Osaka Dental University Academic Repository / 大阪歯科大学学術リポジトリ
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Area detection improves the person-based performance of a deep learning system for classifying the presence of carotid artery calcifications on panoramic radiographs.
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Differentiating odontogenic myxoma from ameloblastoma by focusing on cyst-like areas on MR images.
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齲蝕検知液を併用したEr:YAGレーザーによる齲蝕の選択的除去
Get PDF大阪歯科大学Osaka Dental University博士（歯学）To reduce the amount of tooth cutting during dental caries treatment, the improvement of dental caries-detecting liquid and development of apparatuses to selectively remove dental caries have been performed. We experimentally produced a dental caries-detecting liquid containing a compound with a primary amino group (HLA) to improve the absorptivity of the Er:YAG laser, and evaluated the removal efficiency of dyed artificial carious dentin irradiated by the laser. As a result, because the dental caries-detecting liquid containing HLA increased the laser absorptivity, as well as the depth of cavity preparation and volume of dentin removed by laser irradiation, the possibility of the selective removal of dental caries using a laser with a caries-detecting liquid containing the high laser-absorptive compound was suggesteddoctoral thesi
Environmental scanning electron microscopyおよびEnergy dispersive X-ray spectroscopyによる荷重前における上顎洞内移植骨の組織形態学的解析
Get PDF大阪歯科大学Osaka Dental University博士（歯学）This study aimed to analyze the morphology of bone graft granules, the presence of granule demineralization, and bone morphology in retrieved human maxillary sinus bone graft biopsies. Healthy patients underwent sinus bone augmentation using lateral access. Two different dimensions of the antrostomy were performed, a 4 mm or 8 mm height. After 6 months, all sites received one implant using a flap technique, crestal positioning, and submerged healing. Implant biopsies were retrieved after 3 months and were histologically processed. The ESEM analysis was performed on the entire portion of the peri-implant bone (up to 750 µm from the implant thread). Three different regions of interest (ROIs) were selected: the coronal, middle, and apical portions of the implant. In these areas, EDX was performed, and calcium (Ca), phosphate (P), nitrogen (N), and their atomic ratios (Ca/P, Ca/N, and P/N) were calculated. Different bone tissue electron-dense areas were detected through grayscale intensity quantification of ESEM images with different organic (N) or inorganic (Ca,P) compositions. A total of 16 biopsies from 16 healthy patients were analyzed. Bone graft granules were mostly detected in the apical ROI. New bone tissue bridges were detected in the apical and middle ROI. These structures, with lower Ca/N and P/N ratios, were connected and enveloped the bone graft granules. Cortical ROI revealed the most mineralized bone tissue. Conclusions: After 9 months, bone graft resorption was only partially completed and new bone tissue appeared less mineralized in the middle and apical ROI than in the coronal ROI.doctoral thesi
肥満２型糖尿病モデルラットにおける下顎第一臼歯舌側歯肉の形態学的研究
Get PDF大阪歯科大学Osaka Dental University博士（歯学）Obesity is a major risk factor for type 2 diabetes mellitus, and a bidirectional association between type 2 diabetes mellitus and periodontal disease has been established. However, morphological changes in the lingual gingiva of mandibular first molars in an obese type 2 diabetes mellitus environment in rat models remain poorly studied. In this study, we compared obese rat models of type 2 diabetes mellitus with normal rats to investigate morphological differences in the mucosal epithelium, subepithelial connective tissue, and microvascular architecture of the lingual gingiva. The obese type 2 diabetes mellitus group showed significant mucosal epithelial thickening, particularly in the keratinized and granular layers of the upper gingiva, with enhanced desquamability of superficial epithelial cells. Degenerative changes in the subepithelial connective tissue included fine wavy primary ridges and an increased number of secondary ridges. The microvascular architecture revealed significantly smaller capillary diameters and heterogeneous capillary networks. These findings suggest that the obese type 2 diabetes mellitus environment induces abnormal keratinization, enhanced epithelial desquamability, connective tissue degeneration, and vascular remodeling associated with microangiopathy, potentially affecting periodontal tissue homeostasis, as well as providing insights into the mechanisms of periodontal disease progression in diabetes and obesity.doctoral thesi
MDP/NOD2 enhances RANKL-induced osteoclast differentiation of RAW264.7 cells.
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Barrier effects of a poly (lactic acid/caprolactone) bilayer membrane for guided bone regeneration on skull without periosteum of adult-senior ataged rats.
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