129 research outputs found
The identity of inbetweenship : An post-colonial analysis of Navid Modiris authorship
No full textThe purpose of this essay is to examine how Navid Moodiris concept of "mellanförskap", translated by the author himself as "inbetweenship", the postcolonial we and them as well as different identity constructions are expressed in social debator Navid Modiris authorship. The notion of identity is used from a social psychological perspective and the notion of inbetweenship is based on Modiris own description of the term. The theoretical starting point for the study is the post-colonial theory with focus on Said's construction of "the Other" and Spivak and Halls thoughts on how colonialism influenced and influence today's society. The questions at issue are examined by analysis of three poems from the poem vollection Skrik om du brinner (eng. Cry if you are on fire) and two lyrics. Analysis results are presented through quotes from the texts, which are discussed and commented on the basis of how inbetweenship, we and them as well as different identities are expressed in the texts. Overall, it is mainly through themes such as family relationships, distance, generalizations and lack of limits that the investigated objects are highlighted. The clear conclusion is that it's because of the normative society that we and them, and the feeling of inbetweenship can be produced and that the criticism of this society is the underlying theme of the Modiris entire authorship.Syftet med uppsatsen är att undersöka hur mellanförskap, det postkoloniala vi och dem samt olika identitetskonstruktioner kommer till uttryck i samhällsdebattören Navid Modiris författarskap. Begreppet identitet används utifrån ett socialpsykologiskt perspektiv och mellanförskap utifrån Modiris egen beskrivning av termen. Den teoretiska utgångspunkten för studien är den postkoloniala teorin med fokus på Saids konstruktion av "de Andra" samt Spivak och Halls tankar om hur kolonialismen påverkat och påverkar dagens samhälle. Studiens frågeställningar undersöks genom analys av tre dikter från diktsamlingen Skrik om du brinner samt två låttexter. Analysresultatet presenteras genom citat från texterna, vilka diskuteras och kommenteras utifrån hur mellanförskap, vi och dem samt olika identiteter kommer till uttryck i texterna. Sammantaget är det främst genom teman som släktskap, avstånd, generaliseringar och avsaknaden av gränser som de undersökta objekten lyfts fram. Den tydliga slutsatsen är att det är på grund av det normativa samhället som vi och dem samt känslan av ett mellanförskap kan skapas samt att det är kritiken mot detta samhället som är det underliggande temat för hela Modiris författarskap
Types of Cell Death from a Molecular Perspective
No full textThe former conventional belief was that cell death resulted from either apoptosis or necrosis; however, in recent years, different pathways through which a cell can undergo cell death have been discovered. Various types of cell death are distinguished by specific morphological alterations in the cell’s structure, coupled with numerous biological activation processes. Various diseases, such as cancers, can occur due to the accumulation of damaged cells in the body caused by the dysregulation and failure of cell death. Thus, comprehending these cell death pathways is crucial for formulating effective therapeutic strategies. We focused on providing a comprehensive overview of the existing literature pertaining to various forms of cell death, encompassing apoptosis, anoikis, pyroptosis, NETosis, ferroptosis, autophagy, entosis, methuosis, paraptosis, mitoptosis, parthanatos, necroptosis, and necrosis
Diffractive electron mirror for use in quantum electron microscopy
No full textThesis: S.M., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections."February 2018." Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 66-70).Periodic atomic structures in thin crystals and artificially fabricated periodic structures in transmission gratings have long been used to coherently split electrons by means of electron diffraction for applications such as interferometry, holography and imaging. Due to their reliance on transmission through matter, however, these methods are prone to electron scattering and absorption and are therefore lossy to some extent. This loss becomes a major issue for quantum electron microscopy (QEM), an interaction-free measurement scheme with electrons as probe particles. QEM relies on single electrons completing many round trips inside an electron resonant cavity, splitting and re-coupling during each round trip, effectively multiplying the probability of loss by the number of round trips. Thus, in one of the designs for QEM, the use of reflective diffraction gratings as lossless electron beam splitters is proposed. In this thesis, diffractive electron mirrors were fabricated by integrating one-dimensional diffraction gratings with tetrode electron mirrors. Optical interference lithography was used to fabricated silicon diffraction gratings with pitches varying from 200 nm to 500 nm. Furthermore, a proof-of-principle experiment to demonstrate their function as electron mirrors inside a scanning electron microscope was developed. It was demonstrated that the constructed tetrode electron mirrors satisfied the requirements of QEM for electron energies up to 3 keV. Finally, in a similar experiment, the fabricated diffractive electron mirrors were tested to demonstrate their function as lossless beam splitters. Preliminary results point to the evidence for electron diffraction, suggesting that diffractive electron mirrors could be used as as lossless electron beam splitters for QEM and other applications.by Navid Abedzadeh.S.M
