65 research outputs found
The total synthesis of mycothiol and new inhibitors of carbohydrate processing enzymes
No full textThe work described in this dissertation covers a wide range of disciplines within organic chemistry, with the common goal of obtaining more information about various carbohydrate-processing enzymes. Carbohydrate-processing enzymes are garnering an increasing amount of attention relative to their more well-studied protein-processing counterparts, as they are ubiquitous and implicated in various regulatory, signaling and metabolic processes in eukaryotic cells. Chapter 1 involves the synthesis of anomeric phosphothioates as possible O-GlcNAc transferase inhibitors, and a mechanistic study on the anomeric Pudovik rearrangement of thiophosphites to thiophosphonates is described. Chapter 2 is an account of the development of a facile method for functionalizing 2-methyl thiazoline rings, and several selective GlcNAc-thiazoline-based O-GlcNAcase inhibitors were synthesized by this method. Chapter 3 details the 16-step total synthesis of the M. tuberculosis antioxidant carbohydrate mycothiol by a new intramolecular glycosylation method. The method is amenable to glycosylations of 2-deoxy-2-aminoglyosides, a unique aspect among such reactions. The efficiency of the synthetic route to mycothiol makes it attractive as a template from which to design analogs as potential inhibitors of enzymes involved in the biosynthesis of mycothiol. An apparently unprecedented 1,9-hydride shift is also described in the third chapter. Chapter 4 describes a tripartate prolonged-release drug delivery system, in which the drug of interest (ethynyl estradiol in this study) is coupled, through a variable linker, to another carrier drug with a long half-life and a relatively high inhibitory concentration. The effect of steric bulk on the in vitro release of ethynyl estradiol was evaluated, showing a direct relationship between steric bulk around the ester linkage and ethynyl estradiol release time. In vivo data from pigs also seemed to point to an increase in drug bioavailability with the 3-part system. Finally, chapter 5 describes early efforts to synthesize boronic acid analogs of folic acid and antifolates.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Kehinde Ajay
Book review: The new age of empire: how colonialism and racism still rule the world by Kehinde Andrews
No full textIn The New Age of Empire: How Colonialism and Racism Still Rule the World, Kehinde Andrews explores how the intellectual, political and economic frameworks inherited from colonialism are still governing today’s world, resulting in a new age of empire that perpetuates racism, white supremacy and global economic inequalities. This compact and comprehensive book challenges the grand narratives of the Enlightenment, Western linear progress and developmentalism and offers a broader and more complete picture of the continuing problems of racism and the imperial mentality, writes Ayşe Işın Kirenci. If you are interested in this book review, you can listen to a podcast of author Kehinde Andrews discussing The New Age of Empire at an LSE event held on 27 April 2021. The New Age of Empire: How Colonialism and Racism Still Rule the World. Kehinde Andrews. Penguin Books. 2021
Book review: The new age of empire: how colonialism and racism still rule the world by Kehinde Andrews
No full textIn The New Age of Empire: How Colonialism and Racism Still Rule the World, Kehinde Andrews explores how the intellectual, political and economic frameworks inherited from colonialism are still governing today’s world, resulting in a new age of empire that perpetuates racism, white supremacy and global economic inequalities. This compact and comprehensive book challenges the grand narratives of the Enlightenment, Western linear progress and developmentalism and offers a broader and more complete picture of the continuing problems of racism and the imperial mentality, writes Ayşe Işın Kirenci. If you are interested in this book review, you can listen to a podcast of author Kehinde Andrews discussing The New Age of Empire at an LSE event held on 27 April 2021. The New Age of Empire: How Colonialism and Racism Still Rule the World. Kehinde Andrews. Penguin Books. 2021
Book review: The new age of empire: how colonialism and racism still rule the world by Kehinde Andrews
No full textIn The New Age of Empire: How Colonialism and Racism Still Rule the World, Kehinde Andrews explores how the intellectual, political and economic frameworks inherited from colonialism are still governing today’s world, resulting in a new age of empire that perpetuates racism, white supremacy and global economic inequalities. This compact and comprehensive book challenges the grand narratives of the Enlightenment, Western linear progress and developmentalism and offers a broader and more complete picture of the continuing problems of racism and the imperial mentality, writes Ayşe Işın Kirenci. If you are interested in this book review, you can listen to a podcast of author Kehinde Andrews discussing The New Age of Empire at an LSE event held on 27 April 2021. The New Age of Empire: How Colonialism and Racism Still Rule the World. Kehinde Andrews. Penguin Books. 2021
Art as Symbol of Power and Control among the Yorùbá
No full textThe Yorùbá are popular for the peculiar art forms, which include woodcarving, textile design, metalwork, cloth weaving and embroidery, beadwork, costuming, pottery, architectural ornamentation, mural paintings, body beautification among others. The Yorùbá artists produce unique forms in these diverse areas of art. These forms often bear visual renditions of symbolism that are pregnant with socio-political meanings. This paper is, therefore, aimed at examining the symbolism of power and control among the Yorùbá found on some of the art forms. This is with the view of understanding the belief of the people about power and its control in the development of the Yorùbá nation. Photographic data for the paper were gathered from written literature and fieldwork. Formal and contextual methods were employed in the analysis of the data. In the course of analysis, oral traditions such as songs, proverbs, etc. were used. It was found out that the exercise of socio-political power in the Yorùbá society is a product of their belief system and philosophy as expressed in their art forms
