2,272 research outputs found
Reptricket. Förord till Lars Gustafsson: Mot noll
No full textIntroduction to a collection of philosophical essays by Swedish author Lars Gustafsson (b. 1936)
Author Functions in Lars Kepler\u27s The Hypnotist: An Analysis
No full textThis paper examines Foucault\u27s notion of the author function as it pertains to Lars Kepler\u27s bestselling 2011 crime thriller, The Hypnotist. Lars Kepler is the pseudonym of a Swedish husband-wife writing duo, making him the perfect subject for analysis centering on illusory notion of the author. This paper will answer these questions: Who is the true author of The Hypnotist? What factors influence the author function of this bestelling novel? And what can The Hypnotist phenomenon tell us about the relationships between authors and their readers? This paper will demonstrate that no literary works may be ascribed to an individual person, and that authors hold no privileged knowledge of the works they produce, because authors cease to be authors the moment pen is lifted from page
”Lärda nyheter” i Peter Hernquists korrespondens till Carl von Linné och Abraham Bäck - med kommentarer och utvikningar
No full textI detta Meddelande nr 55 från Veterinärhistoriska museet har författaren - professor emeritus Lars-Erik Appelgren - gjort ett urval av den korrespondens som Peter Hernquist hade med sina mentorer Carl von Linné och Abraham Bäck under sin vistelse i Frankrike, varvid ”Lärda nyheter” varit en ledstjärna för urvalet. Speciellt har breven till Bäck försetts med författarens personliga kommentarer men även kompletterats med faktaupplysningar från andra källor än breven om berörda nyheter. För att underlätta läsningen har dessa kommentarer omgetts med enkelkonturerad och utvikningarna med dubbelkonturerad ram. Lars-Erik Appelgren har inte bara genom sitt veterinärhistoriska författarskap utan också genom att ställa sina fackliga kunskaper och sin eminenta estetiska läggning till förfogande gjort Veterinärhistoriska museet ovärderliga tjänster. Det är med stor glädje jag noterar att region Uppsala nyligen visat sin uppskattning genom att tilldela Lars-Erik sitt Medicinhistoriska stipendium med motiveringen att de vill ”lyfta fram ett viktigt men ofta förbisett område inom medicinhistorien: veterinärmedicinen”. Med de varmaste gratulationer
Systems biology of Streptomyces albus to produce the antituberculosis polyketide pamamycin
No full textStreptomycetes produce a range of polyketides, a class of small natural molecules with interesting bioactive properties that have significantly contributed to human well-being over the past decades. Therefore, the exploration of these microbes towards a streamlined overproduction of polyketides and the discovery of novel ones receives high interest. In this regard, this work deals with the development and establishment of an analytical approach, using LC-MS/MS to quantify intracellular CoA thioesters, the cellular building blocks to derive polyketides, as well as other products of interest. The developed method was validated for various microbes and then used to gain insight into the biosynthesis of pamamycins, a polyketide family with up to 16 isomers, in the heterologous host Streptomyces albus. First, this unraveled the link between CoA thioester availability and pamamycin spectrum. Second, the combined analysis of metabolome and transcriptome of S. albus, grown under different conditions, provided a global view on pamamycin production and its regulation. The amino acid L-valine emerged as beneficial medium supplement, as it substantially increased production. Inter alia, this led to the construction of a bkdR regulator mutant, which provided larger fractions of so far inaccessible heavy pamamycin derivatives.Streptomyceten produzieren zahlreiche Polyketide, eine Klasse kleiner natürlicher Moleküle mit interessanten Eigenschaften, die im Laufe der letzten Jahrzehnte maßgeblich zum Wohlbefinden der Menschheit beigetragen haben. Die Erforschung dieser Mikroben mit dem Ziel einer zielgerichteten Überproduktion, sowie der Entdeckung neuer Substanzen erlangt größtes Interesse. In diesem Zusammenhang befasst sich diese Arbeit mit der Entwicklung und Etablierung einer analytischen Pipeline zur Quantifizierung von intrazellulären CoA-Thioestern mittels LC-MS/MS, wichtige Bausteine für Polyketide sowie anderer interessanter Produkte. Die hier entwickelte Methode wurde an unterschiedlichen Mikroben validiert und danach angewendet um nähere Einblicke in die Biosynthese der Pamamycine, eine Polyketide-Familie mit bis zu 16 Isomeren, in dem heterologen Produzenten Streptomyces albus zu erhalten. Dies enthüllte zunächst den Zusammenhang zwischen der Verfügbarkeit von CoA-Thioestern und dem Pamamycin-Spektrum. Zweitens lieferte die kombinierte Analyse von Metabolom und Transkriptom von S. albus, die unter verschiedenen Bedingungen kultiviert wurden, einen globalen Überblick über die Pamamycin-Produktion und ihrer Regulation. Die Aminosäure L-valin stellte sich als ideale Medienergänzung heraus, da sie die Produktion wesentlich erhöhte. Dies führte unter anderem zur Konstruktion einer bkdR-Regulatormutante, die größere Fraktionen bisher unzugänglicher schwerer Pamamycin-Derivate lieferte
