12 research outputs found
L’esperienza dei moduli formativi in materia economico-aziendale all’Università di Trieste nel triennio 2015-2017
No full textQuesto contributo ha l’obiettivo di presentare la prima esperienza di organizzazione e realizzazione dei Moduli Formativi in materia di economia e gestione aziendale dell’Università di Trieste, realizzati nel mese di settembre degli anni 2015, 2016 e 2017. Questi Moduli, coordinati da Patrizia de Luca (DEAMS – UniTS), sono stati svolti con la collaborazione del Prof. Girolamo Piccolo (Istituto “L. da Vinci – G.R. Carli – S. de Sandrinelli”, Trieste.) nel 2015, della prof.ssa Adele Intini (ISIS G. Galilei, Gorizia) nel 2016 e dei proff. Francesco Venier (DEAMS – UniTS) e Girolamo Piccolo nel 2017. Dopo una breve introduzione del progetto, nei successivi paragrafi viene proposta la descrizione dei moduli del triennio, l’esperienza vissuta dai docenti e dagli studenti, rielaborata attraverso un’analisi qualitativa dei dati raccolti, e la sintesi conclusiva, volta soprattutto a mettere in luce i principali punti di forza e le eventuali criticità, come base su cui intervenire per migliorare la futura attività di orientamento
Traffic modeling for wildland-urban interface fire evacuation
No full textSeveral traffic modeling tools are currently available for evacuation planning and real-time decision support during emergencies. This paper reviews potential traffic-modeling approaches in the context of wildland-urban interface (WUI) fire-evacuation applications. Existing modeling approaches and features are evaluated pertaining to fire-related, spatial, and demographic factors; intended application (planning or decision support); and temporal issues. This systematic review shows the importance of the following modeling approaches: dynamic modeling structures, considering behavioral variability and route choice; activity-based models for short-notice evacuation planning; and macroscopic traffic simulation for real-time evacuation management. Subsequently, the modeling features of 22 traffic models and applications currently available in practice and the literature are reviewed and matched with the benchmark features identified for WUI fire applications. Based on this review analysis, recommendations are made for developing traffic models specifically applicable to WUI fire evacuation, including possible integrations with wildfire and pedestrian models
Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome
No full textColorectal cancer (CRC) is a histologically heterogeneous disease with variable clinical outcome. The role the tumour microenvironment (TME) plays in determining tumour progression is complex and not fully understood. To improve our understanding, it is critical that the TME is studied systematically within clinically annotated patient cohorts with long-term follow-up. Here we studied the TME in three clinical cohorts of metastatic CRC with diverse molecular subtype and treatment history. The MISSONI cohort included cases with microsatellite instability that received immunotherapy (n = 59, 24 months median follow-up). The BRAF cohort included BRAF V600E mutant microsatellite stable (MSS) cancers (n = 141, 24 months median follow-up). The VALENTINO cohort included RAS/RAF WT MSS cases who received chemotherapy and anti-EGFR therapy (n = 175, 32 months median follow-up). Using a Deep learning cell classifier, trained upon >38,000 pathologist annotations, to detect eight cell types within H&E-stained sections of CRC, we quantified the spatial tissue organisation and colocalisation of cell types across these cohorts. We found that the ratio of infiltrating endothelial cells to cancer cells, a possible marker of vascular invasion, was an independent predictor of progression-free survival (PFS) in the BRAF+MISSONI cohort (p = 0.033, HR = 1.44, CI = 1.029–2.01). In the VALENTINO cohort, this pattern was also an independent PFS predictor in TP53 mutant patients (p = 0.009, HR = 0.59, CI = 0.40–0.88). Tumour-infiltrating lymphocytes were an independent predictor of PFS in BRAF+MISSONI (p = 0.016, HR = 0.36, CI = 0.153–0.83). Elevated tumour-infiltrating macrophages were predictive of improved PFS in the MISSONI cohort (p = 0.031). We validated our cell classification using highly multiplexed immunofluorescence for 17 markers applied to the same sections that were analysed by the classifier (n = 26 cases). These findings uncovered important microenvironmental factors that underpin treatment response across and within CRC molecular subtypes, while providing an atlas of the distribution of 180 million cells in 375 clinically annotated CRC patients. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland
