239 research outputs found
In memory of Alexander Y. Mayorov (November 16, 1964 – January 1, 2023)
No full textOn January 1, 2023, Head of the Diabetes Prediction and Innovation Department of the Endocrinology Research Centre, the leader of the public patient organization «Russian Diabetes Association», Doctor of Medical Sciences, Professor Alexander Mayorov, died at the age of 59
Studies in Russian & Soviet Cinema, vol. 6, n° 2, 2012
No full textCette nouvelle livraison de la précieuse revue anglophone consacrée aux cinémas russe et soviétique propose une étude d’Anna Kovalova consacré au scénariste Nikolai Erdman (qui signe plusieurs scénarios de Barnet qu’il écrit avec Volpine), en particulier à ses travaux pour les films destinés aux enfants. Alexander Graham examine la question de « l’immersion dans le temps » (histoire et mémoire) et de la « réadaptabilité » dans les films d’Alexei Guerman. Deux études de Nikolaï Mayorov s’intér..
A glucokinase gene mutation in a young boy with diabetes mellitus, hyperinsulinemia, and insulin resistance
No full textAndrey O Emelyanov,1 Elena Sechko,1 Ekaterina Koksharova,1 Igor Sklyanik,1 Tamara Kuraeva,1,2 Alexander Mayorov,1,2 Valentina Peterkova,1,2 Ivan Dedov1 1Endocrinology Research Centre, Moscow, Russian Federation; 2I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation Abstract: We report the case of a 12-year-old boy with a glucokinase (GCK) mutation, and diabetes with hyperinsulinemia and insulin resistance. For 4 years, the patient intermittently received insulin medications Actrapid HM and Protaphane HM (total dose 5 U/day), with glycated hemoglobin (HbA1c) levels of 6.6%–7.0%. After extensive screening the patient was found to carry a heterozygous mutation (p.E256K) in GCK (MIM #138079, reference sequence NM_000162.3). Insulin therapy was replaced by metformin at 1,700 mg/day. One year later, his HbA1c level was 6.9%, postprandial glycemia at 120 min of oral glucose tolerance test was 15.4 mmol/L, hyperinsulinemia had increased to 508.9 mU/L, homeostasis model assessment index was 114.2 and the Matsuda index was 0.15. Insulin resistance was confirmed by a hyperinsulinemic euglycemic clamp test – M-index was 2.85 mg/kg/min. This observation is a rare case of one of the clinical variants of diabetes, which should be taken into account by a vigilant endocrinologist due to the need for nonstandard diagnostic and therapeutic approaches. Keywords: case report, insulin resistance, diabetes mellitus, MODY2, chil
Tunnelling and noise in GaAs and graphene nanostructures
No full textExperimental studies presented in this thesis have shown the first realisation of resonant tunnelling transport through two impurities in a vertical double-barrier tunnelling diode; have proved the chiral nature of charge carriers in graphene by studying ballistic transport through graphene - junctions; have demonstrated significant differences of noise in graphene compared with conventional two-dimensional systems.
Magnetic field parallel to the current has been used to investigate resonant tunnelling through a double impurity in a vertical double-barrier resonant tunnelling diode, by measuring the current-voltage and differential conductance-voltage characteristics of the structure. It is shown that such experiments allow one to obtain the energy levels, the effective electron mass and spatial positions of the impurities.
The chiral nature of the carriers in graphene has been demonstrated by comparing measurements of the conductance of a graphene -- structure with the predictions of diffusive models. This allowed us to find, unambiguously, the contribution of ballistic resistance of graphene - junctions to the total resistance of the -- structure. In order to do this, the band profile of the -- structure has been calculated using the realistic density of states in graphene. It has been shown that the developed models of diffusive transport can be applied to explain the main features of the magnetoresistance of -- structures.
