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Prognostic role of clusterin in resected adenocarcinomas of the lung
No full textPrognostic role of clusterin in resected adenocarcinomas of the lung.
Panico F, Casali C, Rossi G, Rizzi F, Morandi U, Bettuzzi S, Davalli P, Corbetta L, Storelli ES, Corti A, Fabbri LM, Astancolle S, Luppi F.
Source
Section of Respiratory Diseases, Department of Oncology, Haematology & Pulmonology, University of Modena and Reggio Emilia, Modena, Italy.
Abstract
RATIONALE:
Clusterin expression may change in various human malignancies, including lung cancer. Patients with resectable non-small cell lung cancer (NSCLC), including adenocarcinoma, have a poor prognosis, with a relapse rate of 30-50% within 5 years. Nuclear factor kB (Nf-kB) is an intracellular protein involved in the initiation and progression of several human cancers, including the lung.
OBJECTIVES:
We investigate the role of clusterin and Nf-kB expression in predicting the prognosis of patients with early-stage surgically resected adenocarcinoma of the lung.
FINDINGS:
The level of clusterin gradually decreased from well-differentiated to poorly differentiated adenocarcinomas. Clusterin expression was significantly higher in patients with low-grade adenocarcinoma, in early-stage disease and in women. Clusterin expression was inversely related to relapse and survival in both univariate and multivariate analyses. Finally, we observed an inverse correlation between Nf-kB and clusterin.
CONCLUSIONS:
Clusterin expression represents an independent prognostic factor in surgically resected lung adenocarcinoma and was proven to be a useful biomarker for fewer relapses and longer survival in patients in the early stage of disease. The inverse correlation between Nf-kB and clusterin expression confirm the previously reported role of clusterin as potent down regulator of Nf-kB
Manipulation of the expression of regulatory proteins of polyamine metabolism results in specific alterations of the cell cycle progression
No full textIncreased levels of clusterin (SGP-2) mRNA and protein accompany rat ventral prostate involution following finasteride treatment
No full textVariazioni reciproche nella concentrazione degli RNAm della ornitina decarbossilasi e dell'SGP-2: possibile ruolo nel controllo dell'omeostasi cellulare
No full textTumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (SGP-2) in human prostate cancer specimens
No full textClusterin (SGP-2) gene expression is cell cycle dependent in normal human dermal fibroblasts
No full text
Gene relaxation and aging: changes in the abundance of rat ventral prostate SGP-2 (clusterin) and ornithine decarboxylase mRNAs
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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