33,074 research outputs found
Replication Data for "A Model of Endogenous Risk Intolerance and LSAPs: Asset Prices and Aggregate Demand in a "Covid-19" Shock?"
No full textThis repository contains the code to replicate the figures in "A Model of Endogenous Risk Intolerance and LSAPs: Asset Prices and Aggregate Demand in a "Covid-19" Shock?" by Ricardo Caballero and Alp Simsek (2021). Please start by reading ReadMe.pdf
Association between Alkaline Phosphatase and Anemia in Rural Japanese Men: The Nagasaki Islands study
No full textAlthough bone metabolism is reportedly associated with production and maturation of blood corpuscles, and serum alkaline phosphatase (ALP) levels have been associated with bone metabolism, no published study has investigated the association between ALP and anemia. Furthermore, although ALP is known as an enzyme affected by alcohol consumption, there are no reports in the literature on associations between ALP and the risk of anemia in relation to drinking status. We conducted a cross-sectional study of 907 men aged 30-89 years undergoing a general health check-up to investigate the associations between ALP and anemia in relation to drinking status. Of the 907 participants, 120 men were diagnosed with anemia. The association between ALP and anemia was J-shaped. With the second quartile of ALP (194-228 IU/L) (Q2) as the reference group, the multivariable adjusted OR and 95%CI for anemia were 1.91 (95%CI: 0.96-3.82) for 277 IU/L (Q4). When the analysis was limited to non-drinkers, the associations became stronger with corresponding values of 3.34 (95%CI: 1.28-8.74), 3.18 (95%CI: 1.28-7.88) and 3.22 (95%CI:1.37-7.59). Not only lower but also higher levels of serum ALP are associated with anemia for men, especially non-drinkers. For analyses of associations between ALP and anemia, alcohol consumption should thus be considered a potential confounder
Regulation der Lebensdauer bei Arbeiterinnen der Honigbienen: Bedeutung der Brutpflege, des Nachwuchses und der Volksgrösse
No full textThe relationship between alkaline phosphatase (ALP, in U/L) and age (in months) of 64 Icelandic horses with a fitted geometric curve
No full text<p><b>Copyright information:</b></p><p>Taken from "Radiographic closure time of appendicular growth plates in the Icelandic horse"</p><p>http://www.actavetscand.com/content/49/1/19</p><p>Acta Veterinaria Scandinavica 2007;49(1):19-19.</p><p>Published online 17 Jul 2007</p><p>PMCID:PMC1950711.</p><p></p> The dotted line at the ALP-level of 242.5 U/L represents the mean ALP value of the control group of 11 horses, which were 7 to 16 years of age
Associations between alkaline phosphatase and hypertension in relation to circulating CD34-positive cell levels pertaining to elderly Japanese men
No full textSerum alkaline phosphatase (ALP) could be an indicator of osteoblastic activity, which initiates hematopoietic stem cell (CD34-positive cell) production in bone marrow. Since chronic inflammation, which is a known risk factor for hypertension and endothelium
dysfunction, stimulates bone marrow activity, ALP could be positively associated with hypertension. To clarify those associations, we conducted a cross-sectional study of 479 elderly Japanese men aged 60-69. Circulating CD34-positive cell levels could influence associations between serum ALP and hypertension because CD34-positive cell production is also a factor known to
contribute to endothelial repair. Therefore, participants were stratified by the median value of circulating CD34-positive cell levels (1.00 cells/μL). A low level of circulating CD34-positive cells was identified in 240 members of the study population. A significantly
positive association of ALP with hypertension was detected among participants with low circulating CD34-positive cell levels (multivariable-OR (odds ratio) for hypertension resulting from a 1 standard deviation (SD) increment in serum ALP (58.3 IU/L) = 1.44 (1.06, 1.95)) but not among those with high CD34-positive cell levels (multivariable-OR=0.91 (0.67, 1.23)). We also observed a significant effect of the interaction of circulating CD34-positive cell levels on the association between serum ALP and hypertension (multivariable p=0.011). Serum ALP was found to be positively associated with hypertension among elderly participants with low but not with high circulating CD34-positive cell levels. Since CD34-positive cells are a factor known to contribute to endothelial repair, capability for endothelial repair can be expected to have an effect on the association between serum ALP and hypertension
Pulse Electrodeposition of Copper-Zinc Coatings from an Alkaline Bath
No full textA copper-zinc bath containing EDTA was used for deposition of multi-functional copper-zinc coatings. Copper substrates were used for pulse electrodeposition of copper-zinc coating. Microhardness and wear resistance of copper-zinc coatings has been studied. The films were characterized by scanning electron microscopy and X-ray diffraction. EDS and EDS-dot mapping were also performed to analyse the amount and the distribution of Cu-Zn atoms
Leptonic meson decays into invisible ALP
No full textThe theoretical calculation of pseudo–scalar leptonic decay widths into an invisible ALP, M→ℓνℓa, is reviewed. Assuming generic flavor–conserving ALP couplings to SM fermions and a generic ALP mass, ma, the latest experimental results for pseudo–scalar leptonic decays are used to provide updated bounds on the ALP–fermion Lagrangian sector. Constrains on the ALP-quark couplings obtained from these channels are not yet competitive with the ones derived from FCNC processes, like M→Pa decays. These leptonic decays can, however, provide the most stringent model–independent upper bounds on ALP-leptons couplings for ma in the (sub)–GeV range
歯根膜線維芽細胞におけるsodium-dependent vitamin C transporter2の役割
No full text大阪歯科大学Osaka Dental University博士（歯学）"Aim: Ascorbic acid (AA) is a water-soluble vitamin that has antioxidant properties and regulates homeostasis of connective tissue through controlling various enzymatic activities. Two cell surface glycoproteins, sodium-dependent vitamin C transporter (SVCT) 1 and SVCT2, are known as ascorbate transporters. The purpose of this study was to investigate the expression pattern and functions of SVCTs in periodontal ligament (PDL) and PDL fibroblast (PDLF).
