97 research outputs found
Measuring trilinear Higgs coupling in WHH and ZHH productions at the high-luminosity LHC
No full textDetermination of trilinear Higgs coupling (lambda(HHH) = kappa lambda(SM)(HHH)) through Higgs pair productions is a major motivation for the LHC high-luminosity phase. We perform a detailed collider simulation to explore the potential of measuring lambda(HHH) in the VHH (V = W, Z) production at the high-luminosity Large Hadron Collider. We find that the trilinear Higgs coupling in the standard model (lambda(SM)(HHH)) can be measured at the level of 1.3 sigma. Combining with the gluon fusion, vector boson fusion, and t (t) over bar HH channels, lambda(SM)(HHH) is expected to be measured at the level of 3.13 sigma. If no evidence of Higgs pair productions is observed, the VHH production, together with the gluon fusion channel, imposes a bound of 0.5 <= kappa <= 2.2 at the 95% confidence level.National Science Foundation of China [11275009, 11675002, 11635001]SCI(E)ARTICLE79
Título: Philosophia moral de principes, para su buena criança y govierno, y para personas de todos estados
No full textColofón al fin de la segunda parteColofón al final de la segunda parteSign.: ¶\p10\s, 2*\p10\s, A-Z\p8\s, 2A-2B\p8\s; [cum]\p2\s, 2C-2Z\p8\s, 3A-3B\p8\s, 3C\p4\s, 3D-3G\p8\s, 3H\p6\sError de pag., de la p. 769 pasa a la 780Texto a dos col. con apostillas marginalesPorts. a dos tintas, con esc. xil. de los JesuitasTexto a dos colGrab. xil. de la Crucifixión en la última hPort. a dos tintas con esc. xil. de los JesuítasSegunda parte con port. propia (en la que hay esc. xil. de los Jesuítas)La il. es un grab. xil. de la Crucifixión, en h. Hhh\b6\
An attempt to extend the habitat Harshness Hypothesis to tidal flats: a case study of Anomalocardia brasiliana (Bivalvia: Veneridae) reproductive biology
No full textThe Habitat Harshness Hypothesis (HHH) predicts that populations inhabiting the intertidal area of a dissipative beach should produce more gametes and have a longer reproductive cycle than those inhabiting an intermediate or reflective beach. This hypothesis was proposed for the exposed morphodynamic continuum between the reflective and dissipative states; however, no attempt has been made thus far to verify whether the HHH is valid for tidal flats. In this study, we analysed the reproductive cycle of Anomalocardia brasiliana in an intermediate beach and in a tidal flat and compared the results to determine whether the reproductive cycles of A.brasiliana were in agreement with the predictions of the HHH and to examine the possibility of extending this hypothesis to tidal flats. A continuous spawning season and synchrony between sexes were observed at both sites, although the reproductive effort was higher in the intermediate beach. The results of this first attempt did not support the extension of the HHH to tidal flats. It is possible that hypotheses that take into account only physical variables may not be the most adequate for describing environments with such a high species richness and high abundance as tidal flats. Nevertheless, other studies are necessary to confidently expand or refute the HHH with regard to tidal flats, and this topic should be considered as a priority in future investigations in sandy beach ecology.The Habitat Harshness Hypothesis (HHH) predicts that populations inhabiting the intertidal area of a dissipative beach should produce more gametes and have a longer reproductive cycle than those inhabiting an intermediate or reflective beach. This hypothe150A136141FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2008/52392-1We thank the “Fundacão de Amparo à Pesquisa do Estado de SãoPaulo” (FAPESP) for providing a master’s fellowship (Process 2008/52392-1) to the first author, FAEPEX/UNICAMP for financial support for this project, and the Centro de Biologia Marinha (CEBIMar
Studies on the Etiology of Inborn Errors of Aminoacid Metabolism due to a Defect of Membrane Transport
