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    EFFECTS OF SOY-DERIVED ISOFLAVONES ON HOT FLUSHES AND VASCULAR REACTIVITY

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    Objectives: The aim of this study was to investigate the effects of soy-derived isoflavones on hot flushes and vascular reactivity of Uterine Arteries (UA), Internal Carotid Arteries (ICA), Middle Cerebral Arteries (MCA), in post- menopausal women. Materials and methods: This study was a double-blind placebo-controlled randomised trial. 58 postmenopausal Italian women aged between 45 and 60 years entered the study. They all were free from any major illness and com- plained of at least seven hot flushes daily. 28 of them were treated with two tablets daily containing 36mg of soy- derived isoflavones, each. The other 30 patients were treated with two placebo tablets daily. All patients kept a daily diary of hot flushes. Patients were evaluated at basal time, after three months and after six months. At each control time the number of hot flushes was recorded and an_ultrasound scan was performed together with a doppler evaluation of uter- ine and cerebral arteries. Results: The daily mean number of hot flushes at basal time was 9.7 in both groups. After the first month we observed a significant decrease to 6.2 in the soy group and 5.6 in place- bo group. However, no differences were observed between the two groups. This reduction was maintained for both groups till the end of the study. Conclusions: The treatment with soy-derived isoflavones causes a reduction of hot flushes not different from that due to placebo

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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