A new semi-orthotopic bone defect model for cell and biomaterial testing in regenerative medicine
No full textIn recent decades, an increasing number of tissue engineered bone grafts have been developed. However, expensive and laborious screenings in vivo are necessary to assess the safety and efficacy of their formulations. Rodents are the first choice for initial in vivo screens but their size limits the dimensions and number of the bone grafts that can be tested in orthotopic locations. Here, we report the development of a refined murine subcutaneous model for semi-orthotopic bone formation that allows the testing of up to four grafts per mouse one order of magnitude greater in volume than currently possible in mice. Crucially, these defects are also "critical size" and unable to heal within the timeframe of the study without intervention. The model is based on four bovine bone implants, ring-shaped, where the bone healing potential of distinct grafts can be evaluated in vivo. In this study we demonstrate that promotion and prevention of ossification can be assessed in our model. For this, we used a semi-automatic algorithm for longitudinal micro-CT image registration followed by histological analyses. Taken together, our data supports that this model is suitable as a platform for the real-time screening of bone formation, and provides the possibility to study bone resorption, osseointegration and vascularisation.Biomaterials & Tissue Biomechanic
Dataset of traffic dynamics during the 2019 Kincade Wildfire Evacuation
No full textThis dataset has been sourced from the Performance Measurement System of the California Department of Transportation. The data has been processed, analysed, presented and summarized in the paper: Rohaert et al., ‘Traffic dynamics during the 2019 Kincade wildfire evacuation’, [Submitted for peer-review to an international journal.], 2022.
CRediT author statement
Arthur Rohaert: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing - original draft, Writing - review & editing. Erica D. Kuligowski: Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Adam Ardinge: Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Writing - review & editing. Jonathan Wahlqvist: Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Steven M.V. Gwynne: Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Amanda Kimball: Conceptualization, Funding acquisition, Investigation, Methodology, Project Administration, Resources, Supervision, Validation, Writing - review & editing. Noureddine Bénichou: Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Enrico Ronchi: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - original draft, Writing - review & editing
Acknowledgements
This work has been funded under award 60NANB20D191 from the National Institute of Standards and Technology (NIST), U.S. Department of Commerce. The authors would like to thank the WUI-NITY team (Guillermo Rein, Nikolaos Kalogeropoulos, Harry Mitchell, Max Kinateder, Maxime Berthiaume). The authors also acknowledge the technical panel of the project for their support and guidance: Carole Adam, Amy Christianson, Tom Cova, Lauren Folk, Abishek Gaur, Paolo Intini, Justice Jones, Bryan Klein, Chris Lautenberger, Ruggiero Lovreglio, Jerry McAdams, Ruddy Mell, Elise Miller-Hooks, Cathy Stephens, Steve Taylor, Sandra Vaiciulyte, Xilei Zhao, Rita Fahy, Lucian Deaton, and Michele Steinberg
Dataset of traffic dynamics during the 2019 Kincade Wildfire Evacuation
No full textThis dataset has been sourced from the Performance Measurement System of the California Department of Transportation. The data has been processed, analysed, presented and summarized in the paper: Rohaert et al., ‘Traffic dynamics during the 2019 Kincade wildfire evacuation’, [Submitted for peer-review to an international journal.], 2022.