Management Production Systems and Timing Strategies for Cull Cows
No full textReplaced with revised version of paper 06/04/09.Cattle, cull cows, management, marketing, production systems, timing, Farm Management, Marketing,
Mitigating Diabetic Cardiomyopathy: The Synergistic Potential of Sea Buckthorn and Metformin Explored via Bioinformatics and Chemoinformatics
No full textDiabetic cardiomyopathy (DCM), a critical complication of type 2 diabetes mellitus (T2DM), is marked by metabolic dysfunction, oxidative stress, and chronic inflammation, ultimately progressing to heart failure. This study investigated the synergistic therapeutic potential of Hippophae rhamnoides L. (sea buckthorn, SBU) extract and metformin in a mouse model of T2DM-induced DCM. T2DM was induced using a 45% high-fat-AGEs-enriched diet, followed by treatment with SBU, metformin, or their combination. Treatment effects were monitored through bioinformatic analysis, chemoinformatic prediction, behavioral testing, biochemical assays, histopathological evaluations and gene expression profiles. Based on bioinformatic analysis, we identified key hub genes involved in the diabetic cardiomyopathy including SERPINE1, NRG1, MYH11, PTH, NR4A2, NRF2, PGC1α, GPX4, ATF1, ASCL2, NOX1, NLRP3, CCK8, COX2, CCL2, PTGS2, EGFR, and oncostatin, which are pivotal in modulating the ferroptosis pathway. Furthermore, the expression of long non-coding RNAs (lncRNAs) NEAT1 and MALAT1, critical regulators of inflammation and cell death, was effectively downregulated, correlating with decreased levels of the pro-inflammatory marker oncostatin. The combined therapy significantly improved glucose regulation, reduced systemic inflammation and protected the heart from oxidative damage. Histopathological analysis revealed notable reductions in cardiac necrosis and fibrosis. Particularly, the combination therapy of SBU and metformin demonstrated a synergistic effect, surpassing the benefits of individual treatments in preventing cardiac damage. These findings highlight the potential of integrating SBU with metformin as a novel therapeutic strategy for managing DCM by targeting both metabolic and ferroptosis-related pathways. This dual intervention opens promising avenues for future clinical applications in diabetic heart disease management, offering a comprehensive approach to mitigating the progression of DCM
Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, novel monitoring pathological metrics, screening signatures, and innovative management tactic
No full textAbstract Background Prompt identification and assessment of the disease are essential for reducing the death rate associated with colorectal cancer (COL). Identifying specific causal or sensitive components, such as coding RNA (cRNA) and non-coding RNAs (ncRNAs), may greatly aid in the early detection of colorectal cancer. Methods For this purpose, we gave natural chemicals obtained from Sparassis latifolia (SLPs) either alone or in conjunction with chemotherapy (5-Fluorouracil to a mouse colorectal tumor model induced by AOM-DSS. The transcription profile of non-coding RNAs (ncRNAs) and their target hub genes was evaluated using qPCR Real-Time, and ELISA techniques. Results MSX2, MMP7, ITIH4, and COL1A2 were identified as factors in inflammation and oxidative stress, leading to the development of COL. The hub genes listed, upstream regulatory factors such as lncRNA PVT1, NEAT1, KCNQ1OT1, SNHG16, and miR-132-3p have been discovered as biomarkers for prognosis and diagnosis of COL. The SLPs and exercise, effectively decreased the size and quantity of tumors. Conclusions This effect may be attributed to the modulation of gene expression levels, including MSX2, MMP7, ITIH4, COL1A2, PVT1, NEAT1, KCNQ1OT1, SNHG16, and miR-132-3p. Ultimately, SLPs and exercise have the capacity to be regarded as complementing and enhancing chemotherapy treatments, owing to their efficacious components
Gene co-expression patterns shared between chemobrain and neurodegenerative disease models in rodents
