1,720,980 research outputs found
MODIFICAZIONI MICROTUBULARI OSSIDATIVO-INDOTTE IN UNA LINEA DI CELLULE DI SCHWANNOMA DI RATTO SOTTOPOSTE A CONDIZIONI DI IPERGLICEMIA SPERIMENTALE
No full textThe neuropathies of the peripheral and central nervous systems can be caused by hyper -glycemia, a consequence of the deregulation of glucose, resulting in an increase in reactive
oxygen species, with subsequent cellular lesions and impairment of cytoskeletal components
(Maritim et al. 2003; Allen et al. 2005; Drel et al. 2006; Gadau et al., 2009). Microtubules, one
component of the cytoskeleton, are composed of heterodimers of α- and α-tubulin, mainly
α-tubulin, may receives diverse post-translational modifications, consisting in tyrosination,
detyrosination, acetylation, nitrotyrosination, polyglycylation, polyglutamylation, phosphori -lation, palmytoylation (Westermann and Weber, 2003; Fukushima et al., 2009). in the present
work attention has been paid on the possible nitrosative effect of high glucose conditions on
microtubular network in a rat shwannoma cell line. Cells incubated for 72hrs in the presen-ce of 180 mM D-glucose revealed alterations in cell morphology, growth rate and catalase
activity in comparison with controls. in addition, an increase in acetylated α-tubulin and ni -trotyrosine and a downregulation of total, tyrosinated and detyrosinated α-tubulin was found
with Western blot analysis and immunofluorescence. no significant changes in other cytoske -letal components such as actin and GFAP was seen. our work underlined that high glucose
can selectively affects microtubular network in schwannoma cells, exerting its detrimental
effect either through a nitrosylation of tubulin or through the possible inhibition of deacetyla -se enzymes, with subsequent impairment of microtubular functionality
Agritourism, farm income differentiation, and rural development: The case of the region of montiferru (italy)
No full textThe faster increasing of agritourism in the European countries leads to thinking this form of farm diversification as a valid instrument to enhance the rural areas. Numerous personal and social motivations lead the choice of starting an agritourism. However, the agritourism should be understood as firm and must be able to be profitable in the long-term and pay the work of the farmer and his family. This is the necessary condition to allow agritourism contributing to rural development and enable farmers to enjoy their rural lifestyle. Using Serpieri’s model (1950), the paper aims to assess the ability of agritourism activities to improve the income of multifunctional farms operating in a rural area of Sardinia (Italy). This research contributes to the debate on agritourism role and aims, outlines the implications for practitioners, academics and policymakers, and makes recommendations for future research
Insect farming for feed and food production from a circular business model perspective
Full text linkThe studies focused on the use of insects have outlined numerous reasons for using insects as food and feed as an important method to increase food opportunities for consumers. Insects have been emphasized as a food source with a low environmental impact due to the limited requirement for arable land and water, low ecological cost, and high-quality protein provision. In Europe andWestern countries, insect farming is a growing business in which, however, some critical economic aspects must be recognized. The sector needs to be adequately promoted to rationally exploit the huge amount of potential. As such, the aim of this study was to analyze the recent research on economic aspects related to insect farming for feed and food production with the purpose of providing evidence of the critical economic points in this emerging sector. The focus was mainly oriented to understanding how insect farming can foster virtuous circular economic processes, specifically considering economic aspects on the basis of the limited literature currently available and the circular economic principles. A circular business model approach was proposed to address the entire insect-based feed and food supply chain from a circular economic perspective. In our opinion, the findings underline some economic research questions that need to be addressed in the near future, and the conceptual approach can be individualized to help increase cost- and eco-effectiveness from a circular economic perspective
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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