914 research outputs found
Un palais chaldéen d\u27après les découvertes de M. de Sarzec
No full textiii, 117 p., 4 leaves of plates : ill. ; 17 cm.https://commons.library.stonybrook.edu/amar/1210/thumbnail.jp
Différentes réactions suite aux inculpations du représentant Le Cointre (de Versailles) contre les représentants Bilaud-Varenne, Collot d'Herbois, Barère, Vadier, Amar, Voulland et David, lors de la séance du 12 fructidor an II (29 août 1794)
No full textCarrier Jean-Baptiste, Ruamps Pierre, Goujon Jean-Marie Claude-Alexandre, Billaud-Varenne, Bourdon (de l'Oise) François-Louis, Duhem Pierre-Joseph, Cambon Pierre-Joseph, Goupilleau (de Fontenay) Jean-François, Amar André. Différentes réactions suite aux inculpations du représentant Le Cointre (de Versailles) contre les représentants Bilaud-Varenne, Collot d'Herbois, Barère, Vadier, Amar, Voulland et David, lors de la séance du 12 fructidor an II (29 août 1794). In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XCVI - Du 10 fructidor au 22 fructidor an II (27 août au 8 septembre 1794) Paris : CNRS éditions, 1990. pp. 79-82
Différentes réactions suite aux inculpations du représentant Le Cointre (de Versailles) contre les représentants Bilaud-Varenne, Collot d'Herbois, Barère, Vadier, Amar, Voulland et David, lors de la séance du 12 fructidor an II (29 août 1794)
No full textCarrier Jean-Baptiste, Ruamps Pierre, Goujon Jean-Marie Claude-Alexandre, Billaud-Varenne, Bourdon (de l'Oise) François-Louis, Duhem Pierre-Joseph, Cambon Pierre-Joseph, Goupilleau (de Fontenay) Jean-François, Amar André. Différentes réactions suite aux inculpations du représentant Le Cointre (de Versailles) contre les représentants Bilaud-Varenne, Collot d'Herbois, Barère, Vadier, Amar, Voulland et David, lors de la séance du 12 fructidor an II (29 août 1794). In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XCVI - Du 10 fructidor au 22 fructidor an II (27 août au 8 septembre 1794) Paris : CNRS éditions, 1990. pp. 79-82
Plusieurs interventions sur la situation de la poudrerie de Grenelle, lors de la séance du 14 fructidor an II (31 août 1794)
No full textGossuin Constant-Joseph-Eugène, Amar André, Goujon Jean-Marie Claude-Alexandre. Plusieurs interventions sur la situation de la poudrerie de Grenelle, lors de la séance du 14 fructidor an II (31 août 1794). In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XCVI - Du 10 fructidor au 22 fructidor an II (27 août au 8 septembre 1794) Paris : CNRS éditions, 1990. p. 130
Seeking Standardized Definitions for HLA-incompatible Kidney Transplants: A Systematic Review
No full textBACKGROUND: There is no standard definition for "HLA incompatible" transplants. For the first time, we systematically assessed how HLA incompatibility was defined in contemporary peer-reviewed publications and its prognostic implication to transplant outcomes. METHODS: We combined 2 independent searches of MEDLINE, EMBASE, and the Cochrane Library from 2015 to 2019. Content-expert reviewers screened for original research on outcomes of HLA-incompatible transplants (defined as allele or molecular mismatch and solid-phase or cell-based assays). We ascertained the completeness of reporting on a predefined set of variables assessing HLA incompatibility, therapies, and outcomes. Given significant heterogeneity, we conducted narrative synthesis and assessed risk of bias in studies examining the association between death-censored graft failure and HLA incompatibility. RESULTS: Of 6656 screened articles, 163 evaluated transplant outcomes by HLA incompatibility. Most articles reported on cytotoxic/flow T-cell crossmatches (n = 98). Molecular genotypes were reported for selected loci at the allele-group level. Sixteen articles reported on epitope compatibility. Pretransplant donor-specific HLA antibodies were often considered (n = 143); yet there was heterogeneity in sample handling, assay procedure, and incomplete reporting on donor-specific HLA antibodies assignment. Induction (n = 129) and maintenance immunosuppression (n = 140) were frequently mentioned but less so rejection treatment (n = 72) and desensitization (n = 70). Studies assessing death-censored graft failure risk by HLA incompatibility were vulnerable to bias in the participant, predictor, and analysis domains. CONCLUSIONS: Optimization of transplant outcomes and personalized care depends on accurate HLA compatibility assessment. Reporting on a standard set of variables will help assess generalizability of research, allow knowledge synthesis, and facilitate international collaboration in clinical trials.sponsorship: R.S.-P. is supported by a Fonds de recherche du Quebec-Sante chercheur boursier clinicien award (grant no. 254386) and a Genome Canada Large Scale Applied Research Program Award "Precision Medicine CanPREVENT AMR" funded by Genome Quebec, Genome British Columbia, Genome Alberta, and Canadian Institutes of Health Research (LSARP 273AMR and GP1-155871). M.N. is senior clinical investigator of the Research Foundation - Flanders (FWO) (grant no. 1844019N). (Fonds de recherche du Quebec-Sante chercheur boursier clinicien award|254386, Genome Canada Large Scale Applied Research Program Award- Genome Quebec, Genome British Columbia, Genome Alberta, Canadian Institutes of Health Research|LSARP 273AMR, Canadian Institutes of Health Research|GP1-155871, Flanders (FWO)|1844019N)status: Publishe
Correction to: Exome sequencing reveals a novel PLP1 mutation in a Moroccan family with connatal Pelizaeus-Merzbacher disease: a case report
No full textAfter publication of the original article [1] it was brought to our attention that author Bouchra Ouled Amar Bencheikh was incorrectly included as Bouchra Oulad Amar Bencheikh
Deciding on authorship
No full text[Extract] Now that you have read the guidelines for authors and decided that your work is ready for submitting to a suitable journal. Yes, the next step is to decide on authorship. I mean to say "whose name will appear in the manuscript and in what order". It is not at all a problem (issue) when you have worked alone where you will be the sole author in the manuscript. If at all there are multiple authors it is the best time to decide who will be the authors for the publication. This will prevent later arguments. Rational colleagues have become bitter enemies because of difference of opinions on the matter that whose names should be included in the paper and in what order
Preparing to write a paper
No full text[Extract]
• Once you are about to start writing a paper you have to first select the journal you intend to send your article
• Once you select the journal it is important to determine if there are any special requirements of the journal. Read the instructions to
author. It usually differs from journal to journal but there is no much difference. Certain journals may specify the rules of nomenclature or certain style of writing. Do it accordingly.