Interpreting Wage Bargaining Norms
No full textFrom the mid-1990s onwards, Swedish wage bargaining has been characterised by informal co-ordination of the wage claims of big unions and bargaining cartels. In particular, it has been understood that the manufacturing sector should lead by first agreeing on a pay increase, whereafter the service sector and public sector unions choose a similar increase. We analyse his setup with two possible theoretical interpretations: (i) the manufacturing sector as a tackelberg leader and (ii) a normative role for the manufacturing sector’s pay increase, upported either by unmodelled social pressure or a modeled loss aversion (envy) of the heltered sector unions. The conclusion of the analysis is that the normative or leading role of one sector – in the Swedish case the manufacturing sector – can potentially bring big benefits for employment and output. Generalising an idea suggested by Lars Calmfors and Anna Larsson, our analysis also generates a rudimentary theory of why the wage increase norm sometimes binds and sometimes not. A comparison of the model predictions and the observed outcomes of the last five wage bargaining rounds in Sweden suggests that the model is generally consistent with the empirical observations: wage moderation and norm observance are stronger when the manufacturing industry’s initial relative wage is low.wage bargaining; bargaining co-ordination
Dan Andersson
No full textSpecial feature issue on the Swedish author Dan Andersson, with articles by Anders Hallengren, Nisse Munck, Lars Furuland, Lars Järnemo (2), Gösta Ågren, Inge Mattsson, Arne Säll, and Bure Holmbäck.</p
Representation of female characters in the films of Lars von Trier
No full textOslanjajući se na sličnosti u ženskim likovima Lars Von Triera, detektirani su patrijarhalni i religijski obrasci koji su okosnica radnje filmova Lomeći valove, Dogville i Antikrist. Kroz religijsku i patrijarhalnu optiku autor čita Lars Von Triera kao redatelja koji istu optiku kritizira i preispituje u svom stvaralaštvu.Relying on the similarities in Lars von Trier's female characters, patriarchal and religious patterns have been detected that are the backbone of the plot of the films Breaking the Waves, Dogville and the Antichrist. Through religious and patriarchal optics, the author reads Lars Von Trier as a director who criticizes and questions the same optics in his work
Representation of female characters in the films of Lars von Trier
No full textOslanjajući se na sličnosti u ženskim likovima Lars Von Triera, detektirani su patrijarhalni i religijski obrasci koji su okosnica radnje filmova Lomeći valove, Dogville i Antikrist. Kroz religijsku i patrijarhalnu optiku autor čita Lars Von Triera kao redatelja koji istu optiku kritizira i preispituje u svom stvaralaštvu.Relying on the similarities in Lars von Trier's female characters, patriarchal and religious patterns have been detected that are the backbone of the plot of the films Breaking the Waves, Dogville and the Antichrist. Through religious and patriarchal optics, the author reads Lars Von Trier as a director who criticizes and questions the same optics in his work
Representation of female characters in the films of Lars von Trier
No full textOslanjajući se na sličnosti u ženskim likovima Lars Von Triera, detektirani su patrijarhalni i religijski obrasci koji su okosnica radnje filmova Lomeći valove, Dogville i Antikrist. Kroz religijsku i patrijarhalnu optiku autor čita Lars Von Triera kao redatelja koji istu optiku kritizira i preispituje u svom stvaralaštvu.Relying on the similarities in Lars von Trier's female characters, patriarchal and religious patterns have been detected that are the backbone of the plot of the films Breaking the Waves, Dogville and the Antichrist. Through religious and patriarchal optics, the author reads Lars Von Trier as a director who criticizes and questions the same optics in his work
Is all that is new therefore good? The Swedish author Lars Gyllensten and ecocritical tendencies of today
No full textThe article want to raise the awareness of some urgent questions that is concerned with the development of new theory and methods in the service of addressing the problematic situation of the Anthropocene. With the aid of the 20th century Swedish author Lars Gyllensten’s general ideas of the function of critique (iconoclasm) and creativity (iconoplasm), the aim is to point to two basic patterns when moving towards new, and hopefully better paradigms
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