74 research outputs found
The Trajan Markets and their Great Hall – The Conservation Problems and the Structural Intervention for the Improvement of the Seismic Safety
No full textThis paper focuses on the Great Hall of Trajan’s Markets in Rome and describes structural analyses and interventions designed and installed to improve structural stability. Trajan’s Markets were subjected to each of the last four big earthquakes that hit Rome, the last occurring in 1703, with a return period of around three-four centuries. The present geometrical and structural configuration of the Markets is different and weaker with respect to the original one, and also weaker with respect to their configuration in 1703. Numerical FEM analyses have been applied, lightening and emphasising the seismic vulnerability of the structure. In particular, the numerical analyses allowed the identification of the most vulnerable parts of the supporting structures as well as the assessment of an adequate retrofitting intervention criterion, based on the use of reversible techniques
Câncer gástrico: estudo da sobrevida em 74 casos.
No full textTrabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Cirúrgica, Curso de Medicina, Florianópolis, 199
Three-dimensional mandibular motion after closed and open reduction of unilateral mandibular condylar process fractures
No full textObjective: To detect the changes in 3D mandibular motion after two types of condylar fracture therapies. Materials and methods: Using a 3D motion analyzer, free mandibular border movements were recorded in 21 patients successfully treated for unilateral fractures of the mandibular condylar process (nine patients: open reduction, rigid internal fixation, and functional treatment; 12 patients: closed reduction and functional treatment; follow-up: 6-66 months), and in 25 control subjects. Results: No differences were found among the groups at maximum mouth opening (MO), protrusion and in lateral excursions. During opening, the patients had a larger maximal deviation to the fractured side than the controls (controls 2.3 mm, open treatment 3.9 mm, closed treatment 4.2 mm; Kruskal-Wallis test, p = 0.014; closed treatment vs. controls, p = 0.004), with a larger coronal plane angle (controls 2.4°, open treatment 3.6°, closed treatment 4.4°; p = 0.016; closed treatment vs. controls, p = 0.013). In the closed treatment patients, a longer follow-up was related to increased maximum MO (p = 0.04), sagittal plane angle (p = 0.03), and reduced lateral mandibular deviation during MO (p = 0.03). Conclusion: Mandibular condylar fractures can recover good function; some kinematic variables of mandibular motion were more similar to the norm in the open treatment patients than in closed treatment patients
Ameloblastic carcinoma in a young patient
No full textOwing to the rarity of publications describing ameloblastic carcinoma, little is known about this entity in pediatric patients. To our knowledge, malignant transformation from an odontogenic cyst into an ameloblastic carcinoma in a pediatric patient has not been documented to date. We present the case of a 14-year-old boy in whom a large osteolytic lesion associated with an impacted right maxillary third molar germ was fortuitously detected by orthopanoramic radiography. With a preoperative clinical-radiographic diagnosis of odontogenic cyst, the patient underwent surgical enucleation of the lesion. Histologic evaluation rendered a diagnosis of follicular cyst with a focal area of ameloblastic carcinoma. The literature addressing ameloblastic carcinoma is reviewed
Ridisegnare Metropolis = Redrawing Metropolis
No full textLa ricerca ha permesso di comprendere il set cinematografico utilizzato da Fritz Lang per la creazione del film Metropolis, limitatamente alla scena che vede la torre stellata al centro della scena. Sono state recuperate tutti i bozzetti preparatori ed è stato simulato il contesto usando le nuove tecnologie per la visualizzazione digitale. La sequenza analogica, infine, è stata confrontata con la sequenza realizzata in digitale
Per uno studio dei bozzetti della Fabrique neuve de Cortaillod (XVIII-XIX secolo)
No full textPartendo dall’analisi di un gruppo di bozzetti della Fabrique neuve de Cortaillod (XVIII-XIX secolo), l’autrice prende in esame il processo di interazione tra moda e sviluppo industriale nell’Europa
del secondo Settecento, attraverso l’approfondimento dei processi di adattamento dei modelli orientali al gusto europeo e delle tecniche di stampa adottate in EuropaStarting from the analysis of a group of sketches of the Fabrique neuve de Cortaillod (18th-19th
century), the author examines the process of interaction between fashion and industrial development
in Europe in the second half of the 18th century, through an in-depth study of the processes of adaptation of oriental models to European taste and of the printing techniques adopted in Europe
HPV-related papillary squamous cell carcinoma of the tonsil during treatment with fingolimod
