12 research outputs found
Algorithms and analysis of input data for the task of build of the circuitries reduction tree
No full text
Disorder and Civilization: The Future(s) of Ukrainian Medicine
No full textPost-socialist societies are full of uncertainty, fragmentation, and competing discourses on social justice [Steinberg and Wanner 2008; Zigon 2011]. This article focuses on how Ukrainian physicians envision the future, present, and past of the health-care system and make sense of social change in their professional lives and society more broadly. The Ukrainian healthcare system has remained largely untouched by post-socialist reforms, but it is nevertheless undergoing profound changes. These changes are occurring on the level of everyday practice and are shifting responsibility away from the state and onto the individual. The author traces how physicians navigate the persisting structures of the old system, and what hopes they carry for the present and the future. Post-socialist health care is bursting with competing interests, commitments, and notions of how health-care providers should relate to each other, their patients, administrations, and the state in general. This article therefore draws on physicians’ narratives of the disorder in health care through the interpretive prism of ‘ruination ... as a process that weighs on the future and shapes the present’ and that represents a ‘vital reconfi guration’ [Stoler 2008: 194] or crafting of ‘hope’ [Lindquist 2006].82183
A study of the role of oxidative stress and low-grade inflammation in development of Helicobacter pylori-induced insulin resistance in asymptomatic sedentary young men
No full textA study of the role of oxidative stress and low-grade inflammation in development of [i]Helicobacter[/i] pylori-induced insulin resistance in asymptomatic sedentary young men. OCC World Congress / Annual SFRR-E Conferenc
Software-Based Approach towards Automated Authorship Acknowledgement—Chi-Square Test on One Consonant Group
No full textA one-consonant group approach to the authorship attribution has been proposed. The approach is based on determining, by the chi-square test, the consonant group in which the difference between the texts by different authors is statistically significant. The developed model determines author-differentiating capability of each consonant group in a relation of the number of comparisons, in which the difference between the texts by two authors is statistically significant to the total number of comparisons. The determined general author-differentiating capability of the group of stop consonants, which is a statistical parameter of the authorial style, is the highest in the comparisons of texts from the publicist and belles-lettres styles. The one-consonant group approach simplifies the whole process of authorship attribution and ensures a higher level of automation. The conducted experiments on the Java programming language have proved that the chi-square test is a powerful nonparametric statistical test that can be used for author identification on the level of English consonants with a test validity of 95%
"Similis Simili Gaudet": Lavrentii Kordet and Hryhorii Skovoroda
No full textThe paper examines the connections between the rector of Kharkiv Collegium, Archimandrite
Lavrentii Kordet, and some of the close friends, acquaintances, and correspondents of Hryhorii
Skovoroda. The main focus is on Kordet’s intellectual biography and the essential features of
interpersonal communication among the faculty of Kharkiv Collegium in the second half of the
18th century. The study draws on the principles of network analysis and reconstruction of intellectual
network models. The author argues that Lavrentii Kordet, Hryhorii Skovoroda, and some of their
friends connected with Kharkiv Collegium (Mykhailo Kovalynskyi, Yov Bazylevych, etc.) embodied
the type of person whose identity centered on intellectual activity. They devoted a signifi cant portion
of their lives to academic teaching, cared about professional self-improvement, and kept up with the
latest scholarly and literary works. These intellectuals engaged in active "academic communication"
with their colleagues, which was designed to generate specifi c activities aimed at dissemination of
learning. The community of which Lavrentii Kordet and Hryhorii Skovoroda were part clearly
represented a new type of intellectual relations in the lands of Sloboda Ukraine
Applications applicable for terrorist, privacy or accuracy in public information resources
No full textПредставлено атаки на державні інформаційні ресурси, що обробляються
засобами інформаційно-телекомунікаційних систем. Представлено загальну структуру
реалізації атаки. Проведено аналіз атак на системи обробки державних інформаційних
ресурсів. Представлено класифікацію атак та параметри цих атак. Описані стратегії
здійснення атак. Висунуто перелік вимог до методів виявлення атак. Визначено, що
реалізація загроз відбувається за допомогою множини різнонаправлених атак.Attacks on state information resources processed by means of information and telecommunication systems are presented. The overall structure of the attack implementation is presented. The analysis of attacks on state information resources processing systems was carried out. The classification of attacks and parameters of these attacks is presented. The strategies for attacking are described. The list of requirements for methods of detection of attacks is issued. It is determined that the realization of threats occurs through a set of multidirectional attacks
Effects of the lercanidipine - Enalapril combination vs. The corresponding monotherapies on home blood pressure in hypertension: Evidence from a large database
No full textObjective: To compare a combination of a dihydropyridine
calcium-channel blocker with an angiotensin converting
enzyme inhibitor vs. monotherapy with one or the other
drug and placebo for their effects on home blood pressure
(HBP).
