140 research outputs found
Features of the steroid profile of saliva in patients with COVID-19
No full textMaterial and methods. The study included 16 men aged 28 to 81 years (average age 50.3±13.4 years) with confirmed new coronavirus infection of varying severity, were hospitalized in April 2020 in Moscow COVID hospital. Patients were divided into three groups, depending on the severity of COVID-19: the 1 group was a mild course (n=7), the 2 group was a moderate course (n=7), and the 3 group was a severe course of the disease (n=2). All patients were cured. In addition to the steroid profile of saliva, all patients underwent a test for arbitrary breath holding (Stange test), which reflects the reserve capabilities of the lungs, as well as a general blood test. In 6 patients, vitamin D was determined by mass spectrometry. Results and discussion. There was a testosterone deficiency in all patients with COVID-19, while there was a connection between a decrease in testosterone and the severity of the disease: the maximum decrease in testosterone was observed in patients with severe disease. Conclusion. Given the known effect of testosterone on the synthesis of nitric oxide, a deficiency of which leads to the development of not only insulin resistance and oxidative stress, chronic hypoxia, but also bronchospasm and pulmonary edema, it is necessary to include the determination of the steroid profile of saliva in the diagnostic algorithms for managing patients with a new coronavirus infection COVID-19. st nd r
The role of cholecalciferol deficiency in the pathogenesis of polycystic ovary syndrome
No full textObjectives: to evaluate and compare clinical presentations, medical history, and laboratory data of patients with polycystic ovary syndrome, including vitamin 25(OH)D3 level. Methods: In total, 81 patients were examined. The patient group included 51 patients with signs of polycystic ovary syndrome. The control group included 30 healthy women without signs of polycystic ovary syndrome, comparable according to gender and age to the patient group. Polycystic ovary syndrome was verified based on the diagnostic Rotterdam and international polycystic ovary syndrome guidelines’ criteria. The levels of cholecalciferol were determined by mass spectrometry (ng/mL). At the second stage of the study, the patient group with polycystic ovary syndrome was divided into two subgroups depending on the waist circumference and compared with each other by the level of insulin, low-density lipoproteins, triglycerides, anti-Mullerian hormone, follicle-stimulating hormone, and luteinizing hormone. Statistical analysis was carried out using the parametric t-test for two-independent samples with equal or different variance. For nominal data—Pearson’s chi-test, when the means are not calculated and a test is carried out for the presence of a relationship between the nominal variables. Results: Patients with polycystic ovary syndrome and without polycystic ovary syndrome did not have a statistically significant difference in 25(OH)D3 level. Statistically significant differences in the level of 25(OH)D3 were found in women with polycystic ovary syndrome with the waist circumference ⩾80 cm. In these subgroups, differences in insulin, low-density lipoprotein, and triglycerides levels were also revealed. Conclusion: The correlation of the 25(OH)D3 level does not differ in the groups of patients with polycystic ovary syndrome and without polycystic ovary syndrome, but significantly correlates with the metabolic profile of patients. © The Author(s) 2020
Features of the steroid profile of saliva in patients with COVID-19 [Особенности стероидного профиля слюны у пациентов с COVID-19]
No full textMaterial and methods. The study included 16 men aged 28 to 81 years (average age 50.3±13.4 years) with confirmed new coronavirus infection of varying severity, were hospitalized in April 2020 in Moscow COVID hospital. Patients were divided into three groups, depending on the severity of COVID-19: the 1st group was a mild course (n=7), the 2nd group was a moderate course (n=7), and the 3rd group was a severe course of the disease (n=2). All patients were cured. In addition to the steroid profile of saliva, all patients underwent a test for arbitrary breath holding (Stange test), which reflects the reserve capabilities of the lungs, as well as a general blood test. In 6 patients, vitamin D was determined by mass spectrometry. Results and discussion. There was a testosterone deficiency in all patients with COVID-19, while there was a connection between a decrease in testosterone and the severity of the disease: the maximum decrease in testosterone was observed in patients with severe disease. Conclusion. Given the known effect of testosterone on the synthesis of nitric oxide, a deficiency of which leads to the development of not only insulin resistance and oxidative stress, chronic hypoxia, but also bronchospasm and pulmonary edema, it is necessary to include the determination of the steroid profile of saliva in the diagnostic algorithms for managing patients with a new coronavirus infection COVID-19. © 2020 Nutritec. All rights reserved
Mathematical modeling of electromagnetic wave diffraction by inhomogeneous dielectric cylinders of arbitrary cross-section
No full textThe application of integral equations to calculation of diffraction on inhomogeneities in lightguide structures
No full text
Breaking the vicious circle of obesity: the metabolic syndrome and low testosterone by administration of testosterone to a young man with morbid obesity
No full textOBJECTIVE: The metabolic syndrome (MS) is associated with low serum testosterone levels. Conversely, low testosterone levels induce MS. These operational mechanisms reinforce one another and induce a vicious cycle. This is a report on a morbid obesity 42 year-old man with the MS and serum testosterone of 5.0 nmol/L (N: 12.0-33.0), who was resistant to treatment with diet and exercise. He was treated with testosterone undecanoate for 16 months. METHODS: Anthropological and laboratory variables were measured before and during testosterone administration. Also the Aging Male Symptom Scale (AMS), the International Index of Erectile Function (IIEF) and Beck's Depression Inventory were assessed. RESULTS: After 16 months, there was a weight loss of 50 kg and a decrease in waist circumference of 36.5 cm. Blood pressure normalized and laboratory variables returned to the normal range. The patient did not meet the criteria for the MS anymore. There were improvements on the AMS, the IIEF and Beck's Depression Inventory. CONCLUSIONS: Normalizing testosterone in men with morbid obesity in combination with diet and exercise, with the MS and low testosterone levels, may rescue them from the MS, improving their mood and their stamina to follow a diet and to exercise
- …
