1,757 research outputs found
The Investigation of Aromatic Amino Acid Pathway in Potato (Solanum tuberosum) Using Bioinformatics Approaches
No full textAromatik amino asitler (AAA) şikimat metabolik yolu ile elde edilirler ve protein sentezinden sonra çeşitli ikincil metabolitler olan pigmentler, alkaloidler, hormonlar ve hücre duvarı parçaları gibi öncü maddelerin sentezinde kullanılmaktadırlar. AAA olan L-Trp, L-Phe ve L-Tyr amino asitleri korizmattan şikimat metabolik yolunun sonunda meydana gelmektedirler. Bu amino asitler özellike K1 ve B9 vitaminleri ile bitki savunma sisteminin önemli bir parçası olan salisilik asitin öncü maddeleridirler. AAA’ler hayvan hücrelerinde sentezlenemediğinden bitkisel kaynaklı yiyeceklerden karşılanması gerekmektedir. AAA ve türevlerinin bu önemli fonksiyonlarına rağmen, mikrobiyal çalışmalar dışında AAA metabolik yolu ve bu amino asitlerin bitkilerdeki düzenlenme mekanizması üzerine son derece sınırlı çalışmalar yapılmıştır. Bu nedenle bu çalışmada patates (Solanum tuberosum) bitkisinde AAA’lerin sentez mekanizmasında yer alan bazı genlerin hangi genlerle ilişkili olduğu dolayısıyla nasıl düzenlendiği biyoinformatik yaklaşımlarla incelenmiştir. Çalışmanın sonucunda AAA yolağındaki en önemli gen olan korizmat geni ile patates bitkisinde yer alan yaklaşık 39000 gen arasındaki ilişki ko-expresyon ağı ile belirlenmeye çalışılmıştır. Çalışma sonuçları şikimat yolağının anlaşılmasına katkı sunmaktadır
Analysis of Technical Approaches (ATA)
No full textStudies & Prototyping This JSB ATA Study Paper is the author's work product and does not reflec
Uzbek author O'lmas Umarbekov's forensic novel 'Ådam Bo'lish Qiyin' (Review-translation writing-dictionary-book letter text)
No full textSosyal Bilimler Enstitüsü, Türk Dili ve Edebiyatı Ana Bilim DalıTürk dilinin Doğu Türkçesi (Karluk) grubunda yer alan Özbek Türkçesi, 11. ve 12. yüzyıllarda kullanılan Karahanlı Türkçesinin, 13. ve 14. yüzyıllarda kullanılan Harezm Türkçesinin, daha sonra da Tarihî Çağatay Türkçesinin çağdaş devamı olarak gelişmiş bir Türk dilidir. Bu çalışmada Özbek edebiyatının önemli yazarlarından biri olan O'lmas Umarbekov'un "Ådam Bo'liş Qiyin" adlı eserinin dil özellikleri incelenmiştir. Özbek yazar O'lmas Umarbekov'un "Ådam Bo'lish Qiyin" adlı romanı dört bölüm şeklinde incelenerek çalışmaya konu olmuştur. Çalışmanın birinci bölümünde; çalışmaya konu olan eser, eserin özellikleri ve önemi, yazar, çalışmanın amacı ve önemi, yöntem, inceleme, Özbek Türkçesi hakkında bilgilere yer verilmiştir. Çalışmanın ikinci bölümünde; O'lmas Umarbekov'un "Ådam Bo'lish Qiyin" adlı romanı, seslik özellikler ve biçim özellikleri olmak üzere iki başlık altında incelenmiştir. Çalışmanın üçüncü bölümünü; çeviri yazılı metin ve Kiril harfli metin oluşturmaktadır. Dördüncü bölümde ise; metinde kullanılan kelimelerden oluşturulmuş sözlük bölümü ve ekler dizini yer almaktadır.Uzbek Turkish, which is in the Eastern Turkish (Karluk) group of the Turkish language, is a developed Turkish language as a contemporary continuation of Karahanli Turkish used in the 11th and 12th centuries, Harezm Turkish used in the 13th and 14th centuries, and later Historical Cagatay Turkish. In this study, the language characteristics of O'lmas Umarbekov's "Ådam Bo'lyş Qiyin", one of the important authors of Uzbek literature, were examined. Uzbek author O'lmas Umarbekov's novel "Ådam Bo'lish Qiyin" was reviewed in four chapters and was the subject of study. In the first part of the study; information about the work subject to the study, the characteristics and importance of the work, the author, the purpose and importance of the study, method, examination, Uzbek Turkish. In the second part of the study; O'lmas Umarbekov's novel "Ådam Bo'lish Qiyin" is reviewed under two titles: vocal features and form features. The third part of the study; translation is written text and cyrillic text. In the fourth part; the dictionary section and attachments index created from the words used in the text
Alma Ata Declaration
No full textHorder evaluates the current state of health care in Great Britain in
light of the Declaration of Alma Ata, which called upon all countries to
formulate national policies to initiate and maintain primary health care as
the key to achieving "health for all" by the year 2000. While Britain has
developed a good system of primary medical care, primary health care, with its
emphasis on preventive medicine and health promotion, is in a state of flux.
