395 research outputs found
Corresponding author
No full textA Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice Michael Rosemann 1,6,
Contemplating Open Source Enterprise Systems
No full textUntil recently, integration of enterprise systems has been supported largely by monolithic architectures. From a technical perspective, this approach has been challenged by the suggestion of component-based enterprise systems. Lately
''No Gender Difference in Peak Performance in Ultra-Endurance Swimming Performance - Analysis of the 'Zurich 12-h Swim' from 1996 to 2010''
No full textEichenberger, Evelyn | Knechtle, Beat | Christoph, Alexander Rust | Knechtle, Patrizia | Lepers, Romuald | Rosemann, ThomasInternational audience''The aims of the study were to [1] investigate the performance trends at the 'Zurich 12-h Swim' in Switzerland from 1996 to 2010; and [2] determine the gender difference in peak performance in ultra-endurance swimming. In total, 113 male and 53 female swimmers competed in this indoor ultra-endurance event while swimming in a heated pool. The number of male participants significantly increased (r(2) = 0.36, P = 0.04) over time while the participation of females remained unchanged (r(2) = 0.12, P = 0.26). In the age group 0.05). The best performance was achieved in the age groups 30-39 years and 40-49 years for both genders, respectively. The athletes in the age groups 0.05). The best male and female swim performances remained unchanged across the years. Females are able to achieve a similar swim performance in an indoor ultra-endurance swim event of similar to 40 km. Further studies are needed to investigate whether females are able to achieve similar or even better performances than males in open-water ultra-swimming events such as 'Channel Swimming'.'
''Sex-related Trends In Participation and Performance In the 'swiss Bike Masters' From 1994-2012''
No full textGloor, Roman Urs | Knechtle, Beat | Knechtle, Patrizia | Ruest, Christoph Alexander | Haupt, Samuel | Rosemann, Thomas | Lepers, RomualdInternational audience''General participation in contests such as ultra-marathons and ultra-triathlons has increased considerably over the past 30 years, especially among women. This study investigated performance trends in the Swiss Bike Masters, one of the first and most prestigious mountain bike, ultra-endurance races in its class, with comparisons of participation and performance trends to similar races. The development of performance in the Swiss Bike Masters held between 1994 and 2012 was investigated by analysing the number of finishers, their age, sex, and cycling speed. Between 1994 and 2009, the athletes had to cover 120 kilometers with a total difference in altitude of 5,000 meters. Since 2010, the race distance was shortened to 105 kilometers and the total difference in altitude was reduced to 4,400 meters. The total men participating and total finishing decreased significantly, while women's participation has remained low. The age of the annual winners and the annual top three finishers showed no changes over time. Performances of the annual fastest women improved, while performances of the annual fastest men remained unchanged. To summarize, rate of finishing has decreased for men and has been stable, but low, among women. The sex difference in cycling speed for the best cyclists has decreased across the years.'
Program and project management
No full textProgram management serves as an overall vehicle for the transformation effort. It aims to support the implementation of the decided strategy in order to achieve the expected benefits in a business transformation initiative. A program is defined as a group of related projects managed in a coordinated way to obtain benefits and control not available when managing them individually . A project on the other hand, is a temporary endeavor undertaken to create a unique product, service, or result. Projects tend to have definite start and finish points, with the aim of delivering a predetermined output, giving them relatively clear development paths from initiation to delivery. Programs, on the contrary, exist to create value by enriching the management of projects in isolation. Programs typically have a more strategic vision of the desired end goal, but no clearly defined path to get there. Therefore, program management is expected to deal with the uncertainty surrounding the achievement of the vision, whereas projects work best where the outputs can be well defined
Housing, urban renewal and socio-spatial integration: A study on rehabilitating the former socialistic public housing areas in Beijing
No full textUrbanismArchitectur
The comfort triangles: A new tool for bioclimatic design
No full textThis thesis presents a new graphic tool to identify and select bioclimatic strategies according to climate conditions and comfort requirements. The Comfort Triangle relates outdoor daily temperature variations with the modification of thermal performance achieved indoors, using two key variables, average daily temperatures and temperature swings. The variation between indoor and outdoor average daily temperature shows the effectiveness of passive heating and cooling strategies, while the relation between indoor and outdoor swings show the capacity of the building to moderate, control or maintain temperature variations in relation to comfort requirements. It is shown that many bioclimatic strategies aim to modify one or both of these variables. Part 1 introduces concepts of bioclimatic design; Part 2 provides a literature review and defines the state of the art in bioclimatic design, while Part 3 describes the development of the comfort triangles for analysis and evaluation of different bioclimatic design strategies. Part 4 tests the tool using case studies at the urban, architectural and building scales, to demonstrate and verify the use of the Comfort triangles in wide range of different climates, situations and building types. Studies using the comfort triangles at the urban scale show how the built environment produces modifications of climatic conditions, modifying the temperature swing and