440 research outputs found
MIGLIORAMENTO DELLA CLASSIFICAZIONE DEL MELANOMA BASATA SULLA MICROSCOPIA CONFOCALE E APPLICAZIONE DI DOPPIA VALUTAZIONE IN TELEMEDICINA
No full textIl melanoma cutaneo è una malattia complessa, la cui patogenesi è influenzata da fattori genetici e ambientali. Lo scopo di questa ricerca è definire una classificazione di malattia che sia basata sui descrittori di imaging, sulla presenza di biomarcatori cutanei e sulle caratteristiche genetiche della neoplasia; al fine di poter predire i diversi comportamenti clinici del melanoma, in modo da identificare con precisione la prognosi del paziente e il suo rischio di recidiva. Abbiamo analizzato retrospettivamente un ampio numero di melanomi di nevi melanocitici e di lesion in diagnosi differenziale con dermoscopia, microscopia a riflettanza confocale, immunoistochimica delle principali vie di segnale, e analisi delle mutazioni genetiche più comunemente associate al melanoma. Una valutazione retrospettiva di nevi e melanoma è stata condotta al fine di identificare i differenti sottotipi morfologici correlati alle diverse caratteristiche cliniche e al fenotipo del paziente. L’analisi dermoscopica, di microscopia confocale, immunoistochimica, e delle mutazioni somatiche è stata la base morfologica e biomolecolare utilizzata per costruire una nuova classificazione e per corrrelare le alterazioni biologiche con l’aggressività tumorale, come stimata sulla base dei parametri istopatologici, del pattern di crescita e della stadiazione della malattia. In aggiunta, l’accuratezza diagnostica della telemedicina, di tipo store-and-forward, è stata testata attraverso 1000 casi analizzati da due valutatori per definire l’applicabilità e chiarire i potenziali della telemedicina per la futura gestione clinica dei pazienti, così come per verificare il costo-beneficio della metodica nella realtà clinica.Cutaneous melanoma is a complex disorder with genetic, environmental and host factors contributing to its pathogenesis. The aim of our research proposal was to define a better classification of this disease based on imaging characteristics, tissue biomarkers and genetic signature that can explain different melanoma behavior, help in melanoma diagnosis and predict clinical outcome and disease relapse. We retrospectively investigated a large series of melanomas and cutaneous lesions in differential diagnosis with dermoscopy, reflectance confocal microscopy, immunohistochemistical analysis of melanoma signaling pathways and analyzed the most common melanoma-associated somatic/germline mutations in a selected high risk population in order to identify different morphologic subtypes related to clinical characteristics and patient phenotype. Dermoscopic and confocal microscopy aspects, immunohistochemistry and somatic mutation analyses were used to characterize the different melanoma subtypes to correlate biological alterations with tumor aggressiveness, as estimated according to histopathologic parameters, tumor growth pattern and staging outcome. Additionally accuracy of melanoma identification through store-and-forward telemedicine reading was tested in a double reader evaluation of 1000 cases to determine the potential for its application in future clinical care as well as potential cost-benefit of applying this technology
Pseudomelanoma follow-up of a recurrent naevus with dermoscopy and reflectance confocal microscopy
No full textPseudomelanom
Сборник тезисов докладов VII Международной научно- практической конференции, Брест, 24–26 октября 2019 г.
No full textOmelyanyuk Alexander Mikhailovich; Witkowski, P.; Medvedeva Gulnara Borangalievna; Zazerskaya Victoria Vasilievna; Chernookaya Elena Viktorovna. Innovation: from theory to practiceВ сборник вошли тезисы докладов по итогам работы VII Международной научно-практической конференции «Инновации: от теории к практике» (24-26 октября 2019 г.,
г. Брест), в которых рассматривается широкий спектр перспектив и возможностей инновационного развития предприятий, регионов и отраслей, а также инструменты инновационной
макроэкономической политики.
Ответственность за содержание и стиль публикуемых материалов несут авторы
Инновации: от теории к практике
No full textOmelyanyuk Alexander Mikhailovich; Witkowski, P.; Medvedeva Gulnara Borangalievna; Zazerskaya Victoria Vasilievna; Chernookaya Elena Viktorovna. Innovation: from theory to practiceВ коллективную монографию вошли научные статьи по итогам работы VII Международной научно-практической конференции «Инновации: от теории к практике» (24-26 октября
2019 г., г. Брест), в которых рассматривается широкий спектр перспектив и возможностей инновационного развития предприятий, регионов и отраслей, а также инструменты инновационной макроэкономической политики.