Methods: Gene expression was examined using real-time polymerase chain reaction (PCR) and reverse transcription PCR. SVCT2 expression was determined by immunofluorescence staining, western blot and flow cytometry. ALP activity and collagen production were examined using ALP staining and collagen staining. Short interfering RNA was used to knock down the gene level of SVCT2. Change of comprehensive gene expression under SVCT2 knockdown condition was examined by RNA-sequencing analysis.
Results: Real-time PCR, fluorescent immunostaining, western blot and flowy cytometry showed that SVCT2 was expressed in PDLF and PDL. ALP activity, collagen production, and SVCT2 expression were enhanced upon AA stimulation in PDLF. The enhancement of ALP activity, collagen production, and SVCT2 expression by AA was abolished under SVCT2 knockdown condition. RNA-sequencing revealed that gene expression of CLDN4, Cyclin E2, CAMK4, MSH5, DMC1, and Nidgen2 were changed by SVCT2 knockdown. Among them, the expression of MSH5 and DMC1, which are related to DNA damage sensor activity, was enhanced by AA, suggesting the new molecular target of AA in PDLF.
Conclusion: Our study reveals the SVCT2 expression in PDL and the pivotal role of SVCT2 in mediating AA-induced enhancements of ALP activity and collagen production in PDLF. Additionally, we identify alterations in gene expression profiles, highlighting potential molecular targets influenced by AA through SVCT2. These findings deepen our understanding of periodontal tissue homeostasis mechanisms and suggest promising intervention targeting AA metabolism."doctoral thesi
Beijing Unfinished Metropolis: Backdoors entry points to detect the multi-scalar perspective of the upcoming Chinese urban spaces
No full textExploring the intersection of architecture, urbanism, and cybersecurity, the concept of
architectural backdoors introduces architects and urban planners as "urban/archi-coders"
and proposes a novel approach to urban design. Inspired by digital security strategies,
where backdoors provide unconventional entry points to bypass security protocols, it
advocates for the speculative perception of cities as programmable entities composed of
layers where socio-spatial conditions define a complex palimpsest. 1 2
From theory to application, the method involves a framework that is not fixed but rather
iterative, adapting to specific urban contexts. The Chinese urban revolution serves as an
emblematic case study to assess the backdoor concept. Specifically, Chinese
metropolises are currently experiencing a slowdown in expansion projects, grappling with
zones encapsulated within the infrastructural network where construction has not been
completed. These areas are shaping a vast stock of unused built space, impacting local
communities, buyers, and investors, and falling short of governmental expectations.
These unfinished areas, flaws in traditional Chinese planning, require thorough
investigation to evaluate the implementation of urban design and governance tools for
contemporary Chinese cities in the post-pandemic era. In the past, assessing the
implementation of planning tools under market pressure revealed the necessity for
municipalities to place strategic plans alongside statutory procedures. Today, these
liminal spaces demand approaches where the neighbourhood scale, negotiation of local
conflicts, and resolution of specific issues cannot be addressed without dedicated new
public-private alliances and the development of processes that beyond the practices used
in the post-reform period.
The objective of this paper is to map Beijing through the lens of the unfinished. It explores
utilizing historical, statistical, and spatial data to re-code the urban environment by
identifying specific backdoor spaces for re-entry and exploiting the correlation between
design interventions and their long-term physical impacts
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