74 research outputs found
Calibration of a conceptual rainfall-runoff model combining manual and automatic optimization for high mountain systems
Get PDF[EN] The calibration of a conceptual rainfall-runoff model is a complicated process that can take a long time and effort. Its success depends on the experience of the modeler and on the knowledge of the basin. For this reason, in this paper, a combination of manual and automatic calibration has been proposed to obtain the effective parameters of a hydrological model applied to a high mountain basin. This is because calibrating hydrological parameters and snow melting parameters simultaneously may not adequately represent the real conditions of high mountain systems. The methodology proposed in this paper has been implemented using the distributed hydrological TETIS model developed at the Universitat Politècnica de València. The results obtained are acceptable, because the Nash-Sutcliffe efficiency index is reached close to 0.9 in calibration and 0.8 validation, with parameters within the ranges established in the scientific literature.[ES] La calibración de un modelo lluvia-escorrentía es un proceso complicado que puede llevar mucho tiempo y esfuerzo. Su éxito está condicionado a la experiencia del modelador y al conocimiento que se tenga del sistema físico que se desea modelar. Por ello, en este trabajo, se propone una metodología que combina la calibración manual y automática para obtener los parámetros efectivos de un modelo hidrológico aplicado a una cuenca de alta montaña. Lo anterior se debe a que calibrar simultáneamente los parámetros hidrológicos y los parámetros de fusión de nieve puede no representar adecuadamente las condiciones reales de los sistemas de alta montaña. La metodología propuesta ha sido probada usando el modelo hidrológico distribuido TETIS desarrollado en la Universitat Politècnica de València. Los resultados obtenidos son buenos al alcanzarse índices de eficiencia de Nash-Sutcliffe cercanos a 0.9 en calibración y a 0.8 en validación, con parámetros dentro de los rangos establecidos en la literatura científica.Esta investigación ha sido apoyada por la Dirección General de Educación Superior Universitaria (DGESU)
de la Secretaría de Educación Pública, a través de su Programa para el Desarrollo Profesional Docente (Folio
prodep: UGTO-PTC 613) y por la División de Ingenierías de la Universidad de Guanajuato.Orozco Medina, I.; Ramirez, A.; Francés, F. (2019). Calibración de un modelo lluvia-escorrentía combinando la optimización manual y automática para un sistema de alta montaña. Acta Universitaria (Online). 29:1-15. https://doi.org/10.15174/au.2019.2187S1152
Apoyo familiar en escolares de alta capacidad intelectual de diferentes contextos socioeducativos
No full textEl objetivo del trabajo fue analizar la percepción del apoyo familiar al aprendizaje en 79 alumnos de 6to grado con aptitud intelectual superior de tres contextos educativos (escuela urbana pública y privada, y rural indígena) en Morelos, México. Los alumnos respondieron la prueba SAGES-2 (Johnson & Corn, 2001) y el Cuestionario de Apoyo Familiar de Bazán & Domínguez (2009). Solamente se encontraron diferencias significativas entre los contextos analizados en la percepción de la comunicación regular con maestros relacionada con la materia Español, que fue percibida con mayor frecuencia en el contexto de la escuela privada, respecto al público indígena, independientemente del área de capacidades detectada. Se enfatiza la urgencia de investigar las variables del contexto socioeconómico y familiar para la comprensión de la manifestación, desarrollo y educación de las altas capacidades en alumnos de entornos culturales diferentes
Publisher Correction: Unveiling the strong interaction among hadrons at the LHC (Nature, (2020), 588, 7837, (232-238), 10.1038/s41586-020-3001-6)
No full textIn Fig. 1c of this Article, owing to an error during the production process, the equation incorrectly began ‘C(k*, r*) = …’ instead of ‘C(k*) = …’. In addition, in affiliation 71 ‘Dipartimento di Fisica dell’Università degli studi di Bari Aldo Moro’ has been corrected to read ‘Dipartimento di Fisica dell’Università degli studi di Cagliari’. The original Article has been corrected online. *A list of authors and their affiliations appears online. © 2021, The Author(s), under exclusive licence to Springer Nature Limited
Sistema de control de alimentación para cultivo lote alimentado exponencial en procesos de fermentación
Get PDFEl presente trabajo propone la aplicación de una
ley de control Proporcional Integral Derivativo (PID) aplicadas
en una bomba peristáltica como actuador de alimentación de
sustrato de forma exponencial, permitiendo incrementar en el
volumen de operación del biorreactor y en consecuencia un
aumento en la concentración celular del medio de cultivo.