CRediT author statement
Arthur Rohaert: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing - original draft, Writing - review & editing. Erica D. Kuligowski: Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Adam Ardinge: Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Writing - review & editing. Jonathan Wahlqvist: Conceptualization, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Steven M.V. Gwynne: Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Amanda Kimball: Conceptualization, Funding acquisition, Investigation, Methodology, Project Administration, Resources, Supervision, Validation, Writing - review & editing. Noureddine Bénichou: Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - review & editing. Enrico Ronchi: Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing - original draft, Writing - review & editing
Acknowledgements
This work has been funded under award 60NANB20D191 from the National Institute of Standards and Technology (NIST), U.S. Department of Commerce. The authors would like to thank the WUI-NITY team (Guillermo Rein, Nikolaos Kalogeropoulos, Harry Mitchell, Max Kinateder, Maxime Berthiaume). The authors also acknowledge the technical panel of the project for their support and guidance: Carole Adam, Amy Christianson, Tom Cova, Lauren Folk, Abishek Gaur, Paolo Intini, Justice Jones, Bryan Klein, Chris Lautenberger, Ruggiero Lovreglio, Jerry McAdams, Ruddy Mell, Elise Miller-Hooks, Cathy Stephens, Steve Taylor, Sandra Vaiciulyte, Xilei Zhao, Rita Fahy, Lucian Deaton, and Michele Steinberg
QuaderniCIRD n. 17
No full textIl numero 17 (2018) della rivista QuaderniCIRD, particolarmente corposo, spazia su varie discipline: dalla Linguistica alla Psicologia dell’apprendimento, dalla Didattica della Matematica alla Didattica delle Scienze (in particolare, Astronomia e Geoscienze), dalla Letteratura italiana all’Economia. La prima parte del numero contiene sei contributi. Nel primo di questi, Francisco Marcos Marín, pur partendo dal contesto della Linguistica, offre un vivido esempio di come l’affrontare un problema con un approccio multidisciplinare possa essere molto fruttuoso per la produzione di nuove ipotesi e di nuovi risultati scientifici. Nel secondo, Chiara De Vita, Sandra Pellizzoni e Maria Chiara Passolunghi presentano le possibilità offerte dalla Psicologia cognitiva per riconoscere e stimolare le abilità matematiche fin dalla prima infanzia. I due successivi contributi sono dedicati alla Scuola secondaria di primo grado. L’articolo di Marina Rocco riguarda la Didattica della Matematica: vi si illustra un percorso che, mediante la piegatura della carta, prevede lo svolgimento di attività concrete atte a motivare alcuni concetti di geometria euclidea. Valentina Bologna e Stefano Minussi descrivono, invece, un’esperienza di peer-teaching per l’insegnamento dell’Astronomia. Nel quinto contributo, Costanza Geddes da Filicaia, dopo aver sinteticamente delineato la biografia e le opere di Giani Stuparich, propone una serie di itinerari nella realtà di Trieste, riferendosi alle parole stesse di tale autore. Nel sesto contributo, Patrizia de Luca, Girolamo Piccolo, Adele Intini e Francesco Venier illustrano un’esperienza triennale riguardante l’Economia e la Gestione aziendale, svolta nell’ambito dei Moduli Formativi, un’attività dell’Università di Trieste che si propone di avvicinare il mondo accademico a quello della Scuola secondaria di secondo grado. La seconda parte del numero contiene due recensioni, una delle quali riguarda un libro e l’altra software, e quattro notizie. Michele Stoppa, nel contesto delle Scienze geologiche, recensisce il testo UNESCOGeoparke in Österreich, Natur- und Kulturerlebnisführer der Universität Salzburg – Band 5, a cura di E. Hejl, H. Ibetsberger e H. Steyrer. Daniel Doz ed Eleonora Doz, nel contesto della Didattica della Matematica, recensiscono l’app per tablet e smartphone Photomath, della Photomath Inc. Ester Colizza presenta un resoconto della conferenza “Da Trieste ai Poli: i viaggi che hanno portato la ricerca triestina agli estremi del pianeta”, svoltasi a Trieste nell’ambito della mostra interattiva e multimediale “Trieste e la Scienza”. Verena Zudini segnala lo svolgimento a Trieste del XVII Congresso SISM - Società Italiana di Storia delle Matematiche. Dolores Ross relaziona sul Dutch Friday, evento con il quale la Sezione di Neerlandistica del Corso di Studi di Lingue Moderne per Interpreti e Traduttori dell’Università di Trieste ha festeggiato il suo cinquantacinquesimo anniversario. Francesco Princivalle, nell’esporre lo svolgimento della cerimonia di presentazione di un tronco fossilizzato di “araucaria”, recentemente messo a disposizione del Museo di Mineralogia e Petrografia dell’Università di Trieste, illustra le caratteristiche di questo reperto unico, dal valore scientifico inestimabile. LUCIANA ZUCCHERI, Direttore della rivista QuaderniCIRD CIRD - Università di Triest
