante chez les receveurs bénéficiant d’une transplantation avec un donneur jeune, et ceci indépendamment du degré d’amélioration la fonction rénale observée dans la période post-greffe.Elle est aussi beaucoup plus marquée chez les patients recevant un greffon rénal provenant d’un donneur vivant.La qualité du greffon, déterminée par l’âge du donneur ou son origine (donneur vivant vs donneur décédé) est donc capitale pour prédire l’amélioration des paramètres artériels chez le receveur et indirectement son pronostic CV à moyen terme.Chronic Kidney Disease (CKD) is associated with frequent cardiovascular complications. Arterialstiffness is a marker of cardiovascular (CV) disease and is associated with mortality in patients with end-stagerenal disease (ESRD). Our group has previously suggested that a maladaptative arterial remodeling occurs earlyduring CKD, even in patients with mild kidney dysfunction. Our first prospective study was based on a large CKD cohort. Our data confirm that the large arteries modifications, which include increase of carotid stiffness, decrease of intima-media thickness, carotid arterydilatation with enhancement of circumferential wall stress (CWS), worsen during CKD progression. We also showthat initial CWS is associated with the rate of kidney function deterioration, even after adjustment for other CV andCKD risk factors. In addition, we found that aortic stiffness was associated with both the overall survival and therisk of cardiovascular events. The internal carotid diameter is predictive of the overall mortality, after multivariateanalysis. Kidney transplantation reduces the CV risk of ESRD patients. Our 2 prospective studies demonstratethat aortic stiffness can improve during the first year after transplantation. The maladaptative arterial remodelingcan also reverse after transplantation, with a significant reduction of the carotide diameter, an increase of theintima-media thickness and a partial correction of the CWS. The improvement of the aortic stiffness and thereversal of this maladaptative arterial remodeling is particularily important in patients receiving a kidney allograftform a young allograft donor, independently of the post-transplant renal function. The kidney recipients with aliving donor experience a major improvement of their arterial parameters when compared with recipients withdeceased donors, and this difference remains significant after adjustment for other confounding factors. Inconclusion, the quality of the kidney allograft (age and source) may play an important role in the cardiovascularoutcome of the recipient. This advantage could be mediated a beneficial effect of transplantation on centralarteries structure and function
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