The author concludes by outlining the challenges this situation poses to
general practitioners and other health personnel, district and regional health
authorities, professional organizations, and the government. (KIE
abstract
Using author tri-citation analysis to map knowledge domains in knowledge representations
No full text
Purpose
Previous commonly used author co-citation analysis (ACA) methods have limited the ability to deal with accidental co-citation in constructing a raw co-citation matrix. Therefore, the purpose of this paper is to propose a new method, called author tri-citation analysis (ATA), to better map knowledge domains and depict scientific intellectual structures.
Design/methodology/approach
Different from the previous method of using ACA that captures author co-citation relationships, the ATA method seeks tri-citation relationships among authors. Compared with ACA, ATA can ignore some accidental co-citation relationships between authors and can improve the accuracy of mapping knowledge domains.
Findings
Although ATA does not mine more sub-fields than ACA does, the results of the empirical studies show that ATA, the newly proposed method, performs better in knowledge domain maps based on publications in the field of computer science.
Research limitations/implications
The definition of ATA in this article is simple and still insufficiently informative. Many other pieces of information can be involved; for example, all authors’ information, authors’ sequence in the author list, reference published time and similar. These can be enhanced in future studies.
Practical implications
This research will enrich the methods of mapping knowledge domains due to its new perspective.
Social implications
Knowledge domain mapping is important to understand a discipline, and this research provides more potential methods for this, which benefits the performance of the maps.
Originality/value
ATA can provide a methodological awareness for mapping knowledge domains. This value lies in not only a tri-citation perspective, but also author bibliographic tripling and author tri-operation perspectives (“tri-” perspectives).
</jats:sec
Alma-Ata to Berlin: diabetes prevention and treatment to achieve healthy living
No full textBharti Hosp, Dept Endocrinol, Karnal, Haryana, IndiaAarhus Univ, Dept Publ Hlth, Aarhus, DenmarkKazakh Acad Nutr, Alma Ata, KazakhstanAcad Prevent Med, Alma Ata, KazakhstanKazakh Natl Med Univ, Alma Ata, KazakhstanDubai Hosp, Dept Endocrinol, Dubai, U Arab EmiratesPondicherry Inst Med Sci, Dept Med, Pondicherry, IndiaMinist Hlth, Directorate Epidemiol, Mexico City, DF, MexicoItalian Coll Gen Practitioners, Florence, ItalyUniv Hlth Network, Toronto, ON, CanadaSiberian State Med Univ, Tomsk, RussiaInst Diabet Endocrinol & Metab Dis, Endocrinol Res Ctr, Moscow, RussiaUniv Fed São Paulo, Dept Med, São Paulo, BrazilPrimary Care Diabet Europe, Barcelona, SpainDubai Hlth Author, Dubai, U Arab EmiratesPeking Union Med Coll, Beijing, Peoples R ChinaUniv Fed São Paulo, Dept Med, São Paulo, BrazilWeb of Scienc
Me-Liyan-kan Perempuan dalam Filsafat Relasionalitas Armada Riyanto dan Ata Pe’ang dalam Budaya Manggarai
No full textFocus this paper is comparing the concept of othering women in Armada's Relational Philosophy and the concept of ata pe'ang (outsider) in Manggarai culture. The method used is a critical analysis with a comparative approach between the concept of othering women in Armada's Relational Philosophy and the concept of ata pe'ang in Manggarai culture. The author finds that the label of ata pe'ang has shackled women, thus viewing them as the other. This shackling is rooted in a misunderstanding of the concept of ata pe'ang as intended by the Manggarai ancestors. Relational