841 research outputs found
Rana w językach świata
No full textIn accordance with the saussurean principle of arbitrariness of the linguistic sign the word rana has manifold senses in the languages of the world. From among numerous examples the author pays special attention to the Romance rana ‘frog’ and the Slavonic (in particular Polish) rana ‘wound’. The discussion concerns the earliest attestations of the word in Old Polish, modern phrases and collocations, cross‑linguistic literary and cultural associations and homonyms.Zgodnie z saussurowską zasadą dowolności znaku językowego słowo rana ma różnorodne znaczenia w językach świata. Spośród licznych przykładów uwagę autora przykuwa przede wszystkim rana romańska, czyli ‘żaba’ oraz rana słowiańska, zwłaszcza polska. Omówione są najstarsze wystąpienia tego słowa w okresie staropolskim, współczesne kolokacje i frazeologizmy, skojarzenia literackie i kulturowe w aspekcie komparatystycznym, a takżehomonimy
A Wellness and Hospitality Resort Inspired
No full textViolet Bloom Resort
By
Student name: Rana Alsalmani
Student ID: S19105838
Submitted in the partial fulfillment of the requirements
for the degree of Bachelor of Science in Architecture
At
Department of Architecture
Effat College of Architecture & Design
Effat University
2025
VIOLET BLOOM RESORT: A Wellness and Hospitality Resort Inspired by Abha’s Jacaranda Landscape
By
Rana Yahya Alsalmani
S19105838
Submitted in the partial fulfillment of the requirements
for the degree of Bachelor of Science in Architecture
At
Department of Architecture
Effat College of Architecture & Design
Effat University
@ Copyright by Rana Alsalmani, 2025
EFFAT UNIVERSITY
EFFAT COLLEGE OF ARCHITECTURE & DESIGN
DEPARTMENT OF ARCHITECTURE
The undersigned here by certify that they have read and recommend to the college of Architecture and Design for acceptance a thesis entitled “VIOLET BLOOM RESORT: A Wellness and Hospitality Resort Inspired by Abha’s Jacaranda Landscape” by Rana Alsalmani in partial fulfillment of the requirement for the Degree of Bachelor of Science in Architecture.
Dated: August 2, 2025
Supervisor: Dr. Ibrahim Saleh
Readers: ____________________
EFFAT UNIVERSITY
AUTHOR: Rana Alsalmani DATE: August 2, 2025
TITLE: THE ARTS CORE: Visual and Performing Art School
DEPARTMENT OF: Architecture
DEGREE: Bachelor of Science in Architecture CONVOCATION: August
YEAR: 2025
Permission is herewith granted to Effat University to circulate and to have copied for non-commercial purposes, at its discretion, the above title upon the request of individuals or institutions. I understand that my thesis will be electronically available to the public. The author reserves other publication rights, and neither the thesis nor extensive extracts from it may be printed or otherwise reproduced without the author’s written permission. The author attests that permission has been obtained for the use of any copyrighted material appearing in the thesis (other than the brief excerpts requiring only proper acknowledgement in scholarly writing), and that all such use is clearly acknowledged.
______________________________
Signature of Author
Abstract
This project is an investigation of design and construction of a sustainable resort in the mountainous area of Asir Region of Saudi Arabia that aims at achieving objectives that are within the eco-tourism and environmental stewardship setting of the Kingdom Vision 2030 agenda. With 18 o 10 38 inN 42 o 35 09 inE, the study area (or shortly, the study site) that borders with Abha, presents impressive topography, rich cultural context, and unrivalled natural landscape.
Two broad issues are addressed in the work, namely, the steepness of the land and the ecological sensitivity of the land. To address the limitations, a unique design has been used which complements the environment. Terracing, cantilever structural forms, and restrained earthworks are some of the techniques that build on the existing contours to raise privacy and comfort of the guests. The core sustainability measures, including renewable energy technology, passive cooling and strong water-saving strategies, will maintain the environmental footprint to be minimal and maximize energy efficiency.
The adherence to the local codes of building structures and environmental policies will provide balanced natural ecosystems and protection of cultural heritage. The conclusion makes the thesis argument that the modernized resort has attained functional and aesthetic goals and it is an attractive paradigm to be used in future developments of eco-tourism in the area.
Introduction: The current thesis looks into the viability of a mid-market resort in Abha, Saudi Arabia, which is a region that promotes scenic mountains and favorable geography, whose area as stated in Vision 2030. Chapter 1 starts the report with a project proposal, and this places the venture on a bigger context that is tourism potential in Abha and national structure of the country. The following chapters will then discuss the details of comparative analysis (Chapter 2), space programming (Chapter 3), site conditions (Chapter 4) and the final out come (Chapter 5) into storytelling.
