194,990 research outputs found
Environmental (waste) compliance control systems for UK SMEs
No full textWhile the ‘environment’ is often perceived as a heavily regulated area of business, in reality, directly-regulated businesses represent a small proportion of the business community. This study aimed to evaluate and outline potential improvements to compliance controls for small and medium-sized enterprises (SMEs), particularly those involved in the waste sector. Forty-four SMEs from England were interviewed/audited between April-September 2008. Using a UK-based system as a case-in-point, the Environment Agency’s (EA) Operational Risk Appraisal (‘Opra’)/Compliance Assessment Report (CAR) system was analysed. Environmental compliance performance indicators and an initial assessment methodology for SMEs were developed. The study showed:• Compliance with permitting legislation was poor in many areas.• Regulatory authorities are either unable/failing to implement their enforcement policies or unable/failing to identify non-compliances due to the infrequency or limited nature of their inspections.• Improvements are needed to the EA Opra/CAR system – control measures are not fully taken into account when calculating risk.Recommendations to improve SME compliance controls include using internationally applicable general and specific compliance and non-compliance performance indicators, re-designing the Opra system and using an initial assessment methodology based on understanding the hazardousness of SME categories, compliance levels and operator competency.<br/
In vivo overexpression of MMP28wt-GFP and MMP28-EA-GFP.
No full text(a, b) In situ hybridization for Twist in uninjected embryos (a) and embryos injected with 900 pg MMP28wt-GFP or MMP28-EA-GFP mRNA (b). (c) Mean dorsoventral migration of NC cells in uninjected controls or after MMP28 overexpression, normalised to control side. ANOVA, followed by multiple comparisons. Uninjected vs. MMP28wt-GFP, p = 0.132 (ns); uninjected vs. MMP28-EA-GFP, p = 0.699 (ns); MMP28wt-GFP vs. MMP28-EA-GFP, p = 0.189 (ns). Note that MMP28 overexpression does not affect neural crest migration and does not induce ectopic Twist expression. (TIF)</p
A comprehensive EA benefit realization model -- An exploratory study
No full textEnterprise architecture (EA) management has be-come an intensively discussed approach to manage enterprise transformations. While there is a strong interest in EA frameworks and EA modeling, a lack of knowledge remains about the theoretical foundation of EA benefits. In this paper, we identify EA success factors and EA benefits through a literature review, and integrate these findings with the DeLone & McLean IS success model to propose a theoretical model explaining the realization of EA benefits. In addition, we con-ducted semi-structured interviews with EA experts for a preliminary validation and further exploration of the model. We see this model as a first step to gain insights in and start a discussion on the theory of EA benefit realization. In future research, we plan to empirically validate the proposed model
Emotional availability (EA) teleintervention for adoptive families
No full text2012 Fall.Includes bibliographical references.This study evaluated the new online Emotional Availability (EA) Intervention for use with adoptive families in enhancing parent-child EA, parental perceptions of EA, child attachment behaviors, parent-child emotional attachment, and reducing parent-reported child behavioral problems and parenting-related stress. Participants in this study were adoptive parents and their adopted children ages 1.5 - 5 years old (N = 15 dyads). Participants were placed in an immediate intervention group (IG) or a delayed intervention group (DG) that would receive the 6-week EA Intervention after the IG. Results revealed significant differences in the IG in child behavioral problems, parent-child EA, parental perceptions of EA, and parent-child emotional attachment, improvements not seen in the DG. Analysis of effects of the DG after receiving the EA Intervention revealed significant differences over time also in child behavioral problems, parent-child EA, parental perceptions of EA, and parent-child emotional attachment. Implications, limitations, and future directions are discussed
Navigating Enterprise Architecture (EA) Institutionalization: The Interplay of EA and Agile
No full textIn the rapidly evolving context of digital transformation, the effective adoption, management, and institutionalization of Enterprise Architecture (EA) have emerged as significant efforts for organizations looking for ways to navigate the complex requirements of modern business environments. This Ph.D. thesis embarks on a comprehensive exploration of different aspects of EA, ranging from its adoption challenges to its interaction with agile transformations. This study's main objective is to shed light on different aspects of EA adoption, management, challenges, and integration within large-scale organizations.