Art as Symbol of Power and Control among the Yorùbá
No full textThe Yorùbá are popular for the peculiar art forms, which include woodcarving, textile design, metalwork, cloth weaving and embroidery, beadwork, costuming, pottery, architectural ornamentation, mural paintings, body beautification among others. The Yorùbá artists produce unique forms in these diverse areas of art. These forms often bear visual renditions of symbolism that are pregnant with socio-political meanings. This paper is, therefore, aimed at examining the symbolism of power and control among the Yorùbá found on some of the art forms. This is with the view of understanding the belief of the people about power and its control in the development of the Yorùbá nation. Photographic data for the paper were gathered from written literature and fieldwork. Formal and contextual methods were employed in the analysis of the data. In the course of analysis, oral traditions such as songs, proverbs, etc. were used. It was found out that the exercise of socio-political power in the Yorùbá society is a product of their belief system and philosophy as expressed in their art forms
Yoruba Woodcarving: New Characteristics, New Uses
No full textYoruba traditional woodcarving has existed for immemorial generations, though the perishable nature of woodcarving makes it impossible to ascertain when it actually started. It is one of the most prominent and profuse art practices of the Yoruba. It is used majorly to service the pantheon of Yoruba gods like Sango, Ogun, Ifa, et cetera, cults like Oro and Ogboni including other religioninclined worships and acts of veneration. It is also used as anarchitectural support in the palace and in the houses of Yoruba title holders. Since the contacts of the Yoruba with the agents of westernization such as colonialism, urbanization, education, new technology, Christian religion etc., the traditional Yoruba woodcarving has changed to contemporary whereby it possesses new characteristics and new uses. This paper, therefore, aims at focusing on the transition of Yoruba woodcarving from traditionalto contemporary. It takes a cursory look at the contemporary characteristics and uses of the Yoruba woodcarving that make it different from its traditional forms. Data for the study were sourced from secondary literature and oral interviews The works of a two Yoruba woodcarvers were examined and analyzed using formal and contextual methods, the result of the study found that, the contemporary woodcarving now have dimensions of elongation, abstraction and texturisation and they are now mainly used for adornment of homes, decorative pieces and as a souvenirs. The conclusions were drawn based on the outcome of the analysis
A tradução da literatura pós-colonial de Kehinde de Buchi Emecheta para o português brasileiro
No full textDissertação (mestrado) — Universidade de Brasília, Instituto de Letras, Departamento de Línguas Estrangeiras e Tradução, Programa de Pós-Graduação em Estudos da Tradução, 2023.A imposição da língua inglesa como norma de prestígio durante a colonização britânica
desencadeou significativas variações e mudanças no inglês falado nas regiões
colonizadas, originando novos usos da língua. A versão normativa foi, então, substituída
por um discurso adaptado ao espaço onde as colônias foram estabelecidas, como forma
de reconhecimento e valorização de suas próprias culturas e identidades. Do desejo de
libertação de valores e conceitos metropolitanos surge a literatura pós-colonial, com o
intuito de questionar e negar conceitos impostos pelo poder central, tais como a existência
de um código linguístico padrão que deva ser privilegiado. Dentre os escritores pós coloniais está a escritora nigeriana Buchi Emecheta (1944-2017). Em seu livro Kehinde
(1994), a trama desenrola-se através de uma língua desconstruída, permeada pelos ideais
pós-coloniais. Este trabalho tem por objetivo apresentar uma tradução comentada da obra,
inédita para o português brasileiro, investigar e responder que estratégias características
da literatura pós-colonial são de fato utilizadas pela autora e como poderiam ser
traduzidos os aspectos linguísticos e culturais presentes no livro em questão. Para tanto,
serão apresentados exemplos com trechos da tradução em comparação a trechos do texto fonte, com o intuito de oferecer alternativas tradutórias para Kehinde, no contexto
brasileiro. Então serão apresentadas as teorias de tradução que orientam a pesquisa, posto
que a análise a ser elaborada evolui num âmbito não-prescritivo, será apresentada a Teoria
dos Polissistemas, elaborada por Itamar Even-Zohar (1990), e os Estudos Descritivos,
desenvolvidos por Gideon Toury (1995). O contexto cultural, histórico e literário e a
prática tradutória serão discutidos a partir de teóricos como Bill Ashcroft, Jane Tutikian,
Homi Bhabha, Gayatri Spivak, Susan Bassnet, Tejaswini Niranjana, Anthony Pym, entre
outros. Desta forma, visto que ainda são poucas as traduções de literatura pós-colonial,
principalmente para o português brasileiro, pretende-se contribuir com informações para
futuras traduções de textos pós-coloniais.The imposition of the English language as norm of prestige during the British settling
resulted in significant variations and changes in the English spoken in the colonized
regions, originating new uses of the language. Therefore, the normative version was
replaced by a discourse adapted to the places where the colonies had been established, as
a recognition and appreciation of their own cultures and identities. The post-colonial
literature emerged to question and deny concepts imposed by the imperial power, such as
a standard linguistic code that should be privileged. One example of post-colonial
literature is Kehinde (1994), written by the Nigerian writer Buchi Emecheta (1944-2017).