Methods: After a 2-week placebo wash-out, patients with
an elevated office blood pressure (BP) (diastolic 100–109
and systolic <180 mmHg) and HBP (diastolic 85 mmHg)
were randomized double-blind to a 10-week treatment
with placebo, lercanidipine, 10 or 20mg daily, enalapril,
10 or 20mg daily, or the four possible combinations. In
addition to office BP, HBP was self-measured via a
validated semiautomatic device twice in the morning and
twice in the evening during the 7 days before
randomization and at the end of treatment. Baseline and
treatment HBP values were separately averaged for each
day, morning, evening or the whole monitoring period,
excluding the first day. Day-by-day HBP variability was
defined as the SD or the variation coefficient of the daily
BP averages.
Results: Eight hundred and fifty-four patients with valid
HBP recordings at baseline and at the end of treatment
were analyzed (intention-to-treat population). From the
baseline value (147.011.6 mmHg) systolic/diastolic HBP
showed a small reduction (average baseline-adjusted
change: –1.8/–1.6 mmHg) with placebo, a more marked
significant fall with monotherapies (8.8/5.9 mmHg,
P<0.001/<0.001 vs. placebo) and even more with
combination treatment (11.6/7.6 mmHg, P<0.001/
<0.001 vs. placebo and P<0.01/<0.05 vs.
monotherapy). A similar pattern was observed for each of
the days of the BP self-monitoring period as well as for
either morning or evening values, although the difference
between mono and combination treatment appeared to be
consistently significant for the morning values only. Dayby-
day systolic BP-SD was unaffected by placebo and
slightly reduced by drug treatments, with no, however,
significant changes in SBP-variation coefficient. Baseline
and end of treatment HBP values showed a limited
correlation with office BP values, this being particularly the
case for treatment-induced changes (correlation
coefficients: 0.37 for systolic and 0.45 for diastolic BP).
Conclusion: This large HBP database shows that the
lercanidipine–enalapril combination lowers HBP more
effectively than the corresponding monotherapies and
placebo, and that this greater effect is consistent between
days
Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial
No full textAuteurs : the PRECISION investigatorsInternational audienceBackground Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs. The aim of the study was to assess the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. Methods PRECISION was a multicentre, blinded, randomised, parallel-group, phase 3 study, which was done in hospitals or research centres in Europe, North America, Asia, and Australia. Patients were eligible for randomisation if their sitting systolic blood pressure was 140 mm Hg or higher despite taking standardised background therapy consisting of three antihypertensive drugs, including a diuretic. The study consisted of three sequential parts: part 1 was the 4-week double-blind, randomised, and placebo-controlled part, in which patients received aprocitentan 12•5 mg, aprocitentan 25 mg, or placebo in a 1:1:1 ratio; part 2 was a 32-week single (patient)-blind part, in which all patients received aprocitentan 25 mg; and part 3 was a 12-week double-blind, randomised, and placebo-controlled withdrawal part, in which patients were re-randomised to aprocitentan 25 mg or placebo in a 1:1 ratio. The primary and key secondary endpoints were changes in unattended office systolic blood pressure from baseline to week 4 and from withdrawal baseline to week 40, respectively. Secondary endpoints included 24-h ambulatory blood pressure changes. The study is registered on ClinicalTrials.gov, NCT03541174. Findings The PRECISION study was done from June 18, 2018, to April 25, 2022. 1965 individuals were screened and 730 were randomly assigned. Of these 730 patients, 704 (96%) completed part 1 of the study; of these, 613 (87%) completed part 2 and, of these, 577 (94%) completed part 3 of the study. The least square mean (SE) change in office systolic blood pressure at 4 weeks was-15•3 (SE 0•9) mm Hg for aprocitentan 12•5 mg,-15•2 (0•9) mm Hg for aprocitentan 25 mg, and-11•5 (0•9) mm Hg for placebo, for a difference versus placebo of-3•8 (1•3) mm Hg (97•5% CI-6•8 to-0•8, p=0•0042) and-3•7 (1•3) mm Hg (-6•7 to-0•8; p=0•0046), respectively. The respective difference for 24 h ambulatory systolic blood pressure was-4•2 mm Hg (95% CI-6•2 to-2•1) and-5•9 mm Hg (-7•9 to-3•8). After 4 weeks of withdrawal, office systolic blood pressure significantly increased with placebo versus aprocitentan (5•8 mm Hg, 95% CI 3•7 to 7•9, p<0•0001). The most frequent adverse event was mild-to-moderate oedema or fluid retention, occurring in 9%, 18%, and 2% for patients receiving aprocitentan 12•5 mg, 25 mg, and placebo, during the 4-week double-blind part, respectively. This event led to discontinuation in seven patients treated with aprocitentan. During the trial, a total of 11 treatment-emergent deaths occurred, none of which were regarded by the investigators to be related to study treatment. Interpretation In patients with resistant hypertension, aprocitentan was well tolerated and superior to placebo in lowering blood pressure at week 4 with a sustained effect at week 40
