169,813 research outputs found
Assessing wound vitality in decomposed bodies: a review of the literature
No full textThe capability of discriminating between a vital and a post-mortem injury has always been a central theme in forensic pathology, particularly when the corpse is an advanced state of decomposition. Post-mortem decay of the body can mask or disrupt the classical features of a skin lesion, making it difficult to establish the cause and manner of death. Taphonomically challenging situations pose several interpretative issues of skin lesions which need to be addressed with scientifically recent methods that are still limited in the forensic literature. For that reason, the present research aims at resuming what is currently available in the attempt to provide some insight regarding this topic. This review considers only original researches, in which the markers of vitality were studied a significant amount of time after death, in order to test post-mortem persistency of these markers over time. A number of 132 original articles and reviews were considered, and the most significant results are resumed in an overview table and in two intuitive figures. Though many researchers tried to establish the vitality of lesions in specimen, few analysed samples from bodies when a significant degree of putrefaction or burning had occurred. The most significant marker proved to be GPA, which sowed a satisfying persistence over time (up to 6 months in air putrefaction and 15 days in water). However, what clearly emerged is that further studies are needed to address the challenges of taphonomically transformed specimen and to possibly neutralize the variability of experimental conditions, which affect the reproducibility of results. In conclusion, this study could be a starting point for providing food for thoughts about the most useful markers to search for in unusually tricky autopsy cases
Impella in Takotsubo syndrome complicated by left ventricular outflow tract obstruction and severe mitral regurgitation
No full textThe treatment of cardiogenic shock in patients with Takotsubo syndrome (TTS) is challenging because it depends on the mechanisms leading to the haemodynamic instability. We report the case of a 70-year-old woman admitted for TTS complicated by cardiogenic shock. The early echocardiographic identification of left ventricular outflow tract obstruction (LVOTO) and severe mitral regurgitation (MR) prompted us to implant an Impella CP assist device as a bridge-to-recovery therapy. After device positioning, the haemodynamic status improved and LVOTO and severe MR disappeared. Because of the persistence of severe hypotension, the mechanical circulatory support was continued in intensive care unit and stopped only 5 days later, when intraventricular gradient spontaneously dropped. The patient was discharged after 1 week in stable conditions. Our case suggests that Impella circulating support may be a useful bridge-to-recovery therapeutic option in selected patients with cardiogenic shock due to TTS complicated by LVOTO and severe MR
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A Machine Learning Based Tool to Estimate Coolant Engine Temperature Based on Motorcycle Riding Data
No full textIn the automotive environment, understanding the thermal behavior of the engine is crucial: a fault in measuring the temperature can reduce reliability and poor fuel efficiency. Internal combustion engine temperature is usually measured using a device called coolant temperature sensor. The sensor may fail, and having an indirect system to get that value can avoid unpleasant conditions. This work addresses a novel solution to estimate the coolant temperature based on machine learning models trained using riding data. This solution can back up the physical sensor and monitor abnormal behavior. We also focused on developing a virtual sensor that would behave well in case of thermal shock, which is essential for ensuring safety, improving the engine work, and making the components last longer. We showed how an approach based on the prediction of the temperature delta is better for dealing with this kind of phenomenon. We obtained an RMSE of 2.79°C training a Long short-term memory (LSTM) on more than 1060 h recorded from Ducati Multistrada V4
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
DIPYRIDAMOLE INVITRO SUPPRESSES THE GENERATION OF T-CELL CYTOTOXIC FUNCTIONS - SYNERGISTIC ACTIVITY WITH CYCLOSPORINE
No full textDispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A 3D non invasive assessment of the position of the occlusal plane
No full textIntroduction. The occlusal plane has a key-role in various dental and medical fields. Several methods have analyzed and measured the relative positions of the occlusal and facial planes; most of these investigations used 2D radiographic exams. Currently, 3D assessments may be performed overlapping CT reconstructions and digitized dental casts, but the method requires ionizing radiations, and it is not applicable in reference studies performed with healthy subjects. The efficacy of these measurements could be improved by a 3D, non invasive approach to the problem. Methods. 20 healthy subjects were selected to have their maxillary dental casts digitized by laser scanning, and their 3D facial soft tissue stereophotogrammetry acquisition merged in a single file. The digital 3D coordinates of three facial (right and left Tragus, Subnasale) and three dental landmarks (inter-incisor, tips of the mesio-vestibular cuspids of right and left first permanent molars), were obtained and exported in a 3D CAD (computed aided design) software for a geometrical analysis. The 3D orientation of the planes, referred to a Cartesian orthogonal reference system, was estimated calculating angular values between the sagittal midlines of the two planes. To evaluate the repeatability of the measurements the protocol was performed independently by two different operators. In total 120 measurements were obtained; descriptive statistics were calculated for each variable. To evaluate the method repeatability mean absolute difference between repeated measurements (MAD), technical error of measurement (REM) and Paired Student’s T tests (P<0.05) were computed. Results. In the frontal and horizontal projections, the occlusal plane resulted nearly parallel to Camper’s plane, with average inclinations of 1.5 (frontal) and 1.9 (horizontal) degrees. In the sagittal projection, the two planes had an average angle of 4.9 degrees, with the occlusal plane more anteriorly inclined than Camper’s plane. For all three projections, a fair inter-operator repeatability was found, with all MADs and TEMs slightly lower than 2 degrees. No systematic errors between repeated measurements were found (T test > 0.05). Conclusions. The current non-invasive method resulted appropriate to the aims. Camper’s and occlusal planes resulted almost parallel in the frontal and horizontal projections, while in the sagittal projection the occlusal plane was 5 degrees more anteriorly inclined than Camper’s plane
Three-dimensional facial morphometry in patients rehabilitated with implant-supported prostheses
No full textThe aim of the present study was to assess a low-cost, non-invasive facial morphometric digitizer to assist the practitioner in three-dimensional soft-tissue changes before and after oral rehabilitation. The method should provide quantitative data to support an objective assessment of the facial esthetic outcome [1]. Twenty-two patients aged 45-82 years, all with edentulous maxilla and mandible, were assessed both before and after receiving their definitive complete implant-supported prostheses (each received 4-11 implants in each dental arch; full-arch fixed prostheses were made). The three-dimensional coordinates of 50 soft-tissue facial landmarks were collected with a non-invasive digitizer; labial and facial areas, volumes, angles and distances were compared without/ with the prostheses [2]. Dental prostheses induced significant reductions in the nasolabial, mentolabial and interlabial angles, with increased labial prominence (p<0.05, Wilcoxon test). Lip vermilion area and volume significantly increased; significant increments were found in the vertical and anteroposterior labial dimensions. The presence of the dental prostheses significantly (p<0.001) modified the three-dimensional positions of several soft-tissue facial landmarks. The current approach enabled quantitative evaluation of the final soft-tissue results of oral rehabilitation with implant-supported prostheses, without submitting the patients to invasive procedures. The method could assess the three-dimensional appearance of the facial soft tissues of the patient while planning the provisional prosthetic restoration, providing quantitative information to prepare the best definitive prosthesis. Dote ricerca: FSE, Regione Lombardi
PHENOTYPIC AND FUNCTIONAL-ANALYSIS OF PERIPHERAL-BLOOD LYMPHOCYTES DURING INTERFERON-ALPHA-2B THERAPY IN MULTIPLE-MYELOMA PATIENTS WITH LOW TUMOR MASS
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