640 research outputs found
Oral History Interview with Nancy Lieberman, November 8, 2012
No full textInterview with Nancy Lieberman, a sports broadcast journalist. The interview includes biographical information about her life growing up in New York, her time on the first women's Olympic basketball team, and her career as a coach, author, and journalist on ESPN
Effects of lipopolysaccharide-induced inflammation on expression of growth-associated genes by corticospinal neurons
No full textBackground: Inflammation around cell bodies of primary sensory neurons and retinal ganglion cells enhances expression of neuronal growth-associated genes and stimulates axonal regeneration. We have asked if inflammation would have similar effects on corticospinal neurons, which normally show little response to spinal cord injury. Lipopolysaccharide (LPS) was applied onto the pial surface of the motor cortex of adult rats with or without concomitant injury of the corticospinal tract at C4. Inflammation around corticospinal tract cell bodies in the motor cortex was assessed by immunohistochemistry for OX42 ( a microglia and macrophage marker). Expression of growth-associated genes c-jun, ATF3, SCG10 and GAP-43 was investigated by immunohistochemistry or in situ hybridisation.Results: Application of LPS induced a gradient of inflammation through the full depth of the motor cortex and promoted c-Jun and SCG10 expression for up to 2 weeks, and GAP-43 upregulation for 3 days by many corticospinal neurons, but had very limited effects on neuronal ATF3 expression. However, many glial cells in the subcortical white matter upregulated ATF3. LPS did not promote sprouting of anterogradely labelled corticospinal axons, which did not grow into or beyond a cervical lesion site.Conclusion: Inflammation produced by topical application of LPS promoted increased expression of some growth-associated genes in the cell bodies of corticospinal neurons, but was insufficient to promote regeneration of the corticospinal tract
ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter
No full textBackground: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood. We have examined the expression of the transcription factors ATF3 and c-Jun by non-neuronal cells during Wallerian degeneration following injury to sciatic nerves, dorsal roots and optic nerves of rats and mice, using immunohistochemistry and in situ hybridization.Results: Following sciatic nerve injury-transection or transection and reanastomosis-ATF3 was strongly upregulated by endoneurial, but not perineurial cells, of the distal stumps of the nerves by 1 day post operation (dpo) and remained strongly expressed in the endoneurium at 30 dpo when axonal regeneration was prevented. Most ATF3+ cells were immunoreactive for the Schwann cell marker, S100. When the nerve was transected and reanastomosed, allowing regeneration of axons, most ATF3 expression had been downregulated by 30 dpo. ATF3 expression was weaker in the proximal stumps of the injured nerves than in the distal stumps and present in fewer cells at all times after injury. ATF3 was upregulated by endoneurial cells in the distal stumps of injured neonatal rat sciatic nerves, but more weakly than in adult animals. ATF3 expression in transected sciatic nerves of mice was similar to that in rats. Following dorsal root injury in adult rats, ATF3 was upregulated in the part of the root between the lesion and the spinal cord (containing Schwann cells), beginning at 1 dpo, but not in the dorsal root entry zone or in the degenerating dorsal column of the spinal cord. Following optic nerve crush in adult rats, ATF3 was found in some cells at the injury site and small numbers of cells within the optic nerve displayed weak immunoreactivity. The pattern of expression of c-Jun in all types of nerve injury was similar to that of ATF3.Conclusion: These findings raise the possibility that ATF3/c-Jun heterodimers may play a role in regulating changes in gene expression necessary for preparing the distal segments of injured peripheral nerves for axonal regeneration. The absence of the ATF3 and c-Jun from CNS glia during Wallerian degeneration may limit their ability to support regeneration
New Age Violin: From Tradition to Innovation
No full text Julie Lyonn Lieberman, author of Blues Fiddle and New Age Violin, is equally at home playing jazz violin, Irish music, C & W, bluegrass, blues, New Age, and classical. A singer and composer as well, her music has been heard in several off-Broadway shows, and numerous music festivals, concert halls, clubs, colleges, and radio stations throughout the East Coast. </jats:p
Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing
No full textSummarySpinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder, is caused by a CAG/glutamine expansion in the androgen receptor (polyQ AR). Recent studies demonstrate that skeletal muscle is an important site of toxicity that contributes to the SBMA phenotype. Here, we sought to identify critical pathways altered in muscle that underlie disease manifestations in AR113Q mice. This led to the unanticipated identification of gene expression changes affecting regulators of carbohydrate metabolism, similar to those triggered by denervation. AR113Q muscle exhibits diminished glycolysis, altered mitochondria, and an impaired response to exercise. Strikingly, the expression of genes regulating muscle energy metabolism is rescued following peripheral polyQ AR gene silencing by antisense oligonucleotides (ASO), a therapeutic strategy that alleviates disease. Our data establish the occurrence of a metabolic imbalance in SBMA muscle triggered by peripheral expression of the polyQ AR and indicate that alterations in energy utilization contribute to non-neuronal disease manifestations
The influence of data order on the Lieberman-Ross method
No full textA statistically exact procedure for producing lower bounds on the reliability of a parallel system of independent, exponentially failing components has been produced by Lieberman and Ross. This method uses individual component failure data to estimate system characteristics. The method has the drawback that permuting the order in which components fail (but not the inter-failure times), can alter the estimated bound, i.e., the estimates are Data Order Dependent. In this paper we investigate this dependence of the estimates, and consider the effects of a prior ordering. (Author)N6685676WR00012NAPrepared for: Chief of Naval Research, Arlington, VAhttp://archive.org/details/influenceofdatao00sch
Essentials of medical biochemistry
No full textIncludes indexes.dental bookfair2016Preceded by: Marks' essential medical biochemistry / Michael Lieberman, Allan Marks, Colleen Smith. c2007.Based on: Marks' basic medical biochemistry / Michael Lieberman, Allan Marks, Alisa Peet. 4th ed. c2013.ix, 622 pages :Marks’ Essentials of Medical Biochemistry takes a patient-oriented approach that links biochemistry to physiology and pathophysiology, allowing students to apply fundamental concepts to the practice of medicine. Based on the established text, Marks’ Basic Medical Biochemistry, Marks’ Essentials is streamlined to focus only on the most essential biochemical concepts, while maintaining intuitively organized chapters centered on hypothetical patient vignettes and helpful icons for smooth navigation.
• Full-color illustrations of chemical structures and biochemical pathways elucidate core concepts and enhance understanding of the text
• Hypothetical patient vignettes ensure clinical relevance and help connect biochemistry to human health and disease
• Helpful icons guide you through each chapter and identify key concepts such as signs and symptoms, clinical pearls, treatment options and outcomes, and more
• Chapter Outlines and Key Points allow readers to preview and review chapter content
• End-of-Chapter Review Questions and Summary Disease Tables highlight the take-home messages and reinforce knowledg
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Number 11 in the Katherine Anne Porter Prize in Short Fiction Series
No full textThe short stories in this rich debut collection embody in their complexity Alice Munro’s description of the short story as “a world seen in a quick, glancing light.” In chiseled and elegant prose, Lieberman conjures wildly disparate worlds. A middle aged window washer, mourning his wife and an estranged daughter, begins to grow attached to a young woman he sees through the glass; a writer, against his better judgment, pursues a new relationship with a femme fatale who years ago broke his heart; and the daughter of a Holocaust survivor struggles with the delicate decision of whether to finally ask her aging mother how it was that she survived. It is all here—the exigencies of love, of lust, the raw, unlit terrain of grief. Whether plumbing the darker depths or casting a humorous eye on a doomed relationship, these stories never force a choice between tragedy and redemption, but rather invite us into the private moments and crucibles of lives as hungry and flawed as our own. “Quiet, moving, masterfully crafted. Such are the nine stories in Venus in the Afternoon. Tehila Lieberman writes with precision, restraint, with a compassionate heart. She inhabits her characters, young or old, men or women, honestly, but without judgment, until they rise off the page and stand before us breathing and alive. New York, the Atacama desert, Amsterdam or Cuzco in Peru, the settings in Venus in the Afternoon are just as varied as the lives which they contain. A wonderful collection, one that will stay in your mind long after you have bid it goodbye.” —Miroslav Penkov, author of East of the West and judg
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