554 research outputs found

    Advances in multi-variate analysis methods for new physics searches at the large hadron collider

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    This work is part of a project that has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 675440.Stakia, A.; Dorigo, T.; Banelli, G.; Bortoletto, D.; Casa, A.; Castro, P. de; Delaere, C.; Donini, J.; Finos, L.; Gallinaro, M.; Giammanco, A.; Held, A.; Jiménez Morales, F.; Kotkowski, G.; Liew, S. P.; Maltoni, F.; Menardi, G.; Papavergou, I.; Saggio, A.; Scarpa, B.; Strong, G. C.; Tosciri, C.; Varela, J.; Vischia, P.; Weiler, A

    Author Correction: A portrait of the Higgs boson by the CMS experiment ten years after the discovery

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    In the version of this article initially published, CMS Collaboration author names, affiliations and acknowledgements were omitted and have now been included in the HTML and PDF versions of the articl

    Geometric Optics and Fokker-Planck Equation in spatially varying plasma

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    65 σ.Σε διατάξεις συγκράτησης πλάσματος έχει παρατηρηθεί πως, κοντά στην περιοχή των τοιχωμάτων, εμφανίζονται μικρές περιοχές με σημαντικά μεγαλύτερη πυκνότητα σωματιδίων από τη μέση πυκνότητα στο πλάσμα. Οι περιοχές αυτές μοιάζουν με φουσκάλες (blobs). Είναι, επομένως, ιδιαίτερα σημαντικό να αναλύσουμε θεωρητικά την επίδραση των blobs στη συμπεριφορά του πλάσματος. Στην εργασία αυτή θα μελετήσουμε πώς επηρεάζουν τα blobs τα ηλεκτρομαγνητικά κύματα με τα οποία ακτινοβολούμε το πλάσμα προκειμένου να ελέγξουμε τη συμπεριφορά του. Πιο συγκεκριμένα, υπολογίζουμε τη γωνία κατά την οποία μία ηλεκτρομαγνητική δέσμη εκτρέπεται από την πορεία της λόγω της παρουσίας blobs. Αρχικά, εξηγούμε ένα μοντέλο που έχει αναπτυχθεί, και το οποίο μπορεί να περιγράψει τη διάδοση ηλεκτρομαγνητικών κυμάτων σε χωρικά και χρονικά μεταβαλλόμενο πλάσμα. Το μοντέλο αυτό συνοψίζεται σε ένα χαμιλτονιανό σύστημα διαφορικών εξισώσεων. Στη συνέχεια, παίρνοντας προσεγγίσεις πρώτης τάξης, καταλήγουμε σε μια εξίσωση για την εξέλιξη του κυματοδιανύσματος καθώς το κύμα διαδίδεται μέσα στο πλάσμα. Θεωρώντας ομοιόμορφη κατανομή των blobs, παίρνουμε χωρική μέση τιμή στην παραπάνω εξίσωση, και καταλήγουμε σε μια εξίσωση Fokker-Planck. Ο πίνακας διάχυσης της εξίσωσης αυτής υπολογίζεται αναλυτικά για διάφορες γεωμετρίες των blobs (σφαιρική, ελλειπτική, κυλινδρική). Τέλος, βρίσκουμε τη συνάρτηση Green της εξίσωσής μας και υπολογίζουμε τη μέση γωνία απόκλισης του ηλεκτρομαγνητικού κύματος.In magnetic confinement fusion devices, small areas of significantly higher particle density than the average plasma density have been observed to appear in the edge region; these areas look like and are referred to as blobs. It is, therefore, of vital importance to theoretically approach and analyze the impact of these blobs on plasmas. In this thesis, the various effects of blobs on the electromagnetic waves with which the plasma is irradiated in order for its performance to be optimized, are studied. More specifically, the angle between the course of an electromagnetic ray and the distraction from it, due to the presence of blobs, is calculated. At first, a fully developed model that successfully describes the electromagnetic wave propagation in spatially and temporally varying plasmas is explained. This particular model is summarized in a Hamiltonian system of differential equations. Later on and through first-order approximations, an equation describing the evolution and variation of the wave-vector, during the wave propagation inside the plasma, is deducted. Assuming a uniform distribution of the blobs and using the spatial average of the aforementioned equation, a Fokker-Planck equation is reached. The diffusion tensor of this equation for various blob geometries is, then, analytically calculated, including the cases of spherical, elliptic and cylindrical blobs. Finally, the Green’s function of our equation is calculated and a mean angle of distraction of the electromagnetic wave from its course is defined.Άννα Π. Στακι