Tomando como base los balances de masa y el modelo de
crecimiento de Monod, se predice la cédula de alimentación o
flujo de la bomba peristáltica que permitirá el control de la
velocidad específica de crecimiento. Simulaciones y resultados
experimentales dan cuenta de la efectividad del sistema en lazo
cerrado de un cultivo lote alimentado exponencial de Klebsiella
pneumoniae sp. pneumoniae K63.Público en genera
Glória póstuma :: almanaque objeto de estudo /
Get PDFDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão.Análise da revista Almanaque-cadernos de literatura e ensaio, centrada em seus sete primeiros números, publicados pela Editora Brasiliense e organizados por Walnice Nogueira Galvão e Bento Prado Jr., de 1976 a 1976 a 1978. A partir dos manifestos de crítica literária presentes nessa primeira fase da revista, a dissertação busca respostas para as questões presentes no título: a relação entre discurso acadêmico e indústria cultural, cadernos de literatura e ensaio e almanaques, mapeando as posições defendidas e as alternativas vislumbradas pela crítica literária brasileira no final dos anos 70. A dissertação inclui ainda a indexação completa dos quatorze números do periódico, desenvolvida no banco de dados do projeto "Poéticas contemporâneas: histórias e caminhos", do Núcleo de Estudos Literários e Culturais (NELIC), na UFSC
Publisher Correction: Unveiling the strong interaction among hadrons at the LHC (Nature, (2020), 588, 7837, (232-238), 10.1038/s41586-020-3001-6)
No full textIn Fig. 1c of this Article, owing to an error during the production process, the equation incorrectly began ‘C(k*, r*) = ...’ instead of ‘C(k*) = ...’. In addition, in affiliation 71 ‘Dipartimento di Fisica dell’Università degli studi di Bari Aldo Moro’ has been corrected to read ‘Dipartimento di Fisica dell’Università degli studi di Cagliari’. The original Article has been corrected online. *A list of authors and their affiliations appears online
Development of an in silico methodological protocol to understand the possible interactions between the Staphylococcus aureus YlbF protein with RNA
No full textLa proteína YlbF, que forma parte de la familia de proteínas con dominio com_ylbF estudiadas principalmente en Bacillus subtilis, está involucrada en la regulación de la formación de biofilm, competencia y esporulación. Dado que este dominio es conservado, se postula que proteínas homólogas en otras bacterias Gram positivas podrían cumplir funciones similares. En Staphylococcus aureus, un microorganismo oportunista que causa infecciones intrahospitalarias en pacientes de alto riesgo se sospecha que YlbF está relacionada con la regulación de factores de virulencia, especialmente a nivel transcripcional, como sugiere la presencia de un dominio putativo de unión a ácidos nucleicos y estudios en mutantes nulos.
En este proyecto de grado elaboró un protocolo bioinformático centrado en el desarrollo de un pipeline para obtener parámetros y llevar a cabo una dinámica molecular de la proteína YlbF de S. aureus en complejo con ARN, con el objetivo de evaluar posibles sitios de interacción (hotspots) en términos de energías, distancias y empaquetamiento hidrofóbico y su validación mediante metodologías in silico de análisis termodinámico. El flujo de trabajo incluyó la preparación de datos biológicos, obtención de estructuras proteicas y de ARN, definición de parámetros de simulación, construcción de los sistemas a simular, así como la ejecución de la dinámica molecular, su análisis y validación al realizar sustituciones clave por alanina para evaluar los cambios en las interacciones llevando a cabo un análisis comparativo de energías por aminoácido el fin de identificar aquellos residuos que presentan las energías más favorables entre las variantes mutantes y no mutantes. Hecho esto, se observó la participación de diferentes aminoácidos durante la simulación, destacando Arg193, Lys194, Arg207 y Arg209. Estos residuos mostraron una fuerte interacción con el ARN, lo que sugiere una unión potencialmente estable. La naturaleza de esta interacción parece estar relacionada con la carga positiva de estos aminoácidos, que facilita su unión a los grupos fosfato de la cadena de ARN.Laboratorio de genética molecular bacterianaBioingenieroPregradoThe YlbF protein, part of the com_ylbF domain family studied mainly in Bacillus subtilis, is involved in the regulation of biofilm formation, competence, and sporulation. Given the conserved nature of this domain, it is hypothesized that homologous proteins in other Gram-positive bacteria might perform similar functions. In Staphylococcus aureus, an opportunistic microorganism responsible for nosocomial infections in high-risk patients, YlbF is suspected to be linked to the regulation of virulence factors, particularly at the transcriptional level, as indicated by the presence of a putative nucleic acid-binding domain and studies in null mutants.