Philosophy can serve as a critical lens for this reality. Relational philosophy provides a new contribution, namely that ata pe'ang must be viewed as relational subjects, and it critiques the marginalization of women in Manggarai culture. Furthermore, Armada's philosophical concept helps reconstruct unequal cultural practices and affirms that women, as ata pe'ang, can be agents of change in communal life.AbstrakFokus tulisan ini adalah membuat komparasi konsep me-liyan-kan perempuan dalam filsafat Relasionalitas Armada dan konsep ata pe’ang (orang luar) dalam budaya Manggarai. Metode yang digunakan ialah analisis kritis dengan pendekatan komparatif antara konsep me-liyan-kan perempuan filsafat Relasionlitas Armada dan konsep ata pe’ang dalam budaya Manggarai. Penulis menemukan bahwa pelabelan ata pe’ang telah membelenggu kaum perempuan sehingga perempuan dipandang sebagai liyan. Keterbelengguan tersebut berakar pada kesalahpahaman terhadap konsep ata pe’ang sebagaimana dimaksudkan oleh para leluhur orang Manggarai. Filsafat Relasionalitas dapat menjadi lensa kritik terhadap realitas tersebut. Filsafat relasionlitas memberikan sumbangan baru bahwa Ata pe’ang harus dipandang sebagai subjek relasional, filsafat relasionlitas memberikan kritik marginalisasi perempuan dalam budaya Manggarai. Selain itu, konsep filosofis Armada membantu untuk merekonstruksikan kembali praktik budaya yang timpang serta memberikan penegasan bahwa perempuan sebagai ata pe’ang dapat menjadi agen perubahan dalam kehidupan bersama.
Inflammatory cells in the atherosclerotic abdominal aortic aneurysm
No full textUpalna reakcija definirana je kao ključni regulatorni proces ateroskleroze.
Usporedbom vrste i količine upalnih stanica u stijenci aneurizme trbušne aorte (ATA)
i stijenci samo aterosklerotski promijenjene trbušne aorte istražen je utjecaj upale na
stvaranje aterosklerotskog plaka i razvoj ATA.
U stijenci ATA (40 bolesnika liječenih otvorenim kirurškim popravkom anurizme) i
stijenci samo aterosklerotski promijenjene trbušne aorte (20 bolesnika) rađena je
usporedba vrste i količine upalnih stanica - makrofaga, mastocita, limfocita B,
plazma stanica, pomoćničkih CD4+ limfocita T, citotoksičnih CD8+ limfocita T i
regulacijskih CD4+Foxp3+ limfocita T. Upalne stanice obilježene su prikazom
specifičnih staničnih biljega imunohistokemijskom metodom na parafinskim rezovima
tkiva. Također su analizirane morfološke karakteristike ATA (promjer, morfološki tip -
fuziformna/sakularna, izolirana aneurizma trbušne aorte ili proširena sa
zahvaćanjem jedne i/ili dvije ilijakalne arterije s ograncima, prisutnost
intraluminalnog tromba), laboratorijski pokazatelji (CRP, D-dimer, ukupni kolesterol,
HDL, LDL, trigliceridi) i klinički čimbenici rizika ateroskleroze (dob, spol, tjelesna
visina, tjelesna težina, indeks tjelesne mase (ITM), pušenje, krvni tlak – sistolički/
dijastolički, šećerna bolest, prisutnost znakova periferne ateroskleroze, druga
periferna aneurizma, uzimanje lijekova - statini).
U stijenci ATA nađen je značajno veći broj citotoksičnih CD8+ limfocita T,
regulacijskih CD4+Foxp3+ limfocita T i plazma stanica u odnosu na stijenku samo
aterosklerotski promijenjene trbušne aorte. Značajno veći broj pomoćničkih CD4+
limfocita T i makrofaga nađen je u stijenci trbušne aorte kontrolne skupine. Kod
najvećeg broja bolesnika promjer ATA je iznosio 45-75 mm, aneurizme su bile češće
sakularnog oblika (32/40), izolirane bez zahvaćanja jedne i/ili dvije ilijakalne arterije s
ograncima (36/40) i s prisutnim intraluminalnim trombom (28/40). Usporedbom vrste
i količine ispitivanih upalnih stanica u stijenci ATA i morfoloških karakteristika ATA
nađena je statistički značajna veća učestalost limfocita B u fuziformnom tipu ATA.