Ответственность за содержание и стиль публикуемых материалов несут авторы
The (Post-)Communist Orient: History, Self-Orientalization and Subversion by Michał Witkowski and Vladimir Sorokin
No full textThis article analyses two literary texts: Barbara Radziwiłłówna z Jaworzna-Szczakowej by the Polish author Michał Witkowski (2007) and Sakharnyi
Kreml’ by the Russian author Vladimir Sorokin (2008) in the context of postcolonial studies. I treat the terms coined by post-colonial critique, such as orientalism,
orientalization, subversion or mimicry as not only ideological categories, but also
as aesthetic and narrative ones. These tools turn out to be useful in the interpretation of both these texts which, despite the differences between them, may be read
as examples of post-dependence narration, which articulate issues in connection
with identity-related problems of modern Polish and Russian cultures. Both
Witkowski and Sorokin subversively employ auto- and heterostereotypes and
avail themselves of the strategy of self-orientalization, which enables the play on
foreign notions regarding, respectively, Polish and Russian culture and collective
identity. The novel by Michał Witkowski ironically, perversely addresses national
complexes associated with the systemic transformation of 1989 and takes the
floor in the discussion on post-communism. In turn, Sakharnyi Kreml’ by Vladimir
Sorokin is an example of a futuristic dystopia, in which criticism of Putin’s Russia
commingles with reflections on the non-autonomous and non-independent status
of own culture which, in the year 2028, continues to reproduce foreign discourses
and finds it difficult to articulate its own position
The (Post-)Communist Orient: History, Self-Orientalization and Subversion by Michał Witkowski and Vladimir Sorokin
No full textSummary
This article analyses two literary texts: Barbara Radziwiłłówna z Jaworzna-Szczakowej by the Polish author Michał Witkowski (2007) and Sakharnyi Kreml’ by the Russian author Vladimir Sorokin (2008) in the context of postcolonial studies. I treat the terms coined by post-colonial critique, such as orientalism, orientalization, subversion or mimicry as not only ideological categories, but also as aesthetic and narrative ones. These tools turn out to be useful in the interpretation of both these texts which, despite the differences between them, may be read as examples of post-dependence narration, which articulate issues in connection with identity-related problems of modern Polish and Russian cultures. Both Witkowski and Sorokin subversively employ auto- and heterostereotypes and avail themselves of the strategy of self-orientalization, which enables the play on foreign notions regarding, respectively, Polish and Russian culture and collective identity. The novel by Michał Witkowski ironically, perversely addresses national complexes associated with the systemic transformation of 1989 and takes the floor in the discussion on post-communism. In turn, Sakharnyi Kreml’ by Vladimir Sorokin is an example of a futuristic dystopia, in which criticism of Putin’s Russia commingles with reflections on the non-autonomous and non-independent status of own culture which, in the year 2028, continues to reproduce foreign discourses and finds it difficult to articulate its own position.</jats:p
The role of dermatoscopy and reflectance confocal microscopy in the assessment of relapsing secondary cutaneous follicular B-cell lymphoma
No full textNo abstract availabl
Jak uprawiać humanistykę? W stronę polityki wrażliwości
No full textThe paper reports from the author’s perspective the debate on the book by M.P. Markowski Polityka wrażliwości. Wprowadzenie do humanistyki (Kraków: Universitas, 2013). This debate was organized within the Framework of the Conrad Festival in Cracow in 2013, and the participants were the following professors: Michał Paweł Markowski as the author of the book himself, Ryszard Nycz as the moderator of discussion, Agata Bielik-Robson, Krzysztof Kłosiński and Lech Witkowski, together with Grzegorz Jankowicz represen ing the journal „Tygodnik Powszechny”. The key question for the debate was linked with the issue whether and in what a way one can defend the value of humanities in their contrast with the scientific rigour on one side, and the neoliberal afirmation of equivalence of banality on the other.