Performance assessment in fingerprinting and multi component quantitative NMR analyses
No full textAn inter-laboratory comparison (ILC) was organized with the aim to set up quality control indicators suitable for
multi component quantitative analysis by nuclear magnetic resonance (NMR) spectroscopy. 36 NMR data sets (corresponding to
1260 NMR spectra) were produced by 30 participants using 34 NMR spectrometers. The calibration line method was chosen for the
quantification of a five-component model mixture. Results show that quantitative NMR is a robust quantification tool and that 26
out of 36 data sets resulted in statistically equivalent calibration lines for all considered NMR signals. The performance of each laboratory
was assessed by means of a new performance index (named Qp-score) which is related to the difference between the experimental
and the consensus values of the slope of the calibration lines. Laboratories endowed with Qp-score falling within the suitable
acceptability range are qualified to produce NMR spectra that can be considered statistically equivalent in terms of relative intensities
of the signals. In addition, the specific response of nuclei to the experimental excitation/relaxation conditions was addressed
by means of the parameter named NR. NR is related to the difference between the theoretical and the consensus slopes of
the calibration lines and is specific for each signal produced by a well-defined set of acquisition parameter
Computational pathology applied to clinical colorectal cancer cohorts identifies immune and endothelial cell spatial patterns predictive of outcome.
No full textColorectal cancer (CRC) is a histologically heterogeneous disease with variable clinical outcome. The role the tumour microenvironment (TME) plays in determining tumour progression is complex and not fully understood. To improve our understanding, it is critical that the TME is studied systematically within clinically annotated patient cohorts with long-term follow-up. Here we studied the TME in three clinical cohorts of metastatic CRC with diverse molecular subtype and treatment history. The MISSONI cohort included cases with microsatellite instability that received immunotherapy (n = 59, 24 months median follow-up). The BRAF cohort included BRAF V600E mutant microsatellite stable (MSS) cancers (n = 141, 24 months median follow-up). The VALENTINO cohort included RAS/RAF WT MSS cases who received chemotherapy and anti-EGFR therapy (n = 175, 32 months median follow-up). Using a Deep learning cell classifier, trained upon >38,000 pathologist annotations, to detect eight cell types within H&E-stained sections of CRC, we quantified the spatial tissue organisation and colocalisation of cell types across these cohorts. We found that the ratio of infiltrating endothelial cells to cancer cells, a possible marker of vascular invasion, was an independent predictor of progression-free survival (PFS) in the BRAF+MISSONI cohort (p = 0.033, HR = 1.44, CI = 1.029-2.01). In the VALENTINO cohort, this pattern was also an independent PFS predictor in TP53 mutant patients (p = 0.009, HR = 0.59, CI = 0.40-0.88). Tumour-infiltrating lymphocytes were an independent predictor of PFS in BRAF+MISSONI (p = 0.016, HR = 0.36, CI = 0.153-0.83). Elevated tumour-infiltrating macrophages were predictive of improved PFS in the MISSONI cohort (p = 0.031). We validated our cell classification using highly multiplexed immunofluorescence for 17 markers applied to the same sections that were analysed by the classifier (n = 26 cases). These findings uncovered important microenvironmental factors that underpin treatment response across and within CRC molecular subtypes, while providing an atlas of the distribution of 180 million cells in 375 clinically annotated CRC patients. © 2025 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland
