6 research outputs found
ACKNOWLEDGMENTS
No full textTo my advisor and professor, Dr. Clyde Martin, for all the guidance of his profession and for the prodigious opportunity which he has bestowed upon me, I offer my honest gratitude. Also, I hold a deep appreciation for Dr. Elmus Beale, for his exalted supervision of yours truly, throughout the biological aspects of my undertaking, and furthermore for the forbearance he has granted in these past months. Conjointly, residing on the committee is, Dr Lance Drager, a cogent body in the reconstruction of the department into a beneficial environment for application. Never have I been in lack of reinforcement, individuality or affection owing to Sina Hamza and Osama Al-Hashmi. My ardent mother and father’s equable chivying is a significant factor in my success to this point. I truly believe, without a shadow of a doubt that it will continue to be a prominent staple throughout. Another of the cardinal colonnades of abutment in my academic pursuits is my older cousin, Mohamed Manaf Shihab; thank you for your bearing, courtesy and sustenance. Last but definitely not least, a former diabetes patient, my uncle Farook Hamza 1943
Controversy and consensus on the management of elevated sperm DNA fragmentation in male infertility: A global survey, current guidelines, and expert recommendations
No full textPurpose
Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition.
Materials and Methods
An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method.
Results
A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4–6 months and 38.1% recommend 3 months. For men with unexplained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respondents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical varicocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated.
Conclusions
This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians
Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
No full textPurpose: Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. Materials and Methods: An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method Results: A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4-6 months and 38.1% recommend 3 months. For men with unexplained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respondents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical varicocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated. Conclusions: This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians. © The Author(s), 2023
Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
No full textInternational audienceSperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproduc-tive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition. An online global survey on clinical practices related to SDF was disseminated to reproductive clini-cians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formu-lated and adapted using the Delphi method. A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4-6 months and 38.1% recommend 3 months. For men with unex-plained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respon-dents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical vari-cocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated.This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians
Controversy and Consensus on the Management of Elevated Sperm DNA Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations
No full textPURPOSE: Sperm DNA fragmentation (SDF) has been associated with male infertility and poor outcomes of assisted reproductive technology (ART). The purpose of this study was to investigate global practices related to the management of elevated SDF in infertile men, summarize the relevant professional society recommendations, and provide expert recommendations for managing this condition.
MATERIALS AND METHODS: An online global survey on clinical practices related to SDF was disseminated to reproductive clinicians, according to the CHERRIES checklist criteria. Management protocols for various conditions associated with SDF were captured and compared to the relevant recommendations in professional society guidelines and the appropriate available evidence. Expert recommendations and consensus on the management of infertile men with elevated SDF were then formulated and adapted using the Delphi method.
RESULTS: A total of 436 experts from 55 different countries submitted responses. As an initial approach, 79.1% of reproductive experts recommend lifestyle modifications for infertile men with elevated SDF, and 76.9% prescribe empiric antioxidants. Regarding antioxidant duration, 39.3% recommend 4-6 months and 38.1% recommend 3 months. For men with unexplained or idiopathic infertility, and couples experiencing recurrent miscarriages associated with elevated SDF, most respondents refer to ART 6 months after failure of conservative and empiric medical management. Infertile men with clinical varicocele, normal conventional semen parameters, and elevated SDF are offered varicocele repair immediately after diagnosis by 31.4%, and after failure of antioxidants and conservative measures by 40.9%. Sperm selection techniques and testicular sperm extraction are also management options for couples undergoing ART. For most questions, heterogenous practices were demonstrated.
CONCLUSIONS: This paper presents the results of a large global survey on the management of infertile men with elevated SDF and reveals a lack of consensus among clinicians. Furthermore, it demonstrates the scarcity of professional society guidelines in this regard and attempts to highlight the relevant evidence. Expert recommendations are proposed to help guide clinicians
Nanoparticulas de óxido de grafeno como agente biocida incrustados en membranas de microfiltración electrohiladas para tratamiento de aguas: una revisión sistemática
No full textEn los últimos años, ha tenido gran relevancia el uso de nuevos materiales como las nanopartículas (NPs) de óxido de grafeno (GO) en la fabricación de fibras poliméricas compuestas obtenidas por la técnica de electrospinning a escala micro y nanométricas para aplicaciones en la eliminación de microorganismos presentes en el agua. En este estudio, se realizó una metodología de revisión sistemática con el uso del Software Parsifal, mediante 4 fases: planificación, búsqueda de documentos en las bases de datos, extracción de datos y análisis de datos extraídos. La investigación llevo a un total de 906 artículos donde 169 eran duplicados, quedando 737 artículos a los cuales se realizó un filtro de clasificación por exclusión e inclusión: total artículos seleccionados, aceptados, rechazados y duplicados. De acuerdo al formulario e extracción de datos se utilizaron 222 artículos dando respuesta a las preguntas de investigación que se plantearon en esta revisión sistemática.