    Saignements d’origine indéterminée : approche diagnostique et thérapeutique

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    A bleeding tendency is a frequent cause of hematological consultation. However, despite extensive biological investigations, no hemostasis abnormality is identified in the majority of patients, leading to the diagnosis of bleeding of unknown cause (BUC). Overall, the pathogenesis of BUC is most likely of multifactorial etiology and the accumulation of minor alterations in fibrin clot structure, fibrinolysis, platelet function and thrombin generation can tip the balance of hemostasis towards the bleeding side. In recent years, unconventional biological explorations have found new hemorrhagic abnormalities. Therapeutic options are limited but are usually effective to prevent bleeding.Une tendance hémorragique est une cause fréquente de consultation hématologique. Toutefois, malgré des investigations biologiques étendues, aucune anomalie de l’hémostase n’est identifiée dans la majorité des cas. Il s’agit donc de saignements d’origine indéterminée. Dans l’ensemble, ceux-ci sont le plus vraisemblablement d’étiologie multifactorielle, et l’accumulation d’altérations mineures au niveau de la structure du caillot de fibrine, de la fibrinolyse, de la fonction plaquettaire et de la génération de thrombine peut faire basculer l’équilibre de l’hémostase du côté hémorragique. Ces dernières années, des explorations biologiques non conventionnelles ont permis de mettre en évidence de nouvelles anomalies hémorragipares. Les possibilités thérapeutiques sont peu nombreuses mais s’avèrent efficaces

    Jet Flavour Classification Using DeepJet

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    Jet flavour classification is of paramount importance for a broad range of applications in modern-day high-energy-physics experiments, particularly at the LHC. In this paper we propose a novel architecture for this task that exploits modern deep learning techniques. This new model, called DeepJet, overcomes the limitations in input size that affected previous approaches. As a result, the heavy flavour classification performance improves, and the model is extended to also perform quark-gluon tagging

    Allogeneic hematopoietic stem cell transplantation in non‐Hodgkin lymphoma in Switzerland, 30 years of experience: Sooner is better

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    Abstract Due to relatively high nonrelapse mortality (NRM), allogeneic hematopoietic stem cell transplantation (allo‐HSCT) in non‐Hodgkin's lymphoma (NHL) remains the ultimate line of treatment but the only curable approach in a setting of relapse/refractory disease. Here, we conducted a retrospective, multicenter, registry‐based analysis on patients who underwent allo‐HSCT for NHL in Switzerland, over 30‐year (1985–2020) period. The study included 301 allo‐HSCTs performed for NHL patients in three University Hospitals of Switzerland (Zurich, Basel and Geneva) 09/1985 to 05/2020. We assessed in univariate and multivariable analysis the impact on survivals (overall survival [OS], relapse free survival [RFS], relapse incidence [RI], and non‐treatment related mortality [NRM]). The maximum follow‐up was 25 years with median follow‐up for alive patients of 61 months. The median age at allo‐HSCT was 51 years. Three‐ and ‐year OS was ‐ 59.5% and 55.4%; 3‐ and 5‐year PFS was 50% and 44%; 3‐ and 5‐year NRM was 21.7% and 23.6%. RI at 3 and 5 years was 27.4% and 34.9%. In conclusion, our analysis of the entire Swiss experience of allo‐HSCT in patients with NHL shows promising 5‐ and possibly 10‐year OS and relatively acceptable NRM rates for such population, the majority being not in complete remission (CR) at the time of transplantation
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