It was shown that noise in graphene has much more complicated concentration and temperature dependences near the Dirac point than in usual metallic systems, possibly due to the existence of the electron-hole puddles in the electro-neutrality region. In the regions of high carrier concentration where no inhomogeneity is expected, the noise has an inverse square root dependence on the concentration, which is also in contradiction with the Hooge relation.ORS award schem
Design and Microwave-Assisted Synthesis of Novel Macrocyclic Peptides Active at Melanocortin Receptors: Discovery of Potent and Selective hMC5R Receptor Antagonists
No full textDifferentiation of the physiological role of the melanocortin receptor 5 MC5R from that of other melanocortin receptors will require development of high affinity and selective antagonists. To date, a few synthetic antagonist ligands active at hMC5 receptor are available, but most do not have appreciable selectivity. With the aim to gain more potent and selective antagonists for the MC5R ligands, we have designed, synthesized, and pharmacologically characterized a series of alkylthioaryl-bridged macrocyclic peptide analogues derived from MT-II and SHU9119. These 20-membered macrocycles were synthesized by a tandem combination using solid phase peptide synthesis and microwave-assisted reactions. Biological assays for binding affinities and adenylate cyclase activities for the hMC1R, hMC3R, hMC4R, and hMC5R showed that three analogues, compounds, 9, 4, and 7, are selective antagonists at the hMC5 receptor. In particular, compound 9(PG-20N) is a selective and competitive hMC5R antagonist, with IC50 of 130 ± 11 nM, and a pA2 value of 8.3, and represents an important tool for further biological investigations of the hMC5R. Compounds 4 and 7 (PG14N, PG17N) show potent and selective allosteric inhibition at hMC5R with IC50 values of 38 ± 3 nM and 58 ± 6 nM, respectively. Compound 9 will be used to further investigate and more clearly understand the physiological roles played by the MC5 receptor in humans and other animals
The poetry of the young generation of the 1930s
No full textВ статье на примере анализа творчества П. Когана, М. Кульчицкого, Н. Майорова рассматривается судьба романтической традиции в лирике советской эпохи, показана специфика романтического начала, связанного с диалогической открытостью их лирики и "ученическим" осмыслением художественного наследия предшествующих эпох.The article analyzes the Romantic tendency in the lyrics of the Soviet epoch. The author specific character of the romantic start which is connected with the dialogue openness of the their lyrics and “student” view of the artistic heritage of the previous epochs. Based on the works by P. Kogan, M. Kulchitsky, N. Mayorov
The poetry of the young generation of the 1930s
No full textВ статье на примере анализа творчества П. Когана, М. Кульчицкого, Н. Майорова рассматривается судьба романтической традиции в лирике советской эпохи, показана специфика романтического начала, связанного с диалогической открытостью их лирики и "ученическим" осмыслением художественного наследия предшествующих эпох.The article analyzes the Romantic tendency in the lyrics of the Soviet epoch. The author specific character of the romantic start which is connected with the dialogue openness of the their lyrics and “student” view of the artistic heritage of the previous epochs. Based on the works by P. Kogan, M. Kulchitsky, N. Mayorov
Kommentarii k Rukovodstvu Mezhdunarodnoy Diabeticheskoy Federatsii po kontrolyu postprandial'noy glikemii
No full textВ 2007 г. Рабочей группой National Kidney FoundationKidney Disease Outcomes Quality Initiative (NKFKDOQITM) разработано первое уникальное руководство по ведению больных сахарным диабетом и хронической болезнью почек ? KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease, включающее практические клинические руководства (Clinical Practice Guidelines ? CPGs) и рекомендации (Clinical Practice Recommendations ? CPRs)
The 71st Scientific Session of American Diabetes Association (ADA), June 24-28, 2011, San-Diego
No full textInsulin resistance in pathogenesis of type 2 diabetes mellitus
No full textThis review focuses on the mechanisms of impaired sensitivity to insulin associated withevolution of carbohydrate metabolism disorders from enhanced fasting glycemia (EFG) to impaired glucose tolerance (IGT) and type 2 diabetes.Disturbances of glucose utilization at the receptor and post-receptor levels are considered along with the role of glucose and lipotoxicity. Original dataon insulin resistance (IR) in patients with disorders of carbohydrate metabolism are presented. Insulin sensitivity in DM2, EFG and IGT is shownto be 50, 25 and 15% lower respectively than in normal subjects. M-index positively correlates with BMI and quality of metabolic control (HbA1cand triglyceride levels). The differences in clinical and biochemical characteristics of DM2 patients are analysed depending on the degree of IR.Adiponectin and resistin levels in DM2 are shown to be lower than in healthy subjects while TNF-a and proinsulin levels increase. Therapy withmetformin, pyoglitazone, and insulin improves insulin sensitivity even in patients with early disturbances of carbohydrate metabolism. It is concludedthat intensive hypoglycemic therapy should be initiated before marked deterioration of insulin sensitivity developed
- …
