1,721,686 research outputs found
Prostacyclin in liver disease: a potential therapeutic option. Expert Opin Biol Ther. 2007; 7(6):1-6
No full textExpert Opin Biol The
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Thrombosis in Nephrotic Syndrome
No full textNephrotic syndrome (NS) is characterized by heavy proteinuria, edema, hypoalbuminemia, and hyperlipidemia and the most frequent causes are glomerular diseases. An uncommon presentation is iatrogenic NS, an adverse effect of some drugs administration. In the clinical course of NS, a typical feature is dysregulated coagulation state, promoted by the breakdown of permselectivity barrier of the glomerular capillary wall, resulting in the leakage of high-molecular-mass proteins, at least the size of albumin. This hypercoagulable condition is supported by several factors, such as abnormalities in platelet activation and an imbalance between anticoagulation/antithrombosis and procoagulant/prothrombotic mechanisms. Thus, NS and the risk of developing thromboses are strictly related. Thrombotic events affect the venous system rather than arterial vessels with different features and frequencies. Deep venous system of the lower extremities and renal veins are the most frequent source of pulmonary embolism, the most dangerous NS complication. Prophylactic anticoagulation and thrombosis treatment are not clearly established because large randomized trials and guidelines are lacking. The management of NS and the decision of when and how to anticoagulate the patient represent a teamwork challenge for physicians
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Gut Microbiota as a Target for Food Allergy
Full text linkPurpose of review: The purpose of this review is to present an overview on
the potential role of gut microbiota as target of intervention against food
allergy.
Recent findings: Many studies suggest a key pathogenetic role for
gut microbiota modifications (dysbiosis) in food allergy development.
Several factors responsible for dysbiosis have been associated with the
occurrence of food allergy, such as caesarean delivery, lack of breast milk,
drugs use (mainly antibiotics and gastric acidity inhibitors), antiseptic agents
use, and low fibers/hight fat diet. No specific bacterial taxa have been
consistently associated with food allergy, but evidence suggests that gut
dysbiosis occurs even before food allergy signs and symptoms presentation.
Data from animal and human studies highlight the ability of particular bacterial
taxa to ferment dietary fibers for the production of short chain fatty acids that
affect host immunity and help to explain their health-promoting role.
Summary: Modulation of gut microbiota composition and/or function
represents a promising strategy for treatment and prevention of food
allergy in childhood.
Key Words: butyrate, dysbiosis, oral tolerance, probiotics, short chain
fatty acids
Abbreviations: BLG, beta-lactoglobulin, CMA, cow’s milk allergy, EHCF,
extensively hydrolyzed casein formula, FA, food allergy, HDAC, histone
deacetylase, LGG, Lactobacillus rhamnosus GG, PBMCs, peripheral blood
mononuclear cells, SCFAs, short chain fatty ac
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