Vrsta i učestalost ispitivanih upalnih stanica nisu povezane s ostalim analiziranim
morfološkim karakteristikama ATA. Usporedbom vrste i količine ispitivanih upalnih stanica s ispitivanim laboratorijskim pokazateljima i kliničkim čimbenicima rizika za
aterosklerozu, nađeni statistički signifikantni rezultati povezanosti plazma stanica s
vrijednostima LDL i ukupnog kolesterola, citotoksičnih CD8+ limfocita T i plazma
stanica s vrijednostima dijastoličkog tlaka i regulacijskih CD4+Foxp3+ limfocita s
ITM i tjelesnom težinom bolesnika nemaju specifičan klinički značaj. Usporedbom
morfoloških karakteristika ATA s ispitivanim laboratorijskim pokazateljima i kliničkim
čimbenicima rizika za aterosklerozu vidjelo se da je promjer ATA značajno povezan
s povišenom vrijednosti CRP. Prošireni tip ATA sa zahvaćanjem jedne i/ili dvije
ilijakalne arterije s ograncima bio je statistički značajno češće prisutan u bolesnika
starije životne dobi.
Veća učestalost citotoksičnih CD8+ limfocita T u ATA odgovorna je za oštećenje
glatkomišićnih stanica i destrukciju stijenke aorte. Upalna reakcija u samo
aterosklerotski promijenjenoj stijenci trbušne aorte karakterizirana je većom
učestalošću pomoćničkih CD4+ limfocita T i makrofaga važnih u početnoj fazi i
poticanju upale. Povećan broj regulacijskih CD4+Foxp3+ limfocita T i plazma stanica
u stijenci ATA ukazuje na prevladavanje inhibitornog upalnog odgovora u ATA.
Različite karakteristike upalnog odgovora u stijenci samo aterosklerotski
promijenjene aorte i stijenci ATA ukazuju na promjene karakteristika upalne reakcije
s napredovanjem ateroskleroze i nastankom aneurizmatske komplikacije. Fuziformni
tip ATA karakteriziran je povećanom inhibitornom upalnom reakcijom limfocita B.
Vrsta i učestalost ispitivanih upalnih stanica nisu povezane s ostalim morfološkim
karakteristikama ATA – promjer, izolirana ili proširena aneurizma sa zahvaćanjem
jedne i/ili dvije ilijakalne arterije s ograncima i prisutnost intraluminalnog tromba.
Promjer ATA statistički je značajno povezan s povišenom vrijednosti CRP što
ukazuje na važnost upale u progresiji ateroskleroze i razvoju aneurizmatskih
komplikacija. Prošireni tip ATA sa zahvaćanjem jedne i/ili dvije ilijakalne arterije s
ograncima značajno češće je prisutan u bolesnika starije životne dobi, ukazujući na
tezi klinički oblik ATA kod starijih bolesnika.The inflammatory reaction is defined as the key regulatory atherosclerotic process.
By comparing the type and volume of inflammatory cells in the abdominal aortic
aneurysm (AAA) walls and the only atherosclerotic abdominal aorta abnormalities,
the influence of inflammation on the formation of atherosclerotic plaque and the
development of ATA was investigated.
Comparison of the type and volume of inflammatory cells - macrophage, mast cell,
lymphocyte B, plasma cells, auxiliary CD4 + lymphocytes T, cytotoxic CD8 +
lymphocytes, in the AAA strain (40 patients treated with open surgical aneurysm
repair) and rocks only atherosclerotic altered abdominal aorta (20 patients) T and
regulatory CD4 + Foxp3 + lymphocytes T. Inflammatory cells are characterized by
the representation of specific cellular markers by immunohistochemical method on
paraffinic tissue cuts. The morphological characteristics of AAA (diameter,
morphological type - fusiform / saccular, isolated abdominal aorta aneurysm or
extended with one and / or two iliac arteries , presence of intraluminal thrombus),
laboratory parameters (CRP, D-dimer, total cholesterol (age, gender, body weight,
body weight, body mass index (ITM), smoking, blood pressure - systolic/diastolic,
diabetes mellitus, presence of peripheral atherosclerosis, other peripheral
aneurysms), and clinical risk factors of atherosclerosis, taking medicines - statins).