No full textFingolimod is a commonly used treatment for highly active relapsing-remitting multiple sclerosis (MS). We describe the case of a 50-year old man on fingolimod since 2011 who presented, in April 2017, with a voluminous swelling of the left tonsil. A left tonsillectomy was performed, and histological exam disclosed a papillary squamous cell carcinoma of the palatine tonsil, with an in situ hybridization positive for human papillomavirus (HPV)-16 DNA. Neither lymph nodes involvement nor other metastases were detected. Fingolimod was stopped as a precautionary measure in May 2017, and the patient currently continues his follow up at our Department. Immunocompromised patients are at risk for developing HPV-related malignancies probably in light of the suppression of T-cell immunity, therefore an increased risk for HPV activation in MS patients treated with disease modifying therapies (DMTs) characterized by a more pronounced immunosuppressant activity cannot be excluded. Given the absence of studies on larger cohorts of MS patients exposed to DMTs, additional monitoring for HPV infection during fingolimod treatment is not currently recommended. However, vigilance for this possible association is warranted
Assessing the precision of post-traumatic orbital reconstruction through 3D-3D "mirror" orbital superimposition: 3D surface point-to-point distance versus volume
No full textPosttraumatic orbital fractures are mainly reconstructed through orbital meshes. The most frequently used method to assess the success of orbital reconstruction is based on the comparison of orbital volumes [1]. However, the modern techniques of 3D elaboration enable to perform innovative procedures of comparison, such as the 3D-3D registration and quantification of point-to-point distances. Ten patients who underwent to orbital reconstruction through titanium meshes in the Department of Maxillofacial Surgery, University of Milano-Bicocca, were recruited (patients group), together with a ten patient control group. Volumes of orbits were segmented on CT scans and automatically calculated. The 3D model from the unaffected orbit was then flipped according to the sagittal plane in order to obtain a “mirror” image of the contralateral orbit, and automatically registered on the reconstructed one. Point-to-point RMS (Root Mean Square) distance between the 3D models was then calculated. The same procedure was applied also to the CT-scans from unaffected patients. Possible statistically significant differences in volume and surface RMS distance were assessed through Student’s t-test (p0.05); on the other side, mean RMS value was significantly higher in the former group than in the latter one (0.78 mm versus 0.59 mm,
aubergine gene overexpression in somatic tissues of auberginesting mutants interferes with the RNAi pathway of a yellow hairpin dsRNA in Drosophila melanogaster
No full textAUBERGINE (AUB) is a member of the PPD family of proteins. These proteins are implicated in RNA interference. In this article we demonstrate that the expression of the aub gene and protein increase in aub(sting) mutants. We used a genetic method to test whether aub(sting) overexpression could interfere with proper functioning of the process of RNA interference in somatic tissues of Drosophila melanogaster. This method is based on a transgenic line bearing a construct in which a fragment of the yellow (y) gene is cloned to form an inverted repeat (y-IR) under the control of the upstream activation sequence (UAS) of the yeast transcriptional activator GAL4. The UAS-y-IR transgene and the Act5C-GAL4 driver were brought together on chromosome 3 via recombination. In the resulting strain (Act5C-y-IR), transcriptional activation by GAL4 constitutively produces a dsRNA hairpin bearing cognate sequences to the yellow gene causing continuing degradation of y mRNA resulting in yellow(1) (y(1)) phenocopies. In this genetic background, the mutation of any factor involved in RNAi should repress degradation of y mRNA, restoring the wild-type phenotype. We employed this genetic approach to show that an increased amount of AUBERGINE interferes with the regular functioning of the somatic RNAi pathway
Long-term follow-up of syndromic craniosynostosis after Le Fort III halo distraction: A cephalometric and CT evaluation
No full textBackground: Midface distraction osteogenesis (DO) in craniofacial synostosis (CFS) patients has been described by several authors. However, very few cephalometric and computed tomography (CT) long-term follow-up studies are available.Method: A total of 40 consecutive patients affected by CFS subjected to Le Fort III and rigid external distraction (RED) were examined. All patients had pre-DO cephalometric records, immediately post-DO and 6e12 months post-DO. Twenty-seven patients had mid-term records (3 years post-DO) and 20 patients had long-term records (5e10 years post-DO). Fourteen patients had CT data within 1-year of DO, while 10 patients had long-term CT data (range 5e9 years). Results: Excellent post-surgical stability was recorded. Short- and long-term CT data demon- strated excellent ossification at the osteotomy sites post-DO. In the growing patients, surface resorption in the zygomatic-temporal and in the subspinal area (p < 0.05) was observed in the long-term follow-up, as well as a mild increment of the corrected exorbitism (p < 0.05), as only appositional and no sutural growth occurs post Le Fort III, whereby orbital volume does not increase after surgery.Conclusion: Significant advancement of the midface can be achieved and maintained through Le Fort III and RED. In the long term, in growing patients, in general a class III malocclusion does not re-occur, but physiological remodelling processes at the maxillary-zygomatic level, not coupled with sutural growth, tend to mildly re-express the original midfacial phenotype and the exorbitism
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