3,113 research outputs found
El rey sin reino, edición de Francesca Leonetti y Oana Andreia Sambrian, en Comedias de Lope de Vega. Parte XX, Edición crítica de PROLOPE, coord. Daniel Fernández Rodríguez y Guillermo Gómez Sánchez Ferrer
No full textFrancesca Leonetti se ha encargado de algunas partes del prólogo (problemas textuales, resumen del argumento, sinopsis de la versificación) y de la fijación crítica del texto, incluidos el aparato crítico, las notas lingüísticas y textuales
(también las relativas a la dedicatoria de la comedia), las variantes lingüísticas, la nota onomástica, la lista de erratas y la bibliografía relativa al ámbito lingüístico-filológico
I giorni della neve
No full textUna sarta seduta nella penombra della sua stanza del cucito sta per terminare il vestito azzurro mare che una donna misteriosa le ha commissionato. La sarta è Josefina Manresa, vedova del grande poeta Miguel Hernández, morto a soli 31 anni nelle carceri franchiste. Il rumore della macchina da cucire è la voce del tempo che evoca ricordi intimi, in un’intensa testimonianza di amore e di assenza, in cui si stabilisce il vincolo tra memoria individuale e memoria collettiva. Josefina mette l’ultimo punto al vestito azzurro mare. Ma chi è la donna che lo sta aspettando
Random laser tailored by directional stimulated emission
No full textThe spectrum of a random laser (RL) may appear either as a set of sharp resonances or as a smooth line superimposed on the fluorescence. Recently, Leonetti, Conti, and Lopez accounted for this duality with the onset of a mode-locked regime that is triggered by the increase of both the number of activated modes and of the intermode interaction and is accompanied by a pulse shortening. Here we report an extensive review of the experimental approach used by Leonetti, including the sample preparation and the particulars of the setup. Here we describe also the way in which our approach allows us either to set the degree of interaction between modes or to have a certain degree of control over the effective set of resonances brought to lasing. Moreover we report an investigation on the spatial properties of the RL which brings further confirmation of the synchronization picture, whose physical origin is deepened. © 2012 American Physical Society.This work was supported by ERC Grant (FP7/2007-2013) No. 201766, CINECA, EU FP7 NoE Nanophotonics4Enery Grant No. 248855, the Spanish MICINN CSD2007-0046 (Nanolight.es), MAT2009-07841 (GLUSFA), and Comunidad de Madrid S2009/MAT-1756 (PHAMA).Peer Reviewe
“Enseñanza de ELE inclusiva desde una experiencia práctica”, Francesca Leonetti, María del Pilar Soria Millán
No full textThis paper contains two lines of research: on the one hand, it presents the phases and results of a didactic experience developed with university students of Spanish in Spanish Language and Translation courses at the Università degli Studi Roma Tre, using theatrical practice as a pedagogical instrument to achieve and consolidate specific linguistic objectives and formative and transversal objectives; on the other hand, on the proposal of a practical work for the classrooms of the last year of second grade secondary education (stu-dents between 17-19 years old) in Italy taking into account the presence of two learners with different characteristics: a learner dyslexic and another visually impaired. The choice of both learners as active agents in the ELE classroom turns out to be a fertile field, both for teacher training and for the inclusion of these learners in the classroom, as well as for the personal growth of all the active agents in the classroom.En el presente estudio se contienen dos líneas de investigación: por un lado se presentan las fases y los resultados de una experiencia didáctica desarrollada con estudiantes universitarios de español dentro de cursos de Lengua y traducción española de la Università degli Studi Roma Tre, usando la práctica teatral como instrumento pedagógico para conse-guir y consolidar objetivos específicos lingüísticos y objetivos formativos y transversales; por otro lado, se expone la propuesta de un trabajo práctico para las aulas del último año de educación secundaria de segundo grado (alumnos de entre 17-19 años) en Italia tomando en consideración la presencia de dos aprendientes con características diferentes: un apren-diente con dislexia y otro con discapacidad visual. La elección de ambos aprendientes como agentes activos en el aula ELE resulta ser un campo fértil para la formación del profesorado. Además, contribuye a la inclusión de estos aprendientes en el aula y al crecimiento personal de todos los agentes activos
Breve relación de los indios de Chile. Introducción y notas por Francesca Leonetti.