The research questions that form the foundation of this thesis are designed to explore the complex nuances of an EA's journey within an organization. The thesis investigates the role of stakeholders in influencing the perception and institutionalization of EA in order to respond to the first research question. It highlights the complex interactions between different stakeholders and their different interests, showing how these interactions can have a big impact on how successful EA initiatives are. The study goes deeper into the organizational factors that contributed to the failure of EA management initiatives, explaining the significance of legitimacy and showing challenges to achieving normative and cultural-cognitive legitimacy.
The third research question focuses on the topic of delegitimization of established EA practices. The thesis shows the ways through which EA practices can lose momentum and relevance within organizations by examining the complex interplay of regulatory, pragmatic, normative, and cultural-cognitive legitimacy. Building on this foundation, the thesis navigates the cycles of EA's institutionalization, de-institutionalization, and re-institutionalization within the organizational context. This dynamic approach highlights the importance of regaining legitimacy and adapting to modern organizational approaches in order to achieve successful re-institutionalization.
In light of the growing popularity of agile approaches, the thesis investigates the challenges posed by such paradigm shifts to established EA practices. The study outlines the modifications that must be made to EA practices by identifying the main functions that EA must do to support organizational agility. The outcome of this study is a collection of five papers, each of which shows a different part of EA's journey. Together, these contributions enhance the understanding of EA's adoption, management, and integration with agile paradigms, significantly advancing the body of knowledge in this domain.
This Ph.D. thesis gives a comprehensive overview of EA's strategic, operational, and innovative capacity. It shows how stakeholders, organizational dynamics, and an evolving digital environment all work together. This thesis helps organizations looking to use the advantages of EA in their goals of sustainable growth and agility by addressing the research questions and highlighting different aspects of the EA's role.Fulltext not availabl
Pasantía empresarial realizada como auxiliar de ingeniería en EA Proyectos e Ingeniería
No full textEl presente documento aborda y recopila la labor desempeñada en la empresa EA Proyectos e Ingeniería en la modalidad de pasantía empresarial. Se aborda la pasantía de a través del perfil de la empresa y sus principales actividades económicas, el marco normativo, así como las actividades desarrolladas desde la semana 1 hasta la semana 27. Se realiza un análisis DOFA a nivel empresa y pasante. De las actividades realzadas se mencionan los aportes hechos por el estudiante a la organización, las lecciones aprendidas y las recomendaciones finales producto de la pasantía empresarial.This document addresses and compiles the work carried out in the company EA Proyectos e Ingeniería in the form of business internship. The internship is addressed through the profile of the company and its main economic activities, the regulatory framework, as well as the activities carried out from week 1 to week 27. A SWOT analysis is carried out at the company and intern. Of the highlighted activities, the contributions made by the student to the organization, the lessons learned and the final recommendations resulting from the business internship are mentioned.Ingeniero Civilhttp://www.ustavillavicencio.edu.co/home/index.php/unidades/extension-y-proyeccion/investigacionPregrad
Ea-GANs: Edge-Aware Generative Adversarial Networks for Cross-Modality MR Image Synthesis
No full textMagnetic resonance (MR) imaging is a widely used medical imaging protocol that can be configured to provide different contrasts between the tissues in human body. By setting different scanning parameters, each MR imaging modality reflects the unique visual characteristic of scanned body part, benefiting the subsequent analysis from multiple perspectives. To utilize the complementary information from multiple imaging modalities, cross-modality MR image synthesis has aroused increasing research interest recently. However, most existing methods only focus on minimizing pixel/voxel-wise intensity difference but ignore the textural details of image content structure, which affects the quality of synthesized images. In this paper, we propose edge-aware generative adversarial networks (Ea-GANs) for cross-modality MR image synthesis. Specifically, we integrate edge information, which reflects the textural structure of image content and depicts the boundaries of different objects in images, to reduce this gap. Corresponding to different learning strategies, two frameworks are proposed, i.e., a generator-induced Ea-GAN (gEa-GAN) and a discriminator-induced Ea-GAN (dEa-GAN). The gEa-GAN incorporates the edge information via its generator, while the dEa-GAN further does this from both the generator and the discriminator so that the edge similarity is also adversarially learned. In addition, the proposed Ea-GANs are 3D-based and utilize hierarchical features to capture contextual information. The experimental results demonstrate that the proposed Ea-GANs, especially the dEa-GAN, outperform multiple state-of-the-art methods for cross-modality MR image synthesis in both qualitative and quantitative measures. Moreover, the dEa-GAN also shows excellent generality to generic image synthesis tasks on benchmark datasets about facades, maps, and cityscapes
Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in <it>Clostridium acetobutylicum </it>EA 2018
No full textAbstract Background Clostridium acetobutylicum, a gram-positive and spore-forming anaerobe, is a major strain for the fermentative production of acetone, butanol and ethanol. But a previously isolated hyper-butanol producing strain C. acetobutylicum EA 2018 does not produce spores and has greater capability of solvent production, especially for butanol, than the type strain C. acetobutylicum ATCC 824. Results Complete genome of C. acetobutylicum EA 2018 was sequenced using Roche 454 pyrosequencing. Genomic comparison with ATCC 824 identified many variations which may contribute to the hyper-butanol producing characteristics in the EA 2018 strain, including a total of 46 deletion sites and 26 insertion sites. In addition, transcriptomic profiling of gene expression in EA 2018 relative to that of ATCC824 revealed expression-level changes of several key genes related to solvent formation. For example, spo0A and adhEII have higher expression level, and most of the acid formation related genes have lower expression level in EA 2018. Interestingly, the results also showed that the variation in CEA_G2622 (CAC2613 in ATCC 824), a putative transcriptional regulator involved in xylose utilization, might accelerate utilization of substrate xylose. Conclusions Comparative analysis of C. acetobutylicum hyper-butanol producing strain EA 2018 and type strain ATCC 824 at both genomic and transcriptomic levels, for the first time, provides molecular-level understanding of non-sporulation, higher solvent production and enhanced xylose utilization in the mutant EA 2018. The information could be valuable for further genetic modification of C. acetobutylicum for more effective butanol production.</p
Navigating Enterprise Architecture (EA) Definition: A Story of EA Adoption in a Public Sector Organization
No full textEnterprise architecture (EA) is a strategic approach to manage the digital transformation processes in large-scale organizations. Organizations aim at providing a holistic view of business, technology, and information by adopting EA. Although EA is now well established as a practical digital transformation facilitator, some organizations fail to achieve its benefits. Due to its diverse nature, a lack of shared understanding of EA is one highly cited challenge in its literature. Indeed, during the EA adoption, each actor tries to define EA in a way that fulfills her/his own interests. Therefore, there is a risk of failing to achieve the organizational holistic view in this condition. Through a case study in one large-scale public-sector organization in Norway, we illustrate how different EA stakeholders influence EA\u27s understanding. In addition, by adopting the organizational influence process theory, we explain the reason why EA failed in the studied case
Sympathoinhibitory electroacupuncture (EA) interacts positively with anti-inflammatory EA alleviating blood pressure in hypertensive rats
No full textElevated sympathetic activity and chronic inflammation are known contributory factors observed in hypertension. We have observed that sympathoinhibitory electroacupuncture (SI-EA) at acupoints ST36-37 alleviates sympathetic activity and hypertension. Additionally, EA at acupoints SP6-7 exerts anti-inflammatory (AI-EA) effects. However, it is not known whether simultaneous stimulation of this combination of acupoints attenuates or enhances individual effects. A 2 × 2 factorial design was used to test the hypothesis that combining SI-EA and AI-EA (cEA) leads to greater reduction of hypertension by decreasing sympathetic activity and inflammation in hypertensive rats than either set of acupoints alone. Dahl salt-sensitive hypertensive (DSSH) rats were treated with four EA regimens including cEA, SI-EA, AI-EA, and sham-EA twice weekly for five weeks. A group of normotensive (NTN) rats served as control. Systolic and diastolic BP (SBP and DBP) and heart rate (HR) were measured non-invasively by tail-cuff. Plasma norepinephrine (NE), high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6) concentrations were determined with ELISA at the completion of treatments. DSSH rats on high salt diet progressively developed moderate hypertension within five weeks. DSSH rats treated with sham-EA showed continuous increase in SBP and DBP and elevations in plasma NE, hs-CRP, and IL-6 levels relative to NTN control. Both SI-EA and cEA decreased SBP and DBP, and had corresponding changes in biomarkers (NE, hs-CRP, and IL-6) compared with sham-EA. AI-EA prevented SBP and DBP elevation and decreased IL-6 and hs-CRP relative to sham-EA. Importantly in DSSH rats that received repetitive cEA treatment, SI-EA interacted positively with AI-EA leading to greater reduction of SBP, DBP, NE, hs-CRP, and IL-6 than SI-EA or AI-EA alone. These data suggest that by targeting both elevated sympathetic activity and chronic inflammation, cEA regimen results in a greater reduction of BP effects in treating hypertension compared to using individual SI-EA or AI-EA alone
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