In the AAA strains, a significantly higher number of cytotoxic CD8 + lymphocytes T,
regulatory CD4 + Foxp3 + lymphocytes T and plasma cells were found in
comparison to the only atherosclerotic abdominal aortic ventricular wall. Significantly
larger number of auxiliary CD4 + lymphocytes T and macrophages were found in the
abdominal aorta of the control group. In the largest number of patients, the diameter
of AAA was 45-75 mm, aneurysms were more often sacrilege (32/40), isolated
without the involvement of one and/or two iliac arteries with branches (36/40) and
with intraluminal thrombosis (28/40). By comparison of the type and volume of the examined inflammatory cells in the AAA strain and the morphological characteristics
of the AAA, a statistically significant higher incidence of lymphocyte B was found in
the fusiform type of AAA. The type and frequency of the examined inflammatory cells
are not related to other analyzed morphological characteristics of AAA. By
comparing the type and volume of the investigated inflammatory cells with the
investigated laboratory indicators and clinical factors of atherosclerosis risk,
statistically significant results of plasma cell-related correlation with LDL and total
cholesterol, cytotoxic CD8 + lymphocyte T and plasma cells were found with diastolic
pressure values and regulatory CD4 + Foxp3 + lymphocytes with ITM and body
weight of patients have no specific clinical relevance. By comparing the
morphological characteristics of AAA with the investigated laboratory indicators and
the clinical factors of atherosclerosis risk, the AAA diameter was significantly
associated with elevated CRP values. The extended AAA type with the involvement
of one and/or two lipid arteries with the ribs was statistically significantly more
frequent in elderly patients.
The higher incidence of cytotoxic CD8 + lymphocytes T in AAA is responsible for
damage to smooth muscle cells and the destruction of the aortic wall. The
inflammatory reaction in atherosclerotic alteration of the abdominal aorta was
characterized by a higher incidence of auxiliary CD4 + lymphocytes T and
macrophages important in the initial stage and stimulation of inflammation. An
increased number of regulatory CD4 + Foxp3 + T lymphocytes and AAA plasma
cells suggests overcoming the inhibitory inflammatory response in AAA. Different
characteristics of the inflammatory response in the parts only atherosclerotic aortic
and aorta scars indicate changes in the characteristics of the inflammatory reaction
with atherosclerosis and the emergence of aneurysmatic complications. The fusiform
type of AAA is characterized by an increased inhibitory inflammatory response of
lymphocytes B. The type and frequency of the examined inflammatory cells are not
related to other morphological characteristics of the AAA diameter, isolated or
extended aneurysm with the involvement of one and / or two iliac arteries with the
branches and the presence of intraluminal thrombus. The AAA diameter is
statistically significantly associated with elevated CRP values, indicating the
importance of inflammation in atherosclerosis progression and the development of
aneurysmatic complications. The extended AAA type with the involvement of one and/or two iliac arteries with the bra nches is significantly more frequent in elderly
patients, pointing to the aetiology of AAA in elderly patients
Inflammatory cells in the atherosclerotic abdominal aortic aneurysm
No full textUpalna reakcija definirana je kao ključni regulatorni proces ateroskleroze.
Usporedbom vrste i količine upalnih stanica u stijenci aneurizme trbušne aorte (ATA)
i stijenci samo aterosklerotski promijenjene trbušne aorte istražen je utjecaj upale na
stvaranje aterosklerotskog plaka i razvoj ATA.
U stijenci ATA (40 bolesnika liječenih otvorenim kirurškim popravkom anurizme) i
stijenci samo aterosklerotski promijenjene trbušne aorte (20 bolesnika) rađena je
usporedba vrste i količine upalnih stanica - makrofaga, mastocita, limfocita B,
plazma stanica, pomoćničkih CD4+ limfocita T, citotoksičnih CD8+ limfocita T i
regulacijskih CD4+Foxp3+ limfocita T. Upalne stanice obilježene su prikazom
specifičnih staničnih biljega imunohistokemijskom metodom na parafinskim rezovima
tkiva. Također su analizirane morfološke karakteristike ATA (promjer, morfološki tip -
fuziformna/sakularna, izolirana aneurizma trbušne aorte ili proširena sa
zahvaćanjem jedne i/ili dvije ilijakalne arterije s ograncima, prisutnost
intraluminalnog tromba), laboratorijski pokazatelji (CRP, D-dimer, ukupni kolesterol,
HDL, LDL, trigliceridi) i klinički čimbenici rizika ateroskleroze (dob, spol, tjelesna
visina, tjelesna težina, indeks tjelesne mase (ITM), pušenje, krvni tlak – sistolički/
dijastolički, šećerna bolest, prisutnost znakova periferne ateroskleroze, druga
periferna aneurizma, uzimanje lijekova - statini).
