636 research outputs found
Tracing Catalan modernities: the space of book publishing and the graphic arts
No full textItem does not contain fulltextBy relying on a case study of socio-economic restructuring in the sub-sectors of book publishing and the graphic arts, this dissertation proposes that each time Catalonia has acquired the political apparatus of quasi-state functions at the regional level it has severed its ties to a trans-Atlantic space of cultural flows, with direct consequences for its regional economic development trajectory. Through archival research the author traces the particular developmental pathway of Catalan book publishing and the graphic arts emerging during a mid-19th century period of cultural "reawakening", extending through the urban cultural milieu of Barcelona's turn-of-the-century artistic and literary avant-garde , and analyzes the impact on cultural production resulting from Catalonia's intellectual and political elite assuming regional autonomy in the WWI era. The study then focuses on the emergence of an anti-Franco cultural front in Barcelona in the post-war period, harbingers of a reworked cultural politics which situates Barcelona as a central publishing pivot within the broader Spanish-language world. Through extensive use of snow-ball interviews with publishers, literary agents, artists and writers in Barcelona, the author then attempts to reveal the current cultural and economic landscape for both Catalan- and Spanish-language publishers, intent on drawing conclusions vis a vis Barcelona's current role within an increasingly globalized publishing realm. By centering analysis on the norms and social conventions underlying the economic practices of agents in the Catalan publishing field, the author concludes that Barcelona's has lost some of its center of gravity within the wider Spanish-speaking world, and has entered a "post-dissident" phase in Catalan-language publishing characterized by extensive public sector involvement under the guise of neoliberal reform.University of California, 01 januari 1999Promotor : Onbekend, N.N
A pollen analytical study of faeces from wiegon, Anas penelope . A case study
No full textPollen analysis of faeces from bird (also mammals (King 1977)) gives important additional information about attractive and nutrient rich pla nt fodder hardly traceable using macro analysis or by field observation (e.g. Kaasa 1959, n.n 2009). Despite the Anas penelope case study is based on a minimum of samples, new nutrient rich taxa not recorded during field observation are found. References to broader studies are give
Technological University Delft (Holland)
No full textSome data on the organization, the educational program and study results, the social arrangements for students and the building program
A second letter concerning civil comprehension: by the author of the first [electronic resource].
No full textSigned: N.N., i.e. Charlwood Lawton.Drop-head title.Imprint from colophon.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Predicting drug (combination) response through data integration: The whole is greater than the sum of its parts
No full textIn order to improve anti-cancer treatment, we need to better understand why some patients respond to a given anti-cancer treatment, while others do not. To this end, several large-scale drug response screens have been performed in recent years, in which hundreds of tumor cell lines have been characterized formany molecular features (e.g. mutations, CNAs, methylation and gene expression), as well as for response to hundreds of anti-cancer drugs. By statistically associating these molecular features with the drug response, we can identify biomarkers of drug response: markers that (after thorough testing) can ultimately be used to help identify which treatment should be given to which patient.While performing such statistical analyses, we found that there are strong relationships between the different molecular datasets (e.g. mutations, CNAs, methylation and gene expression) and that these relationships can negatively affect our ability to identify biomarkers. Following these results, we have developed TANDEM, a method to identify biomarkers while taking into account these relationships between datasets, and iTOP, a method to infer how different datasets are related to each other.For difficult cases where the number of cell lines is very small, we have developed a method that predicts drug response simultaneously for all drugs in the screen, thereby gaining statistical power. We based this method on a machine learning methodology called multi-task learning. In contrast to other multi-task learning methods, our approach provides insight into which features are important for a given treatment, thereby allowing us to identify biomarkers fromthese models.Finally, we analyzed a screen of 54 drug combinations across 765 cell lines. We report which combinations show synergy (i.e. where the effect of the combination was larger than onewould expect based on the individual drug effects) most frequently, hence making them broadly applicable. In addition, for each drug combination, we statistically associated molecular features (i.e. mutations, copy number aberrations, gene expression and proteomics) with the synergy, from which the strongest associations may be good candidate biomarkers.Pattern Recognition and Bioinformatic
The Virtual Surgical Pelvis: Anatomy Visualization for Education and Surgical Planning
No full textThis thesis deals with visualizing anatomical data for medical education and surgical planning purposes. To this end, we have developed a detailed virtual atlas, the Virtual Surgical Pelvis (VSP),which unifies surgically relevant knowledge on pelvic anatomy. We provide methods to share the knowledge contained in the VSP for educational purposes, and to visualize the VSP in the context of individual patients for pre-operative planning purposes.Chapter 2 deals with a representation developed to unify spatial and non-spatialanatomical knowledge. Via this representation, it is possible to store, access and visualize these heterogeneous datasets through a shared coordinate system. This allows us to construct the VSP atlas, a process which we describe in detail in Chapter 3, where we also detail the application potential of the VSP. We present several examples of the VSP mapped to clinical pre-operative MRI scans, as examples of how the VSP can be used to enrich clinical data with surgically relevant information that is not available from the scans