1,622 research outputs found
Ernesto Palacios. El derecho a la danza
No full textFil: Britos Musa, Mariana. Universidad Nacional de Villa María; Argentina..Fil: Engert, Valeria. Universidad Nacional de Villa María; Argentina..Fil: Granada, Marilyn. Universidad Nacional de Villa María; Argentina..Fil: Miranda, Adriana. Universidad Nacional de Villa María; Argentina.
EXTEND PIX301: a phase III randomized trial of pixantrone versus other chemotherapeutic agents as third-line monotherapy in patients with relapsed, aggressive non-Hodgkin's lymphoma.
No full textEngineering of cartilage tissue constructs in a 3-dimensional perfusion bioreactor culture system under controlled oxygen tension
No full textThe most relevant results generated in this thesis can be summarized as follow:
· Adult human articular chondrocytes (AHAC) from elderly individuals expanded in culture
medium supplemented with the growth factors TGFβ-1, FGF-2 and PDGF and subsequently
cultured in 3-d pellets had an enhanced chondrogenic capacity when exposed to more
physiological (i.e. 5%) oxygen levels.
· In correlation with the enhanced tissue forming capacity of AHAC from elderly donors under
low oxygen tension, the mRNA expression levels of selective matrix degrading enzymes
were reduced as compared to conventional in vitro oxygen culture condition.
· We developed an integrated bioreactor system, which streamlines within a single device the
phases of perfusion cell seeding and prolonged perfusion culture of cell seeded scaffolds in
vitro.
· The culturing of uniformly seeded adult human articular chondrocytes under direct perfusion,
where cells are continuously exposed to a normoxic range of oxygen levels, can maintain a
uniform distribution of viable cells throughout thick porous scaffolds as compared to
statically cultured constructs.
· The culturing of constructs uniformly seeded with adult human articular chondrocytes under
a more physiological range of oxygen resulted in a higher chondrogenic differentiation as
compared to culture under normoxic levels. Anyhow, this effect was less pronounced as
compared to statically cultured cell constructs or micromass cell pellets, possibly due to the
flow induced shear forces.
· Reduced perfusion flow rates applied to chondrocytes on porous scaffolds significantly
induced more cartilaginous tissue in the presents of low vs. high oxygen levels. However the
effects of low oxygen were not as marked as in pellet culture
A dominant linear B-cell epitope of ricin A-chain is the target of a neutralizing antibody response in Hodgkin's lymphoma patients treated with an anti-CD25 immunotoxin
No full textEHA Roadmap for European Hematology Research. The European Hematology Association Roadmap for European Hematology Research: a consensus document.
No full textThe European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients
Financial Developments in Canada: Past Trends and Future Challenges
No full textFreedman and Engert focus on the changing pattern of lending and borrowing in Canada in the past thirty to forty years, including the types of financial instruments used and the relative roles of financial institutions and financial markets. They examine how borrowing mechanisms have changed over time and consider the challenges facing the Canadian financial sector, including whether our financial markets are in danger of disappearing because of the size and pre-eminence of U.S. financial markets. Some of the trends examined here include syndicated lending, securitization, and credit derivatives, a form of financial engineering that has become increasingly important in the last few years. They also study bond and equity markets to determine whether Canadian capital markets have been hollowed out or abandoned by Canadian firms and conclude that the data do not provide much support for that view.
The Large-Value Payments System: Insights from Selected Bank of Canada Research
No full textGiven the Bank of Canada's strong interest in the safe and efficient operation of major clearing and settlement systems, the Bank maintains a rigorous research agenda as a means of informing payments system policy and oversight. In this article, Arjani and Engert review recent research undertaken by Bank staff concerning the risk and efficiency of the Large Value Transfer System (LVTS). Based on the findings from this research, the authors conclude that the design of the LVTS strikes an effective balance between risk and efficiency. The article also demonstrates the increased use of simulation analysis as a tool for conducting payments system research. A brief summary of the Bank's oversight strategy for systemically important payments systems is also provided. Goals for future research are noted as well, including modelling of participant behaviour and continued external collaboration with other researchers.
Regulatory Competition in European Corporate and Capital Market Law: An Empirical Analysis
No full textThe Euramet Metrology Research Programme Project: Implementing the new kelvin (InK)
No full textCurrently almost all temperature measurement around the world is based on traceability to a defined scale, either the International Temperature Scale of 1990, ITS-90 or, below 1 K, the Provisional Low Temperature Scale of 2000, PLTS-2000. These scales are empirical in basis, reliant upon a set of fixed points whose temperatures were determined a priori by primary thermometry. However recent technical advances in temperature metrology, the advent of the evolving mise en pratique for the definition of the kelvin (MeP-K) and the forthcoming kelvin redefinition in terms of a fixed value of the Boltzmann constant provide a unique opportunity to fundamentally change the practice of temperature measurement.
In the light of this a European Metrology Research Programme project, known as Implementing the new kelvin (InK), was established; the first phase of which was from Oct 2012 to September 2015. The project has 13 partners and 8 collaborators/universities from around the world working in the field of primary thermometry.
The research to be performed in the InK project has two main thrusts:
The development of primary thermometry methods that both challenge and supplant the defined scales at high (>1000 C) and low (<1 K) temperatures. This will enable, for the first time, and at these temperature extremes, to directly realise and disseminate thermodynamic temperature, with uncertainties that are competitive with the defined scales.
Between these temperatures new values of T – T90 (by a variety of methods) with the lowest uncertainties (1 mK) will be determined. This is required for several reasons: a) in the short term to provide ultra-reliable T – T90 data for the MeP-K, b) to develop the primary thermometry techniques needed to progressively supplant defined scales and c) provide the background thermodynamic temperature data required for any successor temperature scale, namely ITS20XX.
This presentation will give an overview of the project, initial results will be presented and its impact into world thermometry will be discussed
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