No full textLa Breve relación de los indios de Chile, que se edita en este volumen, representa un ejemplo de las relaciones de los misioneros juesuitas que, a fin de justificar su obra evangelizadora, describían de manera muy detallada la vida de las poblaciones americanas, su índole, sus costumbres y sus gobiernos, con los que ellos entraron personalmente en contacto durante las misiones. A diferencia de las primeras crónicas, carentes de antecedentes en los que apoyarse, estos textos cuentan con muchas fuentes escritas, sobre las que se construyen. Se crea, de esta manera, una rica red de referencias intertextuales, funcionales a confutar una idea o bien a reforzar la veracidad de los hechos relatados
Sempre in biblico tra cultura e mercato
No full textA carriera ormai tramontata Valentino Bompiani scrisse di aver scelto di fare l’editore perché il suo desiderio più grande – dopo una vita segnata da lutti e trasferimenti – era quello di vivere in una casa comune con tutti quelli che amava. È la definizione più asciutta e sincera di cosa voglia dire fare – coscientemente – il mestiere dei libri. Un mestiere affascinante e insieme difficile, sempre diviso tra cultura e mercato, tra otium e negotium
A. Leonetti, Note su Gramsci
No full textParis Robert. A. Leonetti, Note su Gramsci. In: Annales. Économies, Sociétés, Civilisations. 27ᵉ année, N. 6, 1972. pp. 1428-1433
Clinical use of lenvatinib in combination with everolimus for the treatment of advanced renal cell carcinoma
No full textAlessandro Leonetti, Francesco Leonardi, Melissa Bersanelli, Sebastiano Buti Medical Oncology Unit, University Hospital of Parma, Parma, Italy Introduction: Renal cell carcinoma (RCC) represents 2%–3% of all cancers in adults, and its pathogenesis is mainly related to altered cellular response to hypoxia. Lenvatinib, a novel multitarget tyrosine kinase inhibitor (TKI), represents a therapeutic option, in combination with mammalian target of rapamycin (mTOR) inhibitor everolimus, for the treatment of metastatic RCC (mRCC).Aim: The objective of this article is to review the evidence about the treatment of mRCC with combination of lenvatinib plus everolimus.Evidence review: Phase I studies supported clinical activity of lenvatinib in mRCC. A randomized, Phase II, open-label, multicenter trial demonstrated the clinical efficacy of combination treatment with lenvatinib plus everolimus in patients with progressive mRCC after prior therapy with TKI. Median progression-free survival was improved by 9 months with the combination therapy compared to the single-agent everolimus, with an overall response rate of 43% for the experimental regimen. Lenvatinib plus everolimus appeared to be slightly less toxic than single-agent lenvatinib and more toxic than single-agent everolimus; grade 3–4 adverse events occurred in 71% of patients. Currently, lenvatinib plus everolimus has US Food and Drug Administration approval for its use in mRCC after failure of previous treatment with TKI.Conclusion: The combination therapy with lenvatinib plus everolimus might be a promising choice for second-line treatment of mRCC patients. Based on the results of the Phase II trial, it is possible to speculate that the combination therapy could be appropriate for patients with high disease burden or strongly symptomatic patients. Keywords: lenvatinib, everolimus, evidence-based review, renal cell carcinoma, RC
Profile of atezolizumab in the treatment of metastatic non-small-cell lung cancer: patient selection and perspectives
No full textFrancesco Facchinetti, Paola Bordi, Alessandro Leonetti, Sebastiano Buti, Marcello Tiseo Medical Oncology Unit, University Hospital of Parma, Parma, Italy Abstract: Programed cell death-1/programed death ligand-1 (PD-1/PD-L1) blockade represents an affirmed reality in the treatment of advanced non-small-cell lung cancer (NSCLC) patients. Atezolizumab, an anti-PD-L1 agent, figures among the drugs that provide previously unenvisaged outcomes in the pretreated setting of metastatic NSCLC. Increasing evidence vouches for the early administration of PD-1/PD-L1 blockers in untreated patients, encompassing atezolizumab combinations with chemotherapy and the anti-angiogenic agent bevacizumab. Moreover, the development of atezolizumab allowed to derive several hints regarding clinical and immunological factors predictive of its activity and efficacy, some of them exclusive among this class of drugs. This review provides an overview of atezolizumab development throughout clinical trials toward its applicability in the routine practice, with a particular focus on patient selection based on clinical and immune-related factors. Keywords: non-small cell lung cancer, NSCLC, immune checkpoint blockers, ICB, PD-1, PD-L1, atezolizumab development, biomarker
Francesco Leonetti a Elio Vittorini : due lettere
No full textPubblicazione delle lettere inedite di Francesco Leonetti a Elio Vittorini del 22 e del 24 maggio 1962, conservate presso gli archivi APICE dell'Università degli Studi di Milano. Alla pubblicazione delle lettere segue un breve commento in cui è rimarcato il ruolo che Leonetti ebbe nell'impostare la posizione della rivista letteraria «Il Menabò» nei confronti della Neoavanguardia, così come sarà espressa nell'editoriale al quinto numero della rivista
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