Project Proposal: Chapter 1 provides the foundation of the Violet Bloom Resorts through the definitions of its concept, objectives, and rationale. The chapter puts the resort into a context of the tourism opportunities in Abha, remarks on its correspondence with Vision 2030, and reveals the conceptual premise of the design.
Case Studies: In chapter 2, two architectural precedents Zenubud Bali and PRY1 retreat hotel will be compared in a bid to inform the spatial, sustainable and experiential approach that will be pursued at the resort. The analysis points out the integration of landscape of the precedents, eco-conscious operations, spatial hierarchy and focus on interaction with the guests.
Program Development: In chapter 3 the functional zoning, circulation, spatial requirement and adjacencies are mapped out in the resort. Specifically, it also implements the concepts of circulation like the island model to promote the sense of difference between the public and the private spaces.
Site Analysis : The fourth chapter discusses the physical, cultural and regulatory limitations of the Abha site including its physical features (topography, climate, accessibility) as well as its cultural contexts. The location is considered to have a mild climate and topography is also a plus; the water sources available in the region, direction of the winds and proximity to the nearest airport are regarded as the challenges.
Design Outcome: Chapter 5 provides the last architectural design solution of the Violet Bloom Resort in plans, sections, elevations, and demands of the environmental systems. The project has a story behind the design, which traces the history of the progress of the project itself, starting with ideas and finishing on a polished scheme, which focuses on spatial strategies rooted in the experience of the guest
Evidence for directional selection at a novel major histocompatibility class I marker in wild common frogs (Rana temporaria) exposed to a viral pathogen (Ranavirus).
No full text(c) 2009 Teacher et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Whilst the Major Histocompatibility Complex (MHC) is well characterized in the anuran Xenopus, this region has not previously been studied in another popular model species, the common frog (Rana temporaria). Nor, to date, have there been any studies of MHC in wild amphibian host-pathogen systems. We characterise an MHC class I locus in the common frog, and present primers to amplify both the whole region, and specifically the antigen binding region. As no more than two expressed haplotypes were found in over 400 clones from 66 individuals, it is likely that there is a single class I locus in this species. This finding is consistent with the single class I locus in Xenopus, but contrasts with the multiple loci identified in axolotls, providing evidence that the diversification of MHC class I into multiple loci likely occurred after the Caudata/Anura divergence (approximately 350 million years ago) but before the Ranidae/Pipidae divergence (approximately 230 mya). We use this locus to compare wild populations of common frogs that have been infected with a viral pathogen (Ranavirus) with those that have no history of infection. We demonstrate that certain MHC supertypes are associated with infection status (even after accounting for shared ancestry), and that the diseased populations have more similar supertype frequencies (lower F(ST)) than the uninfected. These patterns were not seen in a suite of putatively neutral microsatellite loci. We interpret this pattern at the MHC locus to indicate that the disease has imposed selection for particular haplotypes, and hence that common frogs may be adapting to the presence of Ranavirus, which currently kills tens of thousands of amphibians in the UK each year
„Rana” w językach świata
No full textIn accordance with the saussurean principle of arbitrariness of the linguistic sign the word "rana" has manifold senses in the languages of the world. From among numerous examples the author pays special attention to the Romance "rana" ‘frog’ and the Slavonic (in particular Polish) "rana" ‘wound’. The discussion concerns the earliest attestations of the word in Old Polish, modern phrases and collocations, cross‑linguistic literary and cultural associations and homonyms
Music and elite identity in the English country house, c.1790-1840
No full textIn this thesis I investigate two untapped music book collections that belonged to two women. Elizabeth Sykes Egerton (1777-1853) and Lydia Hoare Acland (1786-1856) lived at Tatton Park, Cheshire, and Killerton House, Devon, respectively. Upon their marriage in the early nineteenth century, they brought with them the music books they had compiled so far to their new homes, and they continued to collect and play music after marriage. I examine the vocal music in Elizabeth’s and Lydia’s collections, and I aim to show how selected vocal music repertoires contributed toward the construction of landed elite identity in these women and their husbands, concentrating on gender, class, national identity and religion.In chapter one, I concentrate on songs that depict destitute and suffering individuals to move both listeners and performers to compassion. The songs are topical and provide insights into contemporary understandings of sympathy and landed elite responsibility for the distressed. In chapter two, I focus on the ingoing and outgoing movements of music in the country house, and the consumption of foreign music in the home. I divide the chapter into two sections, first examining Elizabeth’s Italian vocal music that she collected during her girlhood years in London and York in the 1790s. The Italian music that Elizabeth brought to Tatton complemented other Italian objects and items in the home. Italian culture appealed to the Egerton family both before and after Elizabeth and Wilbraham married. In the second section, I investigate Lydia and her family’s journey to Vienna for the Congress in 1814-1815. Lydia took away with her a book of vocal music to remind her of home in a foreign environment. While away in Vienna, the Aclands attended concerts and music salons, and they purchased music books to bring back home to add to their collection. In the final chapter, I concentrate on the man of the house at music and I consider the social expectations, duties and responsibilities that had befallen our landed elite men, Thomas Dyke Acland and Wilbraham Egerton. I discuss Thomas’s and Wilbraham’s musical engagements and occasions for performing music, and how men’s music-making contributed to a masculine identity.By placing the vocal music in broader social and cultural contexts, reading personal correspondence, newspaper articles, account books and diaries, we can begin to understand what our families thought about music, and how they used and experienced music in and around their homes, forming an important part of their lifestyle
Synthetic Nanoparticle Cytokine (SyNK) for Systemic Dosing and Immunotherapy
No full textCytokines are potent proteins responsible for cell signaling and regulation of the immune system. The use of cytokines to modulate macrophage phenotype is a promising therapeutic strategy for immune-mediated diseases; however, translation of recombinant cytokines as drug products is limited by cytokines’ severe systemic side effects and nonspecific biodistribution. While immense pre-clinical effort has been invested in the development of cytokine therapies, the limited number of FDA-approved recombinant cytokine products include either the free protein or its PEGylated variant. No approved products leverage biomaterial-based drug carriers to overcome the biodistribution and toxicity limitations of the recombinant cytokine molecule. While PEGylation improves the pharmacokinetics of intravenously administered cytokine products through extended circulation half-life, it does not provide spatial or temporal control over the cytokine’s activity. Hydrogel nanoparticles (i.e., nanogels, NGs) are a promising platform to address this unmet need to precisely modulate the immune response in target tissues. Through the rational design of nanogel physicochemical and functional properties, NGs can enhance the biodistribution and stability of cytokines while minimizing off-target effects.The overarching goal of this dissertation was to develop a safe and modular platform for the delivery of immunomodulatory cytokines using NGs. We developed a synthetic poly(acrylamide-co-methacrylic acid) nanogel - based cytokine delivery system (called “Synthetic Nanoparticle cytoKine, or SyNK) designed to restrict cytokines’ systemic release under circulatory conditions while preserving bioactivity upon co-localization with, or uptake by, target immune cells. The project had three objectives: (1) characterize the biocompatibility and cellular uptake of the NG in vitro; (2) assess the pharmacokinetics and biodistribution of the NG in vivo; and (3) evaluate molecular mechanisms through which SyNK modulates macrophage phenotype in diverse immunological environments. SyNK showed significant biocompatibility with cultured macrophages and circulating immune cells, with minimal cytotoxicity and immune activation. Macrophages internalized SyNK primarily though clathrin-mediated endocytosis, while interestingly, fibroblasts and circulating whole blood-derived immune cells showed negligible uptake. These observations suggested a degree of selectivity that could facilitate macrophage-based cytokine delivery in vivo. Pharmacokinetic studies revealed that systemically administered SyNK was cleared in less than 1 hour from the circulation and accumulated primarily in the kidneys, liver, and small intestine. Within the liver, cellular distribution studies confirmed uptake primarily by endothelial cells and resident macrophages. Despite accumulation, safety studies did not reveal any toxicity to these organs. Once safety was established, SyNK was synthesized by conjugating either IFNγ, IL4, or IL10 to the nanogel, which effectively eliminated the diffusion-mediated release of free cytokine to aqueous surroundings. Macrophages treated with SyNK exhibited phenotypic changes consistent with free protein, but at a lower potency, indicating that NG-cytokine conjugation influenced bioactivity. Furthermore, the immunomodulatory effects of IL4 and IL10 were dependent on the surrounding immune microenvironment and the intrinsic properties of the NG, suggesting that the platform can provide context-dependent immune modulation. This dissertation establishes the foundation for a tunable and biocompatible delivery platform that can improve the application of cytokines for macrophage immunotherapy. Future research efforts should (1) optimize the conjugation strategy of SyNK to maximize bioactivity, (2) assess the biodistribution and activity of SyNK in relevant disease models, and (3) evaluate its therapeutic potential of SyNK, relative to freely soluble recombinant cytokines, to treat local or systemic inflammatory conditions
Arab Women Writers
No full textA 2009 conversation with the Jordanian author, Rana Azzoubi, about her life and the inspiration for her work in children's literature.http://www.bu.edu/library/guides/caww/azzoubi.htm
Nepal on the eve of the Rana ascendancy
No full textPart of the material in this paper was collected to supplement a very brief discussion of 'Pre-Rana Administration' in Satish Kumar's Rana Polity in Nepal. The author intended to highlight a considerable number of positions within the administrative hierarchy that Kumar failed to mention. However, further study of Hodgson's papers, British Resident in Nepal (1831-43), the author realised a more complete presentation of administration in Nepal could be offered. From the detailed information that Hodson provides, it is possible to identify many of the persons in the higher positions of the..