El desarrollo de esta investigación condujo a la identificación de las propiedades de NPs de GO como agentes biocidas de dos casos de estudio de membranas poliméricas desnudas o puras, (matriz polimérica), las cuales fueron modificadas de la siguiente forma: caso 1, membranas de microfiltración (MF) de poliacrilonitrilo (PAN) modificadas con NPs de plata/oxido de grafeno (Ag/GO) vs membranas de Poli (ácido láctico)/poliacrilonitrilo (PLA/PAN) modificadas con nanocristales de celulosa (NCC) y nanocristales de quitina (NCQ). Para el estudio del caso 2, las membranas de MF de Poli (fluoruro de vinilideno) (PVDF) modificadas con NPs de GO vs membranas de Policaprolactama también llamada (poliamida 6) (PA-6) modificadas con NPs de dióxido de titanio (TiO2).
Como resultado a estos dos casos de estudio , para el caso 1 , las NPs de Ag/GO vs NCC y NCQ tuvieron una excelente actividad antibacteriana y antiincrustante con una efectividad en la eliminación de microorganismos con las NPs de Ag/GO y una tasa de reducción del 100% para la E. coli y un 87.6 % para el S. aureus, en comparación con los NCQ y NCC, la efectividad en la eliminación bacteriana con los dos nanocristales fue de un 85% para la E. coli por exclusión de tamaño y un 95% con el uso de NCQ.
Para el estudio del caso 2, las membranas de MF de (PVDF) modificadas con NPs de GO vs membranas de PA-6 modificadas con NPs de (TiO2), la respuesta fue una tasa de reducción de bacterias con el uso de las NPs de GO en un 100% para la E. coli y un 99% para el S. aureus y con las NPs de TiO2 fue de un 99.99% para el S. aureus después de 6 h de exposición a rayos UV.In recent years, the use of new materials such as graphene oxide (GO) nanoparticles (NPs) has been of great relevance in the manufacture of composite polymeric fibers obtained by the electrospinning technique on a micro and nanometric scale for applications in removal of microorganisms present in the water. In this study, a systematic review methodology was carried out with the use of Parsifal Software, through 4 phases: planning, search for documents in databases, data extraction and analysis of extracted data. The research led to a total of 906 articles where 169 were duplicates, leaving 737 articles to which a classification filter by exclusion and inclusion was performed: total articles selected, accepted, rejected and duplicated. According to the data extraction form, 222 articles were used responding to the research questions posed in this systematic review.
The development of this research led to the identification of the properties of GO NPs as biocidal agents of two case studies of bare or pure polymeric membranes (polymeric matrix), which were modified as follows: case 1, membranes of microfiltration (MF) of polyacrylonitrile (PAN) modified with silver NPs / graphene oxide (Ag / GO) vs Poly (lactic acid) / polyacrylonitrile (PLA / PAN) membranes modified with cellulose nanocrystals (NCC) and chitin nanocrystals (NCQ). For the study of case 2, Poly (vinylidene fluoride) (PVDF) MF membranes modified with GO NPs vs polycaprolactam membranes also called (polyamide 6) (PA-6) modified with titanium dioxide NPs (TiO2)
As a result of these two study cases, for case 1, the Ag / GO NPs vs NCC and NCQ had excellent antibacterial and antifouling activity with an effectiveness in the elimination of microorganisms with the Ag / GO NPs and a rate of reduction of 100% for E. coli and 87.6% for S. aureus, compared to NCQ and NCC, the effectiveness in bacterial elimination with the two nanocrystals was 85% for E. coli by exclusion of size and 95% with the use of NCQ.
For the case study 2, the MF membranes of (PVDF) modified with GO NPs vs PA-6 membranes modified with NPs of (TiO2), the response was a reduction rate of bacteria with the use of the NPs of GO 100% for E. coli and 99% for S. aureus and with the TiO2 NPs it was 99.99% for S. aureus after 6 h of UV exposure.Ingeniero AmbientalPregrad