No full textChemotherapy-related cognitive impairment (CRCI), is a well-recognized phenomenon in cancer patients who have undergone chemotherapy but the exact molecular mechanisms underpinning CRCI remain elusive. Symptoms reported by people with CRCI resemble those experienced by people with age-related neurodegenerative disorders (ARNDDs), yet no clear connection between CRCI and ARNDDs has been reported to date. The existence of shared mechanisms between these conditions offers opportunities for repurposing drugs already approved for the treatment of ARNDDs to improve symptoms of CRCI. Given that there is no available microarray or RNA-Seq data from the brains of people who have experienced CRCI, we investigated to what extent brain gene expression perturbations from validated rodent models of CRCI induced by chemotherapy compared with validated rodent models of Alzheimer’s disease and Parkinson’s disease. We utilized multiple bioinformatic analyses, including functional enrichment, protein-protein interaction network analyses, gene ontology analyses and identification of hub genes to reveal connections between comparable gene expression perturbations observed in these conditions. Collectively 165 genes overlapped between CRCI and Parkinson’s disease and/or Alzheimer’s disease, and 15 overlapped between all three conditions. The joint genes between Alzheimer’s disease, Parkinson’s disease and CRCI demonstrate an average of 83.65% nucleotide sequence similarity to human orthologues. Gene ontology and pathway enrichment analyses suggest mechanisms involved in neural activity and inflammatory response as the key components of the studied neuropathological conditions. Accordingly, genes in which expression was comparably affected in all three condition models could be attributed to neuroinflammation, cell cycle arrest, and changes in physiological neural activity
hennylab/Neuronal-Convex-hull-intersection: Neuronal-Convex-hull-intersection
No full textRaw data, MATLAB scripts and data analysis from:
Geometrical factors determining dendritic domain intersection between neurons: a modeling study
Rafael Ignacio Gatica1, Trinidad Montero1, Navid Farassat2 and Pablo Henny1
1Laboratorio de Neuroanatomía, Departamento de Anatomía, and Centro Interdisciplinario de Neurociencia, NeuroUC, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
2Institute for Neurophysiology, Goethe University, Frankfurt, Germany
*Corresponding author:
E-mail: [email protected]
Finding effective parameters for mitigating traffic congestion near universities
No full textThis paper intends to assess the effect of different parameters on traffic congestion around universities. On the basis of the model outputs, it is possible to propose economic countermeasures for reducing traffic congestion, especially in developing countries. Structural equation modelling was used to assess the relevance between characteristics of students, features of different modes, environmental conditions and daily demand variations with traffic congestion. The Shahid Bahonar University of Kerman in Iran was considered as a case study. The results showed that it is necessary to decrease the demand first. For this purpose, rescheduling courses is essential to distribute classes more effectively within a week. Virtual classes can be used more frequently as a substitute for traditional on-campus courses. The probability of using buses should be increased by reducing waiting time and fares, and promoting their safety. Similarly, taxi use can be increased by improving safety and waiting time. To reduce the likelihood of using private cars, pricing strategies must establish more limitations for using university carparks.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Pavement Engineerin
Three-dimensional CFD-DEM simulation of raceway transport phenomena in a blast furnace
No full textpeer reviewedImproving energy efficiency in a blast furnace (BF) has a significant effect on energy consumption and pollutant emission in a steel plant. In the BF, the blast injection creates a cavity, the so-called raceway, near the inlet. On the periphery of the raceway, a ring-type zone is formed which is associated with the highest coke combustion rate and temperatures in the raceway. Therefore, predicting the raceway size or in other words, the periphery of the ring-type zone with accuracy is important for estimating the BF’s energy and coke consumption. In the present study, Computational Fluid Dynamics (CFD) is coupled to Discrete Element Method (DEM) to develop a three-dimensional (3D) model featuring a gas–solid reacting flow, to study the transport phenomena inside the raceway. The model is compared to a previously developed two-dimensional (2D) model and it is shown that the assumptions associated with a 2D model, result in an overestimation of the size of the raceway. The 3D model is then used to investigate the coke particles’ combustion and heat generation and distribution in the raceway. It is shown that a higher blast flow rate is associated with a higher reaction rate and a larger raceway. A 10% increase in the inlet velocity (from 200 m/s to 220 m/s) caused the raceway volume to grow by almost 40%. The DEM model considers a radial discretization over the particle, therefore the heat and mass distributions over the particle are analyzed as well.Raceway of Blast Furnac
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