U stijenci ATA nađen je značajno veći broj citotoksičnih CD8+ limfocita T,
regulacijskih CD4+Foxp3+ limfocita T i plazma stanica u odnosu na stijenku samo
aterosklerotski promijenjene trbušne aorte. Značajno veći broj pomoćničkih CD4+
limfocita T i makrofaga nađen je u stijenci trbušne aorte kontrolne skupine. Kod
najvećeg broja bolesnika promjer ATA je iznosio 45-75 mm, aneurizme su bile češće
sakularnog oblika (32/40), izolirane bez zahvaćanja jedne i/ili dvije ilijakalne arterije s
ograncima (36/40) i s prisutnim intraluminalnim trombom (28/40). Usporedbom vrste
i količine ispitivanih upalnih stanica u stijenci ATA i morfoloških karakteristika ATA
nađena je statistički značajna veća učestalost limfocita B u fuziformnom tipu ATA.
Vrsta i učestalost ispitivanih upalnih stanica nisu povezane s ostalim analiziranim
morfološkim karakteristikama ATA. Usporedbom vrste i količine ispitivanih upalnih stanica s ispitivanim laboratorijskim pokazateljima i kliničkim čimbenicima rizika za
aterosklerozu, nađeni statistički signifikantni rezultati povezanosti plazma stanica s
vrijednostima LDL i ukupnog kolesterola, citotoksičnih CD8+ limfocita T i plazma
stanica s vrijednostima dijastoličkog tlaka i regulacijskih CD4+Foxp3+ limfocita s
ITM i tjelesnom težinom bolesnika nemaju specifičan klinički značaj. Usporedbom
morfoloških karakteristika ATA s ispitivanim laboratorijskim pokazateljima i kliničkim
čimbenicima rizika za aterosklerozu vidjelo se da je promjer ATA značajno povezan
s povišenom vrijednosti CRP. Prošireni tip ATA sa zahvaćanjem jedne i/ili dvije
ilijakalne arterije s ograncima bio je statistički značajno češće prisutan u bolesnika
starije životne dobi.
Veća učestalost citotoksičnih CD8+ limfocita T u ATA odgovorna je za oštećenje
glatkomišićnih stanica i destrukciju stijenke aorte. Upalna reakcija u samo
aterosklerotski promijenjenoj stijenci trbušne aorte karakterizirana je većom
učestalošću pomoćničkih CD4+ limfocita T i makrofaga važnih u početnoj fazi i
poticanju upale. Povećan broj regulacijskih CD4+Foxp3+ limfocita T i plazma stanica
u stijenci ATA ukazuje na prevladavanje inhibitornog upalnog odgovora u ATA.
Različite karakteristike upalnog odgovora u stijenci samo aterosklerotski
promijenjene aorte i stijenci ATA ukazuju na promjene karakteristika upalne reakcije
s napredovanjem ateroskleroze i nastankom aneurizmatske komplikacije. Fuziformni
tip ATA karakteriziran je povećanom inhibitornom upalnom reakcijom limfocita B.
Vrsta i učestalost ispitivanih upalnih stanica nisu povezane s ostalim morfološkim
karakteristikama ATA – promjer, izolirana ili proširena aneurizma sa zahvaćanjem
jedne i/ili dvije ilijakalne arterije s ograncima i prisutnost intraluminalnog tromba.
Promjer ATA statistički je značajno povezan s povišenom vrijednosti CRP što
ukazuje na važnost upale u progresiji ateroskleroze i razvoju aneurizmatskih
komplikacija. Prošireni tip ATA sa zahvaćanjem jedne i/ili dvije ilijakalne arterije s
ograncima značajno češće je prisutan u bolesnika starije životne dobi, ukazujući na
tezi klinički oblik ATA kod starijih bolesnika.The inflammatory reaction is defined as the key regulatory atherosclerotic process.
