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The IAAF’s hyperandrogenism regulations suspended
No full textOn 27 July, the Court of Arbitration for Sport (‘CAS’) delivered a landmark ruling on the regulation of gender in sport. The decision explores how the categorisation of sport on the basis of sex can be best reconciled with the “biological reality” that human sex cannot necessarily be divided so clearly. Dr. Seema Patel, Senior Lecturer at Nottingham Trent University, Deputy Director of the Centre for Sports Law and author of ‘Inclusion and Exclusion in Competitive Sport: Socio-Legal and Regulatory Perspectives,’ reviews the case and suggests that sport regulation must be cautious of traditional criteria to determine eligibility in sports
Jun N-terminal kinase 1 (JNK1) as a molecular target to limit cellular mortality under hypoxia
No full textMany pathological conditions and environmental impacts lead to a decrease in tissue oxygen supply and severe cellular hypoxia. This secondary hypoxia can disturb cellular homeostasis, limiting the efficacy of the prescribed treatment for the primary disease, eventually leading to cellular and organismal death. Jun N-terminal kinase 1 (JNK1) plays a central role in the development of cellular damage under hypoxia, hypoxia/reoxygenation and ischemia/reperfusion conditions. Therefore, we selected JNK1 protein as a molecular target to limit cellular damage and death during hypoxia. The primary objective of this research was to study the influence of the suppression of JNK1 on the development of cellular hypoxic damage. It was hypothesized that suppression of JNK1 will decrease cellular mortality under hypoxia and may increase the efficacy of traditional treatment of many pathological conditions. The hypothesis was verified under both in vitro and in vivo conditions. Another objective was to develop a non-viral system for intracellular delivery of antisense oligonucleotides (ASO) and small interfering RNA (siRNA). ASO and siRNA targeted to JNK1 mRNA delivered by neutral and cationic liposomes, respectively, showed high efficiency in suppressing JNK1 protein. Such suppression limited the caspase dependent apoptosis signaling pathway and decreased cellular mortality induced by severe hypoxia. The results suggest that JNK1 protein might be an attractive target for antihypoxic therapy to increase resistance to many pathological conditions and diseases accompanied by cellular hypoxia.Ph.D.Includes bibliographical references (p. 138-153)by Seema S. Betiger
The Post Office Horizon system and Seema Misra
Full text linkThe author highlights the significance of the Seema Misra case in raising questions about the reliablity of the Post Office Horizon system and more widely suggesting that all digital systems have the possibility of latent defects, and these can never be discounted. He argues that when the efficacy of digital systems is called into question in legal proceedings, the onus of proof must be placed on the supplier of these systems and not the accuser.Index words: Post Office; Horizon; prosecutions; software errors; disclosure Full transcript of the trial Regina v Seema Misra, T2009007 (England & Wales; theft; electronic evidence; Post Office Horizon System; ‘reliability’ of computers) with case commentary and index to original papers held in the Documents Supplement of Volume 12: 2015
Development of novel zein-cellulose nanocomposite films
No full textZein is a hydrophobic biopolymer, which naturally forms biodegradable films. These films are rigid, brittle, and lack good mechanical and barrier properties for packaging applications. This study aims at improving the mechanical and barrier properties of zein films by the development of zein-cellulose nanocomposites. A ‘nanocomposite’ is a mixture of polymer matrix, which forms the continuous phase and the filler (having at least one dimension less than 100nm), which forms the dispersed phase. Zein-cellulose nanocomposites have zein as the matrix and cellulose as the filler. Nano-sized cellulose was prepared using wet-media milling machine and mass ratios of 1%, 3%, 5% and 10% of both, naked (not stabilized) nano-cellulose and GA - stabilized nano-cellulose were used in the film formulation. Tributyl citrate (TBC) was used as the plasticizer. The films were prepared using solvent-cast technique and characterized to test their mechanical and barrier properties. The controls were pure zein films and films with only plasticizer. Texture Analysis showed that filler loading of 5% was most effective in increasing the elongation-at-break to about 16 to 20 times of the controls. However, the tensile strength did not change. Water vapor permeability of the nanocomposites was minimum at 1% by wt. of naked cellulose (~4 times less than control) or at 5% by wt. of stabilized cellulose (~6 times less than control). Water absorption results showed that the rate of water uptake decreased as the filler loading increased. DSC and FTIR suggested that there is no interaction between the zein and the nano-cellulose in the films. The AFM results showed that the films’ surface is flat, but the thickness of the films increased with filler loading. Therefore, incorporation of nano-cellulose improved the flexibility and water barrier properties of the films. Gum Arabic, which was used as a stabilizer for nano-cellulose, seemed to have aided the even distribution of cellulose in the zein matrix. Thus, these films can be a good starting point to further study the arrangement of cellulose within the zein matrix and test its potential applications on food systems and as edible films.M.S.Includes bibliographical referencesby Seema Lakshmana Ra
Not Available
No full textVersion: 1.0.0
Imports: utils, minimalRSD, stats
Published:2017-03-21
Author: Shwetank Lall [aut, cre], Arpan Bhowmik [ctb], Eldho Varghese [aut], Seema Jaggi [ctb], Cini Varghese [ctb]
Maintainer: Shwetank Lall
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
Citation: FMC citation info
In views: ExperimentalDesignAn R package to generate cost effective minimally changed run sequences for symmetrical as well as asymmetrical factorial designsNot Availabl
FUZZY ROUGH INFORMATION MEASURES AND THEIR APPLICATIONS
No full textFUZZY ROUGH INFORMATION MEASURES AND THEIR APPLICATIONS
Seema Singh1, D.S. Hooda2, S.C. Malik3
1&3Department of Statistics, M.D. University, Rohtak-124001, Haryana, India
2Honorary Professor of Mathematics, G.J. University of Science and
Technology, Hisar- 125001, Haryana, India
Corresponding Author – D.S. Hooda
ABSTRACT
The degree of roughness characterizes the uncertainty contained in a rough set. The rough entropy was
defined to measure the roughness of a rough set. Though, it was effective and useful, but not accurate
enough. Some authors use information measure in place of entropy for better understanding which
measures the amount of uncertainty contained in fuzzy rough set .In this paper three new fuzzy rough
information measures are proposed and their validity is verified. The application of these proposed
information measures in decision making problems is studied and also compared with other existing
information measures.
KEYWORDS AND PHRASES
Fuzzy Rough Set, Similarity Information Measure, Logarithmic Information Measure, Weighted
Information Measure and Decision Making Proble
Design and Development of Gateway Port Scanner
No full textIn today’s enterprise environment hackers and intruders have made many successful
attempts to bring down high-profile company networks and web services. Many
methods have been developed to secure the network infrastructure and communication
over the Internet, like the use of firewalls, encryption, and virtual private networks.. Using prevention systems, information can be collected from known types of attacks and find out if networks or hosts are being compromised. The information collected this way can be used to harden the network security, as well as it can be used to solve legal issues.
Both commercial and open source products are available for this purpose. Many
vulnerability assessment tools are available in the market that can be used to assess different types of security holes present in the network. In this Thesis the focus would be on open source network security tools.
Open-source systems are not going to replace offerings from commercial vendors.
