495 research outputs found
El arte concreto de Oscar Capristo
No full textOscar Capristo es un pintor esteta, fundamentalmente esteta, así como otros son intuitivos, emotivos o anecdóticos. Su labor comprende por rara circunstancia a una generación de ciclo calendario. Comenzó a pintar ya como pintor en el año 41 y su valorización cíclica la realizamos en el año 61. Análisis que podemos facturar sin temor a erratas, como arquetípico para toda la generación de plásticos nuestros
L'intellettuale Antisemita
No full textIl fascismo fu razzista per vocazione o per convenienza? Le leggi razziali del 1938 furono l’esito di un’ideologia autoritaria spinta al suo estremo dalla disumanizzazione della «guerra civile europea» o l’approdo inesorabile di un movimento impegnato nella realizzazione di un progetto totalitario di conquista della società e di eliminazione genocidiaria dei nemici?
Dopo un lungo silenzio – quasi una rimozione – la cultura italiana si sta da qualche tempo applicando per trovare risposta a questi interrogativi, cercando in particolare di chiarire le responsabilità che un intero paese ebbe, a diverso titolo, nella promozione e nel sostegno di una cultura antisemita.
In questa prospettiva, cruciale fu il ruolo svolto dagli intellettuali: un ceto sempre strategico nella formazione dell’opinione pubblica, ma decisivo in un regime autoritario.
Ne hanno discusso, confrontando i loro diversi orientamenti, autorevoli studiosi dell’antisemitismo e della cultura italiana nel Ventennio: Cristina Baldassini, Giovanni Belardelli, Roberta Cairoli, Annalisa Capristo, Alberto Cavaglion, Francesco Germinario, Claudia Mantovani, Renato Moro, Gianni Scipione Rossi, Maurizio Serra
High ghrelin levels in post-treatment euthyroid patients with Hashimoto's thyroiditis: a case-control preliminary study
No full textHashimoto's thyroiditis is a chronic inflammatory condition often associated with changes in appetite and body composition. Ghrelin is an orexigenic peptide involved in the regulation of appetite and food intake. A possible role of ghrelin in mediating inflammation has been suggested. A few contrasting published data are available on the relationship between thyroid status and circulating ghrelin in patients affected by Hashimoto's thyroiditis. The aim of the present case-control study was to provide additional evidence on the relationship between thyroid status and plasma ghrelin levels in post-treatment euthyroid female patients with Hashimoto's thyroiditis, compared to healthy controls
Update on the use of montelukast in pediatric asthma
No full textCysteinyl leukotrienes are inflammatory bioactive lipids produced by various cells. They are present in increased amounts in
airway secretions of all different asthma phenotypes and can induce all the inflammatory changes observed in the airways of
asthmatic patients. For this reason, an attempt to inhibit the actions of these mediators through the use of cysteinyl receptor
antagonists appears rational. Montelukast belongs to this new class of drugs, which has been proved effective in asthmatic
children and its safety profile is comparable with that of placebo. The major advantages of this drug are its once-daily oral
administration, which increases adherence to the therapeutic regimen; its long-term persistent efficacy in the prevention of
exercise-induced bronchoconstriction; its possible preventive activity on viral-induced asthma exacerbations; and its complementary
and additive effects when used with inhaled corticosteroids. As established for all drugs commonly used in the
treatment of asthma, there is an interindividual variability also in response to montelukast. Therefore, it is important that
caregivers evaluate treatment effect objectively in every asthmatic child to provide the single patient with a therapeutic regimen
allowing the best quality of life
Metabolite Changes After Metabolic Surgery – Associations to Parameters Reflecting Glucose Homeostasis and Lipid Levels