In this degree project, a bioinformatics protocol was developed, focusing on creating a pipeline to obtain parameters and conduct molecular dynamics simulations of the S. aureus YlbF protein in complex with RNA. The goal was to evaluate potential interaction sites (hotspots) in terms of energies, distances, and hydrophobic packing, and validate these through in silico thermodynamic analysis methodologies. The workflow included preparing biological data, obtaining protein and RNA structures, defining simulation parameters, constructing the systems to be simulated, executing molecular dynamics, analyzing the results, and validating key substitutions with alanine to assess changes in interactions. This included a comparative analysis of energies per amino acid to identify residues showing the most favorable energies between mutant and non-mutant variants. As a result, different amino acids were highlighted during the simulation, with Arg193, Lys194, Arg207, and Arg209 showing strong interactions with RNA, suggesting a potentially stable binding. This interaction is likely related to the positive charge of these amino acids, which facilitates their binding to the phosphate groups of the RNA chain
The learning experiences and preferred teaching strategies of children who have been identified as Gifted with ADHD
No full textThis qualitative study investigated the educational and social experiences of six children who had been identified as Gifted with Attention Deficit Hyperactivity Disorder (ADHD). The children were aged from six to ten years old. Semi-structured interviews were conducted with the children and their parents and a staff member of the George Parkyn Centre (now The Gifted Education Centre) to explore their educational and social experiences in order to identify their preferred strategies that were also expected to be the most effective educational strategies.
It is important to identify effective educational strategies for Gifted children with ADHD. This is because there are children in New Zealand (as this study has found) who have been identified as Gifted with ADHD but according to the literature review conducted for this study there does not appear to be a significant amount of literature from New Zealand or international writers that informs educators about how to assist these children to learn.
Instead, the literature appeared to focus on misdiagnosis of Giftedness as ADHD, however, these children may benefit from having assistance with their learning as some literature suggested they are not being identified and could be underachievers. It seems that the use of effective educational strategies may be the only way these children could reach their academic potential. Therefore, this study sought to move on from the misdiagnosis debate evident in the Gifted/ADHD literature to identify some effective educational strategies.
This study also investigated the social experiences of Gifted children with ADHD. This is because the literature maintained Gifted children with ADHD could have difficulties with social interactions. Talking to the children about their social interactions could indicate whether the literature's implications are correct and if they are it should allow further understanding regarding how we could assist the Gifted child with ADHD to have more positive social interactions that could also positively impact on learning as social interactions occur within the classroom.
The key findings of this study indicated that some Gifted children with had specific learning preferences that could stimulate them to learn (e.g., when their interests were recognised, information was presented visually, tasks had a meaningful purpose and movement and use of computers was allowed). Ineffective educational strategies were also addressed although not in detail as for the most part they seemed to be the opposite of effective educational strategies. The findings also indicated Gifted children with ADHD could benefit when they find their 'true peer' as this seemed to result in the children within this study wanting to work with others.
Although specific suggestions were recommended (e.g., the use Renzulli's 1977 Enrichment Triad Model) the findings emphasised the depth of information that could be gained by simply talking to children and their parents about their learning. A wider implication may be this Gifted group of children may benefit from the use of specific educational strategies that personalise their learning
Contratos de investigación y desarrollo conjunto
Get PDFJoint research is currently one of the most used and important ways to produce and share knowledge. This type of investigation is generally made through a contract called research and development agreement (R&D) in which two or more individuals combine efforts to create or develop a technology. Therefore, the objective of this paper is to identify the nature, obligations, and characteristics of R&D contracts.Actualmente la investigación conjunta es una de las formas más utilizadas para producir y transferir conocimiento. Dicha modalidad implica que por medio de un contrato de investigación y desarrollo (I+D) dos o más individuos unan esfuerzos para investigar o desarrollar una tecnología. Así las cosas, el objetivo de este artículo es analizar la naturaleza jurídica de estos contratos e identificar las características, las clases, las obligaciones y las etapas contractuales de ellos
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