They do, however, offer an increasingly viable alternative. Open-source solutions
should be evaluated side-by-side with commercial as part of a tender process. Judged on their merits, open-source solutions may prove to be the best solution for many organizations.Computer Science & Engineering Department, Thapar University (Deemed University), Patiala-147004
A policy analysis of two preschool prevention programs in Ontario
Full text linkThe purpose of this research was to examine issues relevant to best practices for preschooler mental health prevention policy so as to inform future prevention policy. Data were gathered through the examination of two preschool prevention programs, Ontario Early Years Centres (OEYCs) and Healthy Babies, Healthy Children (HBHC). These prevention programs were examined with respect to four major issues: (a) the ideology and origins of the program, (b) theoretical underpinnings, (c) research base, and (d) implementation and adaptation issues. To explore these four issues, qualitative methods were used in the form of document reviews (two documents for the Early Years Centres and two documents for the Healthy Babies, Healthy Children) and key informant interviews (seven informants for the Early Years Centres and six informants for Healthy Babies, Healthy Children). The main finding regarding the ideology and origins of the Early Years Centres and Healthy Babies, Healthy Children is that a mixture of values related to both personal well-being and collective well-being was used in the framing of both the problem(s) and solution(s). Furthermore, informants indicated that centres were created by the government in response to both timing (an influx of federal funding for programs for preschool children) and the influences of key people. A key finding regarding the theoretical underpinnings of both programs is that brain-based development theories were used to explain how the quality of early sensory stimulation during critical early periods influences the brain’s ability to develop properly. The centres were used improve the quality of stimulation for preschool children by assisting parents and children through the use of centre-based programs, whereas Healthy Babies, Healthy Children programs used primarily family-based programs. Findings for the research base were based on evaluations conducted on both programs. While the evaluation reports suggest encouraging conclusions regarding the effectiveness and efficiency of both programs, the methodologies used in the evaluations of both programs have major limitations. As for best practices with regard to the Early Years Centres and Healthy Babies, Healthy Children, key informants noted the lack of comprehensiveness, accessibility, follow-up assessments, and theoretical basis of the programs and the issues of insufficient dosage of the interventions. Cultural sensitivity was deemed by informants to be a strong aspect of both programs. Key informants also noted that centres are struggling to provide consistent programming across Ontario. Additionally, the Healthy Babies, Healthy Children program’s home visitation services lack intensity and may not be effective because this program uses lay home visitors in its primary approach to home visitation. Findings regarding implementation and adaptation for the centres include a clear message from informants that the ease of implementation was dependent on whether the centre began in a pre-established organization. Additionally, key informants asserted that the extent of community ownership and adaptation varied from centre-to-centre across Ontario. The implementation and adaptation issues faced by Healthy Babies, Healthy Children are evidenced in the lack of pilot projects the program undertook before it was implemented province-wide. This approach led to implementation that was not based in teachings from research evidence or community-based knowledge. While informants commended HBHC’s ability to adapt to the community’s needs, the community’s sense of ownership of the program is still questionable. The findings of this research have implications for improving preschool mental health prevention policy in all four categories. These implications include: (a) more thorough framing of the problem(s) and solution(s), (b) a deeper understanding of the research base upon which the greatest program impacts can be achieved, and (c) the need for pilot projects before province-wide implementation
Research Reimagined: The Dissertation-to-Book Journey and Building a Scholar-to-Author Presence
No full textThis capstone project, completed for a second master\u27s degree after a Ph.D., discusses aspects of transforming the doctoral dissertation on digital versus manual mediums in fashion design into a research monograph book proposal for academic publication. It reflects on a publisher\u27s requirements and the process, including de-thesizing the dissertation, planning the book\u27s structure, rewriting sample chapters to improve flow and readability, and creating a table of contents that demonstrates the work\u27s development into a publishable book rather than a dissertation. Another part of the project includes developing an author platform through blog posts and platforms such as Substack, preparing the groundwork for connections between the research and broader audiences. Due to the unpublished and proposed nature of the work, some details are not included in this document
Aqueous protocol for allylic arylation of cinnamyl acetates with sodium tetraphenylborate using Bedford-type palladacycle catalyst
No full textAllylic arylation of cinnamyl acetates with sodium tetraphenylborate using 0.002 mol % of Bedford-type palladacycle catalyst is described. The developed methodology is applicable for wide range of cinnamyl acetates furnishing excellent yields up to 93%. Notably all reactions proceed smoothly under mild reaction conditions in water under air atmosphere.The author Seema Arun Ghorpade is thankful to the Institute of Chemical Technology, Matunga, Mumbai and Department of Science and Technology (DST) India for providing DST INSPIRE Senior Research Fellowship (IF110631). This work was supported by the King Abdullah University of Science and Technology (KAUST baseline funding and GCR grant FIC/2010/07). Authors are gratefully acknowledging support from King Abdullah University of Science and Technology (KAUST), Saudi Arabia
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