By comparing the type and volume of inflammatory cells in the abdominal aortic
aneurysm (AAA) walls and the only atherosclerotic abdominal aorta abnormalities,
the influence of inflammation on the formation of atherosclerotic plaque and the
development of ATA was investigated.
Comparison of the type and volume of inflammatory cells - macrophage, mast cell,
lymphocyte B, plasma cells, auxiliary CD4 + lymphocytes T, cytotoxic CD8 +
lymphocytes, in the AAA strain (40 patients treated with open surgical aneurysm
repair) and rocks only atherosclerotic altered abdominal aorta (20 patients) T and
regulatory CD4 + Foxp3 + lymphocytes T. Inflammatory cells are characterized by
the representation of specific cellular markers by immunohistochemical method on
paraffinic tissue cuts. The morphological characteristics of AAA (diameter,
morphological type - fusiform / saccular, isolated abdominal aorta aneurysm or
extended with one and / or two iliac arteries , presence of intraluminal thrombus),
laboratory parameters (CRP, D-dimer, total cholesterol (age, gender, body weight,
body weight, body mass index (ITM), smoking, blood pressure - systolic/diastolic,
diabetes mellitus, presence of peripheral atherosclerosis, other peripheral
aneurysms), and clinical risk factors of atherosclerosis, taking medicines - statins).
In the AAA strains, a significantly higher number of cytotoxic CD8 + lymphocytes T,
regulatory CD4 + Foxp3 + lymphocytes T and plasma cells were found in
comparison to the only atherosclerotic abdominal aortic ventricular wall. Significantly
larger number of auxiliary CD4 + lymphocytes T and macrophages were found in the
abdominal aorta of the control group. In the largest number of patients, the diameter
of AAA was 45-75 mm, aneurysms were more often sacrilege (32/40), isolated
without the involvement of one and/or two iliac arteries with branches (36/40) and
with intraluminal thrombosis (28/40). By comparison of the type and volume of the examined inflammatory cells in the AAA strain and the morphological characteristics
of the AAA, a statistically significant higher incidence of lymphocyte B was found in
the fusiform type of AAA. The type and frequency of the examined inflammatory cells
are not related to other analyzed morphological characteristics of AAA. By
comparing the type and volume of the investigated inflammatory cells with the
investigated laboratory indicators and clinical factors of atherosclerosis risk,
statistically significant results of plasma cell-related correlation with LDL and total
cholesterol, cytotoxic CD8 + lymphocyte T and plasma cells were found with diastolic
pressure values and regulatory CD4 + Foxp3 + lymphocytes with ITM and body
weight of patients have no specific clinical relevance. By comparing the
morphological characteristics of AAA with the investigated laboratory indicators and
the clinical factors of atherosclerosis risk, the AAA diameter was significantly
associated with elevated CRP values. The extended AAA type with the involvement
of one and/or two lipid arteries with the ribs was statistically significantly more
frequent in elderly patients.
The higher incidence of cytotoxic CD8 + lymphocytes T in AAA is responsible for
damage to smooth muscle cells and the destruction of the aortic wall. The
inflammatory reaction in atherosclerotic alteration of the abdominal aorta was
characterized by a higher incidence of auxiliary CD4 + lymphocytes T and
macrophages important in the initial stage and stimulation of inflammation. An
increased number of regulatory CD4 + Foxp3 + T lymphocytes and AAA plasma
cells suggests overcoming the inhibitory inflammatory response in AAA. Different
characteristics of the inflammatory response in the parts only atherosclerotic aortic
and aorta scars indicate changes in the characteristics of the inflammatory reaction
with atherosclerosis and the emergence of aneurysmatic complications. The fusiform
type of AAA is characterized by an increased inhibitory inflammatory response of
lymphocytes B. The type and frequency of the examined inflammatory cells are not
related to other morphological characteristics of the AAA diameter, isolated or
extended aneurysm with the involvement of one and / or two iliac arteries with the
branches and the presence of intraluminal thrombus. The AAA diameter is
statistically significantly associated with elevated CRP values, indicating the
importance of inflammation in atherosclerosis progression and the development of
aneurysmatic complications. The extended AAA type with the involvement of one and/or two iliac arteries with the bra nches is significantly more frequent in elderly
patients, pointing to the aetiology of AAA in elderly patients
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