Artykuł przedstawia z perspektywy autora debatę poświęconą książce M.P. Markowskiego Polityka wrażliwości. Wprowadzenie do humanistyki (Kraków: Universitas, 2013). Debata została zorganizowana w ramach Festiwalu Conrada w Krakowie w 2013 roku, a jej uczestnikami byli następujący profesorowie: Michał Paweł Markowski jako autor książki, Ryszard Nycz jako moderator dyskusji, Agata Bielik-Robson, Krzysztof Kłosiński i Lech Witkowski, a także Grzegorz Jankowicz reprezentujący tygodnik „Tygodnik Powszechny”. Kluczowe pytanie debaty dotyczyło tego, czy i w jaki sposób można bronić wartości nauk humanistycznych w konfrontacji z rygorem naukowym z jednej strony i neoliberalnym afirmowaniem równoważności banalności z drugiej
Robi z nami to, co robi. O „Chwale supermanom…” Przemysława Witkowskiego (Recenzja: Przemysław Witkowski, „Chwała supermanom. Ideologia a popkultura”, Instytut Wydawniczy Książka i Prasa, Warszawa 2017, ss. 318.)
No full textHail to the Supermen: Ideology and Pop Culture (Chwała supermanom. Ideologia a popkultura) by Przemysław Witkowski has been considered by Przemysław Czapliński as ‘the monograph’ of pop culture created in the last thirty years. In his essay, Witkowski has made several attempts to reveal how the neoliberal and nationalistic ideologies are related to the popular or mass movies, TV series and shows, music, books, and other pop cultural phenomena. This article is a review of Hail to the Supermen… The author reconstructs the main assumptions and points out some of the most noticeable simplifications and general problems with the book.Hail to the Supermen: Ideology and Pop Culture (Chwała supermanom. Ideologia a popkultura) by Przemysław Witkowski has been considered by Przemysław Czapliński as ‘the monograph’ of pop culture created in the last thirty years. In his essay, Witkowski has made several attempts to reveal how the neoliberal and nationalistic ideologies are related to the popular or mass movies, TV series and shows, music, books, and other pop cultural phenomena. This article is a review of Hail to the Supermen… The author reconstructs the main assumptions and points out some of the most noticeable simplifications and general problems with the book
Późne spotkanie: Znaniecki, Witkowski i nauki o zarządzaniu. Organizatorska refleksja na temat pewnego fragmentu Uroszczeń i transaktualności w humanistyce Lecha Witkowskiego
No full textAbstract: The author of the article discusses the importance of the reinterpretation of Florian Znaniecki\u27s thought, which is carried out by Lech Witkowski in his monograph Uroszczenia i transaktualność w humanistyce, for management studies. The article focuses on the thesis – extracted from Znaniecki\u27s writings by Witkowski- about “the rationalization demands”. It describes the situation when rationalization transferred from one area to another, causes chaos and suppresses creativity. According to the author of the article, this thesis by Witkowski-Znaniecki can significantly help in the development of humanistic management (this stream of management, created in the early 2000s as a reaction to the hegemony of business corporations that do not care about employees and the environment while weakening the role of the state, is briefly presented in the text). On the one hand, the Witkowski – Znaniecki’ thesis raises awareness of the phenomena of “mathiness” and “lost in mathematics” in management. On the other, it shows the need and possibilities for scholars of humanistic management to undertake legitimate reflection on the epistemological contexts of combining management with the humanities.W artykule omówiono znaczenie reinterpretacji myśli Floriana Znanieckiego, której dokonuje Lech Witkowski na kartach swojej monografii Uroszczenia i transaktualności w humanistyce, dla studiów nad zarządzaniem. Skoncentrowano się na tezie – zaczerpniętej przez Witkowskiego z pism Znanieckiego– o „roszczeniach racjonalizacji”. Teza ta opisuje stan, w którym racjonalizacja przeniesiona z jednego obszaru poznania do drugiego wywołuje chaos i tłumi kreatywność. Zdaniem autora artykułu wspomniana teza może znacząco pomóc w rozwoju zarządzania humanistycznego (ten nurt zarządzania – powstały w pierwszych latach XXI wieku jako reakcja na hegemonię korporacji biznesowych, które nie dbają o pracowników i środowisko, jednocześnie osłabiając rolę państwa – jest krótko przedstawiony w tekście). Z jednej strony teza Witkowskiego/Znanieckiego uwrażliwia na zjawiska mathiness i „zagubienia w matematyce” odniesione do zarządzania, z drugiej zaś wskazuje na potrzebę i możliwości podjęcia przez przedstawicieli zarządzania humanistycznego pogłębionej refleksji nad kontekstami epistemologicznymi łączenia zarządzania z humanistyką
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