increasing average temperatures. At the architectural scale, studies show the impact of building form, orientation and shading on average temperature and temperature swing. At the construction scale, studies of indoor and outdoor conditions show the results of different materials used in different climates. The Comfort Triangles clearly identify the impact of the built environment, permitting a visualization of the change in two key vectors, average temperature and temperature swing. The final part of the thesis analyses the results of the case studies to show the value of this new graphic tool that offers a valuable complement to existing bioclimatic design tools, emphasizing the dynamic nature of thermal performance in natural conditioning. It is shown that the comfort triangles provide a new way to analyse projects in different climates and promote the selection of appropriate bioclimatic design strategies.Architectur
The Spatial Economy in the Urban Informal Settlement
No full textIn the rapidly urbanizing world, the informal settlement has been forming a significant part of the common urban scene in many cities in the developing countries. It holds a particular role in the city as it houses millions of urban poor who has no access to the public housing. However it does not only offer accommodation but also economic opportunities that enables the inhabitants to survive. The informal settlement displays a very specific and particular mechanism of survival that is significantly characterized by the notion of flexibility in term of production and spatial occupation. This research aims to investigate the local spatial economy or the spatial dynamic of survivability in the informal settlement. It focuses on the notion of space and locations of the process of survival in such settlement by analyzing the way the spaces are organized and negotiated as one of the most important tool of production and the place of production. It analyzes the dynamics by relating it to the notions of the social capital and the life chances in the informal settlement. Moreover in order to offer a deeper understanding of the problem, apart from the looking at the actual and the localized problem, it will also look at the root of the problems by relating it to its past as an element of a colonial city; and analyse the major economic forces that contribute to its creation by relating it with the Dual City theory in order to accentuate the nature of the problem and its position in the metropolitan context. The research employs the case of kampong to illustrate the case of the informal settlement in the city of Jakarta, Indonesia. The result of the research shows that the dynamic of the survivability in the informal settlement is characterized by a multi-tier relationship between the formal and the informal economy. The continuity of its production is related to the wider economic sector; namely the formal sector, that creates demands and economic opportunities for them. It is also strongly bounded with its actual location; dislocation would therefore destroy the local livelihood. The local economic activities are also determined by the flexibility of the local spatial organization and production. These particular characters enable the inhabitants to manoeuvre in order to survive amidst the limited capital and resource. The process of production is highly depended on the intensity social relation that makes the spatial negotiation and the flexible production possible to take place. The local survivability therefore is in the same time very flexible and fragile.Architectur
An urban geography of globalisation: New urban structures in the age of hyper-connectivity
No full textHow is Globalisation changing the form and spatial structure of cities today? Deceptively simple, this question presents us with a number of methodological challenges and unanswered theoretical problems. What is globalization? Can we define a series of distinctive new phenomena constituting a coherent and logical outline? Do these phenomena influence the structure of cities today? If so, how? Our hypothesis is that processes related to globalisation have resulted in convergent transformation in urban spatial structure in some areas of global cities. However, convergent transformation emerges from very particular spatial, historic and social contexts. Old and new processes are in constant interplay and spatial outcomes are very different at first sight. The dichotomy between 'globalizing' and 'non-globalizing' spaces may contribute for social and spatial division and polarisation in cities. It also represents a new challenge for planners, who have to deal with often contradictory processes stemming from the global and local arenas. The primary hypothesis is supported by empirical evidence on the location patterns of command activities in the Randstad-Holland and Sao Paulo Metropolitan Region. Impacts on the distribution of economic activity, the constitution of business centralities and changes in spatial structure are evaluated in the two cases. We conclude that despite time-space compression caused by developments in transportation technologies and ICT, there is an enduring tendency towards agglomeration of advanced services. We argue that this is a result of the role played by urban technical networks and urban milieux in the organisation of economic activity. We simultaneously emphasize the importance of accessibility, visibility and face-to-face contacts, as necessary elements for the development of synergies between different agents: the urban 'buzz', essential for the appearance of innovation and creativity. The organisation of functional networks in urban territories where global flows are intense ('global cities') obeys a new logic derived from the acceleration of flows and increasing complexity of functional and technical networks in Post-Fordism. These new logic has produced new polycentric urban landscapes, with 'corporate centralities' structured around hubs of connectivity and transferability, where the transfer between several scales of operation (from local to global) is facilitated.Architectur
- …