No full textHyperornithinemia, hyperammonemia, and homocitrullinuria syndrome （HHH） was first reported by Shih et al. （1969）. The basic metabolic defect has been suggested to be a defective transport of ornithine by hepatic mitochondria （Shih et al., 1982）. The author examined ornithine metabolism in cultured skin fibroblasts from a patient using the double-labeled assay. A liver sample was obtained from this patient by open biopsy and free amino acid contents in the whole tissue and hepatic mitochondria were measured. Familial hyperlysinemia was first described by Woody （1964）. Dancis et al. （1976, 1979） demonstrated that the mechanism of familial hyperlysinemia involved enzyme defects of lysine-α-ketoglutarate reductase and saccharopine dehydrogenase. Recently the author encountered two siblings having familial hyperlysinemia in whom the enzyme activities of lysine-α-ketoglutarate reductase and saccharopine dehydrogenase in liver were normal. The lysine and leucine metabolism in cultured skin fibroblasts from these patients were examined. The following results were obtained. 1） Concentrations of ornithine in hepatic mitochondria of the HHH patient were apparently low, compared with concentrations of ornithine in whole liver tissues. 2） Incorporations of the 14C-label of ornithine into protein in cultured skin fibroblasts of the HHH patient were significantly lower than those of controls. 3） In leucine uptake studies, the amounts of 14CO2 obtained by incubation with the hyperlysinemic patients' fibroblasts were similar to the results obtained by controls. 4） In lysine uptake studies, the amounts of 14CO2 obtained by the hyperlysinemic patients' fibroblasts in the low substrate medium were significantly lower than those of controls, but in the high substrate medium amounts of 14CO2 obtained with the patients' fibroblasts were similar to those obtained with the controls' fibroblasts. 5） From these findings, the mechanism of HHH and these patients with hyperlysinemia have a defective transport of ornithine and lysine in hepatic mitochondria.departmental bulletin pape
膜転送障害に基づく先天性アミノ酸代謝異常症の病因解析に関する研究
No full textHyperornithinemia, hyperammonemia, and homocitrullinuria syndrome （HHH） was first reported by Shih et al. （1969）. The basic metabolic defect has been suggested to be a defective transport of ornithine by hepatic mitochondria （Shih et al., 1982）. The author examined ornithine metabolism in cultured skin fibroblasts from a patient using the double-labeled assay. A liver sample was obtained from this patient by open biopsy and free amino acid contents in the whole tissue and hepatic mitochondria were measured. Familial hyperlysinemia was first described by Woody （1964）. Dancis et al. （1976, 1979） demonstrated that the mechanism of familial hyperlysinemia involved enzyme defects of lysine-α-ketoglutarate reductase and saccharopine dehydrogenase. Recently the author encountered two siblings having familial hyperlysinemia in whom the enzyme activities of lysine-α-ketoglutarate reductase and saccharopine dehydrogenase in liver were normal. The lysine and leucine metabolism in cultured skin fibroblasts from these patients were examined. The following results were obtained. 1） Concentrations of ornithine in hepatic mitochondria of the HHH patient were apparently low, compared with concentrations of ornithine in whole liver tissues. 2） Incorporations of the 14C-label of ornithine into protein in cultured skin fibroblasts of the HHH patient were significantly lower than those of controls. 3） In leucine uptake studies, the amounts of 14CO2 obtained by incubation with the hyperlysinemic patients' fibroblasts were similar to the results obtained by controls. 4） In lysine uptake studies, the amounts of 14CO2 obtained by the hyperlysinemic patients' fibroblasts in the low substrate medium were significantly lower than those of controls, but in the high substrate medium amounts of 14CO2 obtained with the patients' fibroblasts were similar to those obtained with the controls' fibroblasts. 5） From these findings, the mechanism of HHH and these patients with hyperlysinemia have a defective transport of ornithine and lysine in hepatic mitochondria
Persistent hyperammonemia in two related Morgan weanlings