This work intends to present a commented translation of Kehinde, unpublished for
Brazilian Portuguese, investigate and answer which strategies of post-colonial literature
are used by the author and how the linguistic and cultural aspects in the text could be
translated. Therefore, examples will be presented with excerpts from the translation
compared to excerpts from the source text, with the aim of offering translation alternatives
for Kehinde, in the Brazilian context. Furthermore, the translation theories that guide the
research will be presented, since the analysis to be elaborated evolves in a non prescriptive scope, the Polysystem Theory, developed by Itamar Even-Zohar (1990), and
the Descriptive Studies, developed by Gideon Toury (1995). The cultural, historical and
literary context and translation practice will be discussed from theorists such as Bill
Ashcroft, Jane Tutikian, Homi Bhabha, Gayatri Spivak, Susan Bassnet, Tejaswini
Niranjana, Anthony Pym, among others. Still, since post-colonial literature is not so
translated, especially to Brazilian Portuguese, this work can contribute for future
translations of postcolonial texts.Instituto de Letras (IL)Departamento de Línguas Estrangeiras e Tradução (IL LET)Programa de Pós-Graduação em Estudos da Traduçã
Patriarchy, Gender Discrimination and Resistance in Buchi Emecheta’s Second Class Citizen (1974) and Kehinde (1994)
No full text30cm ; 50p.As one of the most figures of the Nigerian Literature, Buchi Emecheta displays a vivid portrayal of the bitter realities of certain patriarchal practices in the African culture, which not only thwarted Black women but also hampered them from having a position in the society. This study selected two of her novels, Second Class Citizen (1974) and Kehinde (1994). It discusses issues of patriarchy, gender discrimination and Resistance in both novels. This thesis is based on Alice Walker’s Womanism, developed in her collection of essays In Search Of Our Mothers Garden: Womanist Prose (1983). In this analysis we have tried to show that despite the fact that the two works are twenty years apart, the author is still discusses the same issues that come from her cultural and personal experiences. The author has portrayed the oppression practiced towards women. She has depicted how women are dominated by men in patriarchal societies. Emecheta has also described how these women rebel and seek for independence through the process of education. This study concludes that Emecheta succeeds in using resistant and powerful female character, aiming at identifying the suffering of women as she underlines a strong autobiographical quality of writing her novels. As well as, women as a subject of oppression are always seeking for freedom
Cultural symbols in textile production and nation building in Nigeria
No full textThe study examined cultural symbols in textile production and nation building in Nigeria with the thesis that the preservation of a nation’s culture is synonymous with nation building. People\u27s culture is a function of the environment in which they are situated physically and naturally. Nigeria is yet to annex her cultural imperatives for nation building, especially through the vehicle of textile production and the associated designs which are the objective and fulcrum around which this study revolves. Practice led studio approach was used in the production of both the mpi-enyi and mbor batiks. In the findings, the significance of mpi-enyi and mbor cultural symbols in the exploration of batik textile design was highlighted and their usage explained. Also, the role of cultural symbols in textile production and nation building through cultural preservation, annexation of development, moral education, preservation of instruments for orderly social mobility, and economic development was explained. The study, therefore, concluded that the preservation of a nation\u27s culture is a sine qua non for nation building. It was therefore recommended that Nigeria should place much premium on her cultural imperatives through the cultural preservation of her artefacts for the requisite nation building
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