No full textAims: To test the hypothesis that adipose tissue gene expression patterns would be affected by metabolic surgery and we aimed to identify genes and metabolic pathways as well as metabolites correlating with metabolic changes following metabolic surgery. Materials and Methods: This observational study was conducted at the Obesity Unit at the Catholic University Hospital of the Sacred Heart in Rome, Italy. Fifteen patients, of which six patients underwent Roux-en-Y gastric bypass and nine patients underwent biliopancreatic diversion, were included. The participants underwent an oral glucose tolerance test and a hyperinsulinemic euglycemic clamp. Small polar metabolites were analyzed with a two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOFMS). Gene expression analysis of genes related to metabolism of amino acids and fatty acids were analyzed in subcutaneous adipose tissue. All procedures were performed at study start and at follow-up (after 185.3 ± 72.9 days). Results: Twelve metabolites were significantly changed after metabolic surgery. Six metabolites were identified as 3-indoleacetic acid, 2-hydroxybutyric acid, valine, glutamic acid, 4-hydroxybenzeneacetic acid and alpha-tocopherol. The branched chain amino acids displayed a significant decrease together with a decrease in BCAT1 adipose tissue mRNA levels. Changes in the identified metabolites were associated to changes in lipid, insulin and glucose levels. Conclusions: Our study has identified metabolites and metabolic pathways that are altered by metabolic surgery and may be used as biomarkers for metabolic improvement
Immune dysregulation in atopic dermatitis
No full textAtopic dermatitis (AD) is a chronic, relapsing, highly pruritic, inflammatory skin disease characterized by cutaneous liyperreactivity to environmentals triggers. Recent data suggest the presence of tivo duferent forms of AD: an extrinsic AD with elevated IgE involving 70-80% ofthe patients and an intrinsic AD with serum IgE not elevated and no specfc IgE. Patients with extrinsic AD have elevated Th2- and decreased Th1-expressing cells in the peripheral blood, with elevated IL-4 and IL-13 expression, as well as lL—5. On the contrary, the intrinsic AD is linked with much lower levels ofll.-4 and lL—13. Genetic factors are involved in the control of the disease and in the intrinsic AD the same chromosomal regions seem to be associated with psoriasis susceptibility. The AD is characterized by a complex of immunological alterations involving interactions between IgE—bearing antigen—presenting cells, T-cell activation, mast-cell degranulation, keratinocytes, eosino-pliils, and a combination of immediate and cellular immune responses Inflammatory dendritic epidermal cells constitute a distinct dendritic cells population that is mainlyfound in AD and could induce the Th2/Th1 isotopic switch contributing to AD chronic phase. Therapy is based on interventation in the pathophysiology of atopic eczema and elimination of exogenous provocation factors
Environmental prevention in atopic eczema dermatitis syndrome (AEDS) and asthma: avoidance of indoor allergens
No full textIndoor allergens represent an important precipitating factor for both asthma and atopic eczema dermatitis syndromes (AEDS). There is also accumulating evi- dence that sensitization to those allergens is associated with the onset of atopic disorders. Patients with AEDS present aeroallergen-specific T-cell responses associated with worsening of symptoms when exposed to specific aeroallergens.
Furthermore, application of indoor allergens to the skin of patient with AEDS induces a local eczematous response in one-third of these patients. Exposure to high concentrations of mite allergens in early infancy have been demonstrated to be a risk factor for developing atopic dermatitis during the first 3 years of life.
Moreover, a clear dose—response relationship has been documented between mite exposure and disease activity. Primary prevention of AEDS by avoiding indoor allergen exposure has been proved to be effective only when allergenic foods have also been avoided. Mite allergen avoidance in infants with AEDS and food allergy may however, prevent mite sensitization and the onset of asthma. Indoor
allergen avoidance has been demonstrated to be eiiective in the majority of studies performed in patients with established AEDS. Negative results may be explained either by individual susceptibility variation. by long duration of dis- ease with the consequent irreversible pathological changes in the target tissue or by exposure to allergens outside the house. Education of the patients and public
consciousness of the problems are crucial for the eiiicacy of indoor allergen avoidance in allergic diseases
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