No full textPersistent hyperammonemia was diagnosed in 2 Morgan fillies with clinical signs that developed early in the postweaning period. Diagnostic evaluation, including routine serum chemistries, CBC, liver biopsy, hepatic ultrasonography, liver function test, and necropsy findings did not support a toxic, developmental, or infectious cause. Abnormal serum amino acid and urine orotic acid concentrations suggest that the foals may have had an inherited disorders described in humans as hyperornithinemia, hyperammonemia, and homocitrullinuria (HHH) syndrome. The disorder is thought to be caused by a defective mitochondrial transporter protein, such that ornithine, required for complete urea synthesis, is deficient, thus causing increases in blood ammonia and ornithine concentrations.LR: 20061115; PUBM: Print; JID: 8708660; 0 (Amino Acids); 7006-33-9 (Ornithine); 7664-41-7 (Ammonia); ppublishSource type: Electronic(1
Radiological evaluation of reduction loss in unstable proximal humeral fractures treated with locking plates
No full textAbstractPurposeThe aim of this study was to radiologically evaluate the risk of reduction loss after locking plate fixation of proximal humerus fractures.MethodsFrom September 2007 to April 2009, 71 patients (28 males, 43 females) with unstable proximal humeral fracture were treated with open reduction and internal fixation by locking plate. The mean follow-up time was 31.2 months (range: 26–47). The head-shaft angulation (HSA) and the humeral head height (HHH) in true anteroposterior (AP) were recorded and compared over time. All complications were noted. Shoulder function was measured by the Constant score.ResultsPatients with ΔHSA >10° (t=2.740, P=0.008) and ΔHHH >5mm (t=2.55, P=0.019) were more likely to have impaired shoulder function. Varus collapse occurred most frequently in patients with initial reduction of HSA <125° (χ2=19.17, P<0.001, Fisher's exact test F<0.001). Patients with >5mm HHH decrease were strongly associated with loss of reduction (χ2=24.23, P<0.001, F<0.001).ConclusionsDynamic change of HSA >10° and HHH >5mm were radiological factors that indicated poor shoulder function. Intra-operative HSA >125° should be achieved to avoid reduction loss following locking plate fixation of proximal humerus fracture.Level of evidencelevel IV
More than a royal vagina
No full textThe HHH column is a monthly blog in which History, Health & Healing members share their thoughts on research, current affairs, or anything to do with medical history. Each edition is written by a different member – in due time, we hope to offer everybody a chance to publish a contribution. This month, the floor is for Leonieke Vermeer, Assistant Professor in History at the University of Groningen, and author of an forthcoming biography of Sophie of Wurtemberg. In this column, Leonieke investigates the life of Sophie, who married her cousin William of Orange, in relation to royal views on heredity and to Sophie’s own reflections
More than a royal vagina
No full textThe HHH column is a monthly blog in which History, Health & Healing members share their thoughts on research, current affairs, or anything to do with medical history. Each edition is written by a different member – in due time, we hope to offer everybody a chance to publish a contribution. This month, the floor is for Leonieke Vermeer, Assistant Professor in History at the University of Groningen, and author of an forthcoming biography of Sophie of Wurtemberg. In this column, Leonieke investigates the life of Sophie, who married her cousin William of Orange, in relation to royal views on heredity and to Sophie’s own reflections
More than a royal vagina
No full textThe HHH column is a monthly blog in which History, Health & Healing members share their thoughts on research, current affairs, or anything to do with medical history. Each edition is written by a different member – in due time, we hope to offer everybody a chance to publish a contribution. This month, the floor is for Leonieke Vermeer, Assistant Professor in History at the University of Groningen, and author of an forthcoming biography of Sophie of Wurtemberg. In this column, Leonieke investigates the life of Sophie, who married her cousin William of Orange, in relation to royal views on heredity and to Sophie’s own reflections
- …