Rana okinavana Boettger 1895
No full textRana okinavana Boettger, 1895 Rana okinavana Boettger, 1895: 266. [Syntypes: SMF (2 specimens), Bremen Mus.; SMF 5830 (formerly SMF 1047.3a), designated lectotype by Mertens (1967). Type-locality: Liukiu (= Ryukyus), Japan.] Rana psaltes Kuramoto, 1985: 150. [Holotype: FUE 80320, by original designation. Type-locality: near the Kampira Falls (Urauchi River), Iriomote Island, Ryukyu Islands, Japan. Synonymy by Matsui (2007).] Material examined. – Japan: Ryukyu Province, Omotadake [NMNS 3430 (4426), 3438 (4455), 3438 (4456), 3466 (4602), 3466 (4603)]. Taxonomic notes. – Recently, an examination of the lectotype and a paralectotype of Rana okinavana revealed that the species is identical with R. psaltes. Therefore, the name R. psaltes is relegated to a subjective junior synonym of R. okinavana (see Matsui, 2007). This author stated that R. psaltes from Taiwan (Chou, 1994) should be mentioned as R. okinavana too. Diagnostic characters. – Rana okinavana is characterized by the following combination of characters: (1) body stocky; (2) SVL of adult males 41.6 ± 1.4 (40–42.8 mm), adult females 46.7 ± 2.9 (44.6–48.8 mm); (3) nostril directed laterally; (4) marginal grooves on fingers present or absent; (5) marginal grooves on toes present; (6) mid-dorsal stripe present; (7) external vocal sac absent; (8) nuptial pad poorly developed, absent on prepollex but present as small pad on median surface of first finger; (9) suprabrachial gland present and elongate; (10) nest construction behavior present; (11) spinules on back absent in adult males and females; (12) spinules on ventrum absent in adult males and females; (13) tibio-tarsal articulation reaching eye center to near nostril; (14) finger tips dilated; (15) toe tips dilated; (16) relative length of fingers II<I<IV<III; (17) relative length of toes I<II<V<III<IV; (18) pigmented eggs; (19) larval keratodont formula 1:1+1/1+1:2; (20) Calling: 17–25 loud, fast-repeated, “gulo” pulses. Distribution. – Japan (Ryukyu Province).Published as part of Chuaynkern, Yodchaiy, Ohler, Annemarie, Inthara, Chantip & Duengkae, Prateep, 2010, A Revision Of Species In The Subgenus Nidirana Dubois, 1992, With Special Attention To The Identity Of Specimens Allocated To Rana Adenopleura Boulenger, 1909, And Rana Chapaensis (Bourret, 1937) (Amphibia: Anura: Ranidae) From Thailand And Laos, pp. 291-310 in Raffles Bulletin of Zoology 58 (2) on page 302, DOI: 10.5281/zenodo.534286
Comics and dementia care: I know how this ends and graphic medicine
No full textPresented at the DC Research Café (May 14, 2020). Peter Wilkins presents the Douglas College Dementia Comics project which explores the potential of comics to enhance the impact of dementia care research. I Know How This Ends is the second volume in a series that started with Parables of Care: Creative Responses to Dementia Care (2017). This comic book presents, in synthesized form, stories crafted from narrative data collected via interviews with professional caregivers, educators, and staff at Douglas College in Vancouver, Canada, who have cared for relatives and people with dementia in hospital. The intention of the book is to show the importance of feeling in care-giving, the professional aspects of which are sometimes at odds with the family systems aspect of dementia. Douglas College Comics Project members also Marie-Pier Caron, Nursing and Ruhina Rana, Nursing
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