themselves.To share the VSP for educational purposes, we present an online tool, the Online Anatomical Human (OAH) in Chapter 4. OAH runs directly in the browser and can be used to explore the complex relation between 2D and 3D anatomy. Furthermore, annotations can be added directly on the 3D structures for quizzing purposes, or to enrich the VSP further with annotations performed by experts. The OAH was successfully deployed in aMassiveOpenOnline Course (MOOC), where thousands of studentsworldwide used the application to study pelvic anatomy.While the VSP is based on multiple datasets, it does not include all potential topological anatomical variations in branching structures such as vessels and nerves. Illustrations and text are traditionally used by medical specialists to study these variations, but it is difficult to compare complex variations in such illustrations. Therefore, in Chapter 5 we present an interactive visualization application for anatomical variations, which allows the user to compare and explore variations of branching structures interactively for educational purposes. With methods inspired by graph theory, users can intuitively select groups of variations, based on a similarity measure, and compare local differences.In Chapter 6, we present a state-of-the-art report on multimodal medical visualization. We describe the basics of medical image acquisition, and the clinical workflow for dealing with such data. We discuss suitable rendering and visualization techniques appropriate for rendering multiple modalities. The core contribution of this work is a taxonomy based on the multimodal medical visualization applications so far, the visualization techniques they employ, and the medical domain context. Additionally, we provide an outlook on open problems and potential future research directions.To make the VSP patient-specific and to enrich the VSP with more datasets, registration is needed. Unfortunately, current registration software is often difficult to use for non-medical-imaging-experts. In Chapter 7 we present a new registration application, RegistrationShop, that allows user to register 3D medical image datasets based on 3D visualizations and simple interactive transformation tools. Based on real-time visual feedback via comparative visualization techniques, users can inspect the current registration result and iteratively improve the alignment. Besides basic interactive transformation tools, we propose a novel way of placing corresponding landmark-pairs in 3D volumes.After combining the VSP atlas with patient-specific pre-operative MRI scans, we visualize the results in an interactive application for surgical planning aimed at pelvic oncological procedures, entitled PelVis, which is described in Chapter 8. We present visualization methods to represent context, target, and risk structures for surgical planning of the Total Mesorectal Excision (TME) procedure. We employ distance-based and occlusion management techniques to represent the patient-specific pathology and anatomy. Furthermore, we visualize the confidence in the registration outcome in relation to the distance of the target structure to the risk zones.The research described in this thesis was supported by the Dutch Technology Foundation STW via project 10903: “High-definition Atlas-based surgical planning for Pelvic Surgery”
Biomass Derived Binder: Development of the scientific basis for methodologies that enable the production of renewable sustainable cement based on ashes derived from the conversion of biomass residues as determined by qualitative mineralogical analysis
No full textThe aim of this project was the development of the scientific basis for methodologies that enable the production of renewable sustainable cement (i.e. BioCement) based on ashes derived from the conversion of biomass residues. Within this project, biomass ash and derived products were developed at the laboratory scale, and their functionality was tested with respect to sustainability and composition (relative to OPC). The ultimate goal was to prove the possibility of replacing traditional Portland cement with a renewable BioCement in typical cement-based products such as concrete. The environmental superiority of theoretical BioCement is based on assumed negligible CO2 emissions during production. Through a Life Cycle Analyses on the developed biomass ashes (and preferably fully functional BioCement), the environmental impact and the potential to replace Portland cement with theoretical BioCement was quantified. The investigations included three types of biomass (ash) utilization:Materials and Environmen
Review of the book by N.N. Ostroumov “The Contract of Carriage of Goods in International Air Transport” (“Statut” publishers, 2009 – 267 p.)
No full textThe book by N.N. Ostroumov, “The Contract of Carriage in International Air Transport Operations”, is the first book in Russia dedicated exclusively to the contract of air carriage and analysis of current problems of carriage by air both on the international level and in Russia. The book may serve as a scientific and practical commentary and comparative analysis of the Montreal Convention 1999 and the system of the Warsaw Convention 1929, as well as Russian and foreign legislation and court practice in this field. The author analyzes the legal sources on international air carriage, conflict of law issues, the legal nature of the contract of carriage and obligations to arrange carriage. A central part of the book is taken by such issues as the carrier’s liability towards passengers for death and personal injury, cargo claims, late delivery of the cargo, recovery of damages. The book also covers the issue of claims against the carrier, and the insurance of carrier’s liability
Towards the development of carbon dioxide neutral renewable cement (biocement)
No full textStructural EngineeringCivil Engineering and Geoscience
TIME RESOLVED ICLAS SPECTROSCOPY of RADICAL
No full textAuthor Institution: Department of kinetics and katalysis, N.N. Semenov Institute of Chemical Physics; Levedev Physical Institute, N.N. Semenov Institute of Chemical Physics radical absorption spectrum was recorded in the 1.22-1.27 mkm range with the spectral resolution using intracavity laser absorption spectrometer based on color centers LiF laser. The rotationnaly resolved vibronic bands: (0,0,0)-(0,0,0), (0,2,0)-(0,1,0) and (0,0,2)-(0,0,1) of the electronic transition were analyzed. The mechanism of the forbiden rotational subbands appearance will be discussed
- …
