1,722,221 research outputs found
Lichen sclerosus et atrophicus: proposta di un percorso diagnostico, terapeutico e assistenziale
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INTEGRINS AND SKIN TUMORS
No full textIt is well know that cell-cell and cell-matrix interactions play an important role in maintaining the integrity of pluristratified epithelia and in different biological processes such as wound healing, inflammation, and immune response. In addition, growing evidence indicates that these interactions are also fundamental in tumour cell growth and invasion. Important advances in the understanding the mechanism of cell adhesion has been possible owing the identification and characterization of a large number of specific cell adhesion molecules. Integrins are a family of transmembrane adhesion receptors that mediate cell adhesion to extracellular matrix protein and to the surface of other cells. In this review the structure and the function of these adhesion receptors are summarized, and their possible involvement in skin tumours is discussed. The peculiar distribution pattern of some members of the integrin famil (α6β4, α5β1, and α10.1.2 integrins) found in neoplastic cells of squamous cell carcinoma (SCC), may reflect the different biological behavior of this tumour as compared to basal cell carcinoma (BCC). Therefore immunohistochemical study of integrins expression may be used for the phenotypic classification of tumours and as indicator of invasiveness. Finally, increasing evidence indicates that integrins are able to transmit signals from the extracellular matrix to the cell interior, that control gene expression, the cell cycle, and tumour growth. Thus, the role of integrins in cancer seems not only to involve cell adhesion events, but may also involve the regulation of cell growth and differentiation
Angioedema delle labbra
Full text linkL’angioedema non sempre è sinonimo di allergia. Esistono, infatti, delle peculiari entità cliniche a patogenesi non-istamino mediata quali l’angioedema ereditario, l’angioedema acquisito e l’angioedema indotto da farmaci ACE inibitori, che pongono al clinico notevoli difficoltà diagnostiche. Negli ultimi anni si è assistito ad un significativo avanzamento delle conoscenze riguardo ai meccanismi molecolari alla base di queste forme che ha permesso, tra l’altro, di chiarire l’importante ruolo patogenetico ricoperto dalle chinine, in particolare dalla bradichinina, consentendo di identificare potenziali target per l’azione di nuovi farmaci. La conoscenza delle basi patogenetiche, degli aspetti clinici e delle peculiari alterazioni biochimiche di queste forme di angioedema è di fondamentale importanza per un corretto inquadramento diagnostico e trattamento terapeutico
A Concurrent, Distributed Architecture for Diagnostic Reasoning
No full textThis paper demonstrates the feasibility of modeling concurrent diagnostic reasoning (CDR) by means of the computational model of actors. Actors have a value added on top of objects, because they include the properties of abstraction, modularity and reuse of objects but allow really concurrent and distributed architectures, in the sense that memory (the environment) is assumed not to be shared among actors. Whether concurrency really implies efficiency is still debated. We are more concerned here with the actor-based design of the diagnostic reasoning model. As a testimony of the feasibility of our proposal, a concrete, actor-based diagnostic program is presented as a module for an Intelligent Tutoring System in the domain of school algebra. CDR is obtained from the coordinated behaviour of actors which possess limited local knowledge and accomplish the global goal of diagnostic reasoning by interacting with each other. We examine how the ’traditional‘ approaches to student modeling, such as overlay and bug models, can be re-visited in a distributed perspective of computational actors and how the latter view outperforms the previous ones
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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