• If your study includes experiments on human beings or animals then ethical committee clearance is a must . You would have got the clearance before you conduct the study. Keep the certificate ready.
• Most of the journals prefer the use of international system for units of measurements [SI units]. If it specifies then use the SI units only
O abandono afetivo de filho menor como fundamento da configuração de dano moral
No full textTCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.O presente trabalho de conclusão de curso tem por objetivo analisar a possibilidade de imputar-se ao genitor condenação a título de danos morais em decorrência do abandono afetivo de sua prole. Nessa senda, o exame foi inicialmente centralizado no estudo da entidade familiar contemporânea, sua evolução e os princípios norteadores relevantes para o deslinde do trabalho. Em sequência, a pesquisa voltou-se para a caracterização da responsabilidade aquiliana conforme o ordenamento jurídico pátrio, focando na normatização do dano extrapatrimonial e sua aplicabilidade no âmbito das relações afetivas. Firmados esses alicerces, passou-se a explorar as nuances do abandono afetivo com o propósito de, ao final, comparar os argumentos lançados pela doutrina e pela jurisprudência contrários à responsabilização paterna pela conduta negligente com os fundamentos elaborados visando a configuração da obrigação de indenizar. Enfim, por intermédio dos fundamentos teóricos levantados, encerra-se com a conclusão de que, presentes os pressupostos essenciais da responsabilidade civil no caso concreto, a interpretação que culmina com a possibilidade de condenação dos pais em virtude do descumprimento dos deveres inerentes ao poder familiar a eles conferidos, denota-se a que melhor coaduna-se com a perspectiva moderna da família e do instituto da responsabilidade aquiliana. Para a realização do presente estudo monográfico, o método científico adotado foi o dedutivo, utilizando-se como principal fonte materiais bibliográficos
Physically interpretable machine learning methods for transcription factor binding site identification using principled energy thresholds and occupancy:
No full textRegulation of gene expression is pivotal to cell behavior. It is achieved predominantly by transcription factor proteins binding to specific DNA sequences (sites) in gene promoters. Identification of these short, degenerate sites is therefore an important problem in biology. The major drawbacks of the probabilistic machine learning methods in vogue are the use of arbitrary thresholds and the lack of biophysical interpretations of statistical quantities. We have developed two machine learning methods and linked them to the biophysics of transcription factor binding by incorporating simple physical interactions. These methods estimate site binding energy, recognizing that it determines a site's function and evolutionary fitness. They use the occupancy probability of a transcription factor on a DNA sequence as the discriminant function because it has a straightforward physical interpretation, forms a bridge between binding energy and evolutionary fitness, and has a natural threshold for classifying sequences into sites that allows establishing the threshold in a principled manner. Our methods incorporate additional characteristics of sites to enhance their identification. The first method, based on a hidden Markov model (HMM), identifies self-overlapping sites by combining the effects of their alternative binding modes. It learns the threshold by training emission probabilities using unaligned sequences containing known sites and estimating transition probabilities to reflect site density in all promoters in a genome. While identifying sites, it adjusts parameters to model site density changing with the distance from the transcription start site. Moreover, it provides guidance for designing padding sequences in experiments involving self-overlapping sites. Our second method, the Phylogeny-based Quadratic Programming Method of Energy Matrix Estimation (PhyloQPMEME), integrates evolutionary conservation to reduce false positives while identifying sites. It learns the threshold by solving an iterative quadratic programming problem to optimize the distribution of correlated binding energies of neutrally evolving orthologous sequences while restricting the values of binding energies of known sites and their orthologs. We have used the NF-κB transcription factor family as a case study for both methods and gained new insights into its biology.Ph.D.Includes bibliographical references (p. 210-